Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tyrosine-protein phosphatase

Gene

Ci-PTP

Organism
Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei862SubstrateUniRule annotation1
Active sitei894Phosphocysteine intermediateUniRule annotation1
Binding sitei938SubstrateUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphataseUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphataseUniRule annotation (EC:3.1.3.48UniRule annotation)
Gene namesi
Name:Ci-PTPImported
Synonyms:ptpImported, PTPN4Imported
OrganismiCiona intestinalis (Transparent sea squirt) (Ascidia intestinalis)Imported
Taxonomic identifieri7719 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataTunicataAscidiaceaEnterogonaPhlebobranchiaCionidaeCiona

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, CytoskeletonUniRule annotation

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ9NDP4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 322FERMInterPro annotationAdd BLAST287
Domaini554 – 626PDZInterPro annotationAdd BLAST73
Domaini686 – 953Tyrosine-protein phosphataseInterPro annotationAdd BLAST268
Domaini870 – 944TYR_PHOSPHATASE_2InterPro annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni894 – 900Substrate bindingUniRule annotation7

Sequence similaritiesi

Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG0792 Eukaryota
COG5599 LUCA
HOVERGENiHBG008322
KOiK18037

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR012151 Tyr_Pase_non-rcpt_typ-3/4
IPR000387 TYR_PHOSPHATASE_dom
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PF00595 PDZ, 1 hit
PF00102 Y_phosphatase, 1 hit
PIRSFiPIRSF000927 Tyr-Ptase_nr3, 1 hit
PRINTSiPR00935 BAND41
PR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM01196 FERM_C, 1 hit
SM00228 PDZ, 1 hit
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF50156 SSF50156, 1 hit
SSF52799 SSF52799, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00660 FERM_1, 1 hit
PS50057 FERM_3, 1 hit
PS50106 PDZ, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NDP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAVKEVSPA VSRNLLTGSG TYNVREPAKE KKQSSVNISV VLLDHTEVVF
60 70 80 90 100
KVNKRDRGQV LLDLVFQHLR VTEIKFFGLQ FPNDVPDTMR WLDPTKSIRK
110 120 130 140 150
QFKRGYPYIL FFRVKFYATD LSTMKDEFTR YQLFMQIKLD LLERRLKCSL
160 170 180 190 200
SEAASIAALA VQSELGDFNS AEHKKNYVAE FRFIPNQTEE FEAQVIHLHK
210 220 230 240 250
MHRGLSPSQA EYYFIKKSQK LEMYGIEMHR AKDNDEEDLD VGVTSTGMLL
260 270 280 290 300
YQNGFKKNEF RWSSIVKISF KRKQFYVQLR SAAKKEVNAI EPIHSFHMEN
310 320 330 340 350
YRACKRLWKS CVDFHSFYRL DRCMSRSCGH QHVANDGLPE QEDEMARQEK
360 370 380 390 400
HLFSYLTLGG RGKGRENDES TDDLTQRQRY LRTRAASTKS KDNMSLACNG
410 420 430 440 450
ESRNEDKAPR RLSAPPSVSI GVGESGMTDE QMMVMLHQQQ ASMQSAHSQP
460 470 480 490 500
KLFVNANYES NNNSEIPPPV KIPIQYHTGD PALTASYRTI HIRPETAGEA
510 520 530 540 550
DETAASELSV LTTGSETSSV LTSLTEKSYI LPNPVPFPHQ SSGQMNGVPD
560 570 580 590 600
DLVIIRIKPD LEGRYGFNVK GGADQNMPIL VSKVAAGSPA AMCTPALNEG
610 620 630 640 650
DEVLQINGRD ISSHSHEQVV RFIRSTREHH TGHLVLIVRP QNQADEDEVE
660 670 680 690 700
VSTDDVGEVV GADDDEGALL ERSMQWLEDM LDSGQILAMF DALYRKKPGA
710 720 730 740 750
TMNDARLPQN VTKNRYRDIS PYDSTRVILN GIVDTDYINA NYVNMFIPGN
760 770 780 790 800
NWTNRYIACQ GPLPNTSFDF WEMVWEQKST LIVMLTTVVE RGRPKCHQYW
810 820 830 840 850
PDGGTSVQFG PFIIESVTEE VTPSFAFRDF KLYKCNEDAE VNGNDLTKGR
860 870 880 890 900
DIRQMQYIAW PDHGVPDDSS DFLDFVLRVR QNRVGMAIPS TVHCSAGIGR
910 920 930 940 950
TGVLITMETA MCLIEANQPV YPIEIARAMR DQRAMMIQTP SQFKFVCDAI
960 970 980
LRVYKEGLAR PIYYDDYDEA DSSADETNII IKKSLQT
Length:987
Mass (Da):112,033
Last modified:October 1, 2000 - v1
Checksum:i87038FD56AEEB1DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB036856 mRNA Translation: BAB00633.1
RefSeqiNP_001027610.1, NM_001032438.1
UniGeneiCin.49507

Genome annotation databases

GeneIDi445608
KEGGicin:445608

Similar proteinsi

Entry informationi

Entry nameiQ9NDP4_CIOIN
AccessioniPrimary (citable) accession number: Q9NDP4
Secondary accession number(s): A0A1W2VN16
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health