UniProtKB - Q9NP79 (VTA1_HUMAN)
Vacuolar protein sorting-associated protein VTA1 homolog
VTA1
Functioni
GO - Molecular functioni
- protein C-terminus binding Source: UniProtKB
GO - Biological processi
- endosomal transport Source: Reactome
- ESCRT III complex disassembly Source: ParkinsonsUK-UCL
- late endosome to vacuole transport via multivesicular body sorting pathway Source: GO_Central
- macroautophagy Source: ParkinsonsUK-UCL
- multivesicular body assembly Source: ParkinsonsUK-UCL
- multivesicular body sorting pathway Source: UniProtKB
- protein transport Source: UniProtKB-KW
- viral budding Source: UniProtKB
- viral life cycle Source: Reactome
Keywordsi
Biological process | Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q9NP79 |
Reactomei | R-HSA-162588, Budding and maturation of HIV virion R-HSA-917729, Endosomal Sorting Complex Required For Transport (ESCRT) |
Names & Taxonomyi
Protein namesi | Recommended name: Vacuolar protein sorting-associated protein VTA1 homologAlternative name(s): Dopamine-responsive gene 1 protein Short name: DRG-1 LYST-interacting protein 5 Short name: LIP5 SKD1-binding protein 1 Short name: SBP1 |
Gene namesi | Name:VTA1 Synonyms:C6orf55 ORF Names:HSPC228, My012 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20954, VTA1 |
MIMi | 610902, gene |
neXtProti | NX_Q9NP79 |
VEuPathDBi | HostDB:ENSG00000009844.15 |
Subcellular locationi
Endosome
- Endosome membrane 1 Publication; Peripheral membrane protein 1 Publication
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Cytosol
- cytosol Source: UniProtKB
Endosome
- endosome membrane Source: UniProtKB-SubCell
- multivesicular body Source: GO_Central
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleoplasm Source: HPA
Other locations
- intracellular membrane-bounded organelle Source: HPA
Keywords - Cellular componenti
Cytoplasm, Endosome, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 51534 |
OpenTargetsi | ENSG00000009844 |
PharmGKBi | PA162408932 |
Miscellaneous databases
Pharosi | Q9NP79, Tbio |
Genetic variation databases
BioMutai | VTA1 |
DMDMi | 30580379 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
ChainiPRO_0000089509 | 2 – 307 | Vacuolar protein sorting-associated protein VTA1 homologAdd BLAST | 306 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources1 Publication | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q9NP79 |
jPOSTi | Q9NP79 |
MassIVEi | Q9NP79 |
MaxQBi | Q9NP79 |
PaxDbi | Q9NP79 |
PeptideAtlasi | Q9NP79 |
PRIDEi | Q9NP79 |
ProteomicsDBi | 18265 81922 [Q9NP79-1] |
PTM databases
iPTMneti | Q9NP79 |
MetOSitei | Q9NP79 |
PhosphoSitePlusi | Q9NP79 |
SwissPalmi | Q9NP79 |
Expressioni
Gene expression databases
Bgeei | ENSG00000009844, Expressed in cortical plate and 220 other tissues |
ExpressionAtlasi | Q9NP79, baseline and differential |
Genevisiblei | Q9NP79, HS |
Organism-specific databases
HPAi | ENSG00000009844, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with VPS4B.
Interacts with CHMP1B.
Interacts with CHMP2A; the interaction probably involves the open conformation of (polymerized) CHMP2A.
Interacts with CHMP3.
Interacts with CHMP5; the interaction involves soluble CHMP5.
Interacts with IST1.
