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Entry version 161 (12 Aug 2020)
Sequence version 2 (21 Jun 2005)
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Protein

E3 ubiquitin-protein ligase highwire

Gene

hiw

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (By similarity). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (By similarity). Required in the presynaptic motoneuron to down-regulate the levels of wnd and restrain synaptic terminal growth at the neuromuscular junction (NMJ) together with Rae1 and Fsn (PubMed:10839352, PubMed:21874015, PubMed:17697379).By similarity3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-threonine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-3-O-ubiquitinyl-L-threonine.By similarity EC:2.3.2.33

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.By similarity
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi4991Zinc 1By similarity1
Metal bindingi4994Zinc 1By similarity1
Metal bindingi5009Zinc 2By similarity1
Metal bindingi5011Zinc 2By similarity1
Metal bindingi5014Zinc 1By similarity1
Metal bindingi5017Zinc 1By similarity1
Metal bindingi5038Zinc 2By similarity1
Metal bindingi5041Zinc 2By similarity1
Metal bindingi5101Zinc 3By similarity1
Metal bindingi5104Zinc 3By similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei5115By similarity1
Metal bindingi5130Zinc 3By similarity1
Metal bindingi5133Zinc 3By similarity1
Metal bindingi5142Zinc 4By similarity1
Metal bindingi5145Zinc 4By similarity1
Metal bindingi5154Zinc 5By similarity1
Metal bindingi5157Zinc 5By similarity1
Metal bindingi5158Zinc 6By similarity1
Active sitei5165By similarity1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei5166Important for catalysisBy similarity1
Sitei5171Important for catalysisBy similarity1
Metal bindingi5172Zinc 5By similarity1
Metal bindingi5175Zinc 5By similarity1
Sitei5179Important for catalysisBy similarity1
Metal bindingi5193Zinc 6By similarity1
Metal bindingi5207Zinc 6By similarity1
Metal bindingi5213Zinc 6By similarity1
Metal bindingi5224Zinc 4By similarity1
Metal bindingi5227Zinc 4By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri4991 – 5042RING-type; atypicalPROSITE-ProRule annotationAdd BLAST52

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processTranscription, Transcription regulation, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase highwire1 Publication (EC:2.3.2.33By similarity)
Alternative name(s):
Protein pam/highwire/rpm-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:hiw1 PublicationImported
ORF Names:CG32592
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0030600, hiw

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Flies display NMJ synapses that grow exuberantly and are expanded in both the number of boutons and in the extent and length of branches.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1 – 4083Missing : Loss of binding to Rae1 and unable to rescue synaptic terminal overgrowth in mutants. 1 PublicationAdd BLAST4083
Mutagenesisi1 – 2419Missing : Unable to rescue synaptic terminal overgrowth in mutants but has no effect on binding to Rae1. 1 PublicationAdd BLAST2419
Mutagenesisi671 – 1011Missing : Unable to rescue synaptic terminal overgrowth in mutants but has no effect on binding to Rae1; when associated with 1012-E--E-1014. 1 PublicationAdd BLAST341
Mutagenesisi1012 – 1014VQV → ELE: Unable to rescue synaptic terminal overgrowth in mutants but has no effect on binding to Rae1; when associated with 671-T--R-1011 DEL. 1 Publication3
Mutagenesisi1266 – 2146Missing : Unable to rescue synaptic terminal overgrowth in mutants but has no effect on binding to Rae1. 1 PublicationAdd BLAST881
Mutagenesisi2885 – 5233Missing : Loss of binding to Rae1 and unable to rescue synaptic terminal overgrowth in mutants. 1 PublicationAdd BLAST2349
Mutagenesisi3800 – 4039Missing : Unable to rescue synaptic terminal overgrowth in mutants but has no effect on binding to Rae1. 1 PublicationAdd BLAST240
Mutagenesisi5038C → S: Unable to rescue synaptic terminal overgrowth in mutants but has no effect on binding to Rae1; when associated with S-5041. 1 Publication1
Mutagenesisi5041C → S: Unable to rescue synaptic terminal overgrowth in mutants but has no effect on binding to Rae1; when associated with S-5038. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000559711 – 5233E3 ubiquitin-protein ligase highwireAdd BLAST5233

