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Entry version 146 (18 Sep 2019)
Sequence version 1 (01 Oct 2000)
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Protein

RNA polymerase II subunit A C-terminal domain phosphatase SSU72

Gene

SSU72

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processmRNA processing

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6807505 RNA polymerase II transcribes snRNA genes

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9NP77

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (EC:3.1.3.16)
Short name:
CTD phosphatase SSU72
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SSU72
ORF Names:HSPC182, PNAS-120
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25016 SSU72

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617680 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NP77

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi12C → S: Abolishes phosphatase activity. 1 Publication1

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000160075

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670866

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NP77

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3317331

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SSU72

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74752877

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003300121 – 194RNA polymerase II subunit A C-terminal domain phosphatase SSU72Add BLAST194

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NP77

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NP77

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NP77

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NP77

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NP77

PeptideAtlas

More...
PeptideAtlasi
Q9NP77

PRoteomics IDEntifications database

More...
PRIDEi
Q9NP77

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
81915 [Q9NP77-1]
81916 [Q9NP77-2]

PTM databases

DEPOD human dephosphorylation database

More...
DEPODi
Q9NP77

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NP77

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NP77

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000160075 Expressed in 199 organ(s), highest expression level in parotid gland

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NP77 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA069290
HPA070604

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with GTF2B (via C-terminus); this interaction is inhibited by SYMPK (PubMed:15659578, PubMed:29158257).

Interacts with RB1 (PubMed:15659578).

Interacts with CD226 (PubMed:15659578).

Interacts with SYMPK (PubMed:20861839, PubMed:23070812).

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
118869, 46 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9NP77

Database of interacting proteins

More...
DIPi
DIP-53666N

Protein interaction database and analysis system

More...
IntActi
Q9NP77, 11 interactors

Molecular INTeraction database

More...
MINTi
Q9NP77

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000291386

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9NP77

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1194
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NP77

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9NP77

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili160 – 186Sequence analysisAdd BLAST27

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SSU72 phosphatase family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2424 Eukaryota
COG5211 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000010165

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000183445

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NP77

KEGG Orthology (KO)

More...
KOi
K15544

Identification of Orthologs from Complete Genome Data

More...
OMAi
PNCYEFG

Database of Orthologous Groups

More...
OrthoDBi
1304061at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NP77

TreeFam database of animal gene trees

More...
TreeFami
TF300194

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006811 RNA_pol_II_suA

The PANTHER Classification System

More...
PANTHERi
PTHR20383 PTHR20383, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04722 Ssu72, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9NP77-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPSSPLRVAV VCSSNQNRSM EAHNILSKRG FSVRSFGTGT HVKLPGPAPD
60 70 80 90 100
KPNVYDFKTT YDQMYNDLLR KDKELYTQNG ILHMLDRNKR IKPRPERFQN
110 120 130 140 150
CKDLFDLILT CEERVYDQVV EDLNSREQET CQPVHVVNVD IQDNHEEATL
160 170 180 190
GAFLICELCQ CIQHTEDMEN EIDELLQEFE EKSGRTFLHT VCFY
Length:194
Mass (Da):22,574
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCA3A3157A2388A77
GO
Isoform 2 (identifier: Q9NP77-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-194: TQNGILHMLD...RTFLHTVCFY → PSGLPFKNPP...RRTDTVWGSP

Show »
Length:153
Mass (Da):16,931
Checksum:i5451647A082E9559
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti182 – 183KS → RV in AAK07538 (Ref. 3) Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03300577 – 194TQNGI…TVCFY → PSGLPFKNPPCGPPWKVLRV ARAQEACHPVQCTHWLLCLC ESLVSIPGARRIVHGLVPVP PMAVGVVRRTDTVWGSP in isoform 2. CuratedAdd BLAST118

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF161530 mRNA Translation: AAF29145.1
AF277178 mRNA Translation: AAK07538.1
AJ276409 mRNA Translation: CAC81713.1
AK001809 mRNA Translation: BAA91921.1
AK023110 mRNA Translation: BAB14410.1
AK291324 mRNA Translation: BAF84013.1
AL645728 Genomic DNA No translation available.
CH471183 Genomic DNA Translation: EAW56182.1
CH471183 Genomic DNA Translation: EAW56183.1
BC008070 mRNA Translation: AAH08070.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS32.1 [Q9NP77-1]

