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Protein

X-linked interleukin-1 receptor accessory protein-like 2

Gene

IL1RAPL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • interleukin-1, Type II, blocking receptor activity Source: InterPro
  • interleukin-1 receptor activity Source: ProtInc

GO - Biological processi

  • central nervous system development Source: ProtInc

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-HSA-388844 Receptor-type tyrosine-protein phosphatases

Names & Taxonomyi

Protein namesi
Recommended name:
X-linked interleukin-1 receptor accessory protein-like 2
Short name:
IL-1 receptor accessory protein-like 2
Short name:
IL-1-RAPL-2
Short name:
IL-1RAPL-2
Short name:
IL1RAPL-2
Alternative name(s):
IL1RAPL-2-related protein
Interleukin-1 receptor 9
Short name:
IL-1R-9
Short name:
IL-1R9
Three immunoglobulin domain-containing IL-1 receptor-related 1
Short name:
TIGIRR-1
Gene namesi
Name:IL1RAPL2
Synonyms:IL1R9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000189108.12
HGNCiHGNC:5997 IL1RAPL2
MIMi300277 gene
neXtProtiNX_Q9NP60

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 354ExtracellularSequence analysisAdd BLAST338
Transmembranei355 – 375HelicalSequence analysisAdd BLAST21
Topological domaini376 – 686CytoplasmicSequence analysisAdd BLAST311

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi26280
OpenTargetsiENSG00000189108
PharmGKBiPA29813

Polymorphism and mutation databases

BioMutaiIL1RAPL2
DMDMi34222651

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000001545917 – 686X-linked interleukin-1 receptor accessory protein-like 2Add BLAST670

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 116PROSITE-ProRule annotation
Glycosylationi63N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi120N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi136N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi162 ↔ 214PROSITE-ProRule annotation
Glycosylationi211N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi265 ↔ 331PROSITE-ProRule annotation
Glycosylationi328N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9NP60
PRIDEiQ9NP60
ProteomicsDBi81891

PTM databases

iPTMnetiQ9NP60
PhosphoSitePlusiQ9NP60

Expressioni

Tissue specificityi

Detected at low levels in fetal and adult brain, in particular in the frontal lobe, temporal lobe and cerebellum. Detected at very low levels in skin, liver, fetal ovary and in placenta.3 Publications

Gene expression databases

BgeeiENSG00000189108
CleanExiHS_IL1RAPL2
ExpressionAtlasiQ9NP60 baseline and differential
GenevisibleiQ9NP60 HS

Organism-specific databases

HPAiHPA036128
HPA036129

Interactioni

Protein-protein interaction databases

BioGridi117663, 1 interactor
STRINGi9606.ENSP00000344976

Structurei

3D structure databases

ProteinModelPortaliQ9NP60
SMRiQ9NP60
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 132Ig-like C2-type 1Add BLAST115
Domaini141 – 232Ig-like C2-type 2Add BLAST92
Domaini239 – 347Ig-like C2-type 3Add BLAST109
Domaini400 – 559TIRPROSITE-ProRule annotationAdd BLAST160

Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF3G Eukaryota
ENOG4110Z8K LUCA
GeneTreeiENSGT00760000119071
HOGENOMiHOG000092977
HOVERGENiHBG052148
InParanoidiQ9NP60
KOiK05170
OMAiADDNKEY
OrthoDBiEOG091G0GXW
PhylomeDBiQ9NP60
TreeFamiTF333913

Family and domain databases

Gene3Di2.60.40.10, 3 hits
3.40.50.10140, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR015621 IL-1_rcpt_fam
IPR004077 IL-1_rcpt_II-typ
IPR013151 Immunoglobulin
IPR000157 TIR_dom
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR11890 PTHR11890, 1 hit
PfamiView protein in Pfam
PF00047 ig, 1 hit
PF13895 Ig_2, 1 hit
PF01582 TIR, 1 hit
PRINTSiPR01539 INTRLEUKN1R2
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00255 TIR, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
SSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS50104 TIR, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NP60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPPFLLALV VCSVVSTNLK MVSKRNSVDG CIDWSVDLKT YMALAGEPVR
60 70 80 90 100
VKCALFYSYI RTNYSTAQST GLRLMWYKNK GDLEEPIIFS EVRMSKEEDS
110 120 130 140 150
IWFHSAEAQD SGFYTCVLRN STYCMKVSMS LTVAENESGL CYNSRIRYLE
160 170 180 190 200
KSEVTKRKEI SCPDMDDFKK SDQEPDVVWY KECKPKMWRS IIIQKGNALL
210 220 230 240 250
IQEVQEEDGG NYTCELKYEG KLVRRTTELK VTALLTDKPP KPLFPMENQP
260 270 280 290 300
SVIDVQLGKP LNIPCKAFFG FSGESGPMIY WMKGEKFIEE LAGHIREGEI
310 320 330 340 350
RLLKEHLGEK EVELALIFDS VVEADLANYT CHVENRNGRK HASVLLRKKD
360 370 380 390 400
LIYKIELAGG LGAIFLLLVL LVVIYKCYNI ELMLFYRQHF GADETNDDNK
410 420 430 440 450
EYDAYLSYTK VDQDTLDCDN PEEEQFALEV LPDVLEKHYG YKLFIPERDL
460 470 480 490 500
IPSGTYMEDL TRYVEQSRRL IIVLTPDYIL RRGWSIFELE SRLHNMLVSG
510 520 530 540 550
EIKVILIECT ELKGKVNCQE VESLKRSIKL LSLIKWKGSK SSKLNSKFWK
560 570 580 590 600
HLVYEMPIKK KEMLPRCHVL DSAEQGLFGE LQPIPSIAMT STSATLVSSQ
610 620 630 640 650
ADLPEFHPSD SMQIRHCCRG YKHEIPATTL PVPSLGNHHT YCNLPLTLLN
660 670 680
GQLPLNNTLK DTQEFHRNSS LLPLSSKELS FTSDIW
Length:686
Mass (Da):78,670
Last modified:October 1, 2000 - v1
Checksum:iE400F7ECD186957C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036592606F → L in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF212016 mRNA Translation: AAF61307.1
AF284436 mRNA Translation: AAG21370.1
AJ272208 mRNA Translation: CAB86868.1
AJ290436 mRNA Translation: CAB89867.1
AK290196 mRNA Translation: BAF82885.1
AL050401 Genomic DNA No translation available.
Z68328 Genomic DNA No translation available.
Z68330 Genomic DNA No translation available.
Z68908 Genomic DNA No translation available.
Z69721 Genomic DNA No translation available.
Z74477 Genomic DNA No translation available.
Z74619 Genomic DNA No translation available.
Z81144 Genomic DNA No translation available.
AF181285 mRNA Translation: AAF59412.1
BC104784 mRNA Translation: AAI04785.1
BC104786 mRNA Translation: AAI04787.1
CCDSiCCDS14517.1
RefSeqiNP_059112.1, NM_017416.1
XP_016884892.1, XM_017029403.1
UniGeneiHs.675519

Genome annotation databases

EnsembliENST00000372582; ENSP00000361663; ENSG00000189108
GeneIDi26280
KEGGihsa:26280
UCSCiuc004elz.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiIRPL2_HUMAN
AccessioniPrimary (citable) accession number: Q9NP60
Secondary accession number(s): Q2M3U3, Q9NZN0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: October 1, 2000
Last modified: June 20, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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