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Protein

WD repeat-containing protein 6

Gene

WDR6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enhances the STK11/LKB1-induced cell growth suppression activity. Negative regulator of amino acid starvation-induced autophagy.2 Publications

GO - Molecular functioni

GO - Biological processi

  • cell cycle arrest Source: UniProtKB
  • negative regulation of autophagy Source: BHF-UCL
  • negative regulation of cell proliferation Source: UniProtKB

Keywordsi

Biological processCell cycle

Enzyme and pathway databases

SignaLinkiQ9NNW5

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 6
Gene namesi
Name:WDR6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000178252.17
HGNCiHGNC:12758 WDR6
MIMi606031 gene
neXtProtiNX_Q9NNW5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000178252
PharmGKBiPA37362

Polymorphism and mutation databases

BioMutaiWDR6
DMDMi12643813

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000513521 – 1121WD repeat-containing protein 6Add BLAST1121

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9NNW5
MaxQBiQ9NNW5
PaxDbiQ9NNW5
PeptideAtlasiQ9NNW5
PRIDEiQ9NNW5
ProteomicsDBi81856

PTM databases

iPTMnetiQ9NNW5
PhosphoSitePlusiQ9NNW5

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000178252
CleanExiHS_WDR6
ExpressionAtlasiQ9NNW5 baseline and differential
GenevisibleiQ9NNW5 HS

Organism-specific databases

HPAiHPA042622

Interactioni

Subunit structurei

Interacts with IRS4 (By similarity). Interacts with STK11/LKB1.By similarity1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi116350, 41 interactors
IntActiQ9NNW5, 51 interactors
MINTiQ9NNW5
STRINGi9606.ENSP00000378857

Structurei

3D structure databases

ProteinModelPortaliQ9NNW5
SMRiQ9NNW5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati53 – 97WD 1Add BLAST45
Repeati105 – 143WD 2Add BLAST39
Repeati147 – 189WD 3Add BLAST43
Repeati200 – 238WD 4Add BLAST39
Repeati247 – 285WD 5Add BLAST39
Repeati289 – 327WD 6Add BLAST39
Repeati335 – 376WD 7Add BLAST42
Repeati381 – 422WD 8Add BLAST42
Repeati425 – 470WD 9Add BLAST46
Repeati476 – 520WD 10Add BLAST45
Repeati559 – 598WD 11Add BLAST40
Repeati604 – 642WD 12Add BLAST39
Repeati645 – 684WD 13Add BLAST40
Repeati739 – 785WD 14Add BLAST47
Repeati848 – 893WD 15Add BLAST46
Repeati901 – 946WD 16Add BLAST46
Repeati970 – 1012WD 17Add BLAST43
Repeati1036 – 1073WD 18Add BLAST38
Repeati1079 – 1121WD 19Add BLAST43

Sequence similaritiesi

Belongs to the WD repeat WDR6 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0974 Eukaryota
ENOG410ZJ6J LUCA
GeneTreeiENSGT00420000029923
HOGENOMiHOG000008701
HOVERGENiHBG004019
InParanoidiQ9NNW5
PhylomeDBiQ9NNW5
TreeFamiTF313984

Family and domain databases

Gene3Di2.130.10.10, 4 hits
InterProiView protein in InterPro
IPR011043 Gal_Oxase/kelch_b-propeller
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50965 SSF50965, 1 hit
SSF50978 SSF50978, 4 hits
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NNW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDALEDYVWP RATSELILLP VTGLECVGDR LLAGEGPDVL VYSLDFGGHL
60 70 80 90 100
RMIKRVQNLL GHYLIHGFRV RPEPNGDLDL EAMVAVFGSK GLRVVKISWG
110 120 130 140 150
QGHFWELWRS GLWNMSDWIW DARWLEGNIA LALGHNSVVL YDPVVGCILQ
160 170 180 190 200
EVPCTDRCTL SSACLIGDAW KELTIVAGAV SNQLLVWYPA TALADNKPVA
210 220 230 240 250
PDRRISGHVG IIFSMSYLES KGLLATASED RSVRIWKVGD LRVPGGRVQN
260 270 280 290 300
IGHCFGHSAR VWQVKLLENY LISAGEDCVC LVWSHEGEIL QAFRGHQGRG
310 320 330 340 350
IRAIAAHERQ AWVITGGDDS GIRLWHLVGR GYRGLGVSAL CFKSRSRPGT
360 370 380 390 400
LKAVTLAGSW RLLAVTDTGA LYLYDVEVKC WEQLLEDKHF QSYCLLEAAP
410 420 430 440 450
GPEGFGLCAM ANGEGRVKVV PINTPTAAVD QTLFPGKVHS LSWALRGYEE
460 470 480 490 500
LLLLASGPGG VVACLEISAA PSGKAIFVKE RCRYLLPPSK QRWHTCSAFL
510 520 530 540 550
PPGDFLVCGD RRGSVLLFPS RPGLLKDPGV GGKARAGAGA PVVGSGSSGG
560 570 580 590 600
GNAFTGLGPV STLPSLHGKQ GVTSVTCHGG YVYTTGRDGA YYQLFVRDGQ
610 620 630 640 650
LQPVLRQKSC RGMNWLAGLR IVPDGSMVIL GFHANEFVVW NPRSHEKLHI
660 670 680 690 700
VNCGGGHRSW AFSDTEAAMA FAYLKDGDVM LYRALGGCTR PHVILREGLH
710 720 730 740 750
GREITCVKRV GTITLGPEYG VPSFMQPDDL EPGSEGPDLT DIVITCSEDT
760 770 780 790 800
TVCVLALPTT TGSAHALTAV CNHISSVRAV AVWGIGTPGG PQDPQPGLTA
810 820 830 840 850
HVVSAGGRAE MHCFSIMVTP DPSTPSRLAC HVMHLSSHRL DEYWDRQRNR
860 870 880 890 900
HRMVKVDPET RYMSLAVCEL DQPGLGPLVA AACSDGAVRL FLLQDSGRIL
910 920 930 940 950
QLLAETFHHK RCVLKVHSFT HEAPNQRRRL LLCSAATDGS LAFWDLTTML
960 970 980 990 1000
DHDSTVLEPP VDPGLPYRLG TPSLTLQAHS CGINSLHTLP TREGHHLVAS
1010 1020 1030 1040 1050
GSEDGSLHVF VLAVEMLQLE EAVGEAGLVP QLRVLEEYSV PCAHAAHVTG
1060 1070 1080 1090 1100
LKILSPSIMV SASIDQRLTF WRLGHGEPTF MNSTVFHVPD VADMDCWPVS
1110 1120
PEFGHRCALG GQGLEVYNWY D
Length:1,121
Mass (Da):121,725
Last modified:October 1, 2000 - v1
Checksum:i4E408D5D893FF005
GO

Sequence cautioni

The sequence BAG58164 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38D → N in BAG58164 (PubMed:14702039).Curated1
Sequence conflicti545S → R in BAG58164 (PubMed:14702039).Curated1
Sequence conflicti651V → I in BAG58164 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF099100 mRNA Translation: AAF80244.1
AK295145 mRNA Translation: BAG58164.1 Different initiation.
AC137630 Genomic DNA No translation available.
BC101707 mRNA Translation: AAI01708.1
BC113467 mRNA Translation: AAI13468.1
AL133589 mRNA Translation: CAB63730.1
PIRiJC7329
T43496
RefSeqiNP_001307475.1, NM_001320546.1
NP_001307476.1, NM_001320547.1
NP_060501.3, NM_018031.4
UniGeneiHs.654815

Genome annotation databases

EnsembliENST00000608424; ENSP00000477389; ENSG00000178252
GeneIDi11180
KEGGihsa:11180
UCSCiuc062job.1 human

Similar proteinsi

Entry informationi

Entry nameiWDR6_HUMAN
AccessioniPrimary (citable) accession number: Q9NNW5
Secondary accession number(s): B4DHK2, Q3MIT1, Q9UF63
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 1, 2000
Last modified: July 18, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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