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei213Phosphoserine1 Publication1
Modified residuei216Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NB71

PRoteomics IDEntifications database

More...
PRIDEi
Q9NB71

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NB71

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Express throughout the nervous system (PubMed:10839352, PubMed:21874015). Stage 13 embryos show expression in the central nervous system (CNS) at the longitudinal axon tracts around which the synaptic neuropil forms (PubMed:10839352). Expression outside the CNS starts at stage 16 in presynaptic terminals at the periactive zone which surround the active zone (PubMed:10839352). Expression at neuromuscular junctions (NMJ) and in the CNS is also seen in third instar larvae (at protein level) (PubMed:10839352).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0030600, Expressed in midgut and 23 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NB71, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NB71, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of an E3 ubiquitin ligase complex composed of hiw, Rae1 and Fsn (PubMed:17697379, PubMed:21874015).

Interacts with Rae1; the interaction with Rae1 may protect hiw from autophagy-mediated degradation (PubMed:21874015).

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
58787, 27 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NB71, 3 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0073787

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NB71

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati615 – 666RCC1 1Sequence analysisAdd BLAST52
Repeati669 – 724RCC1 2Sequence analysisAdd BLAST56
Repeati768 – 818RCC1 3Sequence analysisAdd BLAST51
Repeati931 – 983RCC1 4Sequence analysisAdd BLAST53
Repeati984 – 1033RCC1 5Sequence analysisAdd BLAST50
Repeati1035 – 1084RCC1 6Sequence analysisAdd BLAST50
Repeati2906 – 3000FilaminSequence analysisAdd BLAST95
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4195 – 4374DOCPROSITE-ProRule annotationAdd BLAST180

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1436 – 1587PHR domain 11 PublicationAdd BLAST152
Regioni2014 – 2169PHR domain 21 PublicationAdd BLAST156
Regioni2885 – 4082Required for interaction with Rae11 PublicationAdd BLAST1198
Regioni5096 – 5231Tandem cysteine domainBy similarityAdd BLAST136

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PHR domains are compact beta-sandwich folds composed of 11 antiparallel strands and decorated with conserved apical loops. They are likely to play a structural role and mediate interactions with substrates or partners (By similarity).By similarity
The tandem cysteine domain region confers threonine specificity and contains the two essential catalytic cysteine residues that relay ubiquitin. It binds four zinc ions in a C5HC7HC2 configuration.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RING-Cys relay (RCR) family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri4991 – 5042RING-type; atypicalPROSITE-ProRule annotationAdd BLAST52

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1428, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000063_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NB71

KEGG Orthology (KO)

More...
KOi
K10693

Identification of Orthologs from Complete Genome Data

More...
OMAi
EPSMLCH

Database of Orthologous Groups

More...
OrthoDBi
215263at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NB71

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.30, 2 hits
2.60.120.820, 2 hits
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004939, APC_su10/DOC_dom
IPR017868, Filamin/ABP280_repeat-like
IPR008979, Galactose-bd-like_sf
IPR014756, Ig_E-set
IPR012983, PHR
IPR038648, PHR_sf
IPR009091, RCC1/BLIP-II
IPR000408, Reg_chr_condens
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08005, PHR, 2 hits
PF00415, RCC1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00633, RCCNDNSATION

