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UniProtKB - Q9NP79 (VTA1_HUMAN)

Entry version 152 (13 Feb 2019)
Sequence version 1 (01 Oct 2000)
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Protein

Vacuolar protein sorting-associated protein VTA1 homolog

Gene

VTA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity). Involved in HIV-1 budding.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protein C-terminus binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

  • ESCRT III complex disassembly Source: ParkinsonsUK-UCL
  • macroautophagy Source: ParkinsonsUK-UCL
  • multivesicular body assembly Source: ParkinsonsUK-UCL
  • multivesicular body sorting pathway Source: UniProtKB
  • protein transport Source: UniProtKB-KW
  • viral budding Source: UniProtKB
  • viral life cycle Source: Reactome
View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-162588 Budding and maturation of HIV virion
R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein VTA1 homolog
Alternative name(s):
Dopamine-responsive gene 1 protein
Short name:
DRG-1
LYST-interacting protein 5
Short name:
LIP5
SKD1-binding protein 1
Short name:
SBP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VTA1
Synonyms:C6orf55
ORF Names:HSPC228, My012
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000009844.15

Human Gene Nomenclature Database

More...HGNCi		HGNC:20954 VTA1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		610902 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NP79

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		51534

Open Targets

More...OpenTargetsi		ENSG00000009844

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162408932

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		VTA1

Domain mapping of disease mutations (DMDM)

More...DMDMi		30580379

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000895092 – 307Vacuolar protein sorting-associated protein VTA1 homologAdd BLAST306

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9NP79

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NP79

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NP79

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NP79

PeptideAtlas

More...PeptideAtlasi		Q9NP79

PRoteomics IDEntifications database

More...PRIDEi		Q9NP79

ProteomicsDB human proteome resource

More...ProteomicsDBi		81922

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NP79

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NP79

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9NP79

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000009844 Expressed in 205 organ(s), highest expression level in amniotic fluid

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NP79 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NP79 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA030968
HPA030969

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with VPS4B. Interacts with CHMP1B. Interacts with CHMP2A; the interaction probably involves the open conformation of (polymerized) CHMP2A. Interacts with CHMP3. Interacts with CHMP5; the interaction involves soluble CHMP5. Interacts with IST1.6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
ZBTB16Q055163EBI-740160,EBI-711925

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		119595, 41 interactors

Protein interaction database and analysis system

More...IntActi		Q9NP79, 25 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000356602

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1307
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LXLNMR-A1-183[»]
2LXMNMR-A1-168[»]
4TXPX-ray3.01A/B/C1-162[»]
4TXQX-ray2.21A/B1-162[»]
4TXRX-ray1.00A1-162[»]
4U7EX-ray1.60B1-162[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q9NP79

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9NP79

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 186Interaction with IST1Add BLAST185
Regioni2 – 75Interaction with CHMP5Add BLAST74
Regioni198 – 307Interaction with VPS4BBy similarityAdd BLAST110

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the VTA1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0917 Eukaryota
ENOG4111H3M LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000011342

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000265547

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG050907

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NP79

KEGG Orthology (KO)

More...KOi		K12199

Identification of Orthologs from Complete Genome Data

More...OMAi		QTADTFQ

Database of Orthologous Groups

More...OrthoDBi		1450538at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NP79

TreeFam database of animal gene trees

More...TreeFami		TF105917

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.270, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR023175 VPS_Vta1/CALS_N
IPR039431 Vta1/CALS_N

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04652 Vta1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NP79-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAALAPLPPL PAQFKSIQHH LRTAQEHDKR DPVVAYYCRL YAMQTGMKID 
        60         70         80         90        100
SKTPECRKFL SKLMDQLEAL KKQLGDNEAI TQEIVGCAHL ENYALKMFLY 
       110        120        130        140        150
ADNEDRAGRF HKNMIKSFYT ASLLIDVITV FGELTDENVK HRKYARWKAT 
       160        170        180        190        200
YIHNCLKNGE TPQAGPVGIE EDNDIEENED AGAASLPTQP TQPSSSSTYD 
       210        220        230        240        250
PSNMPSGNYT GIQIPPGAHA PANTPAEVPH STGVASNTIQ PTPQTIPAID 
       260        270        280        290        300
PALFNTISQG DVRLTPEDFA RAQKYCKYAG SALQYEDVST AVQNLQKALK 

LLTTGRE
Length:307
Mass (Da):33,879
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC7DE611E50B58BF9
GO
Isoform 2 (identifier: Q9NP79-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-69: MAALAPLPPL...LSKLMDQLEA → MTSETLWWLIT
     234-260: Missing.

