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Entry version 182 (12 Aug 2020)
Sequence version 1 (01 Oct 2000)
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Protein

CD209 antigen

Gene

CD209

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response.1 Publication
On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells.3 Publications
(Microbial infection) Acts as an attachment receptor for HIV-1 and HIV-2.3 Publications
(Microbial infection) Acts as an attachment receptor for Ebolavirus.2 Publications
(Microbial infection) Acts as an attachment receptor for Cytomegalovirus.2 Publications
(Microbial infection) Acts as an attachment receptor for HCV.2 Publications
(Microbial infection) Acts as an attachment receptor for Dengue virus.1 Publication
(Microbial infection) Acts as an attachment receptor for Measles virus.1 Publication
(Microbial infection) Acts as an attachment receptor for Herpes simplex virus 1.1 Publication
(Microbial infection) Acts as an attachment receptor for Influenzavirus A.1 Publication
(Microbial infection) Acts as an attachment receptor for SARS-CoV.1 Publication
(Microbial infection) Acts as an attachment receptor for Japanese encephalitis virus.1 Publication
(Microbial infection) Acts as an attachment receptor for Lassa virus (PubMed:23966408). Acts as an attachment receptor for Marburg virusn.1 Publication
(Microbial infection) Acts as an attachment receptor for Respiratory syncytial virus.1 Publication
(Microbial infection) Acts as an attachment receptor for Rift valley fever virus and uukuniemi virus.1 Publication
(Microbial infection) Acts as an attachment receptor for West-nile virus.1 Publication
(Microbial infection) Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of bacterial pathogen antigens, including Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri-mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA (PubMed:16379498). Recognition of M.tuberculosis by dendritic cells occurs partially via this molecule (PubMed:16092920, PubMed:21203928).3 Publications

Miscellaneous

In vitro, is a receptor for HIV-1 and transmits HIV-1 either in trans without DC infection, or in cis following a DC infection to permissive T-cells to induce a robust infection. Bound HIV-1 remains infectious over a prolonged period of time and it is proposed that bound HIV-1 is not degraded but protected in non-lysosomal acidic organelles within the DCs close to the cell membrane thus contributing to the HIV-1 infectious potential during transport by DCs from the periphery to lymphoid organs.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi347Calcium1
Metal bindingi349Calcium1
Metal bindingi351Calcium; via carbonyl oxygen1
Metal bindingi354Calcium1
Metal bindingi365Calcium1
Metal bindingi366Calcium1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHost cell receptor for virus entry, Receptor
Biological processAdaptive immunity, Cell adhesion, Endocytosis, Host-virus interaction, Immunity, Innate immunity
LigandCalcium, Lectin, Mannose-binding, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9NNX6

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5621575, CD209 (DC-SIGN) signaling
R-HSA-8851680, Butyrophilin (BTN) family interactions

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9NNX6

Protein family/group databases

UniLectin database of carbohydrate-binding proteins

More...
UniLectini
Q9NNX6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CD209 antigen
Alternative name(s):
C-type lectin domain family 4 member L
Dendritic cell-specific ICAM-3-grabbing non-integrin 1
Short name:
DC-SIGN
Short name:
DC-SIGN1
CD_antigen: CD209
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CD209
Synonyms:CLEC4L
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000090659.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1641, CD209

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604672, gene+phenotype

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NNX6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 37CytoplasmicCuratedAdd BLAST37
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei38 – 58Helical; Signal-anchor for type II membrane proteinCuratedAdd BLAST21
Topological domaini59 – 404ExtracellularCuratedAdd BLAST346