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01337, APC10, 1 hit
SM00184, RING, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49785, SSF49785, 1 hit
SSF50985, SSF50985, 1 hit
SSF81296, SSF81296, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51284, DOC, 1 hit
PS50194, FILAMIN_REPEAT, 1 hit
PS00626, RCC1_2, 2 hits
PS50012, RCC1_3, 1 hit
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9NB71-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVGLLNPLKY GDHFYELYTN STRRKMQHDR KVLTKRKSRK DKSAAAMAAA
60 70 80 90 100
AAAAVLEGNA GAGGLVNPLD PPLVKEQLMI LPSFPVAHIE LDPNASKFAV
110 120 130 140 150
FSAIRSTVLE AETRYSLFQE GGAPSGQSGS NQKKWSNNVN SACCMMCAHS
160 170 180 190 200
CMISNLLDCS CHAHMAMHGA VGPGNAGPGG PVGVLVDGRI PAPVPVVVGG
210 220 230 240 250
PGLPAEKRPR RDSANSDADS DTEEPTEREP VYATVPLIVG AGLRSLFELI
260 270 280 290 300
ADARHVHPLL CTKALKALLD VIQGQQPESF KLEPEELINP LYDLLLDLAT
310 320 330 340 350
MPAALNSATG AEANWSAMAC AALLGLCIAR GDTGKMLKAI AAMLMTPRQL
360 370 380 390 400
SAQIVQLPVV LATLQHTVIS AALNKPTRPD FHSHGVPHNS LIDEFPVKLP
410 420 430 440 450
PLSTGAPITS PAMACDGVFV YLLYGGTLLK IGTGFGGSYK GHIYAQNEDF
460 470 480 490 500
SHERSAWLGY SGGQLYFRRT CRRSAGDQLQ MVGLDTLAIK AMSPLSMLHM
510 520 530 540 550
REGLNYVLFT DDDSLHAICS NRDDTLVVKK LNLYHNSYNI DPPPFELPLQ
560 570 580 590 600
LARKKFRTLG YAAFEDELLN QYQIQRIQSA HNSFEPKLPA PCRDADVDVM
610 620 630 640 650
GMACGKEFGL VRASNGRVYY YGKSAALGLK CVGRTPTLKL TELVISKAAN
660 670 680 690 700
IVHVAVGHDG IHALLVNDDG TVFFAGTARR GEDGDSSKNR RQPKAVKPKK
710 720 730 740 750
MTKIDGHVVV HAACNNGTSA FVTKTGKLIM YGKDTAHCDA MGFVSELLEQ
760 770 780 790 800
HVTKVALGKA HCVALNAKGQ LFSFGLNNKG QCGRIFNKLQ PVKDVPPFAS
810 820 830 840 850
SSTAAACFAS LLPLDKRLKL DFSTLCDYDD HNLVQGQCRV CVICRECTGY
860 870 880 890 900
NVSCVSALNV PLDQRLAGSI CPCGHGDAGC AKCGLCAACI ALQDSDEAKT
910 920 930 940 950
ELKPPPSDVQ QRQQRSKTLI MRRKERKGEL ETGAAGGGAA TPTDLDKDPP
960 970 980 990 1000
RVAPLAPQLL QLTSSSPVVQ VACGLHHTVV LTLAGEVYTF GSNQYGQLGS
1010 1020 1030 1040 1050
GDLQPVSGPV RVQVPGAISQ VAAGSNHTVL LTSKGMVYTF GNYQKGQLGR
1060 1070 1080 1090 1100
LPSDYGLKPP PQDDDSPVGA GSDGGAGGSP TVAPVGMPGP ERSQSPANVQ
1110 1120 1130 1140 1150
PSGSKEMPPL LPVLTQRQKF LWNCSPGAVF GLGPCYGKKV TWIGANGDQT
1160 1170 1180 1190 1200
FIKIDESLIT AQMLPKMHVV ANKKTILLIP SIPLSFHTLS INRRDGSCTA
1210 1220 1230 1240 1250
HYRGQTNFVK LMQAQPEQQQ PEINSNLDVA VTPVADSPAH ASTSSLLAAL
1260 1270 1280 1290 1300
TGTATAGVPI NEQMSRSMHE ARNQIFEEQL PEVGSSAAAA AVAAPGTPVS
1310 1320 1330 1340 1350
AGSVPRSRRG GKQGTSSPEP IPSPPQLAFT MDPTYNVLWV FDGAARKLRC
1360 1370 1380 1390 1400
HNVVASDIND SDANAATYRS LLSPELSLPD RVDSRVARSQ ASLNLLACLD
1410 1420 1430 1440 1450
ILTSAQDNIP GCFEQPLLKQ TQQTAETQAG EFQVVNRFDN FGGGWGYSGH
1460 1470 1480 1490 1500
SVEAIRFSAD TDIVICGFGM FGGRGEYSCK LKLFDLGGDG GGYEKEGILI
1510 1520 1530 1540 1550
SETKEVPYEC GARSKHHILL PKPVSAVAGR WYLVWARIAG PSSDCGSCGQ
1560 1570 1580 1590 1600
ASVTTEDQVV FSFKSSKKAN NGTDVNSGQI PAILYRLVTQ DCKQTPAQMD
1610 1620 1630 1640 1650
ADPVQRISRA FANSVSRECF ESLVVLLSWS WDCFKLQLRE ERDRSRPLQL
1660 1670 1680 1690 1700
QQSLQYLGYV IKSCLRLLRK YTIEIYPQRN SSTSVATGGG SNAAHGSGVV
1710 1720 1730 1740 1750
TTAKSVQSKP NKDKNTPRVV GNAGVMAKYF GDPSTSVAPA MISSASSGGA
1760 1770 1780 1790 1800
PSTSASAAVA PGSGTPVTRK TNMENIQLAE CIGNVRALLI GIFCDDIFKD
1810 1820 1830 1840 1850
IATDEGYELS LEILDECHLS FVACFDAFYP TSSLKWNCLC DLLAQMDRGA
1860 1870 1880 1890 1900
LHSRLLSAIL AGLCSPSVKL RATFSLLSAA GNERQSIISP SDNSGLPMLS
1910 1920 1930 1940 1950
STDAHPYPVL VEQMIYRTQQ EKSDFLSNSW TFKDVLVRLL DIIASPIRSR
1960 1970 1980 1990 2000
IEAIYSRSLG SLGYPGGKDC VNQGLIDNCC HLLARVLAEI VYQTAMGEYD
2010 2020 2030 2040 2050
KLFMPPRTLH STGARFARCD VSRTWNTGNF GPDAIAFAVD RPGVAIAGAM
2060 2070 2080 2090 2100
VYSGSGSYDY QLELLYDNTA DLQPQHKWET LESVSGSYDQ DAVHNDLAEI
2110 2120 2130 2140 2150
KFDHPVHIKE NARYALRLCS QGARTCSGDA GMPAVRGPCG AQFHFYACDL
2160 2170 2180 2190 2200
SFNGTTPARG QLPCILYYST PMKQDGHSAS GRTGDGSNVA THLEDRIMLL
2210 2220 2230 2240 2250
GPHEVSTRDT ALQIAADITK KCTELLILAR NAMAASCSPS DNSSNHTQTI
2260 2270 2280 2290 2300
DSEHNITPIE EHMDINWANN SRTAALPTAI DPQLSTARDL GKRIESFSKG
2310 2320 2330 2340 2350
LMETLKFDKR STNPFEMEIE IGATEVEESA DLRNGQSQSV SQSQSQSQSV
2360 2370 2380 2390 2400
PINGNERTAD FEFAEQSAQQ SMPQHLHSDS EEAPLEVAGM AAGGGVSVAD
2410 2420 2430 2440 2450
GSGGVAGVGS QAAAVQLLEV FNLAASNMFH TLLPLVYAHI ANLACSDPKS
2460 2470 2480 2490 2500
SVQILGLIKE ILPHIAALNQ LHVSKDQRQP EPAIFATQTS GSGNSNSSST
2510 2520 2530 2540 2550
TSNHYCVVES DHPYKSASIS SYRVEFPPCV QWLTIEFDPQ CGTAQLEDYL
2560 2570 2580 2590 2600
LLSIPMRPAS QAPPVPHVDD YLEQADNNVN GAGDRRRNTG GGIAGSGAAP
2610 2620 2630 2640 2650
NTHQRSASVQ LTMASCCRSP GCGNAPGSAA APSSMPLRSQ DPNDREWIVV
2660 2670 2680 2690 2700
KKFNTASTWL HNVLILPGNC VEFSLETASL YAQDPHNNRY GFKCLVVGYD
2710 2720 2730 2740 2750
NPTSINASNS CLIRLEQELA YLGGMCSANL MKKELNLPDD KDVEDMSGIE
2760 2770 2780 2790 2800
ETINTHHTLL SKGFALSEPQ LTVHQALESY LPIGSQSNER QFLKDFISGA
2810 2820 2830 2840 2850
PGSSGARLAA WLQPESRLDP NKCELNTITE PLRYGWPSQV TVTIRDQYGD
2860 2870 2880 2890 2900
AVLVPELKVE IKAIPTGSGP NGSATGTGTS CTSVAEVSAP GPNLWMRRAS
2910 2920 2930 2940 2950
RDTWGWGGMA PPPRINYEPT VKDKMVFKAI TFMKPYANYS FEELRYASPV
2960 2970 2980 2990 3000
QTRVTELLNA KDMEDGTFSV QWTPSSVGAY CLAVTIDGIP LEEVYRVDVK
3010 3020 3030 3040 3050
EGILPPPTQR NSAQRRPQAP SKLRRFQARH SSGLRIRSHP TLQSEQVGVV
3060 3070 3080 3090 3100
RVGGVISFID EIENDDGVWL RLSTESIRQH CTMGWYPTEA WCLQFNQHLA
3110 3120 3130 3140 3150
RMLLQPVTDK EVNPVRKGVG AEEDVEEQPP VTPSASGEAS PEPEPDPSPV
3160 3170 3180 3190 3200
LSPAKTKPGR FLSGHQSTNP FLYPAKHADL AEREAQVQEE REKEEEQVDD
3210 3220 3230 3240 3250
EDADDREPEQ EALPAVELLP AHIGSAIAGV VGGGAIKLQA LQKWFKGDAV
3260 3270 3280 3290 3300
DGPQPLTPSH SPPLAGVSVR ELVRAMGGQD SPRGNGNRSQ QEQDPEFSLA
3310 3320 3330 3340 3350
SMRRPNYSAS QTAALLSTPK HTPKRSAVVA SETSGLEDEL SLLQITTTTT
3360 3370 3380 3390 3400
GQGEQQSELQ LATTSTASSA SKRNPMGPIK RAMPPSFAES IRAVFAALLW
3410 3420 3430 3440 3450
HEGVVHDAMA CASFLKFHPG LPKEGATVVT RRGESGDPRL QLSREQKAQQ
3460 3470 3480 3490 3500
RHSVEVANAG NYLNIRPSTL ETLTKSGNCS LHNRSKYRKN LLSGGGGAIN
3510 3520 3530 3540 3550
SGDDTAQKLQ ALPEMVSVLP PALRCLVYLW EQICSGCVQI VQSNALEQRE
3560 3570 3580 3590 3600
PRLLSPGSRD LNGDADTEGK EGKNSDQASA GEKDLGRKCK RKKKDDGSWC
3610 3620 3630 3640 3650
EICELFLPMP VTYHMRIAHP GCGKSAKGKG YNSVGIFCEG WAGNCGEGGK
3660 3670 3680 3690 3700
GASSWFLMCD PCRDRYLASC RSANNINSAA RQLESSAAEG NELNLFGVKS
3710 3720 3730 3740 3750
TTLIANAEVY TTMRENATFL LELCSSSSSA SGAAGSLAAT SSSSKRSPQQ
3760 3770 3780 3790 3800
MSVVAMPVVI EHQLGNSDLK PSTSRCSRMA RLSGSKFCPG VGSGAFRKSF
3810 3820 3830 3840 3850
VGGPPTAPEN VWLAPESFAC LECLGTAGHE DLPYEMFGLG PNSNDNGYDR
3860 3870 3880 3890 3900
PLSEISYESC EPNNYDMLSG SLAPGTTAAA SVGGGNLSKF HRSYSMGQGW
3910 3920 3930 3940 3950
ASLAQHNHPP PHHPQQQHHQ QQQMNLQLQQ HQAPPVDGQP KVVYRRRNNS
3960 3970 3980 3990 4000
TSEGDGSLLI CYPSEHLRRL VPQKLLASVS VMQTASGEGT GKDHATGTLG
4010 4020 4030 4040 4050
LDQSAGQNGG GNLLLTRPAM AFITQKHELD RLRAAMRRSL RIAACRIYAL
4060 4070 4080 4090 4100
QALNWLLRSV TQGVCLHDLM WWFVSSLNPT GGHQPVERGE EASEPALEHP
4110 4120 4130 4140 4150
VAYTQISGRF AHLITQSLHV FLQSVADLTL HLPLGSPLQR VAIQCFGIRF
4160 4170 4180 4190 4200
RQADHQFLHS SHVFGNISKI LSKSDEQNDA MAVSTILKPD CDVEHNQVHS
4210 4220 4230 4240 4250
VATGGSSGAG ARLLCYTDLA GMFEVTVSSR PAMAESLTDN STETFWESDE
4260 4270 4280 4290 4300
EDRNKCKIIE LSLTKLNYAC RYLLVHIDNS RDIQNKVLNV VFYAGQSLGD
4310 4320 4330 4340 4350
TNIIKSADVD PKACSWISAK ICDDSCTHFR LELHGPENTL RVRQIKLLGL
4360 4370 4380 4390 4400
PIGGAVGSDD SSDHKHQPHL RLSHASRIQQ QICEAETLRV FRLITGQVFG
4410 4420 4430 4440 4450
KLISNVSSDL VPPDSAGIGP PSGGAASTSL LADSLDLREH MVGILFSRSK
4460 4470 4480 4490 4500
LSHLQKQVIV HIVHAIRKEA QRAKEDWELA NLAHVLKQSP QQQTAPALAA
4510 4520 4530 4540 4550
SASCESTPER SRAPDTYCFE MLSMVLALSG SVVGRSYLSQ QHGLLRDLLG
4560 4570 4580 4590 4600
LLHTGSDRVQ RQVTALLRRI LPEITPESFA ELLGVQRLPP ADYSIAHQSA
4610 4620 4630 4640 4650
SDFDMSRLGL LDIFLAVIAK SLQLQVKVKT TVASTGPSGS GGVSGSSSGN
4660 4670 4680 4690 4700
GGAVLKAGQQ EKTPAFVRLW SSLDLSVQQL RSRPPTGEPG TTDPFQFDAL
4710 4720 4730 4740 4750
PPRKESKRNL NQRWFLNGVI STKQAESIIS LIRDLASGKL SEKWSQITKA
4760 4770 4780 4790 4800
AIAESVLNLT RLEEIYRSPE HCTKTSTLWL ALASLCVLER DHVEKLSSGQ
4810 4820 4830 4840 4850
WSKLCDTRPL CSNHDDGETA AIIQCETCGS LCGDCDRFLH LNRKTRSHKR
4860 4870 4880 4890 4900
TVCKEEEEAI RVELHESCGR TKLFWLLALA DSKTLKAMVE FRDGSHTIIS
4910 4920 4930 4940 4950
GPQEAVGRCR FCGLTGNSGL LEIGNVCADA QCQEYAANSC LKTKPCGHAC
4960 4970 4980 4990 5000
GGVTGERKCL PCLQHVCHTR ENELAEELRD PKLTQDADDM CMICFVEALS
5010 5020 5030 5040 5050
CAPSIHLECG HVFHYHCCKA VLEKRWSGPR ITFGFSLCPI CKADIQHPLL
5060 5070 5080 5090 5100
SDILEPINGL KQDVKRKALM RIKYEGVVKD TDSKNVNMTQ LAMDRYAYYV
5110 5120 5130 5140 5150
CFKCQKAYYG GEARCDAEIG EKFDPEELVC GGCSDVARAQ MCPKHGTDFL
5160 5170 5180 5190 5200
EYKCRYCCSV AVFFCFGTTH FCDTCHDDFQ RLTNIPKVKL PQCPAGPKAK
5210 5220 5230
QLLGDECPLH VMHPPTGEEF ALGCGVCRNA QTF
Length:5,233
Mass (Da):565,631
Last modified:June 21, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE5220FFDC91A58E7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X2JF19X2JF19_DROME
RCR-type E3 ubiquitin transferase
hiw CG9041, CG9049, Dmel\CG32592, HIW, Hiw
5,233Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF48411 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAM29381 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti137N → D in AAF76150 (PubMed:10839352).Curated1
Sequence conflicti604C → R in AAF76150 (PubMed:10839352).Curated1
Sequence conflicti1620F → S in AAF76150 (PubMed:10839352).Curated1
Sequence conflicti4652G → E in AAF76150 (PubMed:10839352).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF262977 mRNA Translation: AAF76150.1
AE014298 Genomic DNA Translation: AAF48411.2 Sequence problems.
AY113376 mRNA Translation: AAM29381.1 Different initiation.

