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Entry version 135 (29 Sep 2021)
Sequence version 3 (10 Jul 2007)
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Protein

SUMO-activating enzyme subunit uba-2

Gene

uba-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The dimeric enzyme acts as an E1 ligase for smo-1. It mediates ATP-dependent activation of smo-1 and formation of a thioester with a conserved cysteine residue on uba-2 (Probable).

3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein sumoylation

This protein is involved in the pathway protein sumoylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein sumoylation and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei44ATPBy similarity1
Binding sitei68ATPBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi154ZincBy similarity1
Metal bindingi157ZincBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei170Glycyl thioester intermediatePROSITE-ProRule annotation1
Metal bindingi431ZincBy similarity1
Metal bindingi434ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi20 – 25ATPBy similarity6
Nucleotide bindingi52 – 55ATPBy similarity4
Nucleotide bindingi91 – 92ATPBy similarity2
Nucleotide bindingi113 – 118ATPBy similarity6

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-3065676, SUMO is conjugated to E1 (UBA2:SAE1)
R-CEL-3065678, SUMO is transferred from E1 to E2 (UBE2I, UBC9)

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00886

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SUMO-activating enzyme subunit uba-2 (EC:2.3.2.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:uba-2
ORF Names:W02A11.4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
W02A11.4 ; CE40719 ; WBGene00006700 ; uba-2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002701901 – 582SUMO-activating enzyme subunit uba-2Add BLAST582

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NAN1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NAN1

PeptideAtlas

More...
PeptideAtlasi
Q9NAN1

PRoteomics IDEntifications database

More...
PRIDEi
Q9NAN1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NAN1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00006700, Expressed in multi-cellular organism and 4 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer with aos-1.

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.W02A11.4

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NAN1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni204 – 235DisorderedSequence analysisAdd BLAST32
Regioni531 – 582DisorderedSequence analysisAdd BLAST52

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi215 – 231Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi531 – 573Basic and acidic residuesSequence analysisAdd BLAST43

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ubiquitin-activating E1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2013, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00550000074924

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_013325_7_4_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NAN1

Identification of Orthologs from Complete Genome Data

More...
OMAi
RTECYDC

Database of Orthologous Groups

More...
OrthoDBi
686413at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NAN1

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.520, 1 hit
3.50.50.80, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000594, ThiF_NAD_FAD-bd
IPR028077, UAE_UbL_dom
IPR042449, Ub-E1_IAD_1
IPR023318, Ub_act_enz_dom_a_sf
IPR030661, Uba2
IPR035985, Ubiquitin-activating_enz
IPR033127, UBQ-activ_enz_E1_Cys_AS

The PANTHER Classification System

More...
PANTHERi
PTHR10953:SF5, PTHR10953:SF5, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00899, ThiF, 1 hit
PF14732, UAE_UbL, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF039133, SUMO_E1B, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF69572, SSF69572, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00865, UBIQUITIN_ACTIVAT_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9NAN1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSWREKHEK IVQSKILVIG AGGIGCELLK NLAVTGFRKV HVIDLDTIDI
60 70 80 90 100
SNLNRQFLFR KEHVSSSKAA TATQVVKQFC PQIELTFDHD SIFEKKYNME
110 120 130 140 150
FFQAYDIVLN ALDNRAARNY VNRMCHAANR PLIDSGSGGY FGQVSVIMRG
160 170 180 190 200
KTECYECVDK PVQQTTYPGC TIRNTPSEHI HCTVWAKHVF NQLFGEVDID
210 220 230 240 250
DDVSPDMDAV DPDNTEAVTT EKEKEAMKEE PAPVGTRQWA ESVDYDAAKV
260 270 280 290 300
FDKLFLHDIE YLCKMEHLWK QRKRPSPLEF HTASSTGGEP QSLCDAQRDD
310 320 330 340 350
TSIWTLSTCA KVFSTCIQEL LEQIRAEPDV KLAFDKDHAI IMSFVAACAN
360 370 380 390 400
IRAKIFGIPM KSQFDIKAMA GNIIPAIAST NAIVAGIIVT EAVRVIEGST
410 420 430 440 450
VICNSSIATT QSNPRGRIFG GDATNPPNPR CFVCSEKREV FIYVNPDTMT
460 470 480 490 500
VGGLCEKVLK QKLNMLAPDV MDSATSRIIV SSDGDTDDLL PKKLAEVSIE
510 520 530 540 550
DGAILSCDDF QQEMEIKLFI KKGDRLAGDD FEVARSEKEP EPDDRKRKAD
560 570 580
GSEEPEAKRQ KVEEKDDKNG NEAVAEITET MA
Length:582
Mass (Da):64,826
Last modified:July 10, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i318CDD98FEA04BD1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z82062 Genomic DNA Translation: CAB54319.4

Protein sequence database of the Protein Information Resource

More...
PIRi
T26072

NCBI Reference Sequences

More...
RefSeqi
NP_001293154.1, NM_001306225.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
W02A11.4.1; W02A11.4.1; WBGene00006700

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
24104970

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_W02A11.4

UCSC genome browser

More...
UCSCi
W02A11.4, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z82062 Genomic DNA Translation: CAB54319.4
PIRiT26072
RefSeqiNP_001293154.1, NM_001306225.1

3D structure databases

SMRiQ9NAN1
ModBaseiSearch...

Protein-protein interaction databases

STRINGi6239.W02A11.4

PTM databases

iPTMnetiQ9NAN1

Proteomic databases

EPDiQ9NAN1
PaxDbiQ9NAN1
PeptideAtlasiQ9NAN1
PRIDEiQ9NAN1

Genome annotation databases

EnsemblMetazoaiW02A11.4.1; W02A11.4.1; WBGene00006700
GeneIDi24104970
KEGGicel:CELE_W02A11.4
UCSCiW02A11.4, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
24104970
WormBaseiW02A11.4 ; CE40719 ; WBGene00006700 ; uba-2

Phylogenomic databases

eggNOGiKOG2013, Eukaryota
GeneTreeiENSGT00550000074924
HOGENOMiCLU_013325_7_4_1
InParanoidiQ9NAN1
OMAiRTECYDC
OrthoDBi686413at2759
PhylomeDBiQ9NAN1

Enzyme and pathway databases

UniPathwayiUPA00886
ReactomeiR-CEL-3065676, SUMO is conjugated to E1 (UBA2:SAE1)
R-CEL-3065678, SUMO is transferred from E1 to E2 (UBE2I, UBC9)

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9NAN1

Gene expression databases

BgeeiWBGene00006700, Expressed in multi-cellular organism and 4 other tissues

Family and domain databases

Gene3Di1.10.10.520, 1 hit
3.50.50.80, 1 hit
InterProiView protein in InterPro
IPR000594, ThiF_NAD_FAD-bd
IPR028077, UAE_UbL_dom
IPR042449, Ub-E1_IAD_1
IPR023318, Ub_act_enz_dom_a_sf
IPR030661, Uba2
IPR035985, Ubiquitin-activating_enz
IPR033127, UBQ-activ_enz_E1_Cys_AS
PANTHERiPTHR10953:SF5, PTHR10953:SF5, 1 hit
PfamiView protein in Pfam
PF00899, ThiF, 1 hit
PF14732, UAE_UbL, 1 hit
PIRSFiPIRSF039133, SUMO_E1B, 1 hit
SUPFAMiSSF69572, SSF69572, 1 hit
PROSITEiView protein in PROSITE
PS00865, UBIQUITIN_ACTIVAT_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSAE2_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NAN1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: July 10, 2007
Last modified: September 29, 2021
This is version 135 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
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