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Protein

Omega-3 fatty acid desaturase fat-1

Gene

fat-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Omega-3 fatty acid desaturase that acts on a range of substrates. Catalyzes the desaturation of linolenic acid (18:2n-6), dihomo-gamma-linoleic acid (DHGLA) (20:3n-6), and arachidonic acid (20:4n-6), to generate gamma linolenic acid (18:3n-3), eicosatetraenoic acid (20:4n-3) and eicosapentaenoic acid (20:5n-3) respectively. Although the enzyme has been suggested to act on glycerolipids, the precise nature of the fatty acid substrate is unknown.3 Publications

Pathwayi: polyunsaturated fatty acid biosynthesis

This protein is involved in the pathway polyunsaturated fatty acid biosynthesis, which is part of Lipid metabolism.3 Publications
View all proteins of this organism that are known to be involved in the pathway polyunsaturated fatty acid biosynthesis and in Lipid metabolism.

GO - Molecular functioni

  • omega-3 fatty acid desaturase activity Source: WormBase

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayi
UPA00658

Chemistry databases

SwissLipidsiSLP:000000265

Names & Taxonomyi

Protein namesi
Recommended name:
Omega-3 fatty acid desaturase fat-1 (EC:1.14.19.-)
Alternative name(s):
Fatty acid desaturase 1
Gene namesi
Name:fat-1
ORF Names:Y67H2A.8
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiY67H2A.8 ; CE22790 ; WBGene00001393 ; fat-1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Transmembranei101 – 121HelicalSequence analysisAdd BLAST21
Transmembranei235 – 255HelicalSequence analysisAdd BLAST21
Transmembranei260 – 280HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004233831 – 402Omega-3 fatty acid desaturase fat-1Add BLAST402

Proteomic databases

EPDiQ9NEQ0
PaxDbiQ9NEQ0
PeptideAtlasiQ9NEQ0
PRIDEiQ9NEQ0

Expressioni

Gene expression databases

BgeeiWBGene00001393 Expressed in 5 organ(s), highest expression level in adult organism

Interactioni

Protein-protein interaction databases

IntActiQ9NEQ0, 1 interactor
STRINGi6239.Y67H2A.8.1

Structurei

3D structure databases

ProteinModelPortaliQ9NEQ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFN9 Eukaryota
COG3239 LUCA
GeneTreeiENSGT00750000118759
HOGENOMiHOG000201904
InParanoidiQ9NEQ0
KOiK10257
OMAiKFSHHRH
OrthoDBiEOG091G0INF
PhylomeDBiQ9NEQ0

Family and domain databases

InterProiView protein in InterPro
IPR005804 FA_desaturase_dom
PfamiView protein in Pfam
PF00487 FA_desaturase, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NEQ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVAHSSEGLS ATAPVTGGDV LVDARASLEE KEAPRDVNAN TKQATTEEPR
60 70 80 90 100
IQLPTVDAFR RAIPAHCFER DLVKSIRYLV QDFAALTILY FALPAFEYFG
110 120 130 140 150
LFGYLVWNIF MGVFGFALFV VGHDCLHGSF SDNQNLNDFI GHIAFSPLFS
160 170 180 190 200
PYFPWQKSHK LHHAFTNHID KDHGHVWIQD KDWEAMPSWK RWFNPIPFSG
210 220 230 240 250
WLKWFPVYTL FGFCDGSHFW PYSSLFVRNS ERVQCVISGI CCCVCAYIAL
260 270 280 290 300
TIAGSYSNWF WYYWVPLSFF GLMLVIVTYL QHVDDVAEVY EADEWSFVRG
310 320 330 340 350
QTQTIDRYYG LGLDTTMHHI TDGHVAHHFF NKIPHYHLIE ATEGVKKVLE
360 370 380 390 400
PLSDTQYGYK SQVNYDFFAR FLWFNYKLDY LVHKTAGIMQ FRTTLEEKAK

AK
Length:402
Mass (Da):46,559
Last modified:October 1, 2000 - v1
Checksum:iBE1B1CD794EA98C5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti231E → D in AAA67369 (PubMed:9037020).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41807 mRNA Translation: AAA67369.1
AL132951 Genomic DNA Translation: CAC44309.1
RefSeqiNP_001023560.1, NM_001028389.4
UniGeneiCel.23442

Genome annotation databases

EnsemblMetazoaiY67H2A.8; Y67H2A.8; WBGene00001393
GeneIDi178291
KEGGicel:CELE_Y67H2A.8

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41807 mRNA Translation: AAA67369.1
AL132951 Genomic DNA Translation: CAC44309.1
RefSeqiNP_001023560.1, NM_001028389.4
UniGeneiCel.23442

3D structure databases

ProteinModelPortaliQ9NEQ0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9NEQ0, 1 interactor
STRINGi6239.Y67H2A.8.1

Chemistry databases

SwissLipidsiSLP:000000265

Proteomic databases

EPDiQ9NEQ0
PaxDbiQ9NEQ0
PeptideAtlasiQ9NEQ0
PRIDEiQ9NEQ0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY67H2A.8; Y67H2A.8; WBGene00001393
GeneIDi178291
KEGGicel:CELE_Y67H2A.8

Organism-specific databases

CTDi178291
WormBaseiY67H2A.8 ; CE22790 ; WBGene00001393 ; fat-1

Phylogenomic databases

eggNOGiENOG410IFN9 Eukaryota
COG3239 LUCA
GeneTreeiENSGT00750000118759
HOGENOMiHOG000201904
InParanoidiQ9NEQ0
KOiK10257
OMAiKFSHHRH
OrthoDBiEOG091G0INF
PhylomeDBiQ9NEQ0

Enzyme and pathway databases

UniPathwayi
UPA00658

Miscellaneous databases

PROiPR:Q9NEQ0

Gene expression databases

BgeeiWBGene00001393 Expressed in 5 organ(s), highest expression level in adult organism

Family and domain databases

InterProiView protein in InterPro
IPR005804 FA_desaturase_dom
PfamiView protein in Pfam
PF00487 FA_desaturase, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFAT1_CAEEL
AccessioniPrimary (citable) accession number: Q9NEQ0
Secondary accession number(s): Q21056
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 18, 2013
Last sequence update: October 1, 2000
Last modified: September 12, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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Main funding by: National Institutes of Health

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