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UniProtKB - Q9NP50 (SHCAF_HUMAN)

Entry version 147 (02 Jun 2021)
Sequence version 1 (01 Oct 2000)
Previous versions | rss
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Protein

SIN3-HDAC complex-associated factor

Gene

SINHCAF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this subunit is important for the repression of genes encoding components of the TGF-beta signaling pathway (PubMed:22865885, PubMed:22984288).

Core component of a SIN3A complex (composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1) present in embryonic stem (ES) cells. Promotes the stability of SIN3A and its presence on chromatin and is essential for maintaining the potential of ES cells to proliferate rapidly, while ensuring a short G1-phase of the cell cycle, thereby preventing premature lineage priming (By similarity).

By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NP50

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SIN3-HDAC complex-associated factorImported
Alternative name(s):
Protein FAM60A
Tera protein homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SINHCAFImported
Synonyms:C12orf14, FAM60A
ORF Names:L4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:30702, SINHCAF

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		615027, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NP50

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000139146.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		58516

Open Targets

More...OpenTargetsi		ENSG00000139146

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134921007

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NP50, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SINHCAF

Domain mapping of disease mutations (DMDM)

More...DMDMi		71151891

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001870861 – 221SIN3-HDAC complex-associated factorAdd BLAST221

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9NP50

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NP50

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NP50

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NP50

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NP50

PeptideAtlas

More...PeptideAtlasi		Q9NP50

PRoteomics IDEntifications database

More...PRIDEi		Q9NP50

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		81884 [Q9NP50-1]
81885 [Q9NP50-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NP50

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NP50

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9NP50

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Peaks during G1 and S phases of the cell cycle in U2OS cells. Up-regulated in squamous cell carcinoma (SCC), adenocarcinoma (AC), colon, ovary, rectum and stomach tumors.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000139146, Expressed in kidney and 117 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NP50, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NP50, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000139146, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the Sin3/HDAC corepressor complex at least composed of BRMS1, BRMS1L, ING2, SAP30, SAP30L and HDAC1 (PubMed:22865885, PubMed:22984288).

Found in a complex composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1.

Interacts with SIN3A and OGT (By similarity).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121842, 67 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-3323, SIN3A histone deacetylase complex, ES cell-specific variant

Protein interaction database and analysis system

More...IntActi		Q9NP50, 52 interactors

Molecular INTeraction database

More...MINTi		Q9NP50

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000337477

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NP50, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni112 – 152DisorderedSequence analysisAdd BLAST41
Regioni201 – 221DisorderedSequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi122 – 152Polar residuesSequence analysisAdd BLAST31

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SINHCAF family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QSAG, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000006485

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_2704143_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NP50

Identification of Orthologs from Complete Genome Data

More...OMAi		PCCRNKQ

Database of Orthologous Groups

More...OrthoDBi		1330424at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NP50

TreeFam database of animal gene trees

More...TreeFami		TF323911

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026065, FAM60A

The PANTHER Classification System

More...PANTHERi		PTHR13422, PTHR13422, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15396, FAM60A, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NP50-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFGFHKPKMY RSIEGCCICR AKSSSSRFTD SKRYEKDFQS CFGLHETRSG 
        60         70         80         90        100
DICNACVLLV KRWKKLPAGS KKNWNHVVDA RAGPSLKTTL KPKKVKTLSG 
       110        120        130        140        150
NRIKSNQISK LQKEFKRHNS DAHSTTSSAS PAQSPCYSNQ SDDGSDTEMA 
       160        170        180        190        200
SGSNRTPVFS FLDLTYWKRQ KICCGIIYKG RFGEVLIDTH LFKPCCSNKK 
       210        220 
AAAEKPEEQG PEPLPISTQE W
Length:221
Mass (Da):24,852
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF5905C8AAC76AD45
GO
Isoform 2 (identifier: Q9NP50-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-148: Missing.

Show »
Length:73
Mass (Da):8,292
Checksum:i051702E1E409F11E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GZ82F5GZ82_HUMAN
SIN3-HDAC complex-associated factor
SINHCAF
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YGG0H0YGG0_HUMAN
SIN3-HDAC complex-associated factor
SINHCAF
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H6U2F5H6U2_HUMAN
SIN3-HDAC complex-associated factor
SINHCAF
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049027117R → H. Corresponds to variant dbSNP:rs2304459Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0147051 – 148Missing in isoform 2. 1 PublicationAdd BLAST148

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY598323 mRNA Translation: AAT06734.1
AF087885 mRNA Translation: AAP97184.1
AF212220 mRNA Translation: AAF87322.1
AK026932 mRNA Translation: BAB15592.1
AL157432 mRNA Translation: CAB75656.1
AC024940 Genomic DNA No translation available.
CH471116 Genomic DNA Translation: EAW88561.1
CH471116 Genomic DNA Translation: EAW88562.1
CH471116 Genomic DNA Translation: EAW88564.1
CH471116 Genomic DNA Translation: EAW88566.1
CH471116 Genomic DNA Translation: EAW88567.1
BC000024 mRNA Translation: AAH00024.1
BC004462 mRNA Translation: AAH04462.1
BC071966 mRNA Translation: AAH71966.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS8723.1 [Q9NP50-1]