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi14 – 15LL → AA: Loss of antigen internalization by endocytosis. 1 Publication2
Mutagenesisi320D → A: Loss of binding to ICAM3 and HIV-1 gp120. 1 Publication1
Mutagenesisi324E → A: Loss of binding to ICAM3 and HIV-1 gp120. 1 Publication1
Mutagenesisi347E → Q: Loss of binding to ICAM3 and HIV-1 gp120. 1 Publication1
Mutagenesisi349N → D: Loss of binding to ICAM3 and HIV-1 gp120. 1 Publication1
Mutagenesisi350N → A: Loss of binding to ICAM3 and HIV-1 gp120. 1 Publication1
Mutagenesisi355D → A: Loss of binding to ICAM3 and HIV-1 gp120. 1 Publication1
Mutagenesisi365N → D: Loss of binding to ICAM3 and HIV-1 gp120. 1 Publication1
Mutagenesisi366D → A: Loss of binding to ICAM3 and HIV-1 gp120. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
30835

MalaCards human disease database

More...
MalaCardsi
CD209
MIMi604672, gene+phenotype
607948, phenotype
614371, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000090659

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26199

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NNX6, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1795114

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CD209

Domain mapping of disease mutations (DMDM)

More...
DMDMi
46396012

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000465951 – 404CD209 antigenAdd BLAST404

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi80N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi256 ↔ 267
Disulfide bondi284 ↔ 377
Disulfide bondi356 ↔ 369

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NNX6

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9NNX6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NNX6

PeptideAtlas

More...
PeptideAtlasi
Q9NNX6

PRoteomics IDEntifications database

More...
PRIDEi
Q9NNX6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
33898
81864 [Q9NNX6-1]
81865 [Q9NNX6-10]
81866 [Q9NNX6-11]
81867 [Q9NNX6-12]
81869 [Q9NNX6-2]
81870 [Q9NNX6-3]
81871 [Q9NNX6-4]
81872 [Q9NNX6-5]
81873 [Q9NNX6-6]
81874 [Q9NNX6-7]
81875 [Q9NNX6-8]
81876 [Q9NNX6-9]

2D gel databases

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
Q9NNX6

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9NNX6, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NNX6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NNX6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in dendritic cells and in DC-residing tissues. Also found in placental macrophages, endothelial cells of placental vascular channels, peripheral blood mononuclear cells, and THP-1 monocytes.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000090659, Expressed in adrenal gland and 176 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9NNX6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9NNX6, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000090659, Tissue enhanced (lymphoid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.

Interacts with C1QBP; the interaction is indicative for a C1q:C1QBP:CD209 signaling complex.

Interacts with ICAM2 and ICAM3 by binding to mannose-like carbohydrates.

Interacts (via C-type lectin domain) with CEACAM1 (via Lewis X moieties); this interaction is regulated by the glycosylation pattern of CEACAM1 on cell types and regulates contact between dendritic cells and neutrophils (PubMed:16246332).

6 Publications

(Microbial infection) Interacts with HIV-1 and HIV-2 gp120 (PubMed:11799126, PubMed:12502850, PubMed:1518869).

3 Publications

(Microbial infection) Interacts with ebolavirus envelope glycoproteins (PubMed:12502850, PubMed:12504546).

2 Publications

(Microbial infection) Interacts with cytomegalovirus gB protein (PubMed:12433371, PubMed:22496863).

2 Publications

(Microbial infection) Interacts with HCV E2 protein (PubMed:15371595, PubMed:16816373).

2 Publications

(Microbial infection) Interacts with dengue virus major envelope protein E.

1 Publication

(Microbial infection) Interacts with measles hemagglutinin.

1 Publication

(Microbial infection) Interacts with herpes simplex virus 1 surface proteins.

1 Publication

(Microbial infection) Interacts with Influenzavirus A hemagglutinin.

1 Publication

(Microbial infection) Interacts with SARS-CoV spike glycoprotein.

1 Publication

(Microbial infection) Interacts with Japanese encephalitis virus E protein.

1 Publication

(Microbial infection) Interacts with Lassa virus Glycoprotein.

1 Publication

(Microbial infection) Interacts with marburg virus glycoprotein.

1 Publication

(Microbial infection) Interacts with Respiratory syncytial virus glycoprotein G.

1 Publication

(Microbial infection) Interacts with Rift valley fever virus and uukuniemi virus envelope glycoprotein.

1 Publication

(Microbial infection) Interacts with west-nile virus envelope glycoprotein.

