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Entry version 165 (12 Aug 2020)
Sequence version 1 (01 Oct 2000)
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Protein

High mobility group protein 20A

Gene

HMG20A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in neuronal differentiation as chromatin-associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase KMT2A/MLL1 and consequent increased methylation of histone H3 lysine 4 (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi103 – 171HMG boxPROSITE-ProRule annotationAdd BLAST69

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q9NP66

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
High mobility group protein 20A
Alternative name(s):
HMG box-containing protein 20A
HMG domain-containing protein 1
HMG domain-containing protein HMGX1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HMG20A
Synonyms:HMGX1, HMGXB1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000140382.14

Human Gene Nomenclature Database

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HGNCi
HGNC:5001, HMG20A

Online Mendelian Inheritance in Man (OMIM)

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MIMi
605534, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NP66

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10363

Open Targets

More...
OpenTargetsi
ENSG00000140382

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29331

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NP66, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HMG20A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74734297

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002386491 – 347High mobility group protein 20AAdd BLAST347

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei105PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NP66

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9NP66

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9NP66

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9NP66

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9NP66

PeptideAtlas

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PeptideAtlasi
Q9NP66

PRoteomics IDEntifications database

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PRIDEi
Q9NP66

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
81896 [Q9NP66-1]
81897 [Q9NP66-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NP66

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NP66

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000140382, Expressed in quadriceps femoris and 236 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9NP66, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9NP66, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000140382, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9NP66
With#Exp.IntAct
ADD1 - isoform 5 [P35611-5]3EBI-740641,EBI-10206868
AGR2 [O95994]3EBI-740641,EBI-712648
BACH2 [Q9BYV9]3EBI-740641,EBI-1642333
BYSL [Q13895]3EBI-740641,EBI-358049
C9orf72 [Q96LT7]3EBI-740641,EBI-2961725
CCDC136 - isoform 2 [Q96JN2-2]3EBI-740641,EBI-10171416
CCDC6 [Q16204]3EBI-740641,EBI-1045350
CEP95 [Q96GE4]3EBI-740641,EBI-372775
CFAP53 [Q96M91]3EBI-740641,EBI-742422
CTAG1B [P78358]3EBI-740641,EBI-1188472
DCTN4 [A0A0S2Z5D5]3EBI-740641,EBI-16432590
DDIT4L [Q96D03]3EBI-740641,EBI-742054
DGCR6L [Q9BY27]3EBI-740641,EBI-742953
DTNB [O60941]4EBI-740641,EBI-740402
DTNB - isoform 5 [O60941-5]4EBI-740641,EBI-11984733
EHHADH [Q08426]3EBI-740641,EBI-2339219
FMNL1 - isoform 2 [O95466-2]3EBI-740641,EBI-10191924
FOXD4L1 [Q9NU39]3EBI-740641,EBI-11320806
GADD45GIP1 [Q8TAE8]3EBI-740641,EBI-372506
GPSM1 - isoform 3 [Q86YR5-3]3EBI-740641,EBI-10261098
itself9EBI-740641,EBI-740641
HMG20B [Q9P0W2]6EBI-740641,EBI-713401
HPCAL1 [P37235]4EBI-740641,EBI-749311
HTT [P42858]2EBI-740641,EBI-466029
KIFC3 - isoform 4 [Q9BVG8-5]3EBI-740641,EBI-14069005
KPNA2 [P52292]3EBI-740641,EBI-349938
KRT1 [P04264]3EBI-740641,EBI-298429
LMO1 [P25800]3EBI-740641,EBI-8639312
LNX1 [Q8TBB1]3EBI-740641,EBI-739832
LURAP1 [Q96LR2]5EBI-740641,EBI-741355
MAGOHB [Q96A72]4EBI-740641,EBI-746778
MORF4L1 - isoform 2 [Q9UBU8-2]3EBI-740641,EBI-10288852
NUTF2 [P61970]3EBI-740641,EBI-591778
OLIG3 [Q7RTU3]3EBI-740641,EBI-10225049
PIAS2 - isoform PIAS2-alpha [O75928-2]3EBI-740641,EBI-348567
PICK1 [Q9NRD5]6EBI-740641,EBI-79165
PSMB1 [P20618]3EBI-740641,EBI-372273
PSORS1C2 [Q9UIG4]3EBI-740641,EBI-11974061
PSTPIP1 [A0A0S2Z528]3EBI-740641,EBI-16430249
PTH2R [P49190]3EBI-740641,EBI-1045772
QARS1 [P47897]3EBI-740641,EBI-347462
RAD54L2 [Q9Y4B4]3EBI-740641,EBI-948156
RIN1 [Q13671]3EBI-740641,EBI-366017
RPP30 [P78346]11EBI-740641,EBI-366553
RPRD1B [Q9NQG5]3EBI-740641,EBI-747925
RSPH9 [Q9H1X1]3EBI-740641,EBI-10305303
RUSC1 [Q9BVN2]3EBI-740641,EBI-6257312
SCNM1 [Q9BWG6]7EBI-740641,EBI-748391
SLC30A8 [Q8IWU4]3EBI-740641,EBI-10262251
SMYD1 [Q8NB12]3EBI-740641,EBI-8463848
SUOX [P51687]3EBI-740641,EBI-3921347
SYTL4 [Q96C24]7EBI-740641,EBI-747142
TBC1D22B [Q9NU19]3EBI-740641,EBI-8787464
TCHP [Q9BT92]3EBI-740641,EBI-740781
TCP11L1 [Q9NUJ3]3EBI-740641,EBI-2555179
TESC [Q96BS2]2EBI-740641,EBI-740653
TRAF4 [Q9BUZ4]3EBI-740641,EBI-3650647
TRAPPC5 [Q8IUR0]5EBI-740641,EBI-3246160
USHBP1 [Q8N6Y0]3EBI-740641,EBI-739895
WDYHV1 [Q96HA8]5EBI-740641,EBI-741158

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
115643, 117 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9NP66

Protein interaction database and analysis system

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IntActi
Q9NP66, 112 interactors

Molecular INTeraction database

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MINTi
Q9NP66

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000371133

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q9NP66, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9NP66

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili229 – 273Sequence analysisAdd BLAST45

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0381, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000158464

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_060006_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9NP66

Identification of Orthologs from Complete Genome Data

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OMAi
NSQRNGD

Database of Orthologous Groups

More...
OrthoDBi
1458939at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NP66

TreeFam database of animal gene trees

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TreeFami
TF106440

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.30.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009071, HMG_box_dom
IPR036910, HMG_box_dom_sf

Pfam protein domain database

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Pfami
View protein in Pfam
PF00505, HMG_box, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00398, HMG, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47095, SSF47095, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50118, HMG_BOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NP66-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MENLMTSSTL PPLFADEDGS KESNDLATTG LNHPEVPYSS GATSSTNNPE
60 70 80 90 100
FVEDLSQGQL LQSESSNAAE GNEQRHEDEQ RSKRGGWSKG RKRKKPLRDS
110 120 130 140 150
NAPKSPLTGY VRFMNERREQ LRAKRPEVPF PEITRMLGNE WSKLPPEEKQ
160 170 180 190 200
RYLDEADRDK ERYMKELEQY QKTEAYKVFS RKTQDRQKGK SHRQDAARQA
210 220 230 240 250
THDHEKETEV KERSVFDIPI FTEEFLNHSK AREAELRQLR KSNMEFEERN
260 270 280 290 300
AALQKHVESM RTAVEKLEVD VIQERSRNTV LQQHLETLRQ VLTSSFASMP
310 320 330 340
LPGSGETPTV DTIDSYMNRL HSIILANPQD NENFIATVRE VVNRLDR
Length:347
Mass (Da):40,144
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD8632FFAAA162587
GO
Isoform 2 (identifier: Q9NP66-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     80-81: QR → VS
     82-347: Missing.

Show »
Length:81
Mass (Da):8,671
Checksum:i053ED03B6B492E96
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YKM5H0YKM5_HUMAN
High mobility group protein 20A
HMG20A
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YNS8H0YNS8_HUMAN
High mobility group protein 20A
HMG20A
156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YM80H0YM80_HUMAN
High mobility group protein 20A
HMG20A
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YK55H0YK55_HUMAN
High mobility group protein 20A
HMG20A
26Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YMG2H0YMG2_HUMAN
High mobility group protein 20A
HMG20A
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YKL0H0YKL0_HUMAN
High mobility group protein 20A
HMG20A
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YMS9H0YMS9_HUMAN
High mobility group protein 20A
HMG20A
29Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti320L → P in BAD96820 (Ref. 5) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01862180 – 81QR → VS in isoform 2. 1 Publication2
Alternative sequenceiVSP_01862282 – 347Missing in isoform 2. 1 PublicationAdd BLAST266

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF146222 mRNA Translation: AAF66706.1
AL355736 mRNA Translation: CAB90815.1 Different termination.
AL355737 mRNA Translation: CAB90816.1
AK001601 mRNA Translation: BAA91782.1
BT006716 mRNA Translation: AAP35362.1
AK223100 mRNA Translation: BAD96820.1
AC090984 Genomic DNA No translation available.
CH471136 Genomic DNA Translation: EAW99201.1
CH471136 Genomic DNA Translation: EAW99202.1
CH471136 Genomic DNA Translation: EAW99203.1
BC021959 mRNA Translation: AAH21959.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS10295.1 [Q9NP66-1]

