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UniProtKB - Q9NFU6 (COPB_TRYBB)

Entry version 59 (07 Oct 2020)
Sequence version 1 (01 Oct 2000)
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Protein

Coatomer subunit beta

Gene
N/A
Organism
Trypanosoma brucei brucei
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coatomer subunit betaBy similarity
Alternative name(s):
Beta-coat proteinBy similarity
Short name:
Beta-COPBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTrypanosoma brucei brucei
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Discoba › Euglenozoa › Kinetoplastea › Metakinetoplastina › Trypanosomatida › Trypanosomatidae › Trypanosoma ›

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004089481 – 982Coatomer subunit betaAdd BLAST982

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.

By similarity

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati16 – 53HEAT 1Sequence analysisAdd BLAST38
Repeati130 – 167HEAT 2Sequence analysisAdd BLAST38
Repeati241 – 278HEAT 3Sequence analysisAdd BLAST38
Repeati317 – 352HEAT 4Sequence analysisAdd BLAST36

Keywords - Domaini

Repeat

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR002553, Clathrin/coatomer_adapt-like_N
IPR011710, Coatomer_bsu_C
IPR016460, COPB1
IPR029446, COPB1_appendage_platform_dom

The PANTHER Classification System

More...PANTHERi		PTHR10635, PTHR10635, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01602, Adaptin_N, 1 hit
PF07718, Coatamer_beta_C, 1 hit
PF14806, Coatomer_b_Cpla, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF005727, Coatomer_beta_subunit, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9NFU6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAKAEGFCS FLVGLSGAPV NSKELKSALE KGDMKARASA LEALIRMHLN 
        60         70         80         90        100
GEPQNHMIMT VIKFITPLDD HYIKKLVLYF WEVVDKTDAS GKLLSEMILI 
       110        120        130        140        150
CSFLREDLLH PNEYIRGLAL RFMCKVKERE LVEPLVSSVV QNLTHRVTYV 
       160        170        180        190        200
RRNAVLAVHR IFKRFPELLP DAAELVEKFI SEENDVSASR NAFEMLVECS 
       210        220        230        240        250
PDRVVKFLAE LRESKNLESL GATLQMSIVD FAGHMIRANP YDKGRYVTVL 
       260        270        280        290        300
FSILQSNNPA VRYQCASTLL SISTSPTAIR QAALTFIDLL KTHTDISVRL 
       310        320        330        340        350
IVVDQLDAMR ERFSKILQDS LLDILSVLAN GTMEIRKRIV TLGVELVSNQ 
       360        370        380        390        400
NSEVFVQAIK KELYWVKNEC DVDDKESLLE YKKLLIRATR TAVARRPHMA 
       410        420        430        440        450
SAVIPLVLEY LYEEDDSGFE VVSLIREVLQ LQPSLRSETL RQLRQTLRMI 
       460        470        480        490        500
RCPSVIRTVL WLLGTHVTSA DDALEVIRLL INTLEPLPLE PTVKEQMKQQ 
       510        520        530        540        550
EDFDGHKGGQ QKPRMQMTTI VQEDGTYVMS SVPSNKTQED AEGNDSNCGL 
       560        570        580        590        600
RGVLTGGKFF IAAPLASTLS KLIIRLFNHH SSGVDESTMK EAQNSAIMLL 
       610        620        630        640        650
NEVLRFCTMD GAAGMIDDAT HEQIRLALLN ITNPRSPLLA TFVEDSSKAL 
       660        670        680        690        700
DSLTNKVGSI AGGDGFDFNK RNNDNVVGRT SFDEQQVALC SVDTPVMFTQ 
       710        720        730        740        750
IMEGKGSLLE LEAVDDLGSV VANASIEKTE EFLIKLEKTV PLSGFCDPLY 
       760        770        780        790        800
CEASVTVHQF DITVDWYIAN CTANVLRDVS IELTPLGSMK LCERPQVHTI 
       810        820        830        840        850
QPHGSVRIRT ALKVGSPETG VICASVLYEG PQNERGCVVL NNVRVDIMNY 
       860        870        880        890        900
VRPAKCSASE FRDKWCKYDW ENAVAIRTEK TDMREYVEYV MQGTNTRLLE 
       910        920        930        940        950
PYPEEDDEVV SAFDGKGDNG HRYVSCNMYA RTLFGDDALL NVSIERDAEG 
       960        970        980 
KLSGMVRVRA NKRPVAYGFG EKLNILNRRI VS
Length:982
Mass (Da):110,021
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9A52B163617CCBD9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ271083 Genomic DNA Translation: CAB87383.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ271083 Genomic DNA Translation: CAB87383.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR002553, Clathrin/coatomer_adapt-like_N
IPR011710, Coatomer_bsu_C
IPR016460, COPB1
IPR029446, COPB1_appendage_platform_dom
PANTHERiPTHR10635, PTHR10635, 1 hit
PfamiView protein in Pfam
PF01602, Adaptin_N, 1 hit
PF07718, Coatamer_beta_C, 1 hit
PF14806, Coatomer_b_Cpla, 1 hit
PIRSFiPIRSF005727, Coatomer_beta_subunit, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOPB_TRYBB
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NFU6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: October 1, 2000
Last modified: October 7, 2020
This is version 59 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
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