1 Publication

(Microbial infection) Interacts with whole M.bovis cells in a Ca2+-dependent and independent manner; in vitro experiments suggest it interacts with CH60.1 (groL1), DnaK, GADPH (gap) and LrpG (PubMed:21203928).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
119051, 14 interactors

Database of interacting proteins

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DIPi
DIP-60629N

Protein interaction database and analysis system

More...
IntActi
Q9NNX6, 11 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000315477

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9NNX6

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9NNX6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1404
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9NNX6

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9NNX6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati96 – 1181Add BLAST23
Repeati119 – 1412Add BLAST23
Repeati142 – 1643Add BLAST23
Repeati165 – 1874Add BLAST23
Repeati188 – 2105Add BLAST23
Repeati211 – 2336Add BLAST23
Repeati234 – 2577Add BLAST24
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini263 – 378C-type lectinPROSITE-ProRule annotationAdd BLAST116

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni96 – 2577 X approximate tandem repeatsAdd BLAST162

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi14 – 15Endocytosis signal2
Motifi16 – 18Endocytosis signalSequence analysis3
Motifi31 – 34Endocytosis signalSequence analysis4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The tandem repeat domain, also called neck domain, mediates oligomerization.

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4297, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155012

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_1577990_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NNX6

KEGG Orthology (KO)

More...
KOi
K06563

Identification of Orthologs from Complete Genome Data

More...
OMAi
FEQYWNR

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NNX6

TreeFam database of animal gene trees

More...
TreeFami
TF333341

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03590, CLECT_DC-SIGN_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR018378, C-type_lectin_CS
IPR033989, CD209-like_CTLD
IPR016187, CTDL_fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00059, Lectin_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00034, CLECT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56436, SSF56436, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00615, C_TYPE_LECTIN_1, 1 hit
PS50041, C_TYPE_LECTIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (12+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 12 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist. Several splicing events may be used independently in a modular way. Deletion of the transmembrane domain encoding exon through alternative splicing produces soluble isoforms.1 Publication

This entry has 12 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NNX6-1) [UniParc]FASTAAdd to basket
Also known as: mDC-SIGN1A type I

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDSKEPRLQ QLGLLEEEQL RGLGFRQTRG YKSLAGCLGH GPLVLQLLSF
60 70 80 90 100
TLLAGLLVQV SKVPSSISQE QSRQDAIYQN LTQLKAAVGE LSEKSKLQEI
110 120 130 140 150
YQELTQLKAA VGELPEKSKL QEIYQELTRL KAAVGELPEK SKLQEIYQEL
160 170 180 190 200
TWLKAAVGEL PEKSKMQEIY QELTRLKAAV GELPEKSKQQ EIYQELTRLK
210 220 230 240 250
AAVGELPEKS KQQEIYQELT RLKAAVGELP EKSKQQEIYQ ELTQLKAAVE
260 270 280 290 300
RLCHPCPWEW TFFQGNCYFM SNSQRNWHDS ITACKEVGAQ LVVIKSAEEQ
310 320 330 340 350
NFLQLQSSRS NRFTWMGLSD LNQEGTWQWV DGSPLLPSFK QYWNRGEPNN
360 370 380 390 400
VGEEDCAEFS GNGWNDDKCN LAKFWICKKS AASCSRDEEQ FLSPAPATPN

PPPA
Length:404
Mass (Da):45,775
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA23FA246014533C0
GO
Isoform 2 (identifier: Q9NNX6-2) [UniParc]FASTAAdd to basket
Also known as: mDC-SIGN1A type II

The sequence of this isoform differs from the canonical sequence as follows:
     301-306: Missing.

Show »
Length:398
Mass (Da):45,031
Checksum:iD925764886701D2E
GO
Isoform 3 (identifier: Q9NNX6-3) [UniParc]FASTAAdd to basket
Also known as: mDC-SIGN1A type III

The sequence of this isoform differs from the canonical sequence as follows:
     158-249: Missing.

