UniProtKB - Q9NFU0 (FMR1_DROME)
Synaptic functional regulator FMR1
Fmr1
Functioni
GO - Molecular functioni
- DEAD/H-box RNA helicase binding Source: UniProtKB
- identical protein binding Source: IntAct
- mRNA 3'-UTR binding Source: GO_Central
- protein homodimerization activity Source: GO_Central
- protein self-association Source: FlyBase
- RNA binding Source: FlyBase
- translation regulator activity Source: CACAO
GO - Biological processi
- adult locomotory behavior Source: FlyBase
- anterograde axonal transport Source: GO_Central
- associative learning Source: FlyBase
- axonal fasciculation Source: FlyBase
- axon guidance Source: FlyBase
- axonogenesis Source: FlyBase
- brain development Source: FlyBase
- cellularization Source: FlyBase
- central nervous system development Source: GO_Central
- circadian rhythm Source: FlyBase
- circadian sleep/wake cycle, sleep Source: FlyBase
- dendrite morphogenesis Source: FlyBase
- detection of mechanical stimulus involved in sensory perception of touch Source: FlyBase
- gene silencing by RNA Source: FlyBase
- germarium-derived oocyte fate determination Source: FlyBase
- germ cell development Source: FlyBase
- germ-line cyst formation Source: FlyBase
- grooming behavior Source: FlyBase
- habituation Source: FlyBase
- heterochromatin assembly Source: FlyBase
- larval locomotory behavior Source: FlyBase
- locomotion Source: FlyBase
- locomotor rhythm Source: FlyBase
- long-term memory Source: FlyBase
- male courtship behavior Source: FlyBase
- medium-term memory Source: FlyBase
- mitotic cell cycle, embryonic Source: FlyBase
- mRNA transport Source: FlyBase
- mushroom body development Source: FlyBase
- negative regulation of dendrite morphogenesis Source: FlyBase
- negative regulation of gene expression Source: FlyBase
- negative regulation of insulin receptor signaling pathway Source: FlyBase
- negative regulation of mRNA polyadenylation Source: FlyBase
- negative regulation of stem cell proliferation Source: FlyBase
- negative regulation of synapse assembly Source: FlyBase
- negative regulation of synaptic growth at neuromuscular junction Source: FlyBase
- negative regulation of translation Source: FlyBase
- neuromuscular junction development Source: FlyBase
- neuron projection morphogenesis Source: FlyBase
- neuron remodeling Source: FlyBase
- olfactory behavior Source: FlyBase
- olfactory learning Source: FlyBase
- oocyte dorsal/ventral axis specification Source: FlyBase
- pole cell formation Source: FlyBase
- positive regulation of neuroblast proliferation Source: FlyBase
- positive regulation of programmed cell death Source: FlyBase
- positive regulation of translation Source: GO_Central
- post-embryonic digestive tract morphogenesis Source: FlyBase
- posttranscriptional regulation of gene expression Source: FlyBase
- regulation of cell population proliferation Source: FlyBase
- regulation of dendrite morphogenesis Source: FlyBase
- regulation of dendritic spine development Source: GO_Central
- regulation of mitotic cell cycle, embryonic Source: FlyBase
- regulation of modification of synaptic structure Source: GO_Central
- regulation of mRNA stability Source: GO_Central
- regulation of neuromuscular synaptic transmission Source: FlyBase
- regulation of olfactory learning Source: FlyBase
- regulation of synapse organization Source: FlyBase
- regulation of synapse structural plasticity Source: FlyBase
- regulation of translation Source: FlyBase
- regulation of translation at postsynapse, modulating synaptic transmission Source: GO_Central
- response to odorant Source: FlyBase
- short-term memory Source: FlyBase
- social behavior Source: FlyBase
- sperm axoneme assembly Source: FlyBase
- synapse organization Source: FlyBase
- synapse pruning Source: FlyBase
- synaptic vesicle budding Source: FlyBase
- synaptic vesicle clustering Source: FlyBase
- terminal button organization Source: FlyBase
- visual perception Source: UniProtKB-KW
Keywordsi
Molecular function | Repressor, Ribonucleoprotein, RNA-binding |
Biological process | Neurogenesis, RNA-mediated gene silencing, Sensory transduction, Translation regulation, Vision |
Names & Taxonomyi
Protein namesi | Recommended name: Synaptic functional regulator FMR1CuratedAlternative name(s): Fragile X mental retardation syndrome-related protein 1By similarity Short name: dFMR11 Publication |
Gene namesi | ORF Names:CG6203 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0028734, Fmr1 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 2 Publications
Other locations
- Perikaryon 1 Publication
- neuron projection 1 Publication
- synapse 1 Publication
- Stress granule By similarity
- Cytoplasmic ribonucleoprotein granule 1 Publication
Note: Localizes in the neuronal soma and cell processes, and in pre- and postsynaptic neurons, as well as in postsynaptic muscles.1 Publication
Golgi apparatus
- Golgi membrane Source: FlyBase
Nucleus
- nucleus Source: GO_Central
Other locations
- axon Source: GO_Central
- axon cytoplasm Source: GOC
- cytoplasm Source: FlyBase
- cytoplasmic ribonucleoprotein granule Source: GO_Central
- cytoplasmic stress granule Source: FlyBase
- dendritic spine Source: GO_Central
- membrane Source: GO_Central
- messenger ribonucleoprotein complex Source: UniProtKB
- neuron projection Source: FlyBase
- neuronal cell body Source: FlyBase
- neuronal ribonucleoprotein granule Source: UniProtKB
- P granule Source: FlyBase
- perikaryon Source: UniProtKB-SubCell
- plasma membrane bounded cell projection cytoplasm Source: FlyBase
- polysome Source: GO_Central
- postsynaptic density Source: GO_Central
- presynapse Source: GOC
- RISC complex Source: UniProtKB
Keywords - Cellular componenti
Cell junction, Cell projection, Cytoplasm, SynapsePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 244 | I → N: Impairs RNA-binding. 1 Publication | 1 | |
Mutagenesisi | 307 | I → N: Impairs RNA-binding. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000050109 | 1 – 684 | Synaptic functional regulator FMR1Add BLAST | 684 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 403 | Phosphoserine1 Publication | 1 | |
Modified residuei | 408 | Phosphoserine1 Publication | 1 | |
Modified residuei | 409 | Phosphoserine1 Publication | 1 | |
Modified residuei | 413 | Phosphoserine1 Publication | 1 | |
Modified residuei | 532 | Phosphoserine1 Publication | 1 | |
Modified residuei | 533 | Phosphoserine1 Publication | 1 | |
Modified residuei | 539 | Phosphoserine1 Publication | 1 | |
Modified residuei | 541 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q9NFU0 |
PRIDEi | Q9NFU0 |
PTM databases
iPTMneti | Q9NFU0 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | FBgn0028734, Expressed in imaginal disc and 42 other tissues |
ExpressionAtlasi | Q9NFU0, baseline and differential |
Genevisiblei | Q9NFU0, DM |
Interactioni
Subunit structurei
Homodimer (PubMed:11046149).
Interacts with AGO2, Dcr-1, Rm62, vig, RpL5 and RpL11; these interactions form the RNA-induced silencing complex (RISC), a messenger ribonucleoprotein particle (RNP) complex involved in translation regulation (PubMed:12368261, PubMed:14508492). As part of the RISC complex, interacts with Tudor-SN (PubMed:14508492).
Component of a neuronal RNP at least composed of Fmr1, tral and me31B (PubMed:17178403).
Interacts with piwi and vas; these interactions occur in the polar granules (PubMed:16949822).
Interacts with Sra-1 (PubMed:12818175). Associates with polyribosome (PubMed:12368261).
6 PublicationsBinary interactionsi
Hide detailsQ9NFU0
With | #Exp. | IntAct |
---|---|---|
AGO2 [Q9VUQ5] | 4 | EBI-422631,EBI-442476 |
itself | 2 | EBI-422631,EBI-422631 |
Rm62 [P19109] | 4 | EBI-422631,EBI-200734 |
RpL11 [P46222] | 5 | EBI-422631,EBI-183104 |
RpL5 [Q9NIU2] | 5 | EBI-422631,EBI-605695 |
GO - Molecular functioni
- DEAD/H-box RNA helicase binding Source: UniProtKB
- identical protein binding Source: IntAct
- protein homodimerization activity Source: GO_Central
- protein self-association Source: FlyBase
Protein-protein interaction databases
BioGRIDi | 63147, 124 interactors |
IntActi | Q9NFU0, 22 interactors |
MINTi | Q9NFU0 |
STRINGi | 7227.FBpp0300445 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 49 | Agenet-like 1PROSITE-ProRule annotationAdd BLAST | 49 | |
Domaini | 65 – 117 | Agenet-like 2PROSITE-ProRule annotationAdd BLAST | 53 | |
Domaini | 221 – 282 | KH 1PROSITE-ProRule annotationAdd BLAST | 62 | |
Domaini | 284 – 353 | KH 2PROSITE-ProRule annotationAdd BLAST | 70 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 474 – 489 | RNA-binding RGG-boxAdd BLAST | 16 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 419 – 499 | Gly-richAdd BLAST | 81 | |
Compositional biasi | 574 – 669 | Gln-richAdd BLAST | 96 |
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502QPKJ, Eukaryota |
InParanoidi | Q9NFU0 |
OMAi | NERETCG |
PhylomeDBi | Q9NFU0 |
Family and domain databases
Gene3Di | 3.30.1370.10, 2 hits |
InterProi | View protein in InterPro IPR008395, Agenet-like_dom IPR040148, FMR1 IPR040472, FMRP_KH0 IPR022034, FXMRP1_C_core IPR004087, KH_dom IPR004088, KH_dom_type_1 IPR036612, KH_dom_type_1_sf IPR041560, Tudor_FRX1 |
PANTHERi | PTHR10603, PTHR10603, 1 hit |
Pfami | View protein in Pfam PF12235, FXMRP1_C_core, 1 hit PF00013, KH_1, 2 hits PF17904, KH_9, 1 hit PF18336, Tudor_FRX1, 1 hit |
SMARTi | View protein in SMART SM00322, KH, 2 hits |
SUPFAMi | SSF54791, SSF54791, 2 hits |
PROSITEi | View protein in PROSITE PS51641, AGENET_LIKE, 2 hits PS50084, KH_TYPE_1, 2 hits |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEDLLVEVRL DNGAYYKGQV TAVADDGIFV DVDGVPESMK YPFVNVRLPP
60 70 80 90 100
EETVEVAAPI FEEGMEVEVF TRTNDRETCG WWVGIIKMRK AEIYAVAYIG
110 120 130 140 150
FETSYTEICE LGRLRAKNSN PPITAKTFYQ FTLPVPEELR EEAQKDGIHK
160 170 180 190 200
EFQRTIDAGV CNYSRDLDAL IVISKFEHTQ KRASMLKDMH FRNLSQKVML
210 220 230 240 250
LKRTEEAARQ LETTKLMSRG NYVEEFRVRD DLMGLAIGSH GSNIQAARTV
260 270 280 290 300
DGVTNIELEE KSCTFKISGE TEESVQRARA MLEYAEEFFQ VPRELVGKVI
310 320 330 340 350
GKNGRIIQEI VDKSGVFRIK VSAIAGDDEQ DQNIPRELAH VPFVFIGTVE
360 370 380 390 400
SIANAKVLLE YHLSHLKEVE QLRQEKMEID QQLRAIQESS MGSTQSFPVT
410 420 430 440 450
RRSERGYSSD IESVRSMRGG GGGQRGRVRG RGGGGPGGGN GLNQRYHNNR
460 470 480 490 500
RDEDDYNSRG DHQRDQQRGY NDRGGGDNTG SYRGGGGGAG GPGNNRRGGI
510 520 530 540 550
NRRPPRNDQQ NGRDYQHHNH TTEEVRETRE MSSVERADSN SSYEGSSRRR
560 570 580 590 600
RRQKNNNGPS NTNGAVANNN NKPQSAQQPQ QQQPPAPGNK AALNAGDASK
610 620 630 640 650
QNSGNANAAG GASKPKDASR NGDKQQAGTQ QQQPSQVQQQ QAAQQQQPKP
660 670 680
RRNKNRSNNH TDQPSGQQQL AENVKKEGLV NGTS
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0B4K618 | A0A0B4K618_DROME | Fmr1, isoform G | Fmr1 AT24755, BcDNA:GM08679, cg6203, dFMR, dfmr | 729 | Annotation score: | ||
A0A0B4KGP6 | A0A0B4KGP6_DROME | Fmr1, isoform H | Fmr1 AT24755, BcDNA:GM08679, cg6203, dFMR, dfmr | 577 | Annotation score: | ||
A0A126GUS7 | A0A126GUS7_DROME | Fmr1, isoform J | Fmr1 AT24755, BcDNA:GM08679, cg6203, dFMR, dfmr | 681 | Annotation score: | ||
B3LF78 | B3LF78_DROME | Fmr1, isoform F | Fmr1 AT24755, BcDNA:GM08679, cg6203, dFMR, dfmr | 646 | Annotation score: | ||
A0A0B4KFN9 | A0A0B4KFN9_DROME | Fmr1, isoform I | Fmr1 AT24755, BcDNA:GM08679, cg6203, dFMR, dfmr | 639 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 343 | F → L in AAG22045 (PubMed:11046149).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_050783 | 1 – 38 | Missing in isoform E. 1 PublicationAdd BLAST | 38 | |
Alternative sequenceiVSP_050785 | 321 – 330 | Missing in isoform B. 1 Publication | 10 | |
Alternative sequenceiVSP_050784 | 321 – 323 | Missing in isoform C and isoform E. 5 Publications | 3 | |
Alternative sequenceiVSP_050786 | 537 – 539 | ADS → DTN in isoform B. 1 Publication | 3 | |
Alternative sequenceiVSP_050787 | 540 – 684 | Missing in isoform B. 1 PublicationAdd BLAST | 145 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF305881 mRNA Translation: AAG22045.1 AF205596 mRNA Translation: AAF14639.1 AF205597 Genomic DNA Translation: AAF14640.1 AJ271221 mRNA Translation: CAB66340.1 AJ413217 mRNA Translation: CAC88757.2 AJ422082 mRNA Translation: CAD19443.1 AJ422083 mRNA Translation: CAD19444.1 AE014297 Genomic DNA Translation: AAF54493.2 AE014297 Genomic DNA Translation: AAN13451.1 AE014297 Genomic DNA Translation: AAN13452.1 AE014297 Genomic DNA Translation: AAN13453.1 AE014297 Genomic DNA Translation: AAN13454.1 AY069182 mRNA Translation: AAL39327.2 BT031124 mRNA Translation: ABX00746.1 |
RefSeqi | NP_001303443.1, NM_001316514.1 [Q9NFU0-2] NP_001303444.1, NM_001316515.1 [Q9NFU0-2] NP_611645.1, NM_137801.4 [Q9NFU0-1] NP_731443.1, NM_169324.2 [Q9NFU0-2] NP_731444.1, NM_169325.3 [Q9NFU0-2] NP_731445.1, NM_169326.3 [Q9NFU0-3] NP_731446.1, NM_169327.2 [Q9NFU0-4] |
Genome annotation databases
EnsemblMetazoai | FBtr0082196; FBpp0081674; FBgn0028734 [Q9NFU0-4] FBtr0082197; FBpp0081675; FBgn0028734 [Q9NFU0-1] FBtr0082198; FBpp0081676; FBgn0028734 [Q9NFU0-2] FBtr0082199; FBpp0081677; FBgn0028734 [Q9NFU0-2] FBtr0082200; FBpp0081678; FBgn0028734 [Q9NFU0-3] FBtr0347104; FBpp0312465; FBgn0028734 [Q9NFU0-2] FBtr0347105; FBpp0312466; FBgn0028734 [Q9NFU0-2] |
GeneIDi | 37528 |
KEGGi | dme:Dmel_CG6203 |
UCSCi | CG6203-RD, d. melanogaster |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF305881 mRNA Translation: AAG22045.1 AF205596 mRNA Translation: AAF14639.1 AF205597 Genomic DNA Translation: AAF14640.1 AJ271221 mRNA Translation: CAB66340.1 AJ413217 mRNA Translation: CAC88757.2 AJ422082 mRNA Translation: CAD19443.1 AJ422083 mRNA Translation: CAD19444.1 AE014297 Genomic DNA Translation: AAF54493.2 AE014297 Genomic DNA Translation: AAN13451.1 AE014297 Genomic DNA Translation: AAN13452.1 AE014297 Genomic DNA Translation: AAN13453.1 AE014297 Genomic DNA Translation: AAN13454.1 AY069182 mRNA Translation: AAL39327.2 BT031124 mRNA Translation: ABX00746.1 |
RefSeqi | NP_001303443.1, NM_001316514.1 [Q9NFU0-2] NP_001303444.1, NM_001316515.1 [Q9NFU0-2] NP_611645.1, NM_137801.4 [Q9NFU0-1] NP_731443.1, NM_169324.2 [Q9NFU0-2] NP_731444.1, NM_169325.3 [Q9NFU0-2] NP_731445.1, NM_169326.3 [Q9NFU0-3] NP_731446.1, NM_169327.2 [Q9NFU0-4] |
3D structure databases
SMRi | Q9NFU0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 63147, 124 interactors |
IntActi | Q9NFU0, 22 interactors |
MINTi | Q9NFU0 |
STRINGi | 7227.FBpp0300445 |
PTM databases
iPTMneti | Q9NFU0 |
Proteomic databases
PaxDbi | Q9NFU0 |
PRIDEi | Q9NFU0 |
Genome annotation databases
EnsemblMetazoai | FBtr0082196; FBpp0081674; FBgn0028734 [Q9NFU0-4] FBtr0082197; FBpp0081675; FBgn0028734 [Q9NFU0-1] FBtr0082198; FBpp0081676; FBgn0028734 [Q9NFU0-2] FBtr0082199; FBpp0081677; FBgn0028734 [Q9NFU0-2] FBtr0082200; FBpp0081678; FBgn0028734 [Q9NFU0-3] FBtr0347104; FBpp0312465; FBgn0028734 [Q9NFU0-2] FBtr0347105; FBpp0312466; FBgn0028734 [Q9NFU0-2] |
GeneIDi | 37528 |
KEGGi | dme:Dmel_CG6203 |
UCSCi | CG6203-RD, d. melanogaster |
Organism-specific databases
CTDi | 2332 |
FlyBasei | FBgn0028734, Fmr1 |
Phylogenomic databases
eggNOGi | ENOG502QPKJ, Eukaryota |
InParanoidi | Q9NFU0 |
OMAi | NERETCG |
PhylomeDBi | Q9NFU0 |
Miscellaneous databases
BioGRID-ORCSi | 37528, 0 hits in 3 CRISPR screens |
ChiTaRSi | Fmr1, fly |
GenomeRNAii | 37528 |
PROi | PR:Q9NFU0 |
Gene expression databases
Bgeei | FBgn0028734, Expressed in imaginal disc and 42 other tissues |
ExpressionAtlasi | Q9NFU0, baseline and differential |
Genevisiblei | Q9NFU0, DM |
Family and domain databases
Gene3Di | 3.30.1370.10, 2 hits |
InterProi | View protein in InterPro IPR008395, Agenet-like_dom IPR040148, FMR1 IPR040472, FMRP_KH0 IPR022034, FXMRP1_C_core IPR004087, KH_dom IPR004088, KH_dom_type_1 IPR036612, KH_dom_type_1_sf IPR041560, Tudor_FRX1 |
PANTHERi | PTHR10603, PTHR10603, 1 hit |
Pfami | View protein in Pfam PF12235, FXMRP1_C_core, 1 hit PF00013, KH_1, 2 hits PF17904, KH_9, 1 hit PF18336, Tudor_FRX1, 1 hit |
SMARTi | View protein in SMART SM00322, KH, 2 hits |
SUPFAMi | SSF54791, SSF54791, 2 hits |
PROSITEi | View protein in PROSITE PS51641, AGENET_LIKE, 2 hits PS50084, KH_TYPE_1, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FMR1_DROME | |
Accessioni | Q9NFU0Primary (citable) accession number: Q9NFU0 Secondary accession number(s): A4V2M8 Q9VH27 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2004 |
Last sequence update: | October 1, 2000 | |
Last modified: | April 7, 2021 | |
This is version 188 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families