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Entry version 176 (07 Apr 2021)
Sequence version 2 (11 Jul 2002)
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Protein

Protein vav

Gene

Vav

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases. Probably plays a pivotal role as a signal transducer protein during fruit fly development.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri552 – 601Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST50

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-114604, GPVI-mediated activation cascade
R-DME-1257604, PIP3 activates AKT signaling
R-DME-1433557, Signaling by SCF-KIT
R-DME-193648, NRAGE signals death through JNK
R-DME-194840, Rho GTPase cycle
R-DME-2424491, DAP12 signaling
R-DME-2871796, FCERI mediated MAPK activation
R-DME-2871809, FCERI mediated Ca+2 mobilization
R-DME-3928665, EPH-ephrin mediated repulsion of cells
R-DME-416482, G alpha (12/13) signalling events
R-DME-4420097, VEGFA-VEGFR2 Pathway
R-DME-445144, Signal transduction by L1
R-DME-512988, Interleukin-3, Interleukin-5 and GM-CSF signaling
R-DME-5218920, VEGFR2 mediated vascular permeability
R-DME-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-DME-912631, Regulation of signaling by CBL
R-DME-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9NHV9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein vav
Short name:
DroVav
Short name:
dVAV
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Vav
ORF Names:CG7893
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0040068, Vav

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000809831 – 793Protein vavAdd BLAST793

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine residues.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NHV9

PeptideAtlas

More...
PeptideAtlasi
Q9NHV9

PRoteomics IDEntifications database

More...
PRIDEi
Q9NHV9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed both maternally and zygotically in all stages of development.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0040068, Expressed in antenna and 57 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9NHV9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NHV9, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via SH2 domain) with Egfr (when phosphorylated on tyrosine residues).

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
59225, 11 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0112228

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NHV9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini18 – 137Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST120
Domaini216 – 396DHPROSITE-ProRule annotationAdd BLAST181
Domaini432 – 541PHPROSITE-ProRule annotationAdd BLAST110
Domaini622 – 726SH2PROSITE-ProRule annotationAdd BLAST105
Domaini726 – 788SH3PROSITE-ProRule annotationAdd BLAST63

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri552 – 601Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST50

Keywords - Domaini

Repeat, SH2 domain, SH3 domain, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2996, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000168738

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NHV9

Identification of Orthologs from Complete Genome Data

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OMAi
GEDRGWW

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NHV9

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00029, C1, 1 hit
cd01223, PH_Vav, 1 hit
cd00160, RhoGEF, 1 hit
cd09940, SH2_Vav_family, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 1 hit
1.20.900.10, 1 hit
2.30.29.30, 1 hit
3.30.505.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR002219, PE/DAG-bd
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR037832, PH_Vav
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR035031, Vav_SH2_invertebrate