NCBI Reference Sequences

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RefSeqi
NP_001291433.1, NM_001304504.1 [Q9NP66-1]
NP_001291434.1, NM_001304505.1
NP_060670.1, NM_018200.3 [Q9NP66-1]
XP_011519460.1, XM_011521158.2 [Q9NP66-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000336216; ENSP00000336856; ENSG00000140382 [Q9NP66-1]
ENST00000381714; ENSP00000371133; ENSG00000140382 [Q9NP66-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10363

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10363

UCSC genome browser

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UCSCi
uc002bcr.4, human [Q9NP66-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF146222 mRNA Translation: AAF66706.1
AL355736 mRNA Translation: CAB90815.1 Different termination.
AL355737 mRNA Translation: CAB90816.1
AK001601 mRNA Translation: BAA91782.1
BT006716 mRNA Translation: AAP35362.1
AK223100 mRNA Translation: BAD96820.1
AC090984 Genomic DNA No translation available.
CH471136 Genomic DNA Translation: EAW99201.1
CH471136 Genomic DNA Translation: EAW99202.1
CH471136 Genomic DNA Translation: EAW99203.1
BC021959 mRNA Translation: AAH21959.1
CCDSiCCDS10295.1 [Q9NP66-1]
RefSeqiNP_001291433.1, NM_001304504.1 [Q9NP66-1]
NP_001291434.1, NM_001304505.1
NP_060670.1, NM_018200.3 [Q9NP66-1]
XP_011519460.1, XM_011521158.2 [Q9NP66-1]

3D structure databases

SMRiQ9NP66
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi115643, 117 interactors
CORUMiQ9NP66
IntActiQ9NP66, 112 interactors
MINTiQ9NP66
STRINGi9606.ENSP00000371133

PTM databases

iPTMnetiQ9NP66
PhosphoSitePlusiQ9NP66

Polymorphism and mutation databases

BioMutaiHMG20A
DMDMi74734297

Proteomic databases

EPDiQ9NP66
jPOSTiQ9NP66
MassIVEiQ9NP66
MaxQBiQ9NP66
PaxDbiQ9NP66
PeptideAtlasiQ9NP66
PRIDEiQ9NP66
ProteomicsDBi81896 [Q9NP66-1]
81897 [Q9NP66-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
1449, 293 antibodies

The DNASU plasmid repository

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DNASUi
10363

Genome annotation databases

EnsembliENST00000336216; ENSP00000336856; ENSG00000140382 [Q9NP66-1]
ENST00000381714; ENSP00000371133; ENSG00000140382 [Q9NP66-1]
GeneIDi10363
KEGGihsa:10363
UCSCiuc002bcr.4, human [Q9NP66-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10363
DisGeNETi10363
EuPathDBiHostDB:ENSG00000140382.14

GeneCards: human genes, protein and diseases

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GeneCardsi
HMG20A
HGNCiHGNC:5001, HMG20A
HPAiENSG00000140382, Low tissue specificity
MIMi605534, gene
neXtProtiNX_Q9NP66
OpenTargetsiENSG00000140382
PharmGKBiPA29331

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0381, Eukaryota
GeneTreeiENSGT00940000158464
HOGENOMiCLU_060006_0_0_1
InParanoidiQ9NP66
OMAiNSQRNGD
OrthoDBi1458939at2759
PhylomeDBiQ9NP66
TreeFamiTF106440

Enzyme and pathway databases

PathwayCommonsiQ9NP66

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
10363, 8 hits in 899 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
HMG20A, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
HMG20A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10363
PharosiQ9NP66, Tbio

Protein Ontology

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PROi
PR:Q9NP66
RNActiQ9NP66, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000140382, Expressed in quadriceps femoris and 236 other tissues
ExpressionAtlasiQ9NP66, baseline and differential
GenevisibleiQ9NP66, HS

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071, HMG_box_dom
IPR036910, HMG_box_dom_sf
PfamiView protein in Pfam
PF00505, HMG_box, 1 hit
SMARTiView protein in SMART
SM00398, HMG, 1 hit
SUPFAMiSSF47095, SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118, HMG_BOX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHM20A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NP66
Secondary accession number(s): A6NHY3
, D3DW78, Q53G31, Q9NSF6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: October 1, 2000
Last modified: August 12, 2020
This is version 165 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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