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Entry version 177 (31 Jul 2019)
Sequence version 1 (01 Oct 2000)
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Protein

Synaptic functional regulator FMR1

Gene

Fmr1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Polyribosome-associated RNA-binding protein that plays a role in neuronal development and synaptic plasticity through the regulation of protein synthesis of mRNAs (PubMed:11046149, PubMed:11733059, PubMed:12368261, PubMed:17178403). Plays a role as a negative translational regulator of specific mRNAs (PubMed:11733059, PubMed:17178403). Represses translation of the microtubule-associated protein futsch mRNA to regulate microtubule-dependent synaptic growth and function (PubMed:11733059). May also be involved in microRNA (miRNA)-mediated translational suppression as part of the RNA-induced silencing complex (RISC) (PubMed:12368261, PubMed:14508492). Required for stability of the central pair of microtubules in the spermatid axoneme (PubMed:15183715). Regulates photoreceptor structure and neuromuscular junction (NMJ) neurotransmission in the eye (PubMed:11733059, PubMed:17178403). During embryogenesis, involved in germline fate determination (PubMed:16949822).7 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor, Ribonucleoprotein, RNA-binding
Biological processNeurogenesis, RNA-mediated gene silencing, Sensory transduction, Translation regulation, Vision

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Synaptic functional regulator FMR1Curated
Alternative name(s):
Fragile X mental retardation syndrome-related protein 1By similarity
Short name:
dFMR11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Fmr1Imported
Synonyms:FXRImported
ORF Names:CG6203
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0028734 Fmr1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi244I → N: Impairs RNA-binding. 1 Publication1
Mutagenesisi307I → N: Impairs RNA-binding. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000501091 – 684Synaptic functional regulator FMR1Add BLAST684

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei403Phosphoserine1 Publication1
Modified residuei408Phosphoserine1 Publication1
Modified residuei409Phosphoserine1 Publication1
Modified residuei413Phosphoserine1 Publication1
Modified residuei532Phosphoserine1 Publication1
Modified residuei533Phosphoserine1 Publication1
Modified residuei539Phosphoserine1 Publication1
Modified residuei541Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NFU0

PRoteomics IDEntifications database

More...
PRIDEi
Q9NFU0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NFU0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in testes in the early stages of spermatogenesis before spermatid individualization (at protein level) (PubMed:15183715).1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed during the embryonic development (PubMed:11046149). Expressed both maternally and zygotically in embryos (PubMed:11046149). Until early gastrulation, expression is uniformly distributed in the embryo (PubMed:11046149). At mid-gastrulation (stage 11), expressed everywhere with discernible concentration in the mesoderm (PubMed:11046149). After gastrulation (stage 14), expressed in the mesoderm, ventral nerve cord, and brain (PubMed:11046149). At stage 16, elevated expression is also seen in the muscle (PubMed:11046149). Highly expressed in nervous system throughout later development (at protein level) (PubMed:11046149, PubMed:11733059).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0028734 Expressed in 35 organ(s), highest expression level in wing disc (Drosophila)

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9NFU0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9NFU0 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:11046149).

Interacts with AGO2, Dcr-1, Rm62, vig, RpL5 and RpL11; these interactions form the RNA-induced silencing complex (RISC), a messenger ribonucleoprotein particle (RNP) complex involved in translation regulation (PubMed:12368261, PubMed:14508492). As part of the RISC complex, interacts with Tudor-SN (PubMed:14508492).

Component of a neuronal RNP at least composed of Fmr1, tral and me31B (PubMed:17178403).

Interacts with piwi and vas; these interactions occur in the polar granules (PubMed:16949822).

Interacts with Sra-1 (PubMed:12818175). Associates with polyribosome (PubMed:12368261).

6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
63147, 114 interactors

Protein interaction database and analysis system

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IntActi
Q9NFU0, 22 interactors

Molecular INTeraction database

More...
MINTi
Q9NFU0

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0300445

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9NFU0

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 49Agenet-like 1PROSITE-ProRule annotationAdd BLAST49
Domaini65 – 117Agenet-like 2PROSITE-ProRule annotationAdd BLAST53
Domaini221 – 282KH 1PROSITE-ProRule annotationAdd BLAST62
Domaini284 – 353KH 2PROSITE-ProRule annotationAdd BLAST70

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni474 – 489RNA-binding RGG-boxAdd BLAST16

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi419 – 499Gly-richAdd BLAST81
Compositional biasi574 – 669Gln-richAdd BLAST96

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FMR1 family.Sequence analysis

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IF9J Eukaryota
ENOG410ZDJG LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00950000183189

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NFU0

KEGG Orthology (KO)

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KOi
K15516

Identification of Orthologs from Complete Genome Data

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OMAi
DACANEN

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9NFU0

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.1370.10, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR008395 Agenet-like_dom
IPR040148 FMR1
IPR040472 FMRP_KH0
IPR022034 FXMRP1_C_core
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR041560 Tudor_FRX1

The PANTHER Classification System

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PANTHERi
PTHR10603 PTHR10603, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF12235 FXMRP1_C_core, 1 hit
PF00013 KH_1, 2 hits
PF17904 KH_9, 1 hit
PF18336 Tudor_FRX1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00322 KH, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF54791 SSF54791, 2 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51641 AGENET_LIKE, 2 hits
PS50084 KH_TYPE_1, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform A1 Publication (identifier: Q9NFU0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEDLLVEVRL DNGAYYKGQV TAVADDGIFV DVDGVPESMK YPFVNVRLPP
60 70 80 90 100
EETVEVAAPI FEEGMEVEVF TRTNDRETCG WWVGIIKMRK AEIYAVAYIG
110 120 130 140 150
FETSYTEICE LGRLRAKNSN PPITAKTFYQ FTLPVPEELR EEAQKDGIHK
160 170 180 190 200
EFQRTIDAGV CNYSRDLDAL IVISKFEHTQ KRASMLKDMH FRNLSQKVML
210 220 230 240 250
LKRTEEAARQ LETTKLMSRG NYVEEFRVRD DLMGLAIGSH GSNIQAARTV
260 270 280 290 300
DGVTNIELEE KSCTFKISGE TEESVQRARA MLEYAEEFFQ VPRELVGKVI
310 320 330 340 350
GKNGRIIQEI VDKSGVFRIK VSAIAGDDEQ DQNIPRELAH VPFVFIGTVE
360 370 380 390 400
SIANAKVLLE YHLSHLKEVE QLRQEKMEID QQLRAIQESS MGSTQSFPVT
410 420 430 440 450
RRSERGYSSD IESVRSMRGG GGGQRGRVRG RGGGGPGGGN GLNQRYHNNR
460 470 480 490 500
RDEDDYNSRG DHQRDQQRGY NDRGGGDNTG SYRGGGGGAG GPGNNRRGGI
510 520 530 540 550
NRRPPRNDQQ NGRDYQHHNH TTEEVRETRE MSSVERADSN SSYEGSSRRR
560 570 580 590 600
RRQKNNNGPS NTNGAVANNN NKPQSAQQPQ QQQPPAPGNK AALNAGDASK
610 620 630 640 650
QNSGNANAAG GASKPKDASR NGDKQQAGTQ QQQPSQVQQQ QAAQQQQPKP
660 670 680
RRNKNRSNNH TDQPSGQQQL AENVKKEGLV NGTS
Length:684
Mass (Da):76,076
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i973489A73B97F1FE
GO
Isoform B1 Publication (identifier: Q9NFU0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     321-330: Missing.
     537-539: ADS → DTN
     540-684: Missing.

Show »
Length:529
Mass (Da):59,708
Checksum:i44A6AB3CEC9C4B91
GO
Isoform C1 Publication (identifier: Q9NFU0-2) [UniParc]FASTAAdd to basket
Also known as: D1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     321-323: Missing.