Protein sequence database of the Protein Information Resource

More...PIRi		T46918

NCBI Reference Sequences

More...RefSeqi		NP_001129283.1, NM_001135811.1 [Q9NP50-1]
NP_001129284.1, NM_001135812.1 [Q9NP50-1]
NP_067061.1, NM_021238.2 [Q9NP50-1]
XP_016875247.1, XM_017019758.1 [Q9NP50-1]
XP_016875248.1, XM_017019759.1 [Q9NP50-1]
XP_016875249.1, XM_017019760.1 [Q9NP50-1]
XP_016875250.1, XM_017019761.1 [Q9NP50-1]
XP_016875251.1, XM_017019762.1 [Q9NP50-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000337682; ENSP00000337477; ENSG00000139146 [Q9NP50-1]
ENST00000454658; ENSP00000393279; ENSG00000139146 [Q9NP50-1]
ENST00000539409; ENSP00000443697; ENSG00000139146 [Q9NP50-2]
ENST00000542983; ENSP00000439952; ENSG00000139146 [Q9NP50-2]
ENST00000617411; ENSP00000479093; ENSG00000276371 [Q9NP50-1]
ENST00000631598; ENSP00000488852; ENSG00000276371 [Q9NP50-2]
ENST00000633702; ENSP00000488570; ENSG00000276371 [Q9NP50-1]
ENST00000633815; ENSP00000488406; ENSG00000276371 [Q9NP50-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		58516

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:58516

UCSC genome browser

More...UCSCi		uc001rke.4, human [Q9NP50-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY598323 mRNA Translation: AAT06734.1
AF087885 mRNA Translation: AAP97184.1
AF212220 mRNA Translation: AAF87322.1
AK026932 mRNA Translation: BAB15592.1
AL157432 mRNA Translation: CAB75656.1
AC024940 Genomic DNA No translation available.
CH471116 Genomic DNA Translation: EAW88561.1
CH471116 Genomic DNA Translation: EAW88562.1
CH471116 Genomic DNA Translation: EAW88564.1
CH471116 Genomic DNA Translation: EAW88566.1
CH471116 Genomic DNA Translation: EAW88567.1
BC000024 mRNA Translation: AAH00024.1
BC004462 mRNA Translation: AAH04462.1
BC071966 mRNA Translation: AAH71966.1
CCDSiCCDS8723.1 [Q9NP50-1]
PIRiT46918
RefSeqiNP_001129283.1, NM_001135811.1 [Q9NP50-1]
NP_001129284.1, NM_001135812.1 [Q9NP50-1]
NP_067061.1, NM_021238.2 [Q9NP50-1]
XP_016875247.1, XM_017019758.1 [Q9NP50-1]
XP_016875248.1, XM_017019759.1 [Q9NP50-1]
XP_016875249.1, XM_017019760.1 [Q9NP50-1]
XP_016875250.1, XM_017019761.1 [Q9NP50-1]
XP_016875251.1, XM_017019762.1 [Q9NP50-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi121842, 67 interactors
ComplexPortaliCPX-3323, SIN3A histone deacetylase complex, ES cell-specific variant
IntActiQ9NP50, 52 interactors
MINTiQ9NP50
STRINGi9606.ENSP00000337477

PTM databases

iPTMnetiQ9NP50
PhosphoSitePlusiQ9NP50
SwissPalmiQ9NP50

Genetic variation databases

BioMutaiSINHCAF
DMDMi71151891

Proteomic databases

EPDiQ9NP50
jPOSTiQ9NP50
MassIVEiQ9NP50
MaxQBiQ9NP50
PaxDbiQ9NP50
PeptideAtlasiQ9NP50
PRIDEiQ9NP50
ProteomicsDBi81884 [Q9NP50-1]
81885 [Q9NP50-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		24652, 44 antibodies

The DNASU plasmid repository

More...DNASUi		58516

Genome annotation databases

EnsembliENST00000337682; ENSP00000337477; ENSG00000139146 [Q9NP50-1]
ENST00000454658; ENSP00000393279; ENSG00000139146 [Q9NP50-1]
ENST00000539409; ENSP00000443697; ENSG00000139146 [Q9NP50-2]
ENST00000542983; ENSP00000439952; ENSG00000139146 [Q9NP50-2]
ENST00000617411; ENSP00000479093; ENSG00000276371 [Q9NP50-1]
ENST00000631598; ENSP00000488852; ENSG00000276371 [Q9NP50-2]
ENST00000633702; ENSP00000488570; ENSG00000276371 [Q9NP50-1]
ENST00000633815; ENSP00000488406; ENSG00000276371 [Q9NP50-2]
GeneIDi58516
KEGGihsa:58516
UCSCiuc001rke.4, human [Q9NP50-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		58516
DisGeNETi58516

GeneCards: human genes, protein and diseases

More...GeneCardsi		SINHCAF
HGNCiHGNC:30702, SINHCAF
HPAiENSG00000139146, Low tissue specificity
MIMi615027, gene
neXtProtiNX_Q9NP50
OpenTargetsiENSG00000139146
PharmGKBiPA134921007
VEuPathDBiHostDB:ENSG00000139146.13

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QSAG, Eukaryota
GeneTreeiENSGT00390000006485
HOGENOMiCLU_2704143_0_0_1
InParanoidiQ9NP50
OMAiPCCRNKQ
OrthoDBi1330424at2759
PhylomeDBiQ9NP50
TreeFamiTF323911

Enzyme and pathway databases

PathwayCommonsiQ9NP50

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		58516, 281 hits in 964 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		FAM60A, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		FAM60A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		58516
PharosiQ9NP50, Tdark

Protein Ontology

More...PROi		PR:Q9NP50
RNActiQ9NP50, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000139146, Expressed in kidney and 117 other tissues
ExpressionAtlasiQ9NP50, baseline and differential
GenevisibleiQ9NP50, HS

Family and domain databases

InterProiView protein in InterPro
IPR026065, FAM60A
PANTHERiPTHR13422, PTHR13422, 1 hit
PfamiView protein in Pfam
PF15396, FAM60A, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSHCAF_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NP50
Secondary accession number(s): D3DUV8, Q9BSZ8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 1, 2000
Last modified: June 2, 2021
This is version 147 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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