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Protein

Alcohol dehydrogenase

Gene

Adh

Organism
Drosophila equinoxialis (Fruit fly)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.PROSITE-ProRule annotationCurated
A secondary alcohol + NAD+ = a ketone + NADH.PROSITE-ProRule annotationCurated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei138SubstrateBy similarity1
Active sitei151Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 32NADBy similarityAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase (EC:1.1.1.1)
Gene namesi
Name:Adh
OrganismiDrosophila equinoxialis (Fruit fly)Imported
Taxonomic identifieri46790 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0016178 Dequ\Adh

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000544591 – 254Alcohol dehydrogenaseAdd BLAST254

Proteomic databases

PRIDEiQ9NG42

Interactioni

Subunit structurei

Homodimer.Curated

Structurei

3D structure databases

ProteinModelPortaliQ9NG42
SMRiQ9NG42
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the short-chain dehydrogenases/reductases (SDR) family.UniRule annotationCurated

Family and domain databases

InterProiView protein in InterPro
IPR002425 ADH_Drosophila-type
IPR002424 ADH_insect
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR01168 ALCDHDRGNASE
PR01167 INSADHFAMILY
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NG42-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALTNKNIIF VAGLGGIGLD TSRELVKRDL KNLVILDRID NPAAIAELKA
60 70 80 90 100
INPKVTVTFY PYDVTTPLTE TTKLLKTIFA QLKTVDVLIN GAGILDDHQI
110 120 130 140 150
ERTIAVNFTG LVNTTTAILD FWDKRKGGPG GVICNIGSVT GFNAIYQVPV
160 170 180 190 200
YSASKAAVVS FTQSIAKLAN VTGVTAFTVN PGITKTTLVH KFNSWLDVET
210 220 230 240 250
RVAEKLLEHP TQTTLACAQN FVKAIELNKN GAIWKLDLGT LEPIEWTKHW

DSGI
Length:254
Mass (Da):27,620
Last modified:March 15, 2004 - v2
Checksum:iC20FDF95E89D6E16
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti157A → R in AAF72716 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95268 Genomic DNA Translation: AAD00794.1
U95269 Genomic DNA Translation: AAD00795.1
AF264074 Genomic DNA Translation: AAF72716.1

Similar proteinsi

Entry informationi

Entry nameiADH_DROEQ
AccessioniPrimary (citable) accession number: Q9NG42
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: March 15, 2004
Last modified: May 23, 2018
This is version 70 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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