NCBI Reference Sequences

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RefSeqi
NP_054907.1, NM_014188.2 [Q9NP77-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000291386; ENSP00000291386; ENSG00000160075 [Q9NP77-1]
ENST00000359060; ENSP00000351955; ENSG00000160075 [Q9NP77-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
29101

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:29101

UCSC genome browser

More...
UCSCi
uc001agd.4 human [Q9NP77-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161530 mRNA Translation: AAF29145.1
AF277178 mRNA Translation: AAK07538.1
AJ276409 mRNA Translation: CAC81713.1
AK001809 mRNA Translation: BAA91921.1
AK023110 mRNA Translation: BAB14410.1
AK291324 mRNA Translation: BAF84013.1
AL645728 Genomic DNA No translation available.
CH471183 Genomic DNA Translation: EAW56182.1
CH471183 Genomic DNA Translation: EAW56183.1
BC008070 mRNA Translation: AAH08070.1
CCDSiCCDS32.1 [Q9NP77-1]
RefSeqiNP_054907.1, NM_014188.2 [Q9NP77-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3O2QX-ray2.40B/E1-194[»]
3O2SX-ray2.50B1-194[»]
4H3HX-ray2.20B/E1-194[»]
4H3KX-ray2.00B/E1-194[»]
SMRiQ9NP77
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi118869, 46 interactors
CORUMiQ9NP77
DIPiDIP-53666N
IntActiQ9NP77, 11 interactors
MINTiQ9NP77
STRINGi9606.ENSP00000291386

Chemistry databases

BindingDBiQ9NP77
ChEMBLiCHEMBL3317331

PTM databases

DEPODiQ9NP77
iPTMnetiQ9NP77
PhosphoSitePlusiQ9NP77

Polymorphism and mutation databases

BioMutaiSSU72
DMDMi74752877

Proteomic databases

EPDiQ9NP77
jPOSTiQ9NP77
MassIVEiQ9NP77
MaxQBiQ9NP77
PaxDbiQ9NP77
PeptideAtlasiQ9NP77
PRIDEiQ9NP77
ProteomicsDBi81915 [Q9NP77-1]
81916 [Q9NP77-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
29101

Genome annotation databases

EnsembliENST00000291386; ENSP00000291386; ENSG00000160075 [Q9NP77-1]
ENST00000359060; ENSP00000351955; ENSG00000160075 [Q9NP77-2]
GeneIDi29101
KEGGihsa:29101
UCSCiuc001agd.4 human [Q9NP77-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
29101

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SSU72
HGNCiHGNC:25016 SSU72
HPAiHPA069290
HPA070604
MIMi617680 gene
neXtProtiNX_Q9NP77
OpenTargetsiENSG00000160075
PharmGKBiPA142670866

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2424 Eukaryota
COG5211 LUCA
GeneTreeiENSGT00390000010165
HOGENOMiHOG000183445
InParanoidiQ9NP77
KOiK15544
OMAiPNCYEFG
OrthoDBi1304061at2759
PhylomeDBiQ9NP77
TreeFamiTF300194

Enzyme and pathway databases

ReactomeiR-HSA-6807505 RNA polymerase II transcribes snRNA genes
SIGNORiQ9NP77

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SSU72 human
EvolutionaryTraceiQ9NP77

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
29101
PharosiQ9NP77

Protein Ontology

More...
PROi
PR:Q9NP77

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000160075 Expressed in 199 organ(s), highest expression level in parotid gland
GenevisibleiQ9NP77 HS

Family and domain databases

InterProiView protein in InterPro
IPR006811 RNA_pol_II_suA
PANTHERiPTHR20383 PTHR20383, 1 hit
PfamiView protein in Pfam
PF04722 Ssu72, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSSU72_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NP77
Secondary accession number(s): Q9BZS6, Q9H933
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 1, 2000
Last modified: September 18, 2019
This is version 146 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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