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Protein

Signal transducer and activator of transcription 1

Gene

sta-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Carries out a dual function: signal transduction and activation of transcription. Activated STAT proteins play a role in repression of dauer formation. Neuronal expression is held in check by negative signals through the TGF-beta pathway that target the daf-3 transcription factor.1 Publication

GO - Molecular functioni

  • DNA-binding transcription factor activity Source: InterPro
  • sequence-specific DNA binding Source: WormBase

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-CEL-1059683 Interleukin-6 signaling
R-CEL-1251985 Nuclear signaling by ERBB4
R-CEL-1266695 Interleukin-7 signaling
R-CEL-2586552 Signaling by Leptin
R-CEL-3249367 STAT6-mediated induction of chemokines
R-CEL-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-CEL-6783783 Interleukin-10 signaling
R-CEL-6785807 Interleukin-4 and Interleukin-13 signaling
R-CEL-877300 Interferon gamma signaling
R-CEL-877312 Regulation of IFNG signaling
R-CEL-8854691 Interleukin-20 family signaling
R-CEL-8875791 MET activates STAT3
R-CEL-8983432 Interleukin-15 signaling
R-CEL-8984722 Interleukin-35 Signalling
R-CEL-8985947 Interleukin-9 signaling
R-CEL-9008059 Interleukin-37 signaling
R-CEL-9020558 Interleukin-2 signaling
R-CEL-9020591 Interleukin-12 signaling
R-CEL-9020933 Interleukin-23 signaling
R-CEL-9020956 Interleukin-27 signaling
R-CEL-909733 Interferon alpha/beta signaling
R-CEL-982772 Growth hormone receptor signaling
SignaLinkiQ9NAD6

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer and activator of transcription 1
Gene namesi
Name:sta-11 Publication
ORF Names:Y51H4A.17
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiY51H4A.17a ; CE35668 ; WBGene00013111 ; sta-1
Y51H4A.17b ; CE41061 ; WBGene00013111 ; sta-1
Y51H4A.17c ; CE22342 ; WBGene00013111 ; sta-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002339061 – 706Signal transducer and activator of transcription 1Add BLAST706

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NAD6
PaxDbiQ9NAD6
PeptideAtlasiQ9NAD6
PRIDEiQ9NAD6

PTM databases

iPTMnetiQ9NAD6

Expressioni

Tissue specificityi

Expressed in adult and larval pharynx, head ganglia, tail ganglia, ventral nerve cord and body muscles.1 Publication

Gene expression databases

BgeeiWBGene00013111 Expressed in 4 organ(s), highest expression level in pharyngeal muscle cell (C elegans)

Interactioni

Subunit structurei

Forms a homodimer or a heterodimer with a related family member.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
F37C4.5O444002EBI-312137,EBI-312011

Protein-protein interaction databases

BioGridi43543, 16 interactors
DIPiDIP-24746N
IntActiQ9NAD6, 8 interactors
STRINGi6239.Y51H4A.17a

Structurei

3D structure databases

ProteinModelPortaliQ9NAD6
SMRiQ9NAD6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini477 – 574SH2Sequence analysisAdd BLAST98

Sequence similaritiesi

Belongs to the transcription factor STAT family.Sequence analysis

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG3667 Eukaryota
ENOG410XPN8 LUCA
GeneTreeiENSGT00760000119236
HOGENOMiHOG000276912
InParanoidiQ9NAD6
KOiK11224
OMAiITIAWVN
OrthoDBiEOG091G03O3
PhylomeDBiQ9NAD6

Family and domain databases

Gene3Di2.60.40.630, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR001217 STAT
IPR013800 STAT_TF_alpha
IPR015988 STAT_TF_coiled-coil
IPR013801 STAT_TF_DNA-bd
IPR012345 STAT_TF_DNA-bd_N
PANTHERiPTHR11801 PTHR11801, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF01017 STAT_alpha, 1 hit
PF02864 STAT_bind, 1 hit
SUPFAMiSSF47655 SSF47655, 1 hit
SSF49417 SSF49417, 1 hit
SSF55550 SSF55550, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform a (identifier: Q9NAD6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMGSSSQELQ TALTDVSKTC HHLWEENKDL QGRFVNELGE LQRLQMVIAQ
60 70 80 90 100
LEQQQRLENV FTVKQQMTEL QKRAATLYEH LTQKRNDIVI KLNDGTNFAT
110 120 130 140 150
MLQTQLIGEK LFSWKNAQKL AQIGMPFDNR EQLLDEIQIE FEFLADQNWQ
160 170 180 190 200
LNMFSCWMLD LLRRAPQLND GLAQATIGKL TAITEQLNKL LFMLVSQSFI
210 220 230 240 250
VSVQPEPVLK TQHKFVTEVR LLIGDKLGIR QHLVNTNVSV KIIAEDEAKQ
260 270 280 290 300
LSVDYDAHKE IRNNKTVGTI SNDFEKLTMN ERGHLAAKFN NSKLTRIAHR
310 320 330 340 350
KPPPKGASDL KCAASMQAAT DQKYALLFFI TPFQMGNLSK EEQFDVWTLS
360 370 380 390 400
LPIMVTVHGS QDCDAQVAIL WHRAFASISR NPNTTDVTAV TWDNLAIMLR
410 420 430 440 450
NKFSLFTGAR RPLSDSDLAY LSEKMLMPNV ADQKPITFHR FAKQAMRDDL
460 470 480 490 500
PFSFWEWFFS IMQLIKQKLL KFWDEGWCIG FISKNDASQS MMMCQHSSFL
510 520 530 540 550
LRFSDSQTGA VSIGFVCEEA DGQKIPFHLA PFTIKDLDQL SLASRIASCP
560 570 580 590 600
QLKDIRYMYP AIDKEEMLRF FESEERHRVG GGDSPTGYIQ SEIVMVAKTN
610 620 630 640 650
GNFRRMSNAP SMFGADSPSP LSVQSKLDWS PGEVHQNHMM EMSDELGQIL
660 670 680 690 700
TVSDMSGDVE TLLGPAFKNN ITNYNPHDGN HQHNLHFVDM SQQGMMQQHH

NQFYPS
Note: No experimental confirmation available.
Length:706
Mass (Da):80,581
Last modified:July 5, 2004 - v2
Checksum:i39F3755A1573A03C
GO
Isoform b (identifier: Q9NAD6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     557-567: YMYPAIDKEEM → LVLDAKSLPCC
     568-706: Missing.