Show »
Length:312
Mass (Da):35,236
Checksum:iE915D23CB096AA44
GO
Isoform 4 (identifier: Q9NNX6-4) [UniParc]FASTAAdd to basket
Also known as: mDC-SIGN1A type IV

The sequence of this isoform differs from the canonical sequence as follows:
     74-309: Missing.

Show »
Length:168
Mass (Da):18,646
Checksum:i901718CE96B9F59C
GO
Isoform 5 (identifier: Q9NNX6-5) [UniParc]FASTAAdd to basket
Also known as: mDC-SIGN1B type I

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MSDSKEPRLQQLGLL → MASACPGSDFTSIHS

Show »
Length:404
Mass (Da):45,571
Checksum:iD4D570727D9DCC30
GO
Isoform 6 (identifier: Q9NNX6-6) [UniParc]FASTAAdd to basket
Also known as: sDC-SIGN1A type I

The sequence of this isoform differs from the canonical sequence as follows:
     36-59: Missing.

Show »
Length:380
Mass (Da):43,330
Checksum:iBCF9CC45ABEF6B02
GO
Isoform 7 (identifier: Q9NNX6-7) [UniParc]FASTAAdd to basket
Also known as: sDC-SIGN1A type II

The sequence of this isoform differs from the canonical sequence as follows:
     16-59: Missing.

Show »
Length:360
Mass (Da):41,009
Checksum:i6ABE2B9AAEDFAAA8
GO
Isoform 8 (identifier: Q9NNX6-8) [UniParc]FASTAAdd to basket
Also known as: sDC-SIGN1A type III

The sequence of this isoform differs from the canonical sequence as follows:
     16-59: Missing.
     142-233: Missing.

Show »
Length:268
Mass (Da):30,427
Checksum:i113E1ED1B5748693
GO
Isoform 9 (identifier: Q9NNX6-9) [UniParc]FASTAAdd to basket
Also known as: sDC-SIGN1A type IV

The sequence of this isoform differs from the canonical sequence as follows:
     30-34: GYKSL → RNQKC
     35-404: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:34
Mass (Da):4,046
Checksum:i51F5A6911CDAC150
GO
Isoform 10 (identifier: Q9NNX6-10) [UniParc]FASTAAdd to basket
Also known as: sDC-SIGN1B type I

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MSDSKEPRLQQLGLL → MASACPGSDFTSIHS
     36-59: Missing.

Show »
Length:380
Mass (Da):43,126
Checksum:iF3D098F9FB7D044B
GO
Isoform 11 (identifier: Q9NNX6-11) [UniParc]FASTAAdd to basket
Also known as: sDC-SIGN1B type II

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MSDSKEPRLQQLGLL → MASACPGSDFTSIHS
     36-59: Missing.
     191-236: Missing.

Show »
Length:334
Mass (Da):37,844
Checksum:i8E796FC4111C86BF
GO
Isoform 12 (identifier: Q9NNX6-12) [UniParc]FASTAAdd to basket
Also known as: sDC-SIGN1B type III

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MSDSKEPRLQQLGLL → MASACPGSDFTSIHS
     36-59: Missing.
     301-321: NFLQLQSSRSNRFTWMGLSDL → LQAVLEQRRAQQRWGGRLRGI
     322-404: Missing.

Show »
Length:297
Mass (Da):33,874
Checksum:iC8C0951B915FC5BF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R0P0M0R0P0_HUMAN
CD209 antigen
CD209 hCG_22558
268Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6RB12X6RB12_HUMAN
CD209 antigen
CD209
243Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZG5M0QZG5_HUMAN
CD209 antigen
CD209 hCG_22558
334Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAK91858 differs from that shown. Aberrant splicing.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti152W → Q in AAK91848 (PubMed:11337487).Curated1