NCBI Reference Sequences

More...
RefSeqi
NP_001285258.1, NM_001298329.1
NP_511159.3, NM_078604.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0073970; FBpp0073787; FBgn0030600
FBtr0346087; FBpp0311921; FBgn0030600

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
32429

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG32592

UCSC genome browser

More...
UCSCi
CG32592-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF262977 mRNA Translation: AAF76150.1
AE014298 Genomic DNA Translation: AAF48411.2 Sequence problems.
AY113376 mRNA Translation: AAM29381.1 Different initiation.
RefSeqiNP_001285258.1, NM_001298329.1
NP_511159.3, NM_078604.4

3D structure databases

SMRiQ9NB71
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi58787, 27 interactors
IntActiQ9NB71, 3 interactors
STRINGi7227.FBpp0073787

PTM databases

iPTMnetiQ9NB71

Proteomic databases

PaxDbiQ9NB71
PRIDEiQ9NB71

Genome annotation databases

EnsemblMetazoaiFBtr0073970; FBpp0073787; FBgn0030600
FBtr0346087; FBpp0311921; FBgn0030600
GeneIDi32429
KEGGidme:Dmel_CG32592
UCSCiCG32592-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
32429
FlyBaseiFBgn0030600, hiw

Phylogenomic databases

eggNOGiKOG1428, Eukaryota
HOGENOMiCLU_000063_0_0_1
InParanoidiQ9NB71
KOiK10693
OMAiEPSMLCH
OrthoDBi215263at2759
PhylomeDBiQ9NB71

Enzyme and pathway databases

UniPathwayiUPA00143

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
32429, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
32429

Protein Ontology

More...
PROi
PR:Q9NB71

Gene expression databases

BgeeiFBgn0030600, Expressed in midgut and 23 other tissues
ExpressionAtlasiQ9NB71, baseline and differential
GenevisibleiQ9NB71, DM

Family and domain databases

Gene3Di2.130.10.30, 2 hits
2.60.120.820, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR004939, APC_su10/DOC_dom
IPR017868, Filamin/ABP280_repeat-like
IPR008979, Galactose-bd-like_sf
IPR014756, Ig_E-set
IPR012983, PHR
IPR038648, PHR_sf
IPR009091, RCC1/BLIP-II
IPR000408, Reg_chr_condens
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF08005, PHR, 2 hits
PF00415, RCC1, 1 hit
PRINTSiPR00633, RCCNDNSATION
SMARTiView protein in SMART
SM01337, APC10, 1 hit
SM00184, RING, 2 hits
SUPFAMiSSF49785, SSF49785, 1 hit
SSF50985, SSF50985, 1 hit
SSF81296, SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS51284, DOC, 1 hit
PS50194, FILAMIN_REPEAT, 1 hit
PS00626, RCC1_2, 2 hits
PS50012, RCC1_3, 1 hit
PS50089, ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHIW_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NB71
Secondary accession number(s): Q8MZ36, Q9VXZ5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: August 12, 2020
This is version 161 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
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