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Entry version 100 (12 Aug 2020)
Sequence version 1 (01 Oct 2000)
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Protein
Submitted name:

Cysteine proteinase falcipain 2a

Gene
N/A
Organism
Plasmodium falciparum
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseImported

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C01.046

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Cysteine proteinase falcipain 2aImported (EC:3.4.22.-Imported)
Submitted name:
Falcipain-2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparumImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5833 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei36 – 55HelicalSequence analysisAdd BLAST20

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1697672

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

GlycoproteinARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NAW2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini165 – 222Inhibitor_I29InterPro annotationAdd BLAST58
Domaini261 – 482Pept_C1InterPro annotationAdd BLAST222

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C1 family.ARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02248, Peptidase_C1A, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038765, Papain-like_cys_pep_sf
IPR000169, Pept_cys_AS
IPR025660, Pept_his_AS
IPR000668, Peptidase_C1A_C
IPR039417, Peptidase_C1A_papain-like
IPR013201, Prot_inhib_I29

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08246, Inhibitor_I29, 1 hit
PF00112, Peptidase_C1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00705, PAPAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00848, Inhibitor_I29, 1 hit
SM00645, Pept_C1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001, SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00139, THIOL_PROTEASE_CYS, 1 hit
PS00639, THIOL_PROTEASE_HIS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9NAW2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDYNMDYAPH EVISQQGERF VDKYVDRKIL KNKKSLLVII SLSVLSVVGF
60 70 80 90 100
VLFYFTPNSR KSDLFKNSSV ENNNDDYIIN SLLKSPNGKK FIVSKIDEAL
110 120 130 140 150
SFYDSKKNDI NKYNEGNNNN NADFKGLSLF KENTPSNNFI HNKDYFINFF
160 170 180 190 200
DNKFLMNNAE HINQFYMFIK TNNKQYNSPN EMKERFQVFL QNAHKVNMHN
210 220 230 240 250
NNKNSLYKKE LNRFADLTYH EFKNKYLSLR SSKPLKNSKY LLDQMNYEEV
260 270 280 290 300
IKKYRGEENF DHAAYDWRLH SGVTPVKDQK NCGSCWAFSS IGSVESQYAI
310 320 330 340 350
RKNKLITLSE QELVDCSFKN YGCNGGLINN AFEDMIELGG ICPDGDYPYV
360 370 380 390 400
SDAPNLCNID RCTEKYGIKN YLSVPDNKLK EALRFLGPIS ISVAVSDDFA
410 420 430 440 450
FYKEGIFDGE CGDELNHAVM LVGFGMKEIV NPLTKKGEKH YYYIIKNSWG
460 470 480
QQWGERGFIN IETDESGLMR KCGLGTDAFI PLIE
Length:484
Mass (Da):55,909
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBD3835D59F4D5E19
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF282979 Genomic DNA Translation: AAF97809.1
AF317909 Genomic DNA Translation: AAK06665.1
MG768712 Genomic DNA Translation: AXL96722.1
MN374247 Genomic DNA Translation: QEQ07914.1
MN374248 Genomic DNA Translation: QEQ07915.1
MN374250 Genomic DNA Translation: QEQ07917.1
MN374259 Genomic DNA Translation: QEQ07926.1
MN374262 Genomic DNA Translation: QEQ07929.1
MN374263 Genomic DNA Translation: QEQ07930.1
MN374271 Genomic DNA Translation: QEQ07938.1
MN374274 Genomic DNA Translation: QEQ07941.1
MN374281 Genomic DNA Translation: QEQ07948.1
MN374288 Genomic DNA Translation: QEQ07955.1
MN374299 Genomic DNA Translation: QEQ07966.1
MN374324 Genomic DNA Translation: QEQ07991.1
MN374364 Genomic DNA Translation: QEQ08031.1
MN374375 Genomic DNA Translation: QEQ08042.1
MN374379 Genomic DNA Translation: QEQ08046.1
MN374380 Genomic DNA Translation: QEQ08047.1
MN374381 Genomic DNA Translation: QEQ08048.1
MN374392 Genomic DNA Translation: QEQ08059.1
MN374396 Genomic DNA Translation: QEQ08063.1
MN374397 Genomic DNA Translation: QEQ08064.1
MN374400 Genomic DNA Translation: QEQ08067.1
MN374405 Genomic DNA Translation: QEQ08072.1