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Genetic variations in the CD209 promoter determine M.tuberculosis susceptibility [MIMi:607948] (PubMed:16379498).1 Publication
Genetic variations in CD209 may influence susceptibility or resistance to dengue virus infection, as well as disease progression and severity [MIMi:614371]. A promoter polymorphism in the CD209 gene is associated with protection from dengue fever, but not dengue hemorrhagic fever.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050104168E → D. Corresponds to variant dbSNP:rs1003686123Ensembl.1
Natural variantiVAR_036689214E → D. Corresponds to variant dbSNP:rs11465377EnsemblClinVar.1
Natural variantiVAR_036690242L → V. Corresponds to variant dbSNP:rs11465380Ensembl.1
Natural variantiVAR_050105382A → S. Corresponds to variant dbSNP:rs11465393Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0100371 – 15MSDSK…QLGLL → MASACPGSDFTSIHS in isoform 5, isoform 10, isoform 11 and isoform 12. 2 PublicationsAdd BLAST15
Alternative sequenceiVSP_01003816 – 59Missing in isoform 7 and isoform 8. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_01003930 – 34GYKSL → RNQKC in isoform 9. 1 Publication5
Alternative sequenceiVSP_01004035 – 404Missing in isoform 9. 1 PublicationAdd BLAST370
Alternative sequenceiVSP_01004136 – 59Missing in isoform 6, isoform 10, isoform 11 and isoform 12. 2 PublicationsAdd BLAST24
Alternative sequenceiVSP_01004274 – 309Missing in isoform 4. 1 PublicationAdd BLAST236
Alternative sequenceiVSP_010043142 – 233Missing in isoform 8. 1 PublicationAdd BLAST92
Alternative sequenceiVSP_010044158 – 249Missing in isoform 3. 1 PublicationAdd BLAST92
Alternative sequenceiVSP_010047191 – 236Missing in isoform 11. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_010048301 – 321NFLQL…GLSDL → LQAVLEQRRAQQRWGGRLRG I in isoform 12. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_010049301 – 306Missing in isoform 2. 1 Publication6
Alternative sequenceiVSP_010050322 – 404Missing in isoform 12. 1 PublicationAdd BLAST83

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M98457 mRNA Translation: AAF77072.1
AF209479 Genomic DNA Translation: AAG13814.1
AF290886 mRNA Translation: AAK20997.1
AY042221 mRNA Translation: AAK91846.1
AY042222 mRNA Translation: AAK91847.1
AY042223 mRNA Translation: AAK91848.1
AY042224 mRNA Translation: AAK91849.1
AY042225 mRNA Translation: AAK91850.1
AY042226 mRNA Translation: AAK91851.1
AY042227 mRNA Translation: AAK91852.1
AY042228 mRNA Translation: AAK91853.1
AY042229 mRNA Translation: AAK91854.1
AY042230 mRNA Translation: AAK91855.1
AY042231 mRNA Translation: AAK91856.1
AY042232 mRNA Translation: AAK91857.1
AY042233 mRNA Translation: AAK91858.1 Sequence problems.
AK293089 mRNA Translation: BAF85778.1
AC008763 Genomic DNA No translation available.
AC008812 Genomic DNA No translation available.
CH471139 Genomic DNA Translation: EAW68991.1
CH471139 Genomic DNA Translation: EAW68993.1
CH471139 Genomic DNA Translation: EAW68997.1
CH471139 Genomic DNA Translation: EAW68998.1
BC110615 mRNA Translation: AAI10616.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12186.1 [Q9NNX6-1]
CCDS45949.1 [Q9NNX6-7]
CCDS45950.1 [Q9NNX6-6]
CCDS45951.1 [Q9NNX6-2]
CCDS45952.1 [Q9NNX6-3]
CCDS59344.1 [Q9NNX6-8]

