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Entry version 156 (26 Feb 2020)
Sequence version 1 (01 Oct 2000)
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Protein
Submitted name:

FI21425p1

Gene

Nlg2

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-192456 Digestion of dietary lipid
R-DME-6794361 Neurexins and neuroligins

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...
ESTHERi
drome-CG13772 Neuroligin

MEROPS protease database

More...
MEROPSi
S09.986

Transport Classification Database

More...
TCDBi
8.A.117.1.4 the neuroligin (nlg) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
FI21425p1Imported
Submitted name:
NeuroliginImported
Submitted name:
Neuroligin 2, isoform AImported
Submitted name:
Neuroligin 2, isoform BImported
Submitted name:
Neuroligin 2, isoform CImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nlg2Imported
Synonyms:Dmel\CG13772Imported, dnl2Imported, DNlg2Imported, Dnlg2Imported, dnlg2Imported, NeuroliginImported, neuroliginImported, nl2Imported, Nlg-2Imported, nlg2Imported, Nlg2-RAImported
ORF Names:CG13772Imported, Dmel_CG13772Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0031866 Nlg2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 35HelicalSequence analysisAdd BLAST24
Transmembranei966 – 992HelicalSequence analysisAdd BLAST27

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0031866 Expressed in brain and 14 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9NGK5, 2 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0297876

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini182 – 721COesteraseInterPro annotationAdd BLAST540

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni45 – 85DisorderedSequence analysisAdd BLAST41
Regioni112 – 150DisorderedSequence analysisAdd BLAST39
Regioni875 – 897DisorderedSequence analysisAdd BLAST23
Regioni1178 – 1248DisorderedSequence analysisAdd BLAST71

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1178 – 1193PolyampholyteSequence analysisAdd BLAST16
Compositional biasi1201 – 1237PolarSequence analysisAdd BLAST37

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1516 Eukaryota
COG2272 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006586_5_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
RRSNAMH

Database of Orthologous Groups

More...
OrthoDBi
754103at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029058 AB_hydrolase
IPR002018 CarbesteraseB
IPR019819 Carboxylesterase_B_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00135 COesterase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53474 SSF53474, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00941 CARBOXYLESTERASE_B_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9NGK5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQTKIIQSR FLHIYGLLCL GSLMGCIKTI GASIAQQTLA DADAPDEAKA
60 70 80 90 100
KEREAETDAD ADAEGDAKAE TETGKGTREH TNGDAEADAR IMATGICIIR
110 120 130 140 150
LITLKRFLEN SKTEEHNQRR QQSATSAASA APAGATSPRR RHLHYPGHSA
160 170 180 190 200
VQPGHPEACA LLVLLLLTSL WPDCCECLHG GSNTVKTKYG LLRGIVVRSS
210 220 230 240 250
PLVEAFLGIP YASPPVGSLR FMPPITPSTW KTVRSADRFS PVCPQNIPIP
260 270 280 290 300
PNGPEALLEV PRARLAQLRR LLPLLKNQSE DCLYLNIYVP YETRRQRRNT
310 320 330 340 350
DDTTGEPKTK LSTVVFIHGE SYDWNSGNPY DGSELAAHGN VIVVTINFRL
360 370 380 390 400
GIFGFLKTGG KESAQGNFGL MDLVAGLHWL KENLPAFGGD PQSITLLGYG
410 420 430 440 450
TGAVLANILV VSPVASDLIQ RTVLVSGSAL SPWAIQKNPL FVKRRVAEQT
460 470 480 490 500
GCHGDMLYDD LAPCLRTKSV AELLAVKVDH PRFLVGFAPF VDGTVISPGA
510 520 530 540 550
NPLGSTTLPL GSAIVSTSGI EYANFPKRDL IFCLTSVESY LDLSAQDLEF
560 570 580 590 600
GFNETRRDRI LRTFVRNNFH YHLNEIFAVL KNEYTDWEKA IRNPLSSRDA
610 620 630 640 650
TLQFLSDGHT ASPLIKLGYM HSLRGGRAYF LHFKHKTIEE EYPQRSGSVR
660 670 680 690 700
GEDVPFWLGL PMSPLFPHNY TTQERQIGRL MLRYLSNFAK TGNPNQSTAK
710 720 730 740 750
SVLPNPNEVL ETALHQQKKR STSLTHPNLS EALNLAVLYN QRRSNAMHEK
760 770 780 790 800
RSYIRRRLRS NDAAFTQLGI SSERDVGSYD GDELPFWDAY DVVNQLYVEL
810 820 830 840 850
GNKANIQSHY RGHKLSMWLN LIPQLHRHFN INDQSMRHHQ FQDDMNNRDL
860 870 880 890 900
YEGVVRPQLQ TKPAEDDNII IMQRSRTTTP PPPSKNPSTN ATQALNPLGT
910 920 930 940 950
GTPTTTECGI DGAMSVSELT TTQSPKDNRT GIVRVETQKD LATASTGIIG
960 970 980 990 1000
NLELLRRLGG KQFQSYTTAL IATVAVGCFL LILNVLIFAG IYHQREKRAR
1010 1020 1030 1040 1050
DAKTKEELQE GDNSKNSSIL KLNALMGGGG ACGSGPGDIA DAYTLSGSVV
1060 1070 1080 1090 1100
DSKGGVGVVF GEYSCYDEKT KQLKEEKLLV ELPPSSSTGQ TSLMIDNWGA
1110 1120 1130 1140 1150
CSTSTLDLLK TKPGDPIEMV TYSALPSVME STSAMSSKRG SFVDTTLQFN
1160 1170 1180 1190 1200
SPQQFDYAVQ SSDQMSFKAI EDAVKAAAGH DSEITRDDDI PEPPPPPRSF
1210 1220 1230 1240
LAAQQQQQQQ QQQQQTGILR QTGAGGTSTS GSASGSGKKR VHIQEISV
Length:1,248
Mass (Da):136,846
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3F95AD4289F161DF
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF52450.2
AF251479 mRNA Translation: AAF68455.1
AE014134 Genomic DNA Translation: AFH03590.1
BT150249 mRNA Translation: AGV77151.1
AE014134 Genomic DNA Translation: AHN54208.1

NCBI Reference Sequences

More...
RefSeqi
NP_001245916.1, NM_001258987.2
NP_001285693.1, NM_001298764.1
NP_523496.1, NM_078772.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0079344; FBpp0078972; FBgn0031866
FBtr0307033; FBpp0297876; FBgn0031866
FBtr0343867; FBpp0310405; FBgn0031866

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
33962

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG13772

UCSC genome browser

More...
UCSCi
CG13772-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF52450.2
AF251479 mRNA Translation: AAF68455.1
AE014134 Genomic DNA Translation: AFH03590.1
BT150249 mRNA Translation: AGV77151.1
AE014134 Genomic DNA Translation: AHN54208.1
RefSeqiNP_001245916.1, NM_001258987.2
NP_001285693.1, NM_001298764.1
NP_523496.1, NM_078772.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ9NGK5, 2 interactors
STRINGi7227.FBpp0297876

Protein family/group databases

ESTHERidrome-CG13772 Neuroligin
MEROPSiS09.986
TCDBi8.A.117.1.4 the neuroligin (nlg) family

Genome annotation databases

EnsemblMetazoaiFBtr0079344; FBpp0078972; FBgn0031866
FBtr0307033; FBpp0297876; FBgn0031866
FBtr0343867; FBpp0310405; FBgn0031866
GeneIDi33962
KEGGidme:Dmel_CG13772
UCSCiCG13772-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
33962
FlyBaseiFBgn0031866 Nlg2

Phylogenomic databases

eggNOGiKOG1516 Eukaryota
COG2272 LUCA
HOGENOMiCLU_006586_5_0_1
OMAiRRSNAMH
OrthoDBi754103at2759

Enzyme and pathway databases

ReactomeiR-DME-192456 Digestion of dietary lipid
R-DME-6794361 Neurexins and neuroligins

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
33962

Gene expression databases

BgeeiFBgn0031866 Expressed in brain and 14 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR002018 CarbesteraseB
IPR019819 Carboxylesterase_B_CS
PfamiView protein in Pfam
PF00135 COesterase, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00941 CARBOXYLESTERASE_B_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9NGK5_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NGK5
Secondary accession number(s): Q9VM73
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: February 26, 2020
This is version 156 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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