Show »
Length:681
Mass (Da):75,819
Checksum:i570C388A0A3134C2
GO
Isoform E1 Publication (identifier: Q9NFU0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: Missing.
     321-323: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:643
Mass (Da):71,736
Checksum:i944F771C9E7B9A5C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4KFN9A0A0B4KFN9_DROME
Fmr1, isoform I
Fmr1 AT24755, BcDNA:GM08679, cg6203, dFMR, dfmr
639Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B3LF78B3LF78_DROME
Fmr1, isoform F
Fmr1 AT24755, BcDNA:GM08679, cg6203, dFMR, dfmr
646Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4K618A0A0B4K618_DROME
Fmr1, isoform G
Fmr1 AT24755, BcDNA:GM08679, cg6203, dFMR, dfmr
729Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4KGP6A0A0B4KGP6_DROME
Fmr1, isoform H
Fmr1 AT24755, BcDNA:GM08679, cg6203, dFMR, dfmr
577Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A126GUS7A0A126GUS7_DROME
Fmr1, isoform J
Fmr1 AT24755, BcDNA:GM08679, cg6203, dFMR, dfmr
681Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti343F → L in AAG22045 (PubMed:11046149).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0507831 – 38Missing in isoform E. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_050785321 – 330Missing in isoform B. 1 Publication10
Alternative sequenceiVSP_050784321 – 323Missing in isoform C and isoform E. 5 Publications3
Alternative sequenceiVSP_050786537 – 539ADS → DTN in isoform B. 1 Publication3
Alternative sequenceiVSP_050787540 – 684Missing in isoform B. 1 PublicationAdd BLAST145

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF305881 mRNA Translation: AAG22045.1
AF205596 mRNA Translation: AAF14639.1
AF205597 Genomic DNA Translation: AAF14640.1
AJ271221 mRNA Translation: CAB66340.1
AJ413217 mRNA Translation: CAC88757.2
AJ422082 mRNA Translation: CAD19443.1
AJ422083 mRNA Translation: CAD19444.1
AE014297 Genomic DNA Translation: AAF54493.2
AE014297 Genomic DNA Translation: AAN13451.1
AE014297 Genomic DNA Translation: AAN13452.1
AE014297 Genomic DNA Translation: AAN13453.1
AE014297 Genomic DNA Translation: AAN13454.1
AY069182 mRNA Translation: AAL39327.2
BT031124 mRNA Translation: ABX00746.1

NCBI Reference Sequences

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RefSeqi
NP_001303443.1, NM_001316514.1 [Q9NFU0-2]
NP_001303444.1, NM_001316515.1 [Q9NFU0-2]
NP_611645.1, NM_137801.4 [Q9NFU0-1]
NP_731443.1, NM_169324.2 [Q9NFU0-2]
NP_731444.1, NM_169325.3 [Q9NFU0-2]
NP_731445.1, NM_169326.3 [Q9NFU0-3]
NP_731446.1, NM_169327.2 [Q9NFU0-4]

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0082196; FBpp0081674; FBgn0028734 [Q9NFU0-4]
FBtr0082197; FBpp0081675; FBgn0028734 [Q9NFU0-1]
FBtr0082198; FBpp0081676; FBgn0028734 [Q9NFU0-2]
FBtr0082199; FBpp0081677; FBgn0028734 [Q9NFU0-2]
FBtr0082200; FBpp0081678; FBgn0028734 [Q9NFU0-3]
FBtr0347104; FBpp0312465; FBgn0028734 [Q9NFU0-2]
FBtr0347105; FBpp0312466; FBgn0028734 [Q9NFU0-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
37528

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG6203

UCSC genome browser

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UCSCi
CG6203-RD d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF305881 mRNA Translation: AAG22045.1
AF205596 mRNA Translation: AAF14639.1
AF205597 Genomic DNA Translation: AAF14640.1
AJ271221 mRNA Translation: CAB66340.1
AJ413217 mRNA Translation: CAC88757.2
AJ422082 mRNA Translation: CAD19443.1
AJ422083 mRNA Translation: CAD19444.1
AE014297 Genomic DNA Translation: AAF54493.2
AE014297 Genomic DNA Translation: AAN13451.1
AE014297 Genomic DNA Translation: AAN13452.1
AE014297 Genomic DNA Translation: AAN13453.1
AE014297 Genomic DNA Translation: AAN13454.1
AY069182 mRNA Translation: AAL39327.2
BT031124 mRNA Translation: ABX00746.1
RefSeqiNP_001303443.1, NM_001316514.1 [Q9NFU0-2]
NP_001303444.1, NM_001316515.1 [Q9NFU0-2]
NP_611645.1, NM_137801.4 [Q9NFU0-1]
NP_731443.1, NM_169324.2 [Q9NFU0-2]
NP_731444.1, NM_169325.3 [Q9NFU0-2]
NP_731445.1, NM_169326.3 [Q9NFU0-3]
NP_731446.1, NM_169327.2 [Q9NFU0-4]

3D structure databases

SMRiQ9NFU0
ModBaseiSearch...

Protein-protein interaction databases

BioGridi63147, 114 interactors
IntActiQ9NFU0, 22 interactors
MINTiQ9NFU0
STRINGi7227.FBpp0300445

PTM databases

iPTMnetiQ9NFU0

Proteomic databases

PaxDbiQ9NFU0
PRIDEiQ9NFU0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0082196; FBpp0081674; FBgn0028734 [Q9NFU0-4]
FBtr0082197; FBpp0081675; FBgn0028734 [Q9NFU0-1]
FBtr0082198; FBpp0081676; FBgn0028734 [Q9NFU0-2]
FBtr0082199; FBpp0081677; FBgn0028734 [Q9NFU0-2]
FBtr0082200; FBpp0081678; FBgn0028734 [Q9NFU0-3]
FBtr0347104; FBpp0312465; FBgn0028734 [Q9NFU0-2]
FBtr0347105; FBpp0312466; FBgn0028734 [Q9NFU0-2]
GeneIDi37528
KEGGidme:Dmel_CG6203
UCSCiCG6203-RD d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
2332
FlyBaseiFBgn0028734 Fmr1

Phylogenomic databases

eggNOGiENOG410IF9J Eukaryota
ENOG410ZDJG LUCA
GeneTreeiENSGT00950000183189
InParanoidiQ9NFU0
KOiK15516
OMAiDACANEN
PhylomeDBiQ9NFU0

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Fmr1 fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
37528

Protein Ontology

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PROi
PR:Q9NFU0

Gene expression databases

BgeeiFBgn0028734 Expressed in 35 organ(s), highest expression level in wing disc (Drosophila)
ExpressionAtlasiQ9NFU0 baseline and differential
GenevisibleiQ9NFU0 DM

Family and domain databases

Gene3Di3.30.1370.10, 2 hits
InterProiView protein in InterPro
IPR008395 Agenet-like_dom
IPR040148 FMR1
IPR040472 FMRP_KH0
IPR022034 FXMRP1_C_core
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR041560 Tudor_FRX1
PANTHERiPTHR10603 PTHR10603, 1 hit
PfamiView protein in Pfam
PF12235 FXMRP1_C_core, 1 hit
PF00013 KH_1, 2 hits
PF17904 KH_9, 1 hit
PF18336 Tudor_FRX1, 1 hit
SMARTiView protein in SMART
SM00322 KH, 2 hits
SUPFAMiSSF54791 SSF54791, 2 hits
PROSITEiView protein in PROSITE
PS51641 AGENET_LIKE, 2 hits
PS50084 KH_TYPE_1, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFMR1_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NFU0
Secondary accession number(s): A4V2M8
, Q8INM7, Q8T0M0, Q8WQ60, Q95P21, Q9GSG3, Q9TVY4, Q9VH27
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2000
Last modified: July 31, 2019
This is version 177 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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