6 PublicationsBinary interactionsi
Hide detailsQ9NP79
GO - Molecular functioni
- protein C-terminus binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 119595, 51 interactors |
IntActi | Q9NP79, 33 interactors |
STRINGi | 9606.ENSP00000356602 |
Miscellaneous databases
RNActi | Q9NP79, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q9NP79 |
SMRi | Q9NP79 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 2 – 186 | Interaction with IST1Add BLAST | 185 | |
Regioni | 2 – 75 | Interaction with CHMP5Add BLAST | 74 | |
Regioni | 198 – 307 | Interaction with VPS4BBy similarityAdd BLAST | 110 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0917, Eukaryota |
GeneTreei | ENSGT00390000011342 |
HOGENOMi | CLU_030378_1_1_1 |
InParanoidi | Q9NP79 |
OMAi | QTADTFQ |
OrthoDBi | 1450538at2759 |
PhylomeDBi | Q9NP79 |
TreeFami | TF105917 |
Family and domain databases
Gene3Di | 1.25.40.270, 1 hit |
InterProi | View protein in InterPro IPR023175, VPS_Vta1/CALS_N IPR044538, Vta1-like IPR039431, Vta1/CALS_N IPR041212, Vta1_C |
PANTHERi | PTHR46009, PTHR46009, 1 hit |
Pfami | View protein in Pfam PF04652, Vta1, 1 hit PF18097, Vta1_C, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAALAPLPPL PAQFKSIQHH LRTAQEHDKR DPVVAYYCRL YAMQTGMKID
60 70 80 90 100
SKTPECRKFL SKLMDQLEAL KKQLGDNEAI TQEIVGCAHL ENYALKMFLY
110 120 130 140 150
ADNEDRAGRF HKNMIKSFYT ASLLIDVITV FGELTDENVK HRKYARWKAT
160 170 180 190 200
YIHNCLKNGE TPQAGPVGIE EDNDIEENED AGAASLPTQP TQPSSSSTYD
210 220 230 240 250
PSNMPSGNYT GIQIPPGAHA PANTPAEVPH STGVASNTIQ PTPQTIPAID
260 270 280 290 300
PALFNTISQG DVRLTPEDFA RAQKYCKYAG SALQYEDVST AVQNLQKALK
LLTTGRE
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WY55 | A0A087WY55_HUMAN | Chromosome 6 open reading frame 55,... | VTA1 C6orf55, hCG_18120 | 280 | Annotation score: | ||
Q5TGM0 | Q5TGM0_HUMAN | Vacuolar protein sorting-associated... | VTA1 | 249 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 14 | F → L in CAB66619 (PubMed:11230166).Curated | 1 | |
Sequence conflicti | 155 – 156 | CL → V in AAF36148 (PubMed:11042152).Curated | 2 | |
Sequence conflicti | 282 | A → V in BAG62917 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 307 | E → D in CAG33488 (Ref. 6) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053917 | 239 | I → M. Corresponds to variant dbSNP:rs2232307Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056727 | 1 – 69 | MAALA…DQLEA → MTSETLWWLIT in isoform 2. 1 PublicationAdd BLAST | 69 | |
Alternative sequenceiVSP_056728 | 234 – 260 | Missing in isoform 2. 1 PublicationAdd BLAST | 27 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF271994 mRNA Translation: AAF76210.1 AF060225 mRNA Translation: AAG43125.1 Frameshift. AF151062 mRNA Translation: AAF36148.1 Frameshift. AL136684 mRNA Translation: CAB66619.1 AK000051 mRNA Translation: BAA90909.1 AK301376 mRNA Translation: BAG62917.1 CR457207 mRNA Translation: CAG33488.1 AL033522 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW47883.1 CH471051 Genomic DNA Translation: EAW47885.1 BC005937 mRNA Translation: AAH05937.1 BC006989 mRNA Translation: AAH06989.1 BC022536 mRNA Translation: AAH22536.1 |
CCDSi | CCDS5197.1 [Q9NP79-1] CCDS69214.1 [Q9NP79-2] |
RefSeqi | NP_001273300.1, NM_001286371.1 NP_001273301.1, NM_001286372.1 [Q9NP79-2] NP_057569.2, NM_016485.4 [Q9NP79-1] |
Genome annotation databases
Ensembli | ENST00000367630; ENSP00000356602; ENSG00000009844 [Q9NP79-1] ENST00000452973; ENSP00000395767; ENSG00000009844 [Q9NP79-2] |
GeneIDi | 51534 |
KEGGi | hsa:51534 |
UCSCi | uc003qiw.5, human [Q9NP79-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF271994 mRNA Translation: AAF76210.1 AF060225 mRNA Translation: AAG43125.1 Frameshift. AF151062 mRNA Translation: AAF36148.1 Frameshift. AL136684 mRNA Translation: CAB66619.1 AK000051 mRNA Translation: BAA90909.1 AK301376 mRNA Translation: BAG62917.1 CR457207 mRNA Translation: CAG33488.1 AL033522 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW47883.1 CH471051 Genomic DNA Translation: EAW47885.1 BC005937 mRNA Translation: AAH05937.1 BC006989 mRNA Translation: AAH06989.1 BC022536 mRNA Translation: AAH22536.1 |
CCDSi | CCDS5197.1 [Q9NP79-1] CCDS69214.1 [Q9NP79-2] |
RefSeqi | NP_001273300.1, NM_001286371.1 NP_001273301.1, NM_001286372.1 [Q9NP79-2] NP_057569.2, NM_016485.4 [Q9NP79-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2LXL | NMR | - | A | 1-183 | [»] | |
2LXM | NMR | - | A | 1-168 | [»] | |
4TXP | X-ray | 3.01 | A/B/C | 1-162 | [»] | |
4TXQ | X-ray | 2.21 | A/B | 1-162 | [»] | |
4TXR | X-ray | 1.00 | A | 1-162 | [»] | |
4U7E | X-ray | 1.60 | B | 1-162 | [»] | |
BMRBi | Q9NP79 | |||||
SMRi | Q9NP79 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119595, 51 interactors |
IntActi | Q9NP79, 33 interactors |
STRINGi | 9606.ENSP00000356602 |
PTM databases
iPTMneti | Q9NP79 |
MetOSitei | Q9NP79 |
PhosphoSitePlusi | Q9NP79 |
SwissPalmi | Q9NP79 |
Genetic variation databases
BioMutai | VTA1 |
DMDMi | 30580379 |
Proteomic databases
EPDi | Q9NP79 |
jPOSTi | Q9NP79 |
MassIVEi | Q9NP79 |
MaxQBi | Q9NP79 |
PaxDbi | Q9NP79 |
PeptideAtlasi | Q9NP79 |
PRIDEi | Q9NP79 |
ProteomicsDBi | 18265 81922 [Q9NP79-1] |
Protocols and materials databases
Antibodypediai | 33094, 126 antibodies |
DNASUi | 51534 |
Genome annotation databases
Ensembli | ENST00000367630; ENSP00000356602; ENSG00000009844 [Q9NP79-1] ENST00000452973; ENSP00000395767; ENSG00000009844 [Q9NP79-2] |
GeneIDi | 51534 |
KEGGi | hsa:51534 |
UCSCi | uc003qiw.5, human [Q9NP79-1] |
Organism-specific databases
CTDi | 51534 |
DisGeNETi | 51534 |
GeneCardsi | VTA1 |
HGNCi | HGNC:20954, VTA1 |
HPAi | ENSG00000009844, Low tissue specificity |
MIMi | 610902, gene |
neXtProti | NX_Q9NP79 |
OpenTargetsi | ENSG00000009844 |
PharmGKBi | PA162408932 |
VEuPathDBi | HostDB:ENSG00000009844.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0917, Eukaryota |
GeneTreei | ENSGT00390000011342 |
HOGENOMi | CLU_030378_1_1_1 |
InParanoidi | Q9NP79 |
OMAi | QTADTFQ |
OrthoDBi | 1450538at2759 |
PhylomeDBi | Q9NP79 |
TreeFami | TF105917 |
Enzyme and pathway databases
PathwayCommonsi | Q9NP79 |
Reactomei | R-HSA-162588, Budding and maturation of HIV virion R-HSA-917729, Endosomal Sorting Complex Required For Transport (ESCRT) |
Miscellaneous databases
BioGRID-ORCSi | 51534, 32 hits in 997 CRISPR screens |
ChiTaRSi | VTA1, human |
GeneWikii | VTA1 |
GenomeRNAii | 51534 |
Pharosi | Q9NP79, Tbio |
PROi | PR:Q9NP79 |
RNActi | Q9NP79, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000009844, Expressed in cortical plate and 220 other tissues |
ExpressionAtlasi | Q9NP79, baseline and differential |
Genevisiblei | Q9NP79, HS |
Family and domain databases
Gene3Di | 1.25.40.270, 1 hit |
InterProi | View protein in InterPro IPR023175, VPS_Vta1/CALS_N IPR044538, Vta1-like IPR039431, Vta1/CALS_N IPR041212, Vta1_C |
PANTHERi | PTHR46009, PTHR46009, 1 hit |
Pfami | View protein in Pfam PF04652, Vta1, 1 hit PF18097, Vta1_C, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VTA1_HUMAN | |
Accessioni | Q9NP79Primary (citable) accession number: Q9NP79 Secondary accession number(s): B4DW55 Q9P0Q0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 9, 2003 |
Last sequence update: | October 1, 2000 | |
Last modified: | April 7, 2021 | |
This is version 167 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families