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Protein

Calcium-dependent protein kinase 3

Gene

CPK3

Organism
Plasmodium falciparum (isolate 3D7)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium-dependent kinase that may play a role in the sexual reproduction and mosquito transmission of P.falciparum.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Activity regulationi

Activated by calcium.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei147ATPPROSITE-ProRule annotation1
Active sitei238Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi124 – 132ATPPROSITE-ProRule annotation9
Calcium bindingi431 – 4421PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi466 – 4772PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi501 – 5123PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi542 – 5534PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Kinase, Serine/threonine-protein kinase, Transferase
Biological processDifferentiation
LigandATP-binding, Calcium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-dependent protein kinase 3 (EC:2.7.11.1)
Alternative name(s):
PfCDPK3
Gene namesi
Name:CPK3
Synonyms:CDPK3
ORF Names:MAL3P3.17, PFC0420w
OrganismiPlasmodium falciparum (isolate 3D7)
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_0310100

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000858391 – 562Calcium-dependent protein kinase 3Add BLAST562

Expressioni

Developmental stagei

Expressed in sexual stages, but not in asexual stages.1 Publication

Interactioni

GO - Molecular functioni

Structurei

Secondary structure

1562
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9NJU9
SMRiQ9NJU9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NJU9

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini118 – 373Protein kinasePROSITE-ProRule annotationAdd BLAST256
Domaini418 – 453EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini453 – 487EF-hand 2PROSITE-ProRule annotationAdd BLAST35
Domaini488 – 523EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini529 – 562EF-hand 4PROSITE-ProRule annotationAdd BLAST34

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000233030
InParanoidiQ9NJU9
KOiK13412
OMAiTFEDHKN
PhylomeDBiQ9NJU9

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF13499 EF-hand_7, 2 hits
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SM00220 S_TKc, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 3 hits
PS50222 EF_HAND_2, 4 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NJU9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNDLIIKNNK KGSCDVIIKY KCKKSDENIK RRKSSHKYIK NKSVVLGRSI
60 70 80 90 100
MTNKKEKLKG ALKYKGSKKE IKICNKKSMI KNDKDENTTL KSMKSDNFKF
110 120 130 140 150
SRRGFILSFT GNLEDFYNLS KEPLGKGTYG CVYKATDKLL KISRAVKVVS
160 170 180 190 200
KKKLKNIPRF RQEIDIMKNL DHPNVVKLLE TFEDSNQIYL VMELCTGGEL
210 220 230 240 250
FDKIVKKGCF VETFASFIMK QIFSVLNYLH IRNICHRDIK PENFLFYDMT
260 270 280 290 300
PESLIKIIDF GLASYFTHNN YEMKTKAGTP YYVAPQVLTG SYNYKCDMWS
310 320 330 340 350
SGVLFYILLC GYPPFFGESD HEILSMVKKG KYQFKGKEWN NISEEAKDLI
360 370 380 390 400
KRCLTMDADK RICASEALQH PWFKKKKYAF NMDMKMDIHV LENFKNYGLL
410 420 430 440 450
LKFQKLAMTI IAQQSNDYDV EKLKSTFLVL DEDGKGYITK EQLKKGLEKD
460 470 480 490 500
GLKLPYNFDL LLDQIDSDGS GKIDYTEFIA AALDRKQLSK KLIYCAFRVF
510 520 530 540 550
DVDNDGEITT AELAHILYNG NKKGNITQRD VNRVKRMIRD VDKNNDGKID
560
FHEFSEMMKL KF
Length:562
Mass (Da):65,288
Last modified:October 1, 2000 - v1
Checksum:i80DB5BA4194AC2E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF106064 Genomic DNA Translation: AAF63154.1
AL844502 Genomic DNA Translation: CAB11118.4
PIRiT18445
RefSeqiXP_001351174.1, XM_001351138.1

Genome annotation databases

EnsemblProtistsiCAB11118; CAB11118; PF3D7_0310100
GeneDBiPF3D7_0310100.1:pep
GeneIDi814416
KEGGipfa:PF3D7_0310100

Similar proteinsi

Entry informationi

Entry nameiCDPK3_PLAF7
AccessioniPrimary (citable) accession number: Q9NJU9
Secondary accession number(s): O77333
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: October 1, 2000
Last modified: September 12, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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