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Protein

Palmdelphin

Gene

PALMD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Palmdelphin
Alternative name(s):
Paralemmin-like protein
Gene namesi
Name:PALMD
Synonyms:C1orf11, PALML
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000099260.10
HGNCiHGNC:15846 PALMD
MIMi610182 gene
neXtProtiNX_Q9NP74

Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi54873
OpenTargetsiENSG00000099260
PharmGKBiPA32925

Polymorphism and mutation databases

BioMutaiPALMD
DMDMi74734298

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002625281 – 551PalmdelphinAdd BLAST551

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Cross-linki125Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei135PhosphoserineCombined sources1
Cross-linki179Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki179Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei271PhosphothreonineBy similarity1
Modified residuei321PhosphoserineCombined sources1
Modified residuei370PhosphoserineBy similarity1
Modified residuei384PhosphoserineCombined sources1
Modified residuei385PhosphoserineBy similarity1
Modified residuei498PhosphoserineCombined sources1
Modified residuei515PhosphoserineCombined sources1
Modified residuei520PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9NP74
MaxQBiQ9NP74
PaxDbiQ9NP74
PeptideAtlasiQ9NP74
PRIDEiQ9NP74
ProteomicsDBi81912
81913 [Q9NP74-2]
81914 [Q9NP74-3]

PTM databases

iPTMnetiQ9NP74
PhosphoSitePlusiQ9NP74

Expressioni

Tissue specificityi

Ubiquitous. Most abundant in cardiac and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000099260
CleanExiHS_PALMD
ExpressionAtlasiQ9NP74 baseline and differential
GenevisibleiQ9NP74 HS

Organism-specific databases

HPAiHPA017959
HPA030549

Interactioni

Subunit structurei

Interacts with GLUL.By similarity

Protein-protein interaction databases

BioGridi120221, 10 interactors
IntActiQ9NP74, 11 interactors
STRINGi9606.ENSP00000263174

Structurei

3D structure databases

ProteinModelPortaliQ9NP74
SMRiQ9NP74
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili12 – 106Sequence analysisAdd BLAST95

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi450 – 459Poly-Glu10

Sequence similaritiesi

Belongs to the paralemmin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IH2D Eukaryota
ENOG411033J LUCA
GeneTreeiENSGT00530000063206
HOGENOMiHOG000115435
HOVERGENiHBG082103
InParanoidiQ9NP74
KOiK16519
PhylomeDBiQ9NP74
TreeFamiTF105402

Family and domain databases

InterProiView protein in InterPro
IPR004965 Paralemmin
PfamiView protein in Pfam
PF03285 Paralemmin, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NP74-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEAELVKGR LQAITDKRKI QEEISQKRLK IEEDKLKHQH LKKKALREKW
60 70 80 90 100
LLDGISSGKE QEEMKKQNQQ DQHQIQVLEQ SILRLEKEIQ DLEKAELQIS
110 120 130 140 150
TKEEAILKKL KSIERTTEDI IRSVKVEREE RAEESIEDIY ANIPDLPKSY
160 170 180 190 200
IPSRLRKEIN EEKEDDEQNR KALYAMEIKV EKDLKTGEST VLSSIPLPSD
210 220 230 240 250
DFKGTGIKVY DDGQKSVYAV SSNHSAAYNG TDGLAPVEVE ELLRQASERN
260 270 280 290 300
SKSPTEYHEP VYANPFYRPT TPQRETVTPG PNFQERIKIK TNGLGIGVNE
310 320 330 340 350
SIHNMGNGLS EERGNNFNHI SPIPPVPHPR SVIQQAEEKL HTPQKRLMTP
360 370 380 390 400
WEESNVMQDK DAPSPKPRLS PRETIFGKSE HQNSSPTCQE DEEDVRYNIV
410 420 430 440 450
HSLPPDINDT EPVTMIFMGY QQAEDSEEDK KFLTGYDGII HAELVVIDDE
460 470 480 490 500
EEEDEGEAEK PSYHPIAPHS QVYQPAKPTP LPRKRSEASP HENTNHKSPH
510 520 530 540 550
KNSISLKEQE ESLGSPVHHS PFDAQTTGDG TEDPSLTALR MRMAKLGKKV

I
Length:551
Mass (Da):62,758
Last modified:October 1, 2000 - v1
Checksum:iCC93EAC5ED5625D7
GO
Isoform 2 (identifier: Q9NP74-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-99: MEEAELVKGR...QDLEKAELQI → MASRWNQQRKRTGRDEEAK

Show »
Length:471
Mass (Da):53,254
Checksum:iD5CC2FF395930E9E
GO
Isoform 3 (identifier: Q9NP74-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-175: Missing.

Show »
Length:376
Mass (Da):41,950
Checksum:i26CACB38DBBC9633
GO

Sequence cautioni

The sequence CAC01336 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti248E → K in BAB14946 (PubMed:14702039).Curated1
Sequence conflicti385S → L in CAC01335 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05380573H → Q. Corresponds to variant dbSNP:rs11802902Ensembl.1
Natural variantiVAR_053806229N → S. Corresponds to variant dbSNP:rs35258980Ensembl.1
Natural variantiVAR_053807459E → D. Corresponds to variant dbSNP:rs35317701Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0217861 – 175Missing in isoform 3. 1 PublicationAdd BLAST175
Alternative sequenceiVSP_0217871 – 99MEEAE…AELQI → MASRWNQQRKRTGRDEEAK in isoform 2. 2 PublicationsAdd BLAST99

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ312214 mRNA Translation: CAC59692.1
AF262379 mRNA Translation: AAL33879.1
AK000278 mRNA Translation: BAA91047.1
AK024654 mRNA Translation: BAB14946.1
AL390970 mRNA Translation: CAC01335.1
AL390971 mRNA Translation: CAC01336.1 Sequence problems.
AL390972 mRNA Translation: CAC01337.1
AL390973 mRNA Translation: CAC01338.1
BC012570 mRNA Translation: AAH12570.1
CCDSiCCDS758.1 [Q9NP74-1]
RefSeqiNP_060204.1, NM_017734.4 [Q9NP74-1]
UniGeneiHs.483993

Genome annotation databases

EnsembliENST00000263174; ENSP00000263174; ENSG00000099260 [Q9NP74-1]
ENST00000615664; ENSP00000479820; ENSG00000099260 [Q9NP74-2]
GeneIDi54873
KEGGihsa:54873
UCSCiuc001dsg.4 human [Q9NP74-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPALMD_HUMAN
AccessioniPrimary (citable) accession number: Q9NP74
Secondary accession number(s): Q9H7E6
, Q9NPM5, Q9NPM6, Q9NPS0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 1, 2000
Last modified: June 20, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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