MN374409 Genomic DNA Translation: QEQ08076.1
MN374415 Genomic DNA Translation: QEQ08082.1
MN374441 Genomic DNA Translation: QEQ08108.1
MN374449 Genomic DNA Translation: QEQ08116.1
MN374509 Genomic DNA Translation: QEQ08176.1
MN374512 Genomic DNA Translation: QEQ08179.1
MN374516 Genomic DNA Translation: QEQ08183.1
MN374548 Genomic DNA Translation: QEQ08215.1
MN374558 Genomic DNA Translation: QEQ08225.1
MN374559 Genomic DNA Translation: QEQ08226.1
MN374649 Genomic DNA Translation: QEQ08316.1
MN374658 Genomic DNA Translation: QEQ08325.1
MN374683 Genomic DNA Translation: QEQ08350.1
MN374739 Genomic DNA Translation: QEQ08406.1
MN374747 Genomic DNA Translation: QEQ08414.1
MN374756 Genomic DNA Translation: QEQ08423.1
MN374760 Genomic DNA Translation: QEQ08427.1
MN374786 Genomic DNA Translation: QEQ08453.1
MN374792 Genomic DNA Translation: QEQ08459.1
MN374802 Genomic DNA Translation: QEQ08469.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF282979 Genomic DNA Translation: AAF97809.1
AF317909 Genomic DNA Translation: AAK06665.1
MG768712 Genomic DNA Translation: AXL96722.1
MN374247 Genomic DNA Translation: QEQ07914.1
MN374248 Genomic DNA Translation: QEQ07915.1
MN374250 Genomic DNA Translation: QEQ07917.1
MN374259 Genomic DNA Translation: QEQ07926.1
MN374262 Genomic DNA Translation: QEQ07929.1
MN374263 Genomic DNA Translation: QEQ07930.1
MN374271 Genomic DNA Translation: QEQ07938.1
MN374274 Genomic DNA Translation: QEQ07941.1
MN374281 Genomic DNA Translation: QEQ07948.1
MN374288 Genomic DNA Translation: QEQ07955.1
MN374299 Genomic DNA Translation: QEQ07966.1
MN374324 Genomic DNA Translation: QEQ07991.1
MN374364 Genomic DNA Translation: QEQ08031.1
MN374375 Genomic DNA Translation: QEQ08042.1
MN374379 Genomic DNA Translation: QEQ08046.1
MN374380 Genomic DNA Translation: QEQ08047.1
MN374381 Genomic DNA Translation: QEQ08048.1
MN374392 Genomic DNA Translation: QEQ08059.1
MN374396 Genomic DNA Translation: QEQ08063.1
MN374397 Genomic DNA Translation: QEQ08064.1
MN374400 Genomic DNA Translation: QEQ08067.1
MN374405 Genomic DNA Translation: QEQ08072.1
MN374409 Genomic DNA Translation: QEQ08076.1
MN374415 Genomic DNA Translation: QEQ08082.1
MN374441 Genomic DNA Translation: QEQ08108.1
MN374449 Genomic DNA Translation: QEQ08116.1
MN374509 Genomic DNA Translation: QEQ08176.1
MN374512 Genomic DNA Translation: QEQ08179.1
MN374516 Genomic DNA Translation: QEQ08183.1
MN374548 Genomic DNA Translation: QEQ08215.1
MN374558 Genomic DNA Translation: QEQ08225.1
MN374559 Genomic DNA Translation: QEQ08226.1
MN374649 Genomic DNA Translation: QEQ08316.1
MN374658 Genomic DNA Translation: QEQ08325.1
MN374683 Genomic DNA Translation: QEQ08350.1
MN374739 Genomic DNA Translation: QEQ08406.1
MN374747 Genomic DNA Translation: QEQ08414.1
MN374756 Genomic DNA Translation: QEQ08423.1
MN374760 Genomic DNA Translation: QEQ08427.1
MN374786 Genomic DNA Translation: QEQ08453.1
MN374792 Genomic DNA Translation: QEQ08459.1
MN374802 Genomic DNA Translation: QEQ08469.1

3D structure databases

SMRiQ9NAW2
ModBaseiSearch...

Chemistry databases

ChEMBLiCHEMBL1697672

Protein family/group databases

MEROPSiC01.046

Family and domain databases

CDDicd02248, Peptidase_C1A, 1 hit
InterProiView protein in InterPro
IPR038765, Papain-like_cys_pep_sf
IPR000169, Pept_cys_AS
IPR025660, Pept_his_AS
IPR000668, Peptidase_C1A_C
IPR039417, Peptidase_C1A_papain-like
IPR013201, Prot_inhib_I29
PfamiView protein in Pfam
PF08246, Inhibitor_I29, 1 hit
PF00112, Peptidase_C1, 1 hit
PRINTSiPR00705, PAPAIN
SMARTiView protein in SMART
SM00848, Inhibitor_I29, 1 hit
SM00645, Pept_C1, 1 hit
SUPFAMiSSF54001, SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00139, THIOL_PROTEASE_CYS, 1 hit
PS00639, THIOL_PROTEASE_HIS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9NAW2_PLAFA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NAW2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: August 12, 2020
This is version 100 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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