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00130, C1_1, 1 hit
PF00307, CH, 1 hit
PF00621, RhoGEF, 1 hit
PF00017, SH2, 1 hit
PF00018, SH3_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00109, C1, 1 hit
SM00033, CH, 1 hit
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit
SM00252, SH2, 1 hit
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576, SSF47576, 1 hit
SSF48065, SSF48065, 1 hit
SSF50044, SSF50044, 1 hit
SSF55550, SSF55550, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50021, CH, 1 hit
PS50010, DH_2, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS50001, SH2, 1 hit
PS50002, SH3, 1 hit
PS00479, ZF_DAG_PE_1, 1 hit
PS50081, ZF_DAG_PE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform A (identifier: Q9NHV9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASSSSSNSF GGVAGVNGDL WRECVAWLTR CKVIPPDHKA AQPDAEIRIL
60 70 80 90 100
AMTLRDGVLL CNLVIHLDPS SLDPREFNRK PQMAQFLCSK NIKLFLDVCH
110 120 130 140 150
NNFGIRDADL FEPTMLYDLT NFHRVLITLS KLSQCRKVQQ LHPDLIGFNL
160 170 180 190 200
QLSPTERSHS DEAIYKDLHS TTTDNIACNG TGYDHTNTKE EEVYQDLCAL
210 220 230 240 250
HRTSRSQTAS STSFEQRDYV IRELIDTESN YLDVLTALKT KFMGPLERHL
260 270 280 290 300
NQDELRLIFP RIRELVDIHT KFLDKLRESL TPNAKVKMAQ VFLDFREPFL
310 320 330 340 350
IYGEFCSLLL GAIDYLADVC KKNQIIDQLV QKCERDYNVG KLQLRDILSV
360 370 380 390 400
PMQRILKYHL LLDKLVKETS PLHDDYRSLE RAKEAMIDVS QYINEVKRDS
410 420 430 440 450
DHLVIIQKVK DSICDIHLLQ NGNGSDLLQY GRLLLDGELH IKAHEDQKTK
460 470 480 490 500
LRYAFVFDKI LIMVKALHIK TGDMQYTYRD SHNLADYRVE QSHSRRTIGR
510 520 530 540 550
DTRFKYQLLL ARKSGKTAFT LYLKSEHERD KWRKALTEAM ESLEPPGCQS
560 570 580 590 600
TDHKMEIYTF DAPTTCRHCS KFLKGRIHQG YRCKVCQISV HKGCISSTGR
610 620 630 640 650
CKQNPVSVPP PVCDRQLSEF NWFAGNMDRE TAAHRLENRR IGTYLLRVRP
660 670 680 690 700
QGPSTAHETM YALSLKTDDN VIKHMKINQE NSGDSMLYCL SSRRHFKTIV
710 720 730 740 750
ELVSYYERND LGENFAGLNQ SLQWPYKEVI ATALYDYEPK AGSNQLQLRT
760 770 780 790
DCQVLVIGKD GDSKGWWRGK IGDTVGYFPK EYVQEQKLAS EEL
Length:793
Mass (Da):91,355
Last modified:July 11, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1031929FE4FB8BF3
GO
Isoform B (identifier: Q9NHV9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-171: MASSSSSNSF...EAIYKDLHST → MRRMRASRRP...LPSRRRPNPS

Show »
Length:766
Mass (Da):88,953
Checksum:iA53E704D4DEEF085
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8JUQ9A8JUQ9_DROME
Vav guanine nucleotide exchange fac...
Vav BcDNA:GH01128, Dmel\CG7893, DmVav, DroVav, vav
1,001Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PHJ6M9PHJ6_DROME
Vav guanine nucleotide exchange fac...
Vav BcDNA:GH01128, Dmel\CG7893, DmVav, DroVav, vav
964Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAM12266 differs from that shown.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti53T → M in AAF28765 (PubMed:10781813).Curated1
Sequence conflicti148F → L in AAF28765 (PubMed:10781813).Curated1
Sequence conflicti372L → M in AAF28765 (PubMed:10781813).Curated1
Sequence conflicti503R → E in AAF28765 (PubMed:10781813).Curated1
Sequence conflicti645 – 664LLRVR…MYALS → PVASSSAGPIHCPRDDVCAY in AAF28765 (PubMed:10781813).CuratedAdd BLAST20
Sequence conflicti739P → Q in AAF28765 (PubMed:10781813).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0278011 – 171MASSS…DLHST → MRRMRASRRPCFPTARAAMC ASYPSISPWMWLAPRRMPHP MRSHPRRNRMPANRNHRWPP QRQAFLCPLHRGHLWAVWCP PPPHRRRFWSARASGCSERP PPSTTTAPRWRPPSTSMPTS TARTTRRSTRICATLPSRRR PNPS in isoform B. 1 PublicationAdd BLAST171

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF218780 mRNA Translation: AAF28765.1
AE014298 Genomic DNA Translation: AAF48943.3
AE014298 Genomic DNA Translation: AAN09485.1
AY069536 mRNA Translation: AAL39681.1
AY095173 mRNA Translation: AAM12266.1 Sequence problems.
BT029984 mRNA Translation: ABM92858.1

NCBI Reference Sequences

More...
RefSeqi
NP_573372.1, NM_133144.4 [Q9NHV9-1]
NP_728235.1, NM_167642.3 [Q9NHV9-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0074677; FBpp0074448; FBgn0040068 [Q9NHV9-1]
FBtr0074678; FBpp0074449; FBgn0040068 [Q9NHV9-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
32920

