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Entry version 72 (07 Oct 2020)
Sequence version 1 (01 Oct 2000)
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Protein
Submitted name:

Cadherin-like membrane protein

Gene

btr175b

Organism
Bombyx mori (Silk moth)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalciumARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Cadherin-like membrane proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:btr175bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBombyx mori (Silk moth)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7091 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaLepidopteraGlossataDitrysiaBombycoideaBombycidaeBombycinaeBombyx

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1568 – 1593HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500433054622 – 1716Sequence analysisAdd BLAST1695

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini199 – 289CAInterPro annotationAdd BLAST91
Domaini310 – 397CAInterPro annotationAdd BLAST88
Domaini422 – 516CAInterPro annotationAdd BLAST95
Domaini540 – 621CAInterPro annotationAdd BLAST82
Domaini646 – 756CAInterPro annotationAdd BLAST111
Domaini782 – 880CAInterPro annotationAdd BLAST99
Domaini906 – 1001CAInterPro annotationAdd BLAST96
Domaini1027 – 1119CAInterPro annotationAdd BLAST93
Domaini1154 – 1240CAInterPro annotationAdd BLAST87
Domaini1264 – 1350CAInterPro annotationAdd BLAST87

Keywords - Domaini

RepeatARBA annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002126, Cadherin-like_dom
IPR015919, Cadherin-like_sf
IPR020894, Cadherin_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00028, Cadherin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00205, CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112, CA, 10 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49313, SSF49313, 10 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00232, CADHERIN_1, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q9NDN4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGVDVRILAT LLLIYAETVL AQERCGFMVA IPRPPRPDLP ELDFEGQTWS
60 70 80 90 100
QRPLIPAADR EDVCMDGYHA MTPTYGTQII YMEEEIEGEV PIAKLNYRGP
110 120 130 140 150
NVPYIEPAFL SGSFNLLVPV IRRIPDSNGE WHLIITQRQD YETPGMQQYV
160 170 180 190 200
FNIRIDGETL VAGVSLLIVN IDDNAPIIQA LEPCQVDELG EARLTECVYV
210 220 230 240 250
VTDADGRIST QFMQFRIDSD RGDDKIFYIQ GANIPGEWIR MTMTVGINEP
260 270 280 290 300
LNFETNPLHI FSVTALDSLP NTHTVTLMVQ VENVEHRPPR WVEIFAVQQF
310 320 330 340 350
DEKTAQSFPV RAIDGDTGIN KPIHYRLETA EEDTFFHIRT IEGGRSGAIL
360 370 380 390 400
YVDPIDRDTL QREVFQLSII AYKYDNESSA TAANVVIIVN DINDQRPEPL
410 420 430 440 450
FKEYRLNIME ETALTLNFDQ EFGFHDRDLG QNAQYTVRLE SDYPADAAKA
460 470 480 490 500
FYIAPEVGYQ RQTFIMGTAN HKMLDYEVPE FQRIRLRVIA TDMDNEEHVG
510 520 530 540 550
VAYVYINLIN WNDEEPIFEH SVQNVSFKET EGKGFFVANV RAHDRDIDDR
560 570 580 590 600
VEHTLMGNAN NYLSIDKDTG DIHVTQDDFF DYHRQSELFV QVRADDTLGE
610 620 630 640 650
PFHTATSQLL IHLDDINNTP PTLRLPRGSP NVEENVPEGY IITSEIRATD
660 670 680 690 700
PDTTAELRFE IDWTTSYATK QGREANPIEF HNCVEIETIY PAINNRGSAI
710 720 730 740 750
GRLVVKKIRE NVTIDYEEFE MLYLTVRVRD LNTVIGDDYD ESTFTITIID
760 770 780 790 800
MNDNPPIWVP GTLEQSLRVR EMSDAGVVIG TLTATDIDGP LYNQVRYTMK
810 820 830 840 850
ANEGTPENLL MIDFYTGQIT VKTSGAIDAD VPRRYNLYYT VVATDRSYAE
860 870 880 890 900
DPDDCPDDPT YWETPGQVVI QIIDTNNKIP QPETDQFKAV VYIYEDAVSG
910 920 930 940 950
DEVVKVIGSD LDRDDIYHTI RYQINYAVNP RLRDFFAVDP DTGRVYVYYT
960 970 980 990 1000
TDEVLDRDGD EPQHRIFFNL IDNFFQQGDG NRNQNDAEVL VVLLDVNDNA
1010 1020 1030 1040 1050
PELPEPDELS WSVSESLTKG TRLQPHIYAP DRDEPDTDNS RVGYAIISLT
1060 1070 1080 1090 1100
IANREIEVPE LFTMIQIQNV TGELETAMDL RGYWGTYAIH IKAYDHGIPQ
1110 1120 1130 1140 1150
QMSNETYELV IRPYNFHAPV FVFPQHGATL RLARERAVVN GLLATVDGEF
1160 1170 1180 1190 1200
LNRIVATDED GLHAGQVAFE VVGDTEAVDY FHIVNDGENS GTLMLKQLFP
1210 1220 1230 1240 1250
EDIREFEVTI RATDGGTEPR PLSTDCTFSV VFVPIQGEPI FPTSTHTVAF
1260 1270 1280 1290 1300
IEKEAGLLER HELPRAEDRK NHLCSDDCHN IYYRIVDGNN DGHFGLDEIT
1310 1320 1330 1340 1350
NVLFLVKELD RSVSETYTLT IAASNSPTGG IALTSTITIT VNVREADPQP
1360 1370 1380 1390 1400
YFVRDLYTAG ISTSDSINRE LLILQATHSE NAPIIYTIDL STMVTDPTLA
1410 1420 1430 1440 1450
SVRETAFILN PHTGVLTLNI QPTASMHGMF EFQVVATDPA GYSDRANVKI
1460 1470 1480 1490 1500
YLISTRNRVF FLFVNTLEQV EQNTDFIAQT FSAGFEMTCN IDQVVPATDA
1510 1520 1530 1540 1550
SGVIMNGITE VRGHFIRDNV PVPADEIETL RGDMVLLTAI QSTLATRLLV
1560 1570 1580 1590 1600
LRDLFTDTSP APDAGSAAVL YALAVLSALL AALCLLLLVI FIIRTKKLNR
1610 1620 1630 1640 1650
RLEALTVKKY GSVDSGLNRV GIAAPGTNKH AVEGSNPIWN ETIKAPDFDS
1660 1670 1680 1690 1700
MSDASNDSDL IGIEDLPHFG ENNYFPRDVD EFKTDKPEDI VATHNNNFGF
1710
KSTPFSPEFA NQFQKL
Length:1,716
Mass (Da):193,325
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0C2D5C3571097BC8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1716Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB041509 mRNA Translation: BAA99405.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041509 mRNA Translation: BAA99405.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

InterProiView protein in InterPro
IPR002126, Cadherin-like_dom
IPR015919, Cadherin-like_sf
IPR020894, Cadherin_CS
PfamiView protein in Pfam
PF00028, Cadherin, 1 hit
PRINTSiPR00205, CADHERIN
SMARTiView protein in SMART
SM00112, CA, 10 hits
SUPFAMiSSF49313, SSF49313, 10 hits
PROSITEiView protein in PROSITE
PS00232, CADHERIN_1, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9NDN4_BOMMO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NDN4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: October 7, 2020
This is version 72 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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