Show »
Length:222
Mass (Da):24,553
Checksum:iCEF86AF60A37B628
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WY55A0A087WY55_HUMAN
Chromosome 6 open reading frame 55,...
VTA1 C6orf55, hCG_18120
280Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5TGM0Q5TGM0_HUMAN
Vacuolar protein sorting-associated...
VTA1
249Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF36148 differs from that shown. Reason: Frameshift at positions 131 and 140.Curated
The sequence AAG43125 differs from that shown. Reason: Frameshift at position 269.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti14F → L in CAB66619 (PubMed:11230166).Curated1
Sequence conflicti155 – 156CL → V in AAF36148 (PubMed:11042152).Curated2
Sequence conflicti282A → V in BAG62917 (PubMed:14702039).Curated1
Sequence conflicti307E → D in CAG33488 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053917239I → M. Corresponds to variant dbSNP:rs2232307Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0567271 – 69MAALA…DQLEA → MTSETLWWLIT in isoform 2. 1 PublicationAdd BLAST69
Alternative sequenceiVSP_056728234 – 260Missing in isoform 2. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF271994 mRNA Translation: AAF76210.1
AF060225 mRNA Translation: AAG43125.1 Frameshift.
AF151062 mRNA Translation: AAF36148.1 Frameshift.
AL136684 mRNA Translation: CAB66619.1
AK000051 mRNA Translation: BAA90909.1
AK301376 mRNA Translation: BAG62917.1
CR457207 mRNA Translation: CAG33488.1
AL033522 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47883.1
CH471051 Genomic DNA Translation: EAW47885.1
BC005937 mRNA Translation: AAH05937.1
BC006989 mRNA Translation: AAH06989.1
BC022536 mRNA Translation: AAH22536.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS5197.1 [Q9NP79-1]
CCDS69214.1 [Q9NP79-2]

NCBI Reference Sequences

More...RefSeqi		NP_001273300.1, NM_001286371.1
NP_001273301.1, NM_001286372.1 [Q9NP79-2]
NP_057569.2, NM_016485.4 [Q9NP79-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.431367

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000367630; ENSP00000356602; ENSG00000009844 [Q9NP79-1]
ENST00000452973; ENSP00000395767; ENSG00000009844 [Q9NP79-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		51534

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:51534

UCSC genome browser

More...UCSCi		uc003qiw.5 human [Q9NP79-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF271994 mRNA Translation: AAF76210.1
AF060225 mRNA Translation: AAG43125.1 Frameshift.
AF151062 mRNA Translation: AAF36148.1 Frameshift.
AL136684 mRNA Translation: CAB66619.1
AK000051 mRNA Translation: BAA90909.1
AK301376 mRNA Translation: BAG62917.1
CR457207 mRNA Translation: CAG33488.1
AL033522 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47883.1
CH471051 Genomic DNA Translation: EAW47885.1
BC005937 mRNA Translation: AAH05937.1
BC006989 mRNA Translation: AAH06989.1
BC022536 mRNA Translation: AAH22536.1
CCDSiCCDS5197.1 [Q9NP79-1]
CCDS69214.1 [Q9NP79-2]
RefSeqiNP_001273300.1, NM_001286371.1
NP_001273301.1, NM_001286372.1 [Q9NP79-2]
NP_057569.2, NM_016485.4 [Q9NP79-1]
UniGeneiHs.431367

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LXLNMR-A1-183[»]
2LXMNMR-A1-168[»]
4TXPX-ray3.01A/B/C1-162[»]
4TXQX-ray2.21A/B1-162[»]
4TXRX-ray1.00A1-162[»]
4U7EX-ray1.60B1-162[»]
ProteinModelPortaliQ9NP79
SMRiQ9NP79
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119595, 41 interactors
IntActiQ9NP79, 25 interactors
STRINGi9606.ENSP00000356602

PTM databases

iPTMnetiQ9NP79
PhosphoSitePlusiQ9NP79
SwissPalmiQ9NP79

Polymorphism and mutation databases

BioMutaiVTA1
DMDMi30580379

Proteomic databases

EPDiQ9NP79
jPOSTiQ9NP79
MaxQBiQ9NP79
PaxDbiQ9NP79
PeptideAtlasiQ9NP79
PRIDEiQ9NP79
ProteomicsDBi81922

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		51534
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367630; ENSP00000356602; ENSG00000009844 [Q9NP79-1]
ENST00000452973; ENSP00000395767; ENSG00000009844 [Q9NP79-2]
GeneIDi51534
KEGGihsa:51534
UCSCiuc003qiw.5 human [Q9NP79-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		51534
DisGeNETi51534
EuPathDBiHostDB:ENSG00000009844.15

GeneCards: human genes, protein and diseases

More...GeneCardsi		VTA1

H-Invitational Database, human transcriptome db

More...H-InvDBi		HIX0006262
HGNCiHGNC:20954 VTA1
HPAiHPA030968
HPA030969
MIMi610902 gene
neXtProtiNX_Q9NP79
OpenTargetsiENSG00000009844
PharmGKBiPA162408932

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0917 Eukaryota
ENOG4111H3M LUCA
GeneTreeiENSGT00390000011342
HOGENOMiHOG000265547
HOVERGENiHBG050907
InParanoidiQ9NP79
KOiK12199
OMAiQTADTFQ
OrthoDBi1450538at2759
PhylomeDBiQ9NP79
TreeFamiTF105917

Enzyme and pathway databases

ReactomeiR-HSA-162588 Budding and maturation of HIV virion
R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT)

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		VTA1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		51534

Protein Ontology

More...PROi		PR:Q9NP79

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000009844 Expressed in 205 organ(s), highest expression level in amniotic fluid
ExpressionAtlasiQ9NP79 baseline and differential
GenevisibleiQ9NP79 HS

Family and domain databases

Gene3Di1.25.40.270, 1 hit
InterProiView protein in InterPro
IPR023175 VPS_Vta1/CALS_N
IPR039431 Vta1/CALS_N
PfamiView protein in Pfam
PF04652 Vta1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVTA1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NP79
Secondary accession number(s): B4DW55
, E1P594, E7ETQ7, Q5TGM1, Q6IAE8, Q9H0R2, Q9H3K9, Q9P0Q0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: October 1, 2000
Last modified: February 13, 2019
This is version 152 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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