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG7893

UCSC genome browser

More...
UCSCi
CG7893-RA, d. melanogaster [Q9NHV9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF218780 mRNA Translation: AAF28765.1
AE014298 Genomic DNA Translation: AAF48943.3
AE014298 Genomic DNA Translation: AAN09485.1
AY069536 mRNA Translation: AAL39681.1
AY095173 mRNA Translation: AAM12266.1 Sequence problems.
BT029984 mRNA Translation: ABM92858.1
RefSeqiNP_573372.1, NM_133144.4 [Q9NHV9-1]
NP_728235.1, NM_167642.3 [Q9NHV9-1]

3D structure databases

SMRiQ9NHV9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi59225, 11 interactors
STRINGi7227.FBpp0112228

Proteomic databases

PaxDbiQ9NHV9
PeptideAtlasiQ9NHV9
PRIDEiQ9NHV9

Genome annotation databases

EnsemblMetazoaiFBtr0074677; FBpp0074448; FBgn0040068 [Q9NHV9-1]
FBtr0074678; FBpp0074449; FBgn0040068 [Q9NHV9-1]
GeneIDi32920
KEGGidme:Dmel_CG7893
UCSCiCG7893-RA, d. melanogaster [Q9NHV9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
32920
FlyBaseiFBgn0040068, Vav

Phylogenomic databases

eggNOGiKOG2996, Eukaryota
GeneTreeiENSGT00940000168738
InParanoidiQ9NHV9
OMAiGEDRGWW
PhylomeDBiQ9NHV9

Enzyme and pathway databases

ReactomeiR-DME-114604, GPVI-mediated activation cascade
R-DME-1257604, PIP3 activates AKT signaling
R-DME-1433557, Signaling by SCF-KIT
R-DME-193648, NRAGE signals death through JNK
R-DME-194840, Rho GTPase cycle
R-DME-2424491, DAP12 signaling
R-DME-2871796, FCERI mediated MAPK activation
R-DME-2871809, FCERI mediated Ca+2 mobilization
R-DME-3928665, EPH-ephrin mediated repulsion of cells
R-DME-416482, G alpha (12/13) signalling events
R-DME-4420097, VEGFA-VEGFR2 Pathway
R-DME-445144, Signal transduction by L1
R-DME-512988, Interleukin-3, Interleukin-5 and GM-CSF signaling
R-DME-5218920, VEGFR2 mediated vascular permeability
R-DME-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-DME-912631, Regulation of signaling by CBL
R-DME-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
SignaLinkiQ9NHV9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
32920, 0 hits in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
32920

Protein Ontology

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PROi
PR:Q9NHV9

Gene expression databases

BgeeiFBgn0040068, Expressed in antenna and 57 other tissues
ExpressionAtlasiQ9NHV9, baseline and differential
GenevisibleiQ9NHV9, DM

Family and domain databases

CDDicd00029, C1, 1 hit
cd01223, PH_Vav, 1 hit
cd00160, RhoGEF, 1 hit
cd09940, SH2_Vav_family, 1 hit
Gene3Di1.10.418.10, 1 hit
1.20.900.10, 1 hit
2.30.29.30, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR002219, PE/DAG-bd
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR037832, PH_Vav
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR035031, Vav_SH2_invertebrate
PfamiView protein in Pfam
PF00130, C1_1, 1 hit
PF00307, CH, 1 hit
PF00621, RhoGEF, 1 hit
PF00017, SH2, 1 hit
PF00018, SH3_1, 1 hit
SMARTiView protein in SMART
SM00109, C1, 1 hit
SM00033, CH, 1 hit
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit
SM00252, SH2, 1 hit
SM00326, SH3, 1 hit
SUPFAMiSSF47576, SSF47576, 1 hit
SSF48065, SSF48065, 1 hit
SSF50044, SSF50044, 1 hit
SSF55550, SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50021, CH, 1 hit
PS50010, DH_2, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS50001, SH2, 1 hit
PS50002, SH3, 1 hit
PS00479, ZF_DAG_PE_1, 1 hit
PS50081, ZF_DAG_PE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVAV_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NHV9
Secondary accession number(s): A2RVJ3
, A4V4R6, Q8SWT3, Q8T061, Q9VWJ5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: July 11, 2002
Last modified: April 7, 2021
This is version 176 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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