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Entry version 150 (13 Feb 2019)
Sequence version 1 (01 Oct 2000)
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Protein

BPI fold-containing family A member 1

Gene

BPIFA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC) (PubMed:25223608). Plays a role in the innate immune responses of the upper airways (PubMed:23499554, PubMed:23132494). Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae (PubMed:23499554, PubMed:23132494, PubMed:27145151). Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus (PubMed:24124190, PubMed:24043776). Plays a role in the airway inflammatory response after exposure to irritants (PubMed:11425234). May attract macrophages and neutrophils (PubMed:23132494).7 Publications

Caution

Reported to bind to bacterial lipopolysaccharide (LPS) in vitro (PubMed:15158712, PubMed:27145151). However, the in vivo significance of this is uncertain since other studies indicate little or no specificity for LPS (PubMed:12920053, PubMed:25223608).4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAntibiotic, Antimicrobial
Biological processImmunity, Innate immunity
LigandLipid-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6803157 Antimicrobial peptides

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
BPI fold-containing family A member 1
Alternative name(s):
Lung-specific protein X
Nasopharyngeal carcinoma-related protein
Palate lung and nasal epithelium clone protein
Secretory protein in upper respiratory tracts
Short PLUNC1
Short name:
SPLUNC1
Tracheal epithelium-enriched protein
Von Ebner protein Hl
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BPIFA1
Synonyms:LUNX, NASG, PLUNC, SPLUNC1, SPURT
ORF Names:UNQ787/PRO1606
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000198183.11

Human Gene Nomenclature Database

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HGNCi
HGNC:15749 BPIFA1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
607412 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NP55

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi48A → C: Forms an artificial disulfide bond. Negligible effect on surfactant activity; when associated with C-253. 1 Publication1
Mutagenesisi76I → C: Forms an artificial disulfide bond. Reduced surfactant activity; when associated with C-214. 1 Publication1
Mutagenesisi87 – 92LLGGLL → AAGGAA or SSGGSS: Impaired surfactant activity and lipopolysaccharide (LPS) binding. Reduced bacteriostatic activity. 1 Publication6
Mutagenesisi180C → A: No effect on surfactant activity; when associated with A-224. 1 Publication1
Mutagenesisi191 – 195LLDGL → AADGA: No effect on surfactant activity; when associated with 203-A-A-204. 1 Publication5
Mutagenesisi203 – 204LL → AA: No effect on surfactant activity; when associated with 191-A--A-195. 1 Publication2
Mutagenesisi214V → C: Forms an artificial disulfide bond. Reduced surfactant activity; when associated with C-76. 1 Publication1
Mutagenesisi224C → A: No effect on surfactant activity; when associated with A-180. 1 Publication1
Mutagenesisi253V → C: Forms an artificial disulfide bond. Negligible effect on surfactant activity; when associated with C-48. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
51297

Open Targets

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OpenTargetsi
ENSG00000198183

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA33423

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BPIFA1

Domain mapping of disease mutations (DMDM)

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DMDMi
17380173

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001717520 – 256BPI fold-containing family A member 1Add BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi180 ↔ 224Combined sources3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

May be N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9NP55

PeptideAtlas

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PeptideAtlasi
Q9NP55

PRoteomics IDEntifications database

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PRIDEi
Q9NP55

ProteomicsDB human proteome resource

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ProteomicsDBi
81886

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9NP55

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9NP55

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in lung, upper airways and nasopharyngeal regions, including trachea and nasal epithelium (at protein level) (PubMed:11018263, PubMed:11251963, PubMed:12409287, PubMed:11425234, PubMed:26559477). Specifically expressed in the secretory ducts and submucosal glands of tracheobronchial tissues (at protein level) (PubMed:12409287, PubMed:11425234). Also expressed in the eye where it is detected in lacrimal gland, eyelid, conjunctiva and cornea (at protein level) (PubMed:26559477). Specifically localizes to epithelial cell layers in cornea, eyelid (basal epithelium) and conjunctiva (at protein level) (PubMed:26559477). Detected within acinar cells and ducts in the lacrimal and Meibomian glands (at protein level) (PubMed:26559477). In lung, shows highest expression in the trachea and progressive decrease from proximal (bronchial) to distal (bronchiolar) airways (PubMed:12409287). Also expressed in lung cancers and some other types of cancer (PubMed:11251963).5 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in response to all-trans retinoic acid (ATRA) (PubMed:12409287). Up-regulated in tear fluid of patients suffering from dry eye disease (PubMed:26559477). Up-regulated in response to the proinflammatory cytokines IL1B and TNF, and the bacteria E.coli and P.aeruginosa (PubMed:26559477).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000198183 Expressed in 48 organ(s), highest expression level in epithelium of bronchus

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9NP55 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB025669

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer. Interacts (via N-terminus) with SCNN1B, a subunit of the heterotrimeric epithelial sodium channel (ENaC); this inhibits proteolytic activation of ENaC.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
UBQLN1Q9UMX0-23EBI-953896,EBI-10173939

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
119448, 15 interactors

Protein interaction database and analysis system

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IntActi
Q9NP55, 53 interactors

Molecular INTeraction database

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MINTi
Q9NP55

STRING: functional protein association networks

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STRINGi
9606.ENSP00000346251

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1256
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4KEGX-ray2.50A43-256[»]
4KGHX-ray2.81A/B19-256[»]
4KGOX-ray3.19A/B19-256[»]
4N4XX-ray2.50A43-256[»]
5I7JX-ray2.54A/B19-256[»]
5I7KX-ray2.55A/B19-256[»]
5I7LX-ray2.60A/B19-256[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9NP55

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9NP55

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni87 – 92Important for surfactant activity and antibacterial properties1 Publication6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the BPI/LBP/Plunc superfamily. Plunc family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IWYF Eukaryota
ENOG41114MD LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153099

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231510

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG045573

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9NP55

Identification of Orthologs from Complete Genome Data

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OMAi
QGKVCPL

Database of Orthologous Groups

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OrthoDBi
1275829at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9NP55

TreeFam database of animal gene trees

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TreeFami
TF337052

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR017943 Bactericidal_perm-incr_a/b_dom
IPR032942 BPI/LBP/Plunc
IPR034307 BPIFA1
IPR017942 Lipid-bd_serum_glycop_N

The PANTHER Classification System

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PANTHERi
PTHR10504 PTHR10504, 1 hit
PTHR10504:SF70 PTHR10504:SF70, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01273 LBP_BPI_CETP, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF55394 SSF55394, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9NP55-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFQTGGLIVF YGLLAQTMAQ FGGLPVPLDQ TLPLNVNPAL PLSPTGLAGS
60 70 80 90 100
LTNALSNGLL SGGLLGILEN LPLLDILKPG GGTSGGLLGG LLGKVTSVIP
110 120 130 140 150
GLNNIIDIKV TDPQLLELGL VQSPDGHRLY VTIPLGIKLQ VNTPLVGASL
160 170 180 190 200
LRLAVKLDIT AEILAVRDKQ ERIHLVLGDC THSPGSLQIS LLDGLGPLPI
210 220 230 240 250
QGLLDSLTGI LNKVLPELVQ GNVCPLVNEV LRGLDITLVH DIVNMLIHGL

QFVIKV
Length:256
Mass (Da):26,713
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEDF152FBC35315BC
GO
Isoform 2 (identifier: Q9NP55-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-29: Missing.

Note: No experimental confirmation available.
Show »
Length:242
Mass (Da):25,257
Checksum:iB2A38F50F8229D20
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti220Q → K in AAF70860 (PubMed:11018263).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05734516 – 29Missing in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF214562 Genomic DNA Translation: AAG13653.1
AF172993 mRNA Translation: AAF70860.1
AF158745 mRNA Translation: AAF82622.1
AB024937 mRNA Translation: BAA93633.1
AF439448 mRNA Translation: AAL87636.1
AF417256 mRNA Translation: AAO12198.1
AF417257 mRNA Translation: AAO12199.1
AF421369 Genomic DNA Translation: AAO12200.1
AY359020 mRNA Translation: AAQ89379.1
AK292778 mRNA Translation: BAF85467.1
DQ846869 mRNA Translation: ABI63356.1
AL121901 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76327.1
CH471077 Genomic DNA Translation: EAW76328.1
CH471077 Genomic DNA Translation: EAW76329.1
BC012549 mRNA Translation: AAH12549.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS13217.1 [Q9NP55-1]

NCBI Reference Sequences

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RefSeqi
NP_001230122.1, NM_001243193.1 [Q9NP55-1]
NP_057667.1, NM_016583.3 [Q9NP55-1]
NP_570913.1, NM_130852.2 [Q9NP55-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.211092

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000354297; ENSP00000346251; ENSG00000198183 [Q9NP55-1]
ENST00000375413; ENSP00000364562; ENSG00000198183 [Q9NP55-1]
ENST00000375422; ENSP00000364571; ENSG00000198183 [Q9NP55-1]
ENST00000618484; ENSP00000482297; ENSG00000198183 [Q9NP55-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
51297

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:51297

UCSC genome browser

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UCSCi
uc002wyt.5 human [Q9NP55-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF214562 Genomic DNA Translation: AAG13653.1
AF172993 mRNA Translation: AAF70860.1
AF158745 mRNA Translation: AAF82622.1
AB024937 mRNA Translation: BAA93633.1
AF439448 mRNA Translation: AAL87636.1
AF417256 mRNA Translation: AAO12198.1
AF417257 mRNA Translation: AAO12199.1
AF421369 Genomic DNA Translation: AAO12200.1
AY359020 mRNA Translation: AAQ89379.1
AK292778 mRNA Translation: BAF85467.1
DQ846869 mRNA Translation: ABI63356.1
AL121901 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76327.1
CH471077 Genomic DNA Translation: EAW76328.1
CH471077 Genomic DNA Translation: EAW76329.1
BC012549 mRNA Translation: AAH12549.1
CCDSiCCDS13217.1 [Q9NP55-1]
RefSeqiNP_001230122.1, NM_001243193.1 [Q9NP55-1]
NP_057667.1, NM_016583.3 [Q9NP55-1]
NP_570913.1, NM_130852.2 [Q9NP55-1]
UniGeneiHs.211092

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4KEGX-ray2.50A43-256[»]
4KGHX-ray2.81A/B19-256[»]
4KGOX-ray3.19A/B19-256[»]
4N4XX-ray2.50A43-256[»]
5I7JX-ray2.54A/B19-256[»]
5I7KX-ray2.55A/B19-256[»]
5I7LX-ray2.60A/B19-256[»]
ProteinModelPortaliQ9NP55
SMRiQ9NP55
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119448, 15 interactors
IntActiQ9NP55, 53 interactors
MINTiQ9NP55
STRINGi9606.ENSP00000346251

PTM databases

iPTMnetiQ9NP55
PhosphoSitePlusiQ9NP55

Polymorphism and mutation databases

BioMutaiBPIFA1
DMDMi17380173

Proteomic databases

PaxDbiQ9NP55
PeptideAtlasiQ9NP55
PRIDEiQ9NP55
ProteomicsDBi81886

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
51297
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354297; ENSP00000346251; ENSG00000198183 [Q9NP55-1]
ENST00000375413; ENSP00000364562; ENSG00000198183 [Q9NP55-1]
ENST00000375422; ENSP00000364571; ENSG00000198183 [Q9NP55-1]
ENST00000618484; ENSP00000482297; ENSG00000198183 [Q9NP55-2]
GeneIDi51297
KEGGihsa:51297
UCSCiuc002wyt.5 human [Q9NP55-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51297
DisGeNETi51297
EuPathDBiHostDB:ENSG00000198183.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
BPIFA1
HGNCiHGNC:15749 BPIFA1
HPAiCAB025669
MIMi607412 gene
neXtProtiNX_Q9NP55
OpenTargetsiENSG00000198183
PharmGKBiPA33423

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IWYF Eukaryota
ENOG41114MD LUCA
GeneTreeiENSGT00940000153099
HOGENOMiHOG000231510
HOVERGENiHBG045573
InParanoidiQ9NP55
OMAiQGKVCPL
OrthoDBi1275829at2759
PhylomeDBiQ9NP55
TreeFamiTF337052

Enzyme and pathway databases

ReactomeiR-HSA-6803157 Antimicrobial peptides

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
BPIFA1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Plunc

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
51297

Protein Ontology

More...
PROi
PR:Q9NP55

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000198183 Expressed in 48 organ(s), highest expression level in epithelium of bronchus
GenevisibleiQ9NP55 HS

Family and domain databases

InterProiView protein in InterPro
IPR017943 Bactericidal_perm-incr_a/b_dom
IPR032942 BPI/LBP/Plunc
IPR034307 BPIFA1
IPR017942 Lipid-bd_serum_glycop_N
PANTHERiPTHR10504 PTHR10504, 1 hit
PTHR10504:SF70 PTHR10504:SF70, 1 hit
PfamiView protein in Pfam
PF01273 LBP_BPI_CETP, 1 hit
SUPFAMiSSF55394 SSF55394, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBPIA1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NP55
Secondary accession number(s): A6XMV5
, A8K9R3, E1P5M9, Q9NZT0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: October 1, 2000
Last modified: February 13, 2019
This is version 150 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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