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Entry version 145 (13 Nov 2019)
Sequence version 2 (13 Nov 2007)
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Protein

Helicase domino

Gene

dom

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the ATP-dependent exchange of unmodified histone H2AV for its phosphorylated and acetylated form H2AVK5acS138ph, leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in Notch signaling. Represses E2F target genes. Required for somatic stem cell self-renewal but not for germline stem cell self-renewal. Involved in oogenesis.6 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi939 – 946ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Developmental protein, DNA-binding, Helicase, Hydrolase
Biological processCell cycle, Differentiation, Oogenesis, Transcription, Transcription regulation
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Helicase domino (EC:3.6.4.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dom
ORF Names:CG9696
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0020306 dom

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003112381 – 3198Helicase dominoAdd BLAST3198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei656Phosphoserine1 Publication1
Modified residuei664Phosphoserine1 Publication1
Modified residuei666Phosphoserine1 Publication1
Modified residuei729Phosphothreonine1 Publication1
Modified residuei733Phosphoserine1 Publication1
Modified residuei736Phosphoserine1 Publication1
Modified residuei744Phosphoserine1 Publication1
Modified residuei838Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NDJ2

PRoteomics IDEntifications database

More...
PRIDEi
Q9NDJ2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NDJ2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform B is present at high levels in ovary, in follicle cells, nurse cells and oocyte. Isoform B is also present in germline and somatic stem cells from the germarium. Isoform A is undetectable in adult ovary (at protein level).2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Isoform A and isoform B are present in 0-12 hours embryonic extracts. During embryonic development, isoform A expression is restricted to the developing nervous system, whereas isoform B is ubiquitously expressed. During postembryonic development, isoform B is found in brain, imaginal disks, lymph glands and salivary glands and isoform A is found in some brain regions, photoreceptor cells and sensory organ precursors (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0020306 Expressed in 31 organ(s), highest expression level in embryo

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NDJ2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NDJ2 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the Tip60 chromatin-remodeling complex which contains Domino, Tip60, Tra1, Brd8, E(Pc), DMAP1, Pontin, Reptin, Ing3, Act87E, BAP55, Mrg15, MrgBP, Gas41 and YL-1.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
69802, 97 interactors

Database of interacting proteins

More...
DIPi
DIP-60953N

Protein interaction database and analysis system

More...
IntActi
Q9NDJ2, 8 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0071529

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NDJ2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini507 – 579HSAPROSITE-ProRule annotationAdd BLAST73
Domaini926 – 1091Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST166
Domaini1662 – 1812Helicase C-terminalPROSITE-ProRule annotationAdd BLAST151
Domaini2136 – 2205Myb-likePROSITE-ProRule annotationAdd BLAST70

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili187 – 212Sequence analysisAdd BLAST26
Coiled coili666 – 696Sequence analysisAdd BLAST31
Coiled coili741 – 784Sequence analysisAdd BLAST44
Coiled coili1951 – 1996Sequence analysisAdd BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi95 – 99Poly-Gln5
Compositional biasi101 – 111Poly-AlaAdd BLAST11
Compositional biasi425 – 428Poly-Gly4
Compositional biasi1242 – 1249Poly-Leu8
Compositional biasi2322 – 3188Gln-richAdd BLAST867

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0391 Eukaryota
COG0553 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000167340

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NDJ2

KEGG Orthology (KO)

