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Entry version 162 (02 Jun 2021)
Sequence version 1 (01 Oct 2000)
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Protein
Submitted name:

Brakeless-A

Gene

sbb

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Brakeless-AImported
Submitted name:
RE69316pImported
Submitted name:
Scribbler, isoform CImported
Submitted name:
Scribbler, isoform EImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sbbImported
Synonyms:BksImported, bksImported, BrakelessImported, disc6Imported, Dmel\CG5580Imported, GM04742Imported, Group IIaImported, l(2)04440Imported, mtvImported, pltImported, SBbImported, SbbImported
ORF Names:CG5580Imported, Dmel_CG5580Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0285917, sbb

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0010575, Expressed in eye disc (Drosophila) and 62 other tissues

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni92 – 126DisorderedSequence analysisAdd BLAST35
Regioni150 – 644DisorderedSequence analysisAdd BLAST495
Regioni665 – 707DisorderedSequence analysisAdd BLAST43
Regioni728 – 756DisorderedSequence analysisAdd BLAST29
Regioni776 – 800DisorderedSequence analysisAdd BLAST25
Regioni824 – 855DisorderedSequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi92 – 123Polar residuesSequence analysisAdd BLAST32
Compositional biasi154 – 267Polar residuesSequence analysisAdd BLAST114
Compositional biasi281 – 350Polar residuesSequence analysisAdd BLAST70
Compositional biasi364 – 455Polar residuesSequence analysisAdd BLAST92
Compositional biasi458 – 486Basic and acidic residuesSequence analysisAdd BLAST29
Compositional biasi487 – 590Polar residuesSequence analysisAdd BLAST104
Compositional biasi591 – 609Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi776 – 797Polar residuesSequence analysisAdd BLAST22

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000008748

Identification of Orthologs from Complete Genome Data

More...
OMAi
IYQRHSM

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040010, ZN608/ZN609

The PANTHER Classification System

More...
PANTHERi
PTHR21564, PTHR21564, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9NBW0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKKLAKVAL NSSNVATESN IKNNKLLANL SAAGAATATT ATTGTATTTT
60 70 80 90 100
ATTANQALNF NNKTKATANA TAASANNRHN NNNNSSAIKK HTNTKQLAGK
110 120 130 140 150
SPACNSSSSS LSSSSSSNSS ESKDTNFEYE DEWNIGGIPE LLDDLDADIE
160 170 180 190 200
KSAHSSGGGN QATALNAKQA NSSSTSSSSS SKGGASSSSS SAAATGSSSS
210 220 230 240 250
HKSHKTTLHS NLSATSPTTI KFTRQPVAIG GANSSSSSSA AAAPSGGSAN
260 270 280 290 300
VVAKGSSSSS SSTSSSSSGK HHHHHHHHSN SSSSGSSSKG YKSALVAQLN
310 320 330 340 350
SPSPLNSNSK SLSGSGSGSG NTNGAAGAGA GSTLSSSTFA GFSKGGSLVS
360 370 380 390 400
SSAGAAAALA AGSGQQGSKF SAGGMSSQTG SGSGGNNTSN SNNSSSGSGG
410 420 430 440 450
SGSGSSTGNT ASGSGNNNST SAGGPPSSQG GNNGNGSGSS SSSSSGKSSA
460 470 480 490 500
KMSIDHQATL DKGLKMKIKR TKPGTKSSEA KHEIVKATDQ QQNGALGAGS
510 520 530 540 550
NNSANEDGSS GSSSTNASSL GSTNSSSSAS SGSSSSSGSS SSSSKKHLNN
560 570 580 590 600
ASSGSGSSSS GGGSQNNASG HASGGGSSGS SQSTPQGTKR GSSGHRREKT
610 620 630 640 650
KDKNAHSNRM SVDKSAAAAS AAGEKDTPEK CSGTGAGGSP CSCNGDVGAP
660 670 680 690 700
CSHHACIRRA AHMSNSAGNA NSSAGTGQSG GSSSMSAVPP GVFTPSAGSP
710 720 730 740 750
STGSPSTVVP AAASLLAATG AASSSASQMA SSSAGGVGGS GGGANAPGPP
760 770 780 790 800
GKESAGSIKI SSHIAAQLAA AAASNSYSGS GANTNQGQNS NAGGNGGSES
810 820 830 840 850
KAAAAAQAKL MAPGMISATM HHTISVPAGT GTGDDDTKSP PAKRVKHEAG
860 870 880 890 900
ASGAGGGKEM VDICIGTSVG TITEPDCLGP CEPGTSVTLE GIVWHETEGG
910 920
VLVVNVTWRG KTYVGTLLDC TRHDWAPPR
Length:929
Mass (Da):88,821
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5F1BA2B2B9187ABF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9N693Q9N693_DROME
Brakeless-B
sbb Bks, bks, Brakeless, disc6, Dmel\CG5580
2,302Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4KEU2A0A0B4KEU2_DROME
Scribbler, isoform J
sbb Bks, bks, Brakeless, disc6, Dmel\CG5580
2,330Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E1JGL0E1JGL0_DROME
Scribbler, isoform G
sbb Bks, bks, Brakeless, disc6, Dmel\CG5580
2,312Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A1ZB51A1ZB51_DROME
Scribbler, isoform F
sbb Bks, bks, Brakeless, disc6, Dmel\CG5580
939Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF242193 mRNA Translation: AAF76321.1
BT001722 mRNA Translation: AAN71477.1
AE013599 Genomic DNA Translation: AAS64813.1
AE013599 Genomic DNA Translation: ACZ94462.1

NCBI Reference Sequences

More...
RefSeqi
NP_001163190.1, NM_001169719.2
NP_995884.1, NM_206162.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0086766; FBpp0085945; FBgn0285917
FBtr0301548; FBpp0290763; FBgn0285917

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
44027

UCSC genome browser

More...
UCSCi
CG5580-RC, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF242193 mRNA Translation: AAF76321.1
BT001722 mRNA Translation: AAN71477.1
AE013599 Genomic DNA Translation: AAS64813.1
AE013599 Genomic DNA Translation: ACZ94462.1
RefSeqiNP_001163190.1, NM_001169719.2
NP_995884.1, NM_206162.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
44027

Genome annotation databases

EnsemblMetazoaiFBtr0086766; FBpp0085945; FBgn0285917
FBtr0301548; FBpp0290763; FBgn0285917
GeneIDi44027
UCSCiCG5580-RC, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
44027
FlyBaseiFBgn0285917, sbb

Phylogenomic databases

GeneTreeiENSGT00390000008748
OMAiIYQRHSM

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
44027, 0 hits in 3 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
sbb, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
44027

Gene expression databases

BgeeiFBgn0010575, Expressed in eye disc (Drosophila) and 62 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR040010, ZN608/ZN609
PANTHERiPTHR21564, PTHR21564, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9NBW0_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NBW0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: June 2, 2021
This is version 162 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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