VTA1

Functionⁱ

Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity). Involved in HIV-1 budding.By similarity1 Publication

GO - Molecular functionⁱ

protein C-terminus binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 18385515

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

ESCRT III complex disassembly
Source: ParkinsonsUK-UCL
Non-traceable author statementⁱ
- 20588296
macroautophagy
Source: ParkinsonsUK-UCL
Non-traceable author statementⁱ
- 20588296
multivesicular body assembly
Source: ParkinsonsUK-UCL
Non-traceable author statementⁱ
- 20588296
multivesicular body sorting pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15644320
protein transport Source: UniProtKB-KW
viral budding
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15644320
viral life cycle Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Protein transport, Transport

Biological process

Protein transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-162588 Budding and maturation of HIV virion R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT)

Reactomeⁱ

R-HSA-162588 Budding and maturation of HIV virion
R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT)

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Vacuolar protein sorting-associated protein VTA1 homolog Alternative name(s): Dopamine-responsive gene 1 protein Short name: DRG-1 LYST-interacting protein 5 Short name: LIP5 SKD1-binding protein 1 Short name: SBP1
Gene namesⁱ	Name:VTA1 Synonyms:C6orf55 ORF Names:HSPC228, My012
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000009844.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:20954 VTA1
MIMⁱ	610902 gene
neXtProtⁱ	NX_Q9NP79

Keywords - Cellular componentⁱ

Cytoplasm, Endosome, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	51534
Open Targets More...OpenTargetsⁱ	ENSG00000009844
PharmGKBⁱ	PA162408932

Polymorphism and mutation databases

DMDMⁱ	30580379

DMDMⁱ

30580379

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources1 Publication
ChainⁱPRO_0000089509	2 – 307	Vacuolar protein sorting-associated protein VTA1 homologAdd BLAST		306

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylalanineCombined sources1 Publication		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	Q9NP79
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NP79
PaxDbⁱ	Q9NP79
PeptideAtlas More...PeptideAtlasⁱ	Q9NP79
PRIDEⁱ	Q9NP79
ProteomicsDBⁱ	81922

PTM databases

iPTMnetⁱ	Q9NP79
PhosphoSitePlusⁱ	Q9NP79
SwissPalmⁱ	Q9NP79

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000009844 Expressed in 205 organ(s), highest expression level in amniotic fluid
CleanExⁱ	HS_VTA1
ExpressionAtlasⁱ	Q9NP79 baseline and differential
Genevisibleⁱ	Q9NP79 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA030968 HPA030969

HPAⁱ

HPA030968
HPA030969

Interactionⁱ

Subunit structureⁱ

Interacts with VPS4B. Interacts with CHMP1B. Interacts with CHMP2A; the interaction probably involves the open conformation of (polymerized) CHMP2A. Interacts with CHMP3. Interacts with CHMP5; the interaction involves soluble CHMP5. Interacts with IST1.6 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
ZBTB16	Q05516	3	EBI-740160,EBI-711925

With

Entry

#Exp.

IntAct

Notes

ZBTB16

Q05516

3

EBI-740160,EBI-711925

GO - Molecular functionⁱ

protein C-terminus binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 18385515

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	119595, 41 interactors
IntActⁱ	Q9NP79, 25 interactors
STRINGⁱ	9606.ENSP00000356602

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	2 – 4	Combined sources	3
Helixⁱ	12 – 17	Combined sources	6
Helixⁱ	18 – 26	Combined sources	9
Turnⁱ	27 – 30	Combined sources	4
Helixⁱ	32 – 49	Combined sources	18
Beta strandⁱ	51 – 53	Combined sources	3
Helixⁱ	54 – 73	Combined sources	20
Turnⁱ	74 – 76	Combined sources	3
Helixⁱ	78 – 81	Combined sources	4
Helixⁱ	83 – 106	Combined sources	24
Helixⁱ	112 – 128	Combined sources	17
Helixⁱ	129 – 131	Combined sources	3
Helixⁱ	136 – 158	Combined sources	23

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9NP79
SMRⁱ	Q9NP79
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	2 – 186	Interaction with IST1Add BLAST	185
Regionⁱ	2 – 75	Interaction with CHMP5Add BLAST	74
Regionⁱ	198 – 307	Interaction with VPS4BBy similarityAdd BLAST	110