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KOi
K11320

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NDJ2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.10810, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR014012 HSA_dom
IPR017877 Myb-like_dom
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00271 Helicase_C, 1 hit
PF07529 HSA, 1 hit
PF00176 SNF2_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00573 HSA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51204 HSA, 1 hit
PS50090 MYB_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform A (identifier: Q9NDJ2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNEGNSAGGG HEGLSPAPPA VPDRVTPHST EISVAPANST STTVRAAGSV
60 70 80 90 100
GAALPATRHH QHIATQVKGI ASSSSKQQKQ LASAQLPVPL SPLPQQQQQT
110 120 130 140 150
AEATAAAAAP AHSNVSVSSS TIEASVLPPQ AKRQRLDDNE DRTSAASIVG
160 170 180 190 200
PAESSNIVSS LLPASVASSS EVGGLSSTAL QDLNALKKRI LQQKLQILRN
210 220 230 240 250
LKERHLENVS EYFYLQNGGS MMDYPAWRKK TPTPQFISYS NANRIDQLIH
260 270 280 290 300
EDKPSTSAAA AAAQNQKYTT QQTDSVESSL VSGIGTGATK GAPLDGNISN
310 320 330 340 350
STVKTNTQSQ VPSKIGSFTE STPAATESNS STTVPGTATS GAATSTSATS
360 370 380 390 400
AEASGNVLAV EAEIKIPAVG ATPVAISTKL PAAVVQLTQQ GGTPLLPCNT
410 420 430 440 450
SAGSTALRRP QGQNNASSGS AAASGGGGSL TPTPLYTGNG PAALGGSGGL
460 470 480 490 500
TPGTPTSGSL LSPALGGGSG TPNSAAQEFS FKAKQEVYVM QRISELQREG
510 520 530 540 550
LWTERRLPKL QEPSRPKAHW DYLLEEMVWL AADFAQERKW KKNAAKKCAK
560 570 580 590 600
MVQKYFQDKA TAAQRAEKAQ ELQLKRVASF IAREVKSFWS NVEKLVEYKH
610 620 630 640 650
QTKIEEKRKQ ALDQHLSFIV DQTEKFSQQL VEGMNKSVAD TPSLNSSRLT
660 670 680 690 700
SPKRESDDDF RPESGSEDDE ETIAKAEEDA ADVKEEVTAL AKESEMDFDD
710 720 730 740 750
FLNDLPPGYL ENRDKLMKEE QSSAIKTETP DDSDDSEFEA KEASDDDENT
760 770 780 790 800
ISKQEEAEQE IDHKKEIDEL EADNDLSVEQ LLAKYKSEQP PSPKRRKLAP
810 820 830 840 850
RDPELDSDDD STAVDSTEES EDAATEDEED LSTVKTDTDM EEQDEQEDGL
860 870 880 890 900
KSLMADADAT SGAAGSGSTA GASGNKDDML NDAAALAESL QPKGNTLSST
910 920 930 940 950
NVVTPVPFLL KHSLREYQHI GLDWLVTMNE RKLNGILADE MGLGKTIQTI
960 970 980 990 1000
ALLAHLACAK GNWGPHLIVV PSSVMLNWEM EFKKWCPGFK ILTYYGSQKE
1010 1020 1030 1040 1050
RKLKRVGWTK PNAFHVCITS YKLVVQDQQS FRRKKWKYLI LDEAQNIKNF
1060 1070 1080 1090 1100
KSQRWQLLLN FSTERRLLLT GTPLQNDLME LWSLMHFLMP YVFSSHREFK
1110 1120 1130 1140 1150
EWFSNPMTGM IEGNMEYNET LITRLHKVIR PFLLRRLKKE VEKQMPKKYE
1160 1170 1180 1190 1200
HVITCRLSNR QRYLYEDFMS RAKTRETLQT GNLLSVINVL MQLRKVCNHP
1210 1220 1230 1240 1250
NMFEARPTIS PFQMDGITFH TPRLVCDIME YDPFTQINLE TLNLLLLHLE
1260 1270 1280 1290 1300
QTMTAYVSHK SRLLAPPRKL IEDIDTAPLP APRCPNGKYR FHIRVRSAEL
1310 1320 1330 1340 1350
AQRIKLNAVK VGASPAMRLE GSKIMPMRNL LPSGRVLKRV SASINPVNMA
1360 1370 1380 1390 1400
LKPVVINSVV TTTSSSTTAS SPTGALSVLS NSKLLGARSQ INAPTPAKVA
1410 1420 1430 1440 1450
KTMQDGKPFF YLTPATNSGA AGARLTLTSK TTASASTTTS RTTVTASTTS
1460 1470 1480 1490 1500
GQQLIRDPIV KDLATHVKST VQKQSIANGK TEPEEETEAE DPYKVQELIQ
1510 1520 1530 1540 1550
