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Protein

DnaJ homolog subfamily C member 4

Gene

DNAJC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • unfolded protein binding Source: UniProtKB

GO - Biological processi

  • protein folding Source: UniProtKB
  • response to unfolded protein Source: ProtInc

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 4
Alternative name(s):
DnaJ-like protein HSPF2
Multiple endocrine neoplasia type 1 candidate protein number 18
Gene namesi
Name:DNAJC4
Synonyms:HSPF2, MCG18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000110011.13
HGNCiHGNC:5271 DNAJC4
MIMi604189 gene
neXtProtiNX_Q9NNZ3

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei156 – 175HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3338
OpenTargetsiENSG00000110011
PharmGKBiPA27421

Polymorphism and mutation databases

BioMutaiDNAJC4
DMDMi18203312

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000710491 – 241DnaJ homolog subfamily C member 4Add BLAST241

Proteomic databases

PaxDbiQ9NNZ3
PRIDEiQ9NNZ3
ProteomicsDBi81878

PTM databases

iPTMnetiQ9NNZ3
PhosphoSitePlusiQ9NNZ3

Expressioni

Gene expression databases

BgeeiENSG00000110011
CleanExiHS_DNAJC4
ExpressionAtlasiQ9NNZ3 baseline and differential
GenevisibleiQ9NNZ3 HS

Organism-specific databases

HPAiHPA011947

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HTTP428583EBI-4397791,EBI-466029

GO - Molecular functioni

  • unfolded protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi109570, 3 interactors
IntActiQ9NNZ3, 2 interactors
STRINGi9606.ENSP00000396896

Structurei

3D structure databases

ProteinModelPortaliQ9NNZ3
SMRiQ9NNZ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 99JPROSITE-ProRule annotationAdd BLAST66

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410KDCY Eukaryota
COG0484 LUCA
GeneTreeiENSGT00510000048574
HOGENOMiHOG000112242
HOVERGENiHBG051375
InParanoidiQ9NNZ3
KOiK09524
PhylomeDBiQ9NNZ3
TreeFamiTF105163

Family and domain databases

CDDicd06257 DnaJ, 1 hit
Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR001623 DnaJ_domain
IPR036869 J_dom_sf
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
PROSITEiView protein in PROSITE
PS50076 DNAJ_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NNZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPLLPLRLC RLWPRNPPSR LLGAAAGQRS RPSTYYELLG VHPGASTEEV
60 70 80 90 100
KRAFFSKSKE LHPDRDPGNP SLHSRFVELS EAYRVLSREQ SRRSYDDQLR
110 120 130 140 150
SGSPPKSPRT TVHDKSAHQT HSSWTPPNAQ YWSQFHSVRP QGPQLRQQQH
160 170 180 190 200
KQNKQVLGYC LLLMLAGMGL HYIAFRKVKQ MHLNFMDEKD RIITAFYNEA
210 220 230 240
RARARANRGI LQQERQRLGQ RQPPPSEPTQ GPEIVPRGAG P
Length:241
Mass (Da):27,593
Last modified:October 1, 2000 - v1
Checksum:iEA186D2FA6C2E179
GO

Sequence cautioni

The sequence AAB82426 differs from that shown. Several sequence rearrangements.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF036874 mRNA Translation: AAF97845.1
BC044584 mRNA Translation: AAH44584.1
BC057849 mRNA Translation: AAH57849.1
AF012106 mRNA Translation: AAB82426.1 Sequence problems.
CCDSiCCDS41666.1
PIRiJE0169
RefSeqiNP_001294909.1, NM_001307980.1
NP_001294910.1, NM_001307981.1
NP_005519.2, NM_005528.3
UniGeneiHs.172847

Genome annotation databases

EnsembliENST00000321685; ENSP00000396896; ENSG00000110011
GeneIDi3338
KEGGihsa:3338
UCSCiuc001nys.4 human

Similar proteinsi

Entry informationi

Entry nameiDNJC4_HUMAN
AccessioniPrimary (citable) accession number: Q9NNZ3
Secondary accession number(s): O14716
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: October 1, 2000
Last modified: June 20, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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