Sequence similaritiesⁱ

Belongs to the VTA1 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0917 Eukaryota ENOG4111H3M LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011342
HOGENOMⁱ	HOG000265547
HOVERGENⁱ	HBG050907
InParanoidⁱ	Q9NP79
KEGG Orthology (KO) More...KOⁱ	K12199
OMAⁱ	QTADTFQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0QW9
PhylomeDBⁱ	Q9NP79
TreeFamⁱ	TF105917

Family and domain databases

Gene3Dⁱ	1.25.40.270, 1 hit
InterProⁱ	View protein in InterPro IPR023175 VPS_Vta1/CALS_N IPR039431 Vta1/CALS_N
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04652 Vta1, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9NP79-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAALAPLPPL PAQFKSIQHH LRTAQEHDKR DPVVAYYCRL YAMQTGMKID 
        60         70         80         90        100
SKTPECRKFL SKLMDQLEAL KKQLGDNEAI TQEIVGCAHL ENYALKMFLY 
       110        120        130        140        150
ADNEDRAGRF HKNMIKSFYT ASLLIDVITV FGELTDENVK HRKYARWKAT 
       160        170        180        190        200
YIHNCLKNGE TPQAGPVGIE EDNDIEENED AGAASLPTQP TQPSSSSTYD 
       210        220        230        240        250
PSNMPSGNYT GIQIPPGAHA PANTPAEVPH STGVASNTIQ PTPQTIPAID 
       260        270        280        290        300
PALFNTISQG DVRLTPEDFA RAQKYCKYAG SALQYEDVST AVQNLQKALK 

LLTTGRE

Length:307

Mass (Da):33,879

Last modified:October 1, 2000 - v1

Checksum:ⁱC7DE611E50B58BF9

GO

Isoform 2 (identifier: Q9NP79-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-69: MAALAPLPPL...LSKLMDQLEA → MTSETLWWLIT
234-260: Missing.

« Hide

        10         20         30         40         50
MTSETLWWLI TLKKQLGDNE AITQEIVGCA HLENYALKMF LYADNEDRAG 
        60         70         80         90        100
RFHKNMIKSF YTASLLIDVI TVFGELTDEN VKHRKYARWK ATYIHNCLKN 
       110        120        130        140        150
GETPQAGPVG IEEDNDIEEN EDAGAASLPT QPTQPSSSST YDPSNMPSGN 
       160        170        180        190        200
YTGIQIPPGA HAPANTPAEV PHSTGDVRLT PEDFARAQKY CKYAGSALQY 
       210        220 
EDVSTAVQNL QKALKLLTTG RE

Show »

Length:222

Mass (Da):24,553

Checksum:ⁱCEF86AF60A37B628

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A087WY55	A0A087WY55_HUMAN	Chromosome 6 open reading frame 55,... Chromosome 6 open reading frame 55, isoform CRA_b (Vacuolar protein sorting-associated protein VTA1 homolog)	VTA1 C6orf55, hCG_18120	280	Annotation score:
Q5TGM0	Q5TGM0_HUMAN	Vacuolar protein sorting-associated... Vacuolar protein sorting-associated protein VTA1 homolog	VTA1	249	Annotation score:

Sequence cautionⁱ

The sequence AAF36148 differs from that shown. Reason: Frameshift at positions 131 and 140.Curated

The sequence AAG43125 differs from that shown. Reason: Frameshift at position 269.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	14	F → L in CAB66619 (PubMed:11230166).Curated	1
Sequence conflictⁱ	155 – 156	CL → V in AAF36148 (PubMed:11042152).Curated	2
Sequence conflictⁱ	282	A → V in BAG62917 (PubMed:14702039).Curated	1
Sequence conflictⁱ	307	E → D in CAG33488 (Ref. 6) Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_053917	239	I → M. Corresponds to variant dbSNP:rs2232307Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056727	1 – 69	MAALA…DQLEA → MTSETLWWLIT in isoform 2. 1 PublicationAdd BLAST		69
Alternative sequenceⁱVSP_056728	234 – 260	Missing in isoform 2. 1 PublicationAdd BLAST		27

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF271994 mRNA Translation: AAF76210.1 AF060225 mRNA Translation: AAG43125.1 Frameshift. AF151062 mRNA Translation: AAF36148.1 Frameshift. AL136684 mRNA Translation: CAB66619.1 AK000051 mRNA Translation: BAA90909.1 AK301376 mRNA Translation: BAG62917.1 CR457207 mRNA Translation: CAG33488.1 AL033522 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW47883.1 CH471051 Genomic DNA Translation: EAW47885.1 BC005937 mRNA Translation: AAH05937.1 BC006989 mRNA Translation: AAH06989.1 BC022536 mRNA Translation: AAH22536.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5197.1 [Q9NP79-1] CCDS69214.1 [Q9NP79-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001273300.1, NM_001286371.1 NP_001273301.1, NM_001286372.1 [Q9NP79-2] NP_057569.2, NM_016485.4 [Q9NP79-1]
UniGeneⁱ	Hs.431367

Genome annotation databases

Ensemblⁱ	ENST00000367630; ENSP00000356602; ENSG00000009844 [Q9NP79-1] ENST00000452973; ENSP00000395767; ENSG00000009844 [Q9NP79-2]
GeneIDⁱ	51534
KEGGⁱ	hsa:51534
UCSC genome browser More...UCSCⁱ	uc003qiw.5 human [Q9NP79-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NP79	VTA1 isoform 1		PANTR		307	UniRef100_Q9NP79
Uncharacterized protein		PANPA		307
UPI00029DD288		HUMAN		183
Q9NP79-2	VTA1 isoform 3		PANTR		222	UniRef100_A0A2J8PSG9

Protein	Similar proteins		Species	Score	Length	Source
Q9NP79	Vacuolar protein sorting-associated protein VTA1 homolog		MOUSE		309	UniRef90_Q9NP79
Vacuolar protein sorting-associated protein VTA1 homolog		BOVIN		307
Vacuolar protein sorting-associated protein VTA1 homolog		PONAB		307
VTA1 isoform 1		PANTR		307
Uncharacterized protein		PANPA		307
+135
Q9NP79-2	vacuolar protein sorting-associated protein VTA1 homolog isoform X4		ODORO		221	UniRef90_A0A2U3ZDH0
VTA1 isoform 2		PONAB		222
VTA1 isoform 3		PANTR		222
vacuolar protein sorting-associated protein VTA1 homolog isoform X2		LEPWE		221
vacuolar protein sorting-associated protein VTA1 homolog isoform X2		LIPVE		221
+5

Protein	Similar proteins		Species	Score	Length	Source
Q9NP79	Vacuolar protein sorting-associated protein VTA1 homolog		MOUSE		309	UniRef50_Q9NP79
Vacuolar protein sorting-associated protein VTA1 homolog		PONAB		307
Vacuolar protein sorting-associated protein VTA1 homolog		BOVIN		307
VTA1 isoform 1		PANTR		307
Uncharacterized protein		PANPA		307
+374
Q9NP79-2	Uncharacterized protein		PROCO		254	UniRef50_A0A2K6FE27
VTA1 isoform 3		PANTR		222
VTA1 isoform 2		PONAB		222
vacuolar protein sorting-associated protein VTA1 homolog isoform X4		ODORO		221
vacuolar protein sorting-associated protein VTA1 homolog isoform X2		LEPWE		221
+8

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF271994 mRNA Translation: AAF76210.1 AF060225 mRNA Translation: AAG43125.1 Frameshift. AF151062 mRNA Translation: AAF36148.1 Frameshift. AL136684 mRNA Translation: CAB66619.1 AK000051 mRNA Translation: BAA90909.1 AK301376 mRNA Translation: BAG62917.1 CR457207 mRNA Translation: CAG33488.1 AL033522 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW47883.1 CH471051 Genomic DNA Translation: EAW47885.1 BC005937 mRNA Translation: AAH05937.1 BC006989 mRNA Translation: AAH06989.1 BC022536 mRNA Translation: AAH22536.1
CCDSⁱ	CCDS5197.1 [Q9NP79-1] CCDS69214.1 [Q9NP79-2]
RefSeqⁱ	NP_001273300.1, NM_001286371.1 NP_001273301.1, NM_001286372.1 [Q9NP79-2] NP_057569.2, NM_016485.4 [Q9NP79-1]
UniGeneⁱ	Hs.431367

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2LXL	NMR	-	A	1-183	[»]
	2LXM	NMR	-	A	1-168	[»]
	4TXP	X-ray	3.01	A/B/C	1-162	[»]
	4TXQ	X-ray	2.21	A/B	1-162	[»]
	4TXR	X-ray	1.00	A	1-162	[»]
	4U7E	X-ray	1.60	B	1-162	[»]
ProteinModelPortalⁱ	Q9NP79
SMRⁱ	Q9NP79
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119595, 41 interactors
IntActⁱ	Q9NP79, 25 interactors
STRINGⁱ	9606.ENSP00000356602

PTM databases

iPTMnetⁱ	Q9NP79
PhosphoSitePlusⁱ	Q9NP79
SwissPalmⁱ	Q9NP79

Polymorphism and mutation databases

DMDMⁱ	30580379

DMDMⁱ

30580379

Proteomic databases

EPDⁱ	Q9NP79
MaxQBⁱ	Q9NP79
PaxDbⁱ	Q9NP79
PeptideAtlasⁱ	Q9NP79
PRIDEⁱ	Q9NP79
ProteomicsDBⁱ	81922

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	51534
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000367630; ENSP00000356602; ENSG00000009844 [Q9NP79-1] ENST00000452973; ENSP00000395767; ENSG00000009844 [Q9NP79-2]
GeneIDⁱ	51534
KEGGⁱ	hsa:51534
UCSCⁱ	uc003qiw.5 human [Q9NP79-1]

Organism-specific databases

CTDⁱ	51534
DisGeNETⁱ	51534
EuPathDBⁱ	HostDB:ENSG00000009844.15
GeneCardsⁱ	VTA1
H-InvDBⁱ	HIX0006262
HGNCⁱ	HGNC:20954 VTA1
HPAⁱ	HPA030968 HPA030969
MIMⁱ	610902 gene
neXtProtⁱ	NX_Q9NP79
OpenTargetsⁱ	ENSG00000009844
PharmGKBⁱ	PA162408932
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0917 Eukaryota ENOG4111H3M LUCA
GeneTreeⁱ	ENSGT00390000011342
HOGENOMⁱ	HOG000265547
HOVERGENⁱ	HBG050907
InParanoidⁱ	Q9NP79
KOⁱ	K12199
OMAⁱ	QTADTFQ
OrthoDBⁱ	EOG091G0QW9
PhylomeDBⁱ	Q9NP79
TreeFamⁱ	TF105917

Enzyme and pathway databases

Reactomeⁱ	R-HSA-162588 Budding and maturation of HIV virion R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT)

Reactomeⁱ

R-HSA-162588 Budding and maturation of HIV virion
R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT)

Miscellaneous databases

GeneWikiⁱ	VTA1
GenomeRNAiⁱ	51534
Protein Ontology More...PROⁱ	PR:Q9NP79
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000009844 Expressed in 205 organ(s), highest expression level in amniotic fluid
CleanExⁱ	HS_VTA1
ExpressionAtlasⁱ	Q9NP79 baseline and differential
Genevisibleⁱ	Q9NP79 HS

Family and domain databases

Gene3Dⁱ	1.25.40.270, 1 hit
InterProⁱ	View protein in InterPro IPR023175 VPS_Vta1/CALS_N IPR039431 Vta1/CALS_N
Pfamⁱ	View protein in Pfam PF04652 Vta1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	VTA1_HUMAN
Accessionⁱ	Q9NP79Primary (citable) accession number: Q9NP79 Secondary accession number(s): B4DW55 Q9P0Q0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 9, 2003
	Last sequence update:	October 1, 2000
	Last modified:	October 10, 2018
	This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM

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UniProtKB - Q9NP79 (VTA1_HUMAN)

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Vacuolar protein sorting-associated protein VTA1 homolog

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endosome

Other locations

Cytosol

Endosome

Extracellular region or secreted

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

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