MRKEQRLAAL KRMAMINRRR TDATPIYGED CREAIQRCMQ ATRSLKRSTW
1560 1570 1580 1590 1600
QTRGYANCCT AMAHRNGWSL NHLLKSFEER CADLKPVFAN FVIYVPSVCA
1610 1620 1630 1640 1650
PRIRRYVQNL SSTHWQHEQR IENIVDQALR PKLALLHPII SEMTTKFPDP
1660 1670 1680 1690 1700
RLIQYDCGKL QTMDRLLRQL KVNGHRVLIF TQMTKMLDVL EAFLNYHGHI
1710 1720 1730 1740 1750
YLRLDGSTRV EQRQILMERF NGDKRIFCFI LSTRSGGVGI NLTGADTVIF
1760 1770 1780 1790 1800
YDSDWNPTMD AQAQDRCHRI GQTRDVHIYR LVSERTIEVN ILKKANQKRM
1810 1820 1830 1840 1850
LSDMAIEGGN FTTTYFKSST IKDLFTMEQS EQDESSQEKS ENKDRIVATT
1860 1870 1880 1890 1900
TLSDTPSTVV ETEKQSLRAF EHALAAAEDE QDVQATKTAK AEVAADLAEF
1910 1920 1930 1940 1950
DENIPIATED PNAEGGPQVE LSKADLEMQN LVKQLSPIER YAMRFVEETG
1960 1970 1980 1990 2000
AAWTAEQLRA AEAELEAQKR EWEANRLAAM HKEEELLKQE TEAEEMLTYS
2010 2020 2030 2040 2050
RKDSSNQVWI SRNTMEQMPM WCPPTPPQDN DNDIYIDYSL SFMYELEPIA
2060 2070 2080 2090 2100
ETDLPPVYVR KEHKRSRTDA GYDGSRRPNK MRREDNYVPP RSLFDRPTPQ
2110 2120 2130 2140 2150
LARLRRELKS QRFRGSFKPN MPIPGLKPQL PTKPLTEPEA MAEWCVFEDM
2160 2170 2180 2190 2200
AILHVLVNLQ GLPCSLMLLS PGQTPNWDLV SEMVNFCSKT YRSARQCRWR
2210 2220 2230 2240 2250
YETHIQPREE GKVVESPKKQ KKLKPTLRTE YLKSPLRYLR TTQLYVSDNN
2260 2270 2280 2290 2300
ASFYKTMRSR FDSIKTAYLK KAPPPKRQFS APSLMNPKHM EVLQEFGILN
2310 2320 2330 2340 2350
YDQPVSPQNI AAMKANKIRE KQRGQQMSQP PVGVGVVQQM QQQSQQQQQP
2360 2370 2380 2390 2400
APPPLPQQQQ PQQVVQQVQQ QQQQQQQQQQ QQVVQQQLPT VSNVQQTLPV
2410 2420 2430 2440 2450
QQTVELVQQQ PTTTTTVAVP AAGGQLQQLQ IQHLTSSNVS PGQQTAILLH
2460 2470 2480 2490 2500
QPQQQLRTHP GQGGQSNTQQ LVKTIVGTSS SLTAGQLQQL AQQSAVASGG
2510 2520 2530 2540 2550
QSSVSVVLTT PVQTLPSVVQ PQIGSGAQIV SISSQTLPVN SSPQLGSIVQ
2560 2570 2580 2590 2600
TQSLPQVVSV STLPTVGTVL TTTANQPQQQ HQTTAVTTLN TTMLRGQRIV
2610 2620 2630 2640 2650
STAAGNTLQQ RTTAGGQSIV SMPNLGQGAS PSQFQTQLRL AAVPTSPATQ
2660 2670 2680 2690 2700
TTQLVTTKGI PVSALQQGGK TTVIPVTQQS GGAHIQLYRQ RSLKVLQTTT
2710 2720 2730 2740 2750
QAVPSGSAGA TGATANLVQA GGTIIQASNM ATHVTSQKVA VSGMPGTSTT
2760 2770 2780 2790 2800
VQAGNVVSSV QMHGQARTQF IKQMAAGKQQ LQRQVVSADG TTTTTAAGDM
2810 2820 2830 2840 2850
LLVKRHNILA AQKAQQASGA LFTTTTGQQQ QQQQQQGQLP VAGQPQQVTQ
2860 2870 2880 2890 2900
HQIASLVKAS TAAAASGSSV NAGGVTVSAT NPTVQAGSVN MTLPQLKPGS
2910 2920 2930 2940 2950
QIKVTMPNQM RHLQMQQQLT MPRKISRMTQ LVSASGQPTA TNIITTTGPQ
2960 2970 2980 2990 3000
QQQQGVTVSG GGTLPTVASQ QQQQQHQQKV GGGNSVQAQL LHIQNTKGLS
3010 3020 3030 3040 3050
NSVTMQQIQQ VMRSGQQGTL ATTNLVLGKT SVGRVIPVSV ASQANQRQTI
3060 3070 3080 3090 3100
QVVSAASAQA LAAGNLRTHV AGPSIASTLK VAAPGSAGGQ TTQQTLIAAL
3110 3120 3130 3140 3150
QHNQRQNASP VRLQTTAGGN LLAVVQQQQQ QQHTSIAGPT AGPAEVMTIT
3160 3170 3180 3190
QTTTTLPTVG SLQQQQQQQQ QQGGISQPTT QQVRKLVQKK ILIRSEKE
Length:3,198
Mass (Da):350,239
Last modified:November 13, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE65C3E86E1E64AB7
GO
Isoform B (identifier: Q9NDJ2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2009-3198: WISRNTMEQM...KKILIRSEKE → NTKTDSNSNK...GNASSSGTAR

Show »
Length:2,497
Mass (Da):274,615
Checksum:i4A500F08369326EC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8MLW2Q8MLW2_DROME
Domino, isoform D
dom 27, 4, 8, anon-WO0172774.190, dEP400
3,183Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4LFX8A0A0B4LFX8_DROME
Domino, isoform G
dom 27, 4, 8, anon-WO0172774.190, dEP400
3,233Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL13882 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1598V → G in AAF82185 (PubMed:11262242).Curated1
Sequence conflicti1598V → G in AAK53539 (PubMed:11262242).Curated1
Sequence conflicti1611 – 1612SS → LL in AAF82185 (PubMed:11262242).Curated2
Sequence conflicti1611 – 1612SS → LL in AAK53539 (PubMed:11262242).Curated2
Sequence conflicti1619Q → P in AAF82185 (PubMed:11262242).Curated1
Sequence conflicti1619Q → P in AAK53539 (PubMed:11262242).Curated1
Sequence conflicti1631P → A in AAF82185 (PubMed:11262242).Curated1
Sequence conflicti1631P → A in AAK53539 (PubMed:11262242).Curated1
Sequence conflicti2157V → G in AAF82185 (PubMed:11262242).Curated1
Sequence conflicti2198R → P in AAF82185 (PubMed:11262242).Curated1
Sequence conflicti2340M → MQQQSQQ in AAF82185 (PubMed:11262242).Curated1
Sequence conflicti2369 – 2371Missing in AAF82185 (PubMed:11262242).Curated3
Sequence conflicti2514T → S in AAF82185 (PubMed:11262242).Curated1
Isoform B (identifier: Q9NDJ2-2)
Sequence conflicti2127P → A in AAK53539 (PubMed:11262242).Curated1
Sequence conflicti2174K → N in AAK53539 (PubMed:11262242).Curated1
Sequence conflicti2180N → T in AAK53539 (PubMed:11262242).Curated1
Sequence conflicti2222E → D in AAK53539 (PubMed:11262242).Curated1
Sequence conflicti2229E → D in AAK53539 (PubMed:11262242).Curated1
Sequence conflicti2287G → E in AAK53539 (PubMed:11262242).Curated1
Sequence conflicti2471V → G in AAK53539 (PubMed:11262242).Curated1
Sequence conflicti2474A → T in AAK53539 (PubMed:11262242).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0294432009 – 3198WISRN…RSEKE → NTKTDSNSNKRRLVRENRRN SAQKLSRSVSSHSTGSNNKN SKSATTRGNSQNSLNQTVPV GSGISRVNRTGAGVSSSSRG KSNSTKSTGKGTDAAPQVRR QTRLHSLGAVNMASARTPPT RKTTRTALAASAAASTLEDA SLIVEERPKRQSANIAMSKM MKTPFKQNVPSNISIKTTPP KRGRRDSVAAAATRSKLLER RATIAAPLKHMDDESDQDEE EQEEQESEEDTEGEEANATV DDDEEGEEELASLDEETIQT GSQTNDEEDDDEEEVGEEGM VDIDTEDSEADVKSSSTYGT AADGKPEEAESLDGWDAHDQ VQDTTMTSSTYYNVSEESDT DEHHDSKAEAKEPPQNSDKS DESEAVGHTPRTRSRGTVKI NLWTLDVSPVANALNKSSAN RSLKKAPRTESTPKESQSEP RRKITQPKLPKKEETNNKSN SNIGTLHRWISKSPRVMLRS TPVTAASASSSAAVSGVSGG NASSSGTAR in isoform B. 1 PublicationAdd BLAST1190

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF076776 mRNA Translation: AAF82185.1
AF254373 mRNA Translation: AAK53539.1
AE013599 Genomic DNA Translation: AAM70871.1
AE013599 Genomic DNA Translation: AAM70872.2
AY058653 mRNA Translation: AAL13882.1 Different initiation.

NCBI Reference Sequences

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RefSeqi
NP_524833.2, NM_080094.4 [Q9NDJ2-1]
NP_788424.1, NM_176244.3 [Q9NDJ2-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0071603; FBpp0071529; FBgn0020306 [Q9NDJ2-1]
FBtr0071604; FBpp0071530; FBgn0020306 [Q9NDJ2-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
45655

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG9696

UCSC genome browser

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UCSCi
CG9696-RA d. melanogaster [Q9NDJ2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF076776 mRNA Translation: AAF82185.1
AF254373 mRNA Translation: AAK53539.1
AE013599 Genomic DNA Translation: AAM70871.1
AE013599 Genomic DNA Translation: AAM70872.2
AY058653 mRNA Translation: AAL13882.1 Different initiation.
RefSeqiNP_524833.2, NM_080094.4 [Q9NDJ2-1]
NP_788424.1, NM_176244.3 [Q9NDJ2-2]

3D structure databases

SMRiQ9NDJ2
ModBaseiSearch...

Protein-protein interaction databases

BioGridi69802, 97 interactors
DIPiDIP-60953N
IntActiQ9NDJ2, 8 interactors
STRINGi7227.FBpp0071529

PTM databases

iPTMnetiQ9NDJ2

Proteomic databases

PaxDbiQ9NDJ2
PRIDEiQ9NDJ2

Genome annotation databases

EnsemblMetazoaiFBtr0071603; FBpp0071529; FBgn0020306 [Q9NDJ2-1]
FBtr0071604; FBpp0071530; FBgn0020306 [Q9NDJ2-2]
GeneIDi45655
KEGGidme:Dmel_CG9696
UCSCiCG9696-RA d. melanogaster [Q9NDJ2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
45655
FlyBaseiFBgn0020306 dom

Phylogenomic databases

eggNOGiKOG0391 Eukaryota
COG0553 LUCA
GeneTreeiENSGT00940000167340
InParanoidiQ9NDJ2
KOiK11320
PhylomeDBiQ9NDJ2

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
jumu fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
45655

Protein Ontology

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PROi
PR:Q9NDJ2

Gene expression databases

BgeeiFBgn0020306 Expressed in 31 organ(s), highest expression level in embryo
ExpressionAtlasiQ9NDJ2 baseline and differential
GenevisibleiQ9NDJ2 DM

Family and domain databases

Gene3Di3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR014012 HSA_dom
IPR017877 Myb-like_dom
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
PfamiView protein in Pfam
PF00271 Helicase_C, 1 hit
PF07529 HSA, 1 hit
PF00176 SNF2_N, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00573 HSA, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51204 HSA, 1 hit
PS50090 MYB_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDOM_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NDJ2
Secondary accession number(s): Q7YZ94
, Q95TN6, Q968U6, Q9I7V8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: November 13, 2019
This is version 145 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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