Protein sequence database of the Protein Information Resource

More...
PIRi
A46274

NCBI Reference Sequences

More...
RefSeqi
NP_001138365.1, NM_001144893.1
NP_001138366.1, NM_001144894.1 [Q9NNX6-7]
NP_001138367.1, NM_001144895.1 [Q9NNX6-3]
NP_001138368.1, NM_001144896.1 [Q9NNX6-6]
NP_001138369.1, NM_001144897.1 [Q9NNX6-2]
NP_066978.1, NM_021155.3 [Q9NNX6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000204801; ENSP00000204801; ENSG00000090659 [Q9NNX6-7]
ENST00000315591; ENSP00000315407; ENSG00000090659 [Q9NNX6-6]
ENST00000315599; ENSP00000315477; ENSG00000090659 [Q9NNX6-1]
ENST00000354397; ENSP00000346373; ENSG00000090659 [Q9NNX6-2]
ENST00000394161; ENSP00000377716; ENSG00000090659 [Q9NNX6-4]
ENST00000601256; ENSP00000470658; ENSG00000090659 [Q9NNX6-12]
ENST00000601951; ENSP00000468827; ENSG00000090659 [Q9NNX6-10]
ENST00000602261; ENSP00000471137; ENSG00000090659 [Q9NNX6-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
30835

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:30835

UCSC genome browser

More...
UCSCi
uc002mhr.3, human [Q9NNX6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

DC-SIGN entry

Functional Glycomics Gateway - Glycan Binding

DC-SIGN

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M98457 mRNA Translation: AAF77072.1
AF209479 Genomic DNA Translation: AAG13814.1
AF290886 mRNA Translation: AAK20997.1
AY042221 mRNA Translation: AAK91846.1
AY042222 mRNA Translation: AAK91847.1
AY042223 mRNA Translation: AAK91848.1
AY042224 mRNA Translation: AAK91849.1
AY042225 mRNA Translation: AAK91850.1
AY042226 mRNA Translation: AAK91851.1
AY042227 mRNA Translation: AAK91852.1
AY042228 mRNA Translation: AAK91853.1
AY042229 mRNA Translation: AAK91854.1
AY042230 mRNA Translation: AAK91855.1
AY042231 mRNA Translation: AAK91856.1
AY042232 mRNA Translation: AAK91857.1
AY042233 mRNA Translation: AAK91858.1 Sequence problems.
AK293089 mRNA Translation: BAF85778.1
AC008763 Genomic DNA No translation available.
AC008812 Genomic DNA No translation available.
CH471139 Genomic DNA Translation: EAW68991.1
CH471139 Genomic DNA Translation: EAW68993.1
CH471139 Genomic DNA Translation: EAW68997.1
CH471139 Genomic DNA Translation: EAW68998.1
BC110615 mRNA Translation: AAI10616.1
CCDSiCCDS12186.1 [Q9NNX6-1]
CCDS45949.1 [Q9NNX6-7]
CCDS45950.1 [Q9NNX6-6]
CCDS45951.1 [Q9NNX6-2]
CCDS45952.1 [Q9NNX6-3]
CCDS59344.1 [Q9NNX6-8]
PIRiA46274
RefSeqiNP_001138365.1, NM_001144893.1
NP_001138366.1, NM_001144894.1 [Q9NNX6-7]
NP_001138367.1, NM_001144895.1 [Q9NNX6-3]
NP_001138368.1, NM_001144896.1 [Q9NNX6-6]
NP_001138369.1, NM_001144897.1 [Q9NNX6-2]
NP_066978.1, NM_021155.3 [Q9NNX6-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K9IX-ray2.50A/B/C/D/E/F/G/H/I/J250-404[»]
1SL4X-ray1.55A250-404[»]
1SL5X-ray1.80A250-388[»]
2B6Belectron microscopy25.00D251-404[»]
2IT5X-ray2.40A250-388[»]
2IT6X-ray1.95A250-404[»]
2XR5X-ray1.42A254-404[»]
2XR6X-ray1.35A250-404[»]
6GHVX-ray2.10A/B/C/D/E/F250-404[»]
SMRiQ9NNX6
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi119051, 14 interactors
DIPiDIP-60629N
IntActiQ9NNX6, 11 interactors
STRINGi9606.ENSP00000315477

Chemistry databases

BindingDBiQ9NNX6
ChEMBLiCHEMBL1795114

Protein family/group databases

UniLectiniQ9NNX6

PTM databases

GlyGeniQ9NNX6, 1 site
iPTMnetiQ9NNX6
PhosphoSitePlusiQ9NNX6

Polymorphism and mutation databases

BioMutaiCD209
DMDMi46396012

2D gel databases

REPRODUCTION-2DPAGEiQ9NNX6

Proteomic databases

jPOSTiQ9NNX6
MassIVEiQ9NNX6
PaxDbiQ9NNX6
PeptideAtlasiQ9NNX6
PRIDEiQ9NNX6
ProteomicsDBi33898
81864 [Q9NNX6-1]
81865 [Q9NNX6-10]
81866 [Q9NNX6-11]
81867 [Q9NNX6-12]
81869 [Q9NNX6-2]
81870 [Q9NNX6-3]
81871 [Q9NNX6-4]
81872 [Q9NNX6-5]
81873 [Q9NNX6-6]
81874 [Q9NNX6-7]
81875 [Q9NNX6-8]
81876 [Q9NNX6-9]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
Q9NNX6, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
12203, 1451 antibodies

Genome annotation databases

EnsembliENST00000204801; ENSP00000204801; ENSG00000090659 [Q9NNX6-7]
ENST00000315591; ENSP00000315407; ENSG00000090659 [Q9NNX6-6]
ENST00000315599; ENSP00000315477; ENSG00000090659 [Q9NNX6-1]
ENST00000354397; ENSP00000346373; ENSG00000090659 [Q9NNX6-2]
ENST00000394161; ENSP00000377716; ENSG00000090659 [Q9NNX6-4]
ENST00000601256; ENSP00000470658; ENSG00000090659 [Q9NNX6-12]
ENST00000601951; ENSP00000468827; ENSG00000090659 [Q9NNX6-10]
ENST00000602261; ENSP00000471137; ENSG00000090659 [Q9NNX6-3]
GeneIDi30835
KEGGihsa:30835
UCSCiuc002mhr.3, human [Q9NNX6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
30835
DisGeNETi30835
EuPathDBiHostDB:ENSG00000090659.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CD209
HGNCiHGNC:1641, CD209
HPAiENSG00000090659, Tissue enhanced (lymphoid)
MalaCardsiCD209
MIMi604672, gene+phenotype
607948, phenotype
614371, phenotype
neXtProtiNX_Q9NNX6
OpenTargetsiENSG00000090659
PharmGKBiPA26199

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4297, Eukaryota
GeneTreeiENSGT00940000155012
HOGENOMiCLU_1577990_0_0_1
InParanoidiQ9NNX6
KOiK06563
OMAiFEQYWNR
PhylomeDBiQ9NNX6
TreeFamiTF333341

Enzyme and pathway databases

PathwayCommonsiQ9NNX6
ReactomeiR-HSA-5621575, CD209 (DC-SIGN) signaling
R-HSA-8851680, Butyrophilin (BTN) family interactions
SIGNORiQ9NNX6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
30835, 1 hit in 873 CRISPR screens
EvolutionaryTraceiQ9NNX6

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
DC-SIGN

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
30835
PharosiQ9NNX6, Tbio

Protein Ontology

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PROi
PR:Q9NNX6
RNActiQ9NNX6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000090659, Expressed in adrenal gland and 176 other tissues
ExpressionAtlasiQ9NNX6, baseline and differential
GenevisibleiQ9NNX6, HS

Family and domain databases

CDDicd03590, CLECT_DC-SIGN_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR018378, C-type_lectin_CS
IPR033989, CD209-like_CTLD
IPR016187, CTDL_fold
PfamiView protein in Pfam
PF00059, Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034, CLECT, 1 hit
SUPFAMiSSF56436, SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615, C_TYPE_LECTIN_1, 1 hit
PS50041, C_TYPE_LECTIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCD209_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NNX6
Secondary accession number(s): A8KAM4
, A8MVQ9, G5E9C4, Q2TB19, Q96QP7, Q96QP8, Q96QP9, Q96QQ0, Q96QQ1, Q96QQ2, Q96QQ3, Q96QQ4, Q96QQ5, Q96QQ6, Q96QQ7, Q96QQ8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2000
Last modified: August 12, 2020
This is version 182 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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