UniProtKB - Q9NP50 (SHCAF_HUMAN)
SIN3-HDAC complex-associated factor
SINHCAF
Functioni
GO - Biological processi
- negative regulation of cell differentiation Source: UniProtKB
- negative regulation of cell migration Source: UniProtKB
- positive regulation of cell population proliferation Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q9NP50 |
Names & Taxonomyi
Protein namesi | Recommended name: SIN3-HDAC complex-associated factorImportedAlternative name(s): Protein FAM60A Tera protein homolog |
Gene namesi | ORF Names:L4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000139146.13 |
HGNCi | HGNC:30702, SINHCAF |
MIMi | 615027, gene |
neXtProti | NX_Q9NP50 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- Sin3 complex Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 58516 |
OpenTargetsi | ENSG00000139146 |
PharmGKBi | PA134921007 |
Miscellaneous databases
Pharosi | Q9NP50, Tdark |
Polymorphism and mutation databases
BioMutai | SINHCAF |
DMDMi | 71151891 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000187086 | 1 – 221 | SIN3-HDAC complex-associated factorAdd BLAST | 221 |
Proteomic databases
EPDi | Q9NP50 |
jPOSTi | Q9NP50 |
MassIVEi | Q9NP50 |
MaxQBi | Q9NP50 |
PaxDbi | Q9NP50 |
PeptideAtlasi | Q9NP50 |
PRIDEi | Q9NP50 |
ProteomicsDBi | 81884 [Q9NP50-1] 81885 [Q9NP50-2] |
PTM databases
iPTMneti | Q9NP50 |
PhosphoSitePlusi | Q9NP50 |
SwissPalmi | Q9NP50 |
Expressioni
Inductioni
Gene expression databases
Bgeei | ENSG00000139146, Expressed in kidney and 116 other tissues |
ExpressionAtlasi | Q9NP50, baseline and differential |
Genevisiblei | Q9NP50, HS |
Organism-specific databases
HPAi | ENSG00000139146, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with the Sin3/HDAC corepressor complex at least composed of BRMS1, BRMS1L, ING2, SAP30, SAP30L and HDAC1 (PubMed:22865885, PubMed:22984288).
Found in a complex composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1.
Interacts with SIN3A and OGT (By similarity).
By similarity2 PublicationsBinary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 121842, 65 interactors |
ComplexPortali | CPX-3323, SIN3A histone deacetylase complex, ES cell-specific variant |
IntActi | Q9NP50, 52 interactors |
MINTi | Q9NP50 |
STRINGi | 9606.ENSP00000337477 |
Miscellaneous databases
RNActi | Q9NP50, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG502QSAG, Eukaryota |
GeneTreei | ENSGT00390000006485 |
HOGENOMi | CLU_2704143_0_0_1 |
InParanoidi | Q9NP50 |
OMAi | PCCRNKQ |
OrthoDBi | 1330424at2759 |
PhylomeDBi | Q9NP50 |
TreeFami | TF323911 |
Family and domain databases
InterProi | View protein in InterPro IPR026065, FAM60A |
PANTHERi | PTHR13422, PTHR13422, 1 hit |
Pfami | View protein in Pfam PF15396, FAM60A, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MFGFHKPKMY RSIEGCCICR AKSSSSRFTD SKRYEKDFQS CFGLHETRSG
60 70 80 90 100
DICNACVLLV KRWKKLPAGS KKNWNHVVDA RAGPSLKTTL KPKKVKTLSG
110 120 130 140 150
NRIKSNQISK LQKEFKRHNS DAHSTTSSAS PAQSPCYSNQ SDDGSDTEMA
160 170 180 190 200
SGSNRTPVFS FLDLTYWKRQ KICCGIIYKG RFGEVLIDTH LFKPCCSNKK
210 220
AAAEKPEEQG PEPLPISTQE W
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5GZ82 | F5GZ82_HUMAN | SIN3-HDAC complex-associated factor | SINHCAF | 134 | Annotation score: | ||
H0YGG0 | H0YGG0_HUMAN | SIN3-HDAC complex-associated factor | SINHCAF | 59 | Annotation score: | ||
F5H6U2 | F5H6U2_HUMAN | SIN3-HDAC complex-associated factor | SINHCAF | 126 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049027 | 117 | R → H. Corresponds to variant dbSNP:rs2304459Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_014705 | 1 – 148 | Missing in isoform 2. 1 PublicationAdd BLAST | 148 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY598323 mRNA Translation: AAT06734.1 AF087885 mRNA Translation: AAP97184.1 AF212220 mRNA Translation: AAF87322.1 AK026932 mRNA Translation: BAB15592.1 AL157432 mRNA Translation: CAB75656.1 AC024940 Genomic DNA No translation available. CH471116 Genomic DNA Translation: EAW88561.1 CH471116 Genomic DNA Translation: EAW88562.1 CH471116 Genomic DNA Translation: EAW88564.1 CH471116 Genomic DNA Translation: EAW88566.1 CH471116 Genomic DNA Translation: EAW88567.1 BC000024 mRNA Translation: AAH00024.1 BC004462 mRNA Translation: AAH04462.1 BC071966 mRNA Translation: AAH71966.1 |
CCDSi | CCDS8723.1 [Q9NP50-1] |
PIRi | T46918 |
RefSeqi | NP_001129283.1, NM_001135811.1 [Q9NP50-1] NP_001129284.1, NM_001135812.1 [Q9NP50-1] NP_067061.1, NM_021238.2 [Q9NP50-1] XP_016875247.1, XM_017019758.1 [Q9NP50-1] XP_016875248.1, XM_017019759.1 [Q9NP50-1] XP_016875249.1, XM_017019760.1 [Q9NP50-1] XP_016875250.1, XM_017019761.1 [Q9NP50-1] XP_016875251.1, XM_017019762.1 [Q9NP50-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 121842, 65 interactors |
ComplexPortali | CPX-3323, SIN3A histone deacetylase complex, ES cell-specific variant |
IntActi | Q9NP50, 52 interactors |
MINTi | Q9NP50 |
STRINGi | 9606.ENSP00000337477 |
PTM databases
iPTMneti | Q9NP50 |
PhosphoSitePlusi | Q9NP50 |
SwissPalmi | Q9NP50 |
Polymorphism and mutation databases
BioMutai | SINHCAF |
DMDMi | 71151891 |
Proteomic databases
EPDi | Q9NP50 |
jPOSTi | Q9NP50 |
MassIVEi | Q9NP50 |
MaxQBi | Q9NP50 |
PaxDbi | Q9NP50 |
PeptideAtlasi | Q9NP50 |
PRIDEi | Q9NP50 |
ProteomicsDBi | 81884 [Q9NP50-1] 81885 [Q9NP50-2] |
Protocols and materials databases
Antibodypediai | 24652, 43 antibodies |
DNASUi | 58516 |
Genome annotation databases
Organism-specific databases
CTDi | 58516 |
DisGeNETi | 58516 |
EuPathDBi | HostDB:ENSG00000139146.13 |
GeneCardsi | SINHCAF |
HGNCi | HGNC:30702, SINHCAF |
HPAi | ENSG00000139146, Low tissue specificity |
MIMi | 615027, gene |
neXtProti | NX_Q9NP50 |
OpenTargetsi | ENSG00000139146 |
PharmGKBi | PA134921007 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QSAG, Eukaryota |
GeneTreei | ENSGT00390000006485 |
HOGENOMi | CLU_2704143_0_0_1 |
InParanoidi | Q9NP50 |
OMAi | PCCRNKQ |
OrthoDBi | 1330424at2759 |
PhylomeDBi | Q9NP50 |
TreeFami | TF323911 |
Enzyme and pathway databases
PathwayCommonsi | Q9NP50 |
Miscellaneous databases
BioGRID-ORCSi | 58516, 270 hits in 825 CRISPR screens |
ChiTaRSi | FAM60A, human |
GeneWikii | FAM60A |
GenomeRNAii | 58516 |
Pharosi | Q9NP50, Tdark |
PROi | PR:Q9NP50 |
RNActi | Q9NP50, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000139146, Expressed in kidney and 116 other tissues |
ExpressionAtlasi | Q9NP50, baseline and differential |
Genevisiblei | Q9NP50, HS |
Family and domain databases
InterProi | View protein in InterPro IPR026065, FAM60A |
PANTHERi | PTHR13422, PTHR13422, 1 hit |
Pfami | View protein in Pfam PF15396, FAM60A, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SHCAF_HUMAN | |
Accessioni | Q9NP50Primary (citable) accession number: Q9NP50 Secondary accession number(s): D3DUV8, Q9BSZ8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2005 |
Last sequence update: | October 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 144 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations