UniProtKB - Q9NNZ3 (DNJC4_HUMAN)
Protein
DnaJ homolog subfamily C member 4
Gene
DNAJC4
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- unfolded protein binding Source: UniProtKB
GO - Biological processi
- protein folding Source: UniProtKB
- response to unfolded protein Source: ProtInc
Keywordsi
Molecular function | Chaperone |
Enzyme and pathway databases
PathwayCommonsi | Q9NNZ3 |
Names & Taxonomyi
Protein namesi | Recommended name: DnaJ homolog subfamily C member 4Alternative name(s): DnaJ-like protein HSPF2 Multiple endocrine neoplasia type 1 candidate protein number 18 |
Gene namesi | Name:DNAJC4 Synonyms:HSPF2, MCG18 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000110011.13 |
HGNCi | HGNC:5271, DNAJC4 |
MIMi | 604189, gene |
neXtProti | NX_Q9NNZ3 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: ProtInc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 156 – 175 | HelicalSequence analysisAdd BLAST | 20 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 3338 |
OpenTargetsi | ENSG00000110011 |
PharmGKBi | PA27421 |
Miscellaneous databases
Pharosi | Q9NNZ3, Tdark |
Polymorphism and mutation databases
BioMutai | DNAJC4 |
DMDMi | 18203312 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000071049 | 1 – 241 | DnaJ homolog subfamily C member 4Add BLAST | 241 |
Proteomic databases
MassIVEi | Q9NNZ3 |
PaxDbi | Q9NNZ3 |
PeptideAtlasi | Q9NNZ3 |
PRIDEi | Q9NNZ3 |
ProteomicsDBi | 81878 |
PTM databases
iPTMneti | Q9NNZ3 |
PhosphoSitePlusi | Q9NNZ3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000110011, Expressed in right testis and 205 other tissues |
ExpressionAtlasi | Q9NNZ3, baseline and differential |
Genevisiblei | Q9NNZ3, HS |
Organism-specific databases
HPAi | ENSG00000110011, Low tissue specificity |
Interactioni
Binary interactionsi
Q9NNZ3
With | #Exp. | IntAct |
---|---|---|
HTT [P42858] | 3 | EBI-4397791,EBI-466029 |
GO - Molecular functioni
- unfolded protein binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 109570, 4 interactors |
IntActi | Q9NNZ3, 2 interactors |
STRINGi | 9606.ENSP00000396896 |
Miscellaneous databases
RNActi | Q9NNZ3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 34 – 99 | JPROSITE-ProRule annotationAdd BLAST | 66 |
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0691, Eukaryota |
GeneTreei | ENSGT00510000048574 |
HOGENOMi | CLU_081597_0_0_1 |
InParanoidi | Q9NNZ3 |
OrthoDBi | 1330473at2759 |
PhylomeDBi | Q9NNZ3 |
TreeFami | TF105163 |
Family and domain databases
CDDi | cd06257, DnaJ, 1 hit |
Gene3Di | 1.10.287.110, 1 hit |
InterProi | View protein in InterPro IPR001623, DnaJ_domain IPR036869, J_dom_sf |
Pfami | View protein in Pfam PF00226, DnaJ, 1 hit |
PRINTSi | PR00625, JDOMAIN |
SMARTi | View protein in SMART SM00271, DnaJ, 1 hit |
SUPFAMi | SSF46565, SSF46565, 1 hit |
PROSITEi | View protein in PROSITE PS50076, DNAJ_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
Q9NNZ3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPPLLPLRLC RLWPRNPPSR LLGAAAGQRS RPSTYYELLG VHPGASTEEV
60 70 80 90 100
KRAFFSKSKE LHPDRDPGNP SLHSRFVELS EAYRVLSREQ SRRSYDDQLR
110 120 130 140 150
SGSPPKSPRT TVHDKSAHQT HSSWTPPNAQ YWSQFHSVRP QGPQLRQQQH
160 170 180 190 200
KQNKQVLGYC LLLMLAGMGL HYIAFRKVKQ MHLNFMDEKD RIITAFYNEA
210 220 230 240
RARARANRGI LQQERQRLGQ RQPPPSEPTQ GPEIVPRGAG P
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YGV0 | H0YGV0_HUMAN | DnaJ homolog subfamily C member 4 | DNAJC4 | 167 | Annotation score: | ||
J3KNJ8 | J3KNJ8_HUMAN | DnaJ homolog subfamily C member 4 | DNAJC4 | 249 | Annotation score: | ||
Q96FY5 | Q96FY5_HUMAN | DNAJC4 protein | DNAJC4 hCG_2039176 | 67 | Annotation score: | ||
G3V1T1 | G3V1T1_HUMAN | DnaJ (Hsp40) homolog, subfamily C, ... | DNAJC4 hCG_2039176 | 47 | Annotation score: |
Sequence cautioni
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF036874 mRNA Translation: AAF97845.1 BC044584 mRNA Translation: AAH44584.1 BC057849 mRNA Translation: AAH57849.1 AF012106 mRNA Translation: AAB82426.1 Sequence problems. |
CCDSi | CCDS41666.1 |
PIRi | JE0169 |
RefSeqi | NP_001294909.1, NM_001307980.1 NP_001294910.1, NM_001307981.1 NP_005519.2, NM_005528.3 |
Genome annotation databases
Ensembli | ENST00000321685; ENSP00000396896; ENSG00000110011 |
GeneIDi | 3338 |
KEGGi | hsa:3338 |
UCSCi | uc001nys.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF036874 mRNA Translation: AAF97845.1 BC044584 mRNA Translation: AAH44584.1 BC057849 mRNA Translation: AAH57849.1 AF012106 mRNA Translation: AAB82426.1 Sequence problems. |
CCDSi | CCDS41666.1 |
PIRi | JE0169 |
RefSeqi | NP_001294909.1, NM_001307980.1 NP_001294910.1, NM_001307981.1 NP_005519.2, NM_005528.3 |
3D structure databases
SMRi | Q9NNZ3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 109570, 4 interactors |
IntActi | Q9NNZ3, 2 interactors |
STRINGi | 9606.ENSP00000396896 |
PTM databases
iPTMneti | Q9NNZ3 |
PhosphoSitePlusi | Q9NNZ3 |
Polymorphism and mutation databases
BioMutai | DNAJC4 |
DMDMi | 18203312 |
Proteomic databases
MassIVEi | Q9NNZ3 |
PaxDbi | Q9NNZ3 |
PeptideAtlasi | Q9NNZ3 |
PRIDEi | Q9NNZ3 |
ProteomicsDBi | 81878 |
Protocols and materials databases
Antibodypediai | 2326, 53 antibodies |
DNASUi | 3338 |
Genome annotation databases
Ensembli | ENST00000321685; ENSP00000396896; ENSG00000110011 |
GeneIDi | 3338 |
KEGGi | hsa:3338 |
UCSCi | uc001nys.4, human |
Organism-specific databases
CTDi | 3338 |
DisGeNETi | 3338 |
EuPathDBi | HostDB:ENSG00000110011.13 |
GeneCardsi | DNAJC4 |
HGNCi | HGNC:5271, DNAJC4 |
HPAi | ENSG00000110011, Low tissue specificity |
MIMi | 604189, gene |
neXtProti | NX_Q9NNZ3 |
OpenTargetsi | ENSG00000110011 |
PharmGKBi | PA27421 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0691, Eukaryota |
GeneTreei | ENSGT00510000048574 |
HOGENOMi | CLU_081597_0_0_1 |
InParanoidi | Q9NNZ3 |
OrthoDBi | 1330473at2759 |
PhylomeDBi | Q9NNZ3 |
TreeFami | TF105163 |
Enzyme and pathway databases
PathwayCommonsi | Q9NNZ3 |
Miscellaneous databases
BioGRID-ORCSi | 3338, 6 hits in 846 CRISPR screens |
ChiTaRSi | DNAJC4, human |
GenomeRNAii | 3338 |
Pharosi | Q9NNZ3, Tdark |
PROi | PR:Q9NNZ3 |
RNActi | Q9NNZ3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000110011, Expressed in right testis and 205 other tissues |
ExpressionAtlasi | Q9NNZ3, baseline and differential |
Genevisiblei | Q9NNZ3, HS |
Family and domain databases
CDDi | cd06257, DnaJ, 1 hit |
Gene3Di | 1.10.287.110, 1 hit |
InterProi | View protein in InterPro IPR001623, DnaJ_domain IPR036869, J_dom_sf |
Pfami | View protein in Pfam PF00226, DnaJ, 1 hit |
PRINTSi | PR00625, JDOMAIN |
SMARTi | View protein in SMART SM00271, DnaJ, 1 hit |
SUPFAMi | SSF46565, SSF46565, 1 hit |
PROSITEi | View protein in PROSITE PS50076, DNAJ_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DNJC4_HUMAN | |
Accessioni | Q9NNZ3Primary (citable) accession number: Q9NNZ3 Secondary accession number(s): O14716 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 18, 2001 |
Last sequence update: | October 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM