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Entry version 148 (26 Feb 2020)
Sequence version 4 (21 Jun 2004)
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Protein

Hexokinase type 2

Gene

Hex-t2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the phosphorylation of various hexoses to hexose 6-phosphate.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: hexose metabolism

This protein is involved in the pathway hexose metabolism, which is part of Carbohydrate metabolism.By similarity
View all proteins of this organism that are known to be involved in the pathway hexose metabolism and in Carbohydrate metabolism.

Pathwayi: glycolysis

This protein is involved in step 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.By similarity
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Phosphotransferase (Hex-C), Phosphotransferase (Hex-C), Phosphotransferase (Hex-A), Phosphotransferase (Hex-C), Hexokinase type 2 (Hex-t2), Phosphotransferase (Hex-t2-RA), Phosphotransferase (Hex-A), Hexokinase type 1 (Hex-t1), Phosphotransferase (Hex-C), Phosphotransferase (Hex-C), Phosphotransferase (CG3001), Phosphotransferase (Hex-A), Phosphotransferase (Hex-A), Phosphotransferase (CG3001), Phosphotransferase (Hex-C), Phosphotransferase (CG3001)
  2. Glucose-6-phosphate isomerase (Pgi)
  3. ATP-dependent 6-phosphofructokinase (Pfk), ATP-dependent 6-phosphofructokinase (Pfk-RB), ATP-dependent 6-phosphofructokinase (Pfk), ATP-dependent 6-phosphofructokinase (Pfk), ATP-dependent 6-phosphofructokinase (Pfk-RB), ATP-dependent 6-phosphofructokinase (Pfk-RC)
  4. Fructose-bisphosphate aldolase (Ald-RH), Fructose-bisphosphate aldolase (Ald1), Fructose-bisphosphate aldolase (Ald-RI), Fructose-bisphosphate aldolase (Ald1), Fructose-bisphosphate aldolase (Ald1), Fructose-bisphosphate aldolase (Ald1)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei128ATP1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-DME-70171 Glycolysis

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00109;UER00180
UPA00242

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hexokinase type 2 (EC:2.7.1.1By similarity)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Hex-t2
Synonyms:Hex
ORF Names:CG32849
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0042710 Hex-t2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001975971 – 486Hexokinase type 2Add BLAST486

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NFT7

PRoteomics IDEntifications database

More...
PRIDEi
Q9NFT7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0042710 Expressed in testis and 8 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NFT7 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9NFT7, 1 interactor

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0084383

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NFT7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini36 – 477HexokinasePROSITE-ProRule annotationAdd BLAST442

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni93 – 225Hexokinase small subdomainPROSITE-ProRule annotationAdd BLAST133
Regioni167 – 193Glucose-bindingSequence analysisAdd BLAST27
Regioni226 – 466Hexokinase large subdomainPROSITE-ProRule annotationAdd BLAST241

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the hexokinase family.PROSITE-ProRule annotationCurated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1369 Eukaryota
COG5026 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182787

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_014393_5_3_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NFT7

KEGG Orthology (KO)

More...
KOi
K00844

Identification of Orthologs from Complete Genome Data

More...
OMAi
LMSCAFY

Database of Orthologous Groups

More...
OrthoDBi
1153545at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NFT7

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001312 Hexokinase
IPR019807 Hexokinase_BS
IPR022673 Hexokinase_C
IPR022672 Hexokinase_N

The PANTHER Classification System

More...
PANTHERi
PTHR19443 PTHR19443, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00349 Hexokinase_1, 1 hit
PF03727 Hexokinase_2, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00378 HEXOKINASE_1, 1 hit
PS51748 HEXOKINASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9NFT7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRKSTRLLTH SLFGPVFKIL FHNKTVCGGC NRKMPSLVNT EIEAAVKGFL
60 70 80 90 100
IDQEKMTEVV ERMTKEIKMG LAKDTHARAV IKCFVSHVQD LPTGKERGKY
110 120 130 140 150
LALDLGGSNF RVLLVNLISN SDVETMSKGY NFPQTLMSGS GKALFDFLAE
160 170 180 190 200
CLSEFCHSHG LENESLALGF TFSFPLQQQG LSKGILVAWT KGFSCEGVVG
210 220 230 240 250
KNVVSLLQEA IDRRGDLKIN TVAILNDTVG TLMSCAFYHP NCRIGLIVGT
260 270 280 290 300
GSNACYVEKT VNAECFEGYQ TSPKPSMIIN CEWGAFGDNG VLEFVRTSYD
310 320 330 340 350
KAVDKVTPNP GKQTFEKCIS GMYMGELVRL VITDMIAKGF MFHGIISEKI
360 370 380 390 400
QERWSFKTAY ISDVESDAPG EYRNCNKVLS ELGILGCQEP DKEALRYICE
410 420 430 440 450
AVSSRSAKLC ACGLVTIINK MNINEVAIGI DGSVYRFHPK YHDMLQYHMK
460 470 480
KLLKPGVKFE LVVSEDGSGR GAALVAATAV QAKSKL
Length:486
Mass (Da):53,486
Last modified:June 21, 2004 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i79D011558E1E5ED6
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG22892 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAG22894 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAG22896 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAG22898 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAG22900 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAG22902 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAG22904 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAG22906 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAG22908 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAG22910 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAG22912 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAG22914 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAG22916 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAG22918 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAG22920 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAG22922 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAG22924 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAG22926 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAG22928 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAL13623 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB67701 differs from that shown. Reason: Erroneous gene model prediction. Was originally thought to correspond to two different genes.Curated
The sequence CAB72132 differs from that shown. Reason: Erroneous gene model prediction. Was originally thought to correspond to two different genes.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti167A → P (PubMed:11063694).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti194S → N in strain: HFL97e3_15. 1 Publication1
Natural varianti252S → T in strain: ZIM(S)e3_24. 1 Publication1
Natural varianti380S → N in strain: SC96e3_12.3 and ZIM(S)e3_35. 1 Publication1
Natural varianti484S → N in strain: DPF96e3_23.1, SC96e3_12.3, HFL97e3_8, HFL97e3_12, HFL97e3_16, ZIM(S)e3_24 and ZIM(S)e3_35. 1 Publication1
Natural varianti486L → I in strain: DPF96e3_23.1, SC96e3_12.3, HFL97e3_8, HFL97e3_12, HFL97e3_16 and ZIM(S)e3_24. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF257590 Genomic DNA Translation: AAG22892.1 Different initiation.
AF257591 Genomic DNA Translation: AAG22894.1 Different initiation.
AF257592 Genomic DNA Translation: AAG22896.1 Different initiation.
AF257593 Genomic DNA Translation: AAG22898.1 Different initiation.
AF257594 Genomic DNA Translation: AAG22900.1 Different initiation.
AF257595 Genomic DNA Translation: AAG22902.1 Different initiation.
AF257596 Genomic DNA Translation: AAG22904.1 Different initiation.
AF257597 Genomic DNA Translation: AAG22906.1 Different initiation.
AF257598 Genomic DNA Translation: AAG22908.1 Different initiation.
AF257599 Genomic DNA Translation: AAG22910.1 Different initiation.
AF257600 Genomic DNA Translation: AAG22912.1 Different initiation.
AF257601 Genomic DNA Translation: AAG22914.1 Different initiation.
AF257602 Genomic DNA Translation: AAG22916.1 Different initiation.
AF257603 Genomic DNA Translation: AAG22918.1 Different initiation.
AF257604 Genomic DNA Translation: AAG22920.1 Different initiation.
AF257605 Genomic DNA Translation: AAG22922.1 Different initiation.
AF257606 Genomic DNA Translation: AAG22924.1 Different initiation.
AF257607 Genomic DNA Translation: AAG22926.1 Different initiation.
AF257608 Genomic DNA Translation: AAG22928.1 Different initiation.
AJ271350 Genomic DNA Translation: CAB67701.1 Sequence problems.
AJ271350 Genomic DNA Translation: CAB72132.1 Sequence problems.
AE014297 Genomic DNA Translation: AAN14073.2
AY058394 mRNA Translation: AAL13623.1 Different initiation.

NCBI Reference Sequences

More...
RefSeqi
NP_733151.2, NM_170272.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0085011; FBpp0084383; FBgn0042710

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
43191

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG32849

UCSC genome browser

More...
UCSCi
CG32849-RA d. melanogaster

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257590 Genomic DNA Translation: AAG22892.1 Different initiation.
AF257591 Genomic DNA Translation: AAG22894.1 Different initiation.
AF257592 Genomic DNA Translation: AAG22896.1 Different initiation.
AF257593 Genomic DNA Translation: AAG22898.1 Different initiation.
AF257594 Genomic DNA Translation: AAG22900.1 Different initiation.
AF257595 Genomic DNA Translation: AAG22902.1 Different initiation.
AF257596 Genomic DNA Translation: AAG22904.1 Different initiation.
AF257597 Genomic DNA Translation: AAG22906.1 Different initiation.
AF257598 Genomic DNA Translation: AAG22908.1 Different initiation.
AF257599 Genomic DNA Translation: AAG22910.1 Different initiation.
AF257600 Genomic DNA Translation: AAG22912.1 Different initiation.
AF257601 Genomic DNA Translation: AAG22914.1 Different initiation.
AF257602 Genomic DNA Translation: AAG22916.1 Different initiation.
AF257603 Genomic DNA Translation: AAG22918.1 Different initiation.
AF257604 Genomic DNA Translation: AAG22920.1 Different initiation.
AF257605 Genomic DNA Translation: AAG22922.1 Different initiation.
AF257606 Genomic DNA Translation: AAG22924.1 Different initiation.
AF257607 Genomic DNA Translation: AAG22926.1 Different initiation.
AF257608 Genomic DNA Translation: AAG22928.1 Different initiation.
AJ271350 Genomic DNA Translation: CAB67701.1 Sequence problems.
AJ271350 Genomic DNA Translation: CAB72132.1 Sequence problems.
AE014297 Genomic DNA Translation: AAN14073.2
AY058394 mRNA Translation: AAL13623.1 Different initiation.
RefSeqiNP_733151.2, NM_170272.3

3D structure databases

SMRiQ9NFT7
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9NFT7, 1 interactor
STRINGi7227.FBpp0084383

Proteomic databases

PaxDbiQ9NFT7
PRIDEiQ9NFT7

Genome annotation databases

EnsemblMetazoaiFBtr0085011; FBpp0084383; FBgn0042710
GeneIDi43191
KEGGidme:Dmel_CG32849
UCSCiCG32849-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
43191
FlyBaseiFBgn0042710 Hex-t2

Phylogenomic databases

eggNOGiKOG1369 Eukaryota
COG5026 LUCA
GeneTreeiENSGT00950000182787
HOGENOMiCLU_014393_5_3_1
InParanoidiQ9NFT7
KOiK00844
OMAiLMSCAFY
OrthoDBi1153545at2759
PhylomeDBiQ9NFT7

Enzyme and pathway databases

UniPathwayiUPA00109;UER00180
UPA00242
ReactomeiR-DME-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-DME-70171 Glycolysis

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
43191

Protein Ontology

More...
PROi
PR:Q9NFT7

Gene expression databases

BgeeiFBgn0042710 Expressed in testis and 8 other tissues
GenevisibleiQ9NFT7 DM

Family and domain databases

InterProiView protein in InterPro
IPR001312 Hexokinase
IPR019807 Hexokinase_BS
IPR022673 Hexokinase_C
IPR022672 Hexokinase_N
PANTHERiPTHR19443 PTHR19443, 1 hit
PfamiView protein in Pfam
PF00349 Hexokinase_1, 1 hit
PF03727 Hexokinase_2, 1 hit
PROSITEiView protein in PROSITE
PS00378 HEXOKINASE_1, 1 hit
PS51748 HEXOKINASE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHXK2_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NFT7
Secondary accession number(s): Q95U08, Q9NFT8, Q9VBF1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: June 21, 2004
Last modified: February 26, 2020
This is version 148 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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