Note: No experimental confirmation available.
Show »
Length:567
Mass (Da):64,737
Checksum:i236E842DAB74F7D2
GO
Isoform c (identifier: Q9NAD6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     602-604: Missing.

Note: No experimental confirmation available.
Show »
Length:703
Mass (Da):80,164
Checksum:i18BD9D0862D91C35
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_038159557 – 567YMYPAIDKEEM → LVLDAKSLPCC in isoform b. CuratedAdd BLAST11
Alternative sequenceiVSP_038160568 – 706Missing in isoform b. CuratedAdd BLAST139
Alternative sequenceiVSP_038161602 – 604Missing in isoform c. 1 Publication3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY943817 mRNA Translation: AAY18583.1
AL132952 Genomic DNA Translation: CAB61149.2
AL132952 Genomic DNA Translation: CAN86928.1
AL132952 Genomic DNA Translation: CAN99759.1
RefSeqiNP_001122814.1, NM_001129342.2 [Q9NAD6-2]
NP_001122815.1, NM_001129343.2 [Q9NAD6-3]
NP_502974.2, NM_070573.4 [Q9NAD6-1]
UniGeneiCel.21727

Genome annotation databases

EnsemblMetazoaiY51H4A.17a; Y51H4A.17a; WBGene00013111 [Q9NAD6-1]
GeneIDi178465
KEGGicel:CELE_Y51H4A.17
UCSCiY51H4A.17a c. elegans

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY943817 mRNA Translation: AAY18583.1
AL132952 Genomic DNA Translation: CAB61149.2
AL132952 Genomic DNA Translation: CAN86928.1
AL132952 Genomic DNA Translation: CAN99759.1
RefSeqiNP_001122814.1, NM_001129342.2 [Q9NAD6-2]
NP_001122815.1, NM_001129343.2 [Q9NAD6-3]
NP_502974.2, NM_070573.4 [Q9NAD6-1]
UniGeneiCel.21727

3D structure databases

ProteinModelPortaliQ9NAD6
SMRiQ9NAD6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi43543, 16 interactors
DIPiDIP-24746N
IntActiQ9NAD6, 8 interactors
STRINGi6239.Y51H4A.17a

PTM databases

iPTMnetiQ9NAD6

Proteomic databases

EPDiQ9NAD6
PaxDbiQ9NAD6
PeptideAtlasiQ9NAD6
PRIDEiQ9NAD6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY51H4A.17a; Y51H4A.17a; WBGene00013111 [Q9NAD6-1]
GeneIDi178465
KEGGicel:CELE_Y51H4A.17
UCSCiY51H4A.17a c. elegans

Organism-specific databases

CTDi178465
WormBaseiY51H4A.17a ; CE35668 ; WBGene00013111 ; sta-1
Y51H4A.17b ; CE41061 ; WBGene00013111 ; sta-1
Y51H4A.17c ; CE22342 ; WBGene00013111 ; sta-1

Phylogenomic databases

eggNOGiKOG3667 Eukaryota
ENOG410XPN8 LUCA
GeneTreeiENSGT00760000119236
HOGENOMiHOG000276912
InParanoidiQ9NAD6
KOiK11224
OMAiITIAWVN
OrthoDBiEOG091G03O3
PhylomeDBiQ9NAD6

Enzyme and pathway databases

ReactomeiR-CEL-1059683 Interleukin-6 signaling
R-CEL-1251985 Nuclear signaling by ERBB4
R-CEL-1266695 Interleukin-7 signaling
R-CEL-2586552 Signaling by Leptin
R-CEL-3249367 STAT6-mediated induction of chemokines
R-CEL-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-CEL-6783783 Interleukin-10 signaling
R-CEL-6785807 Interleukin-4 and Interleukin-13 signaling
R-CEL-877300 Interferon gamma signaling
R-CEL-877312 Regulation of IFNG signaling
R-CEL-8854691 Interleukin-20 family signaling
R-CEL-8875791 MET activates STAT3
R-CEL-8983432 Interleukin-15 signaling
R-CEL-8984722 Interleukin-35 Signalling
R-CEL-8985947 Interleukin-9 signaling
R-CEL-9008059 Interleukin-37 signaling
R-CEL-9020558 Interleukin-2 signaling
R-CEL-9020591 Interleukin-12 signaling
R-CEL-9020933 Interleukin-23 signaling
R-CEL-9020956 Interleukin-27 signaling
R-CEL-909733 Interferon alpha/beta signaling
R-CEL-982772 Growth hormone receptor signaling
SignaLinkiQ9NAD6

Miscellaneous databases

PROiPR:Q9NAD6

Gene expression databases

BgeeiWBGene00013111 Expressed in 4 organ(s), highest expression level in pharyngeal muscle cell (C elegans)

Family and domain databases

Gene3Di2.60.40.630, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR001217 STAT
IPR013800 STAT_TF_alpha
IPR015988 STAT_TF_coiled-coil
IPR013801 STAT_TF_DNA-bd
IPR012345 STAT_TF_DNA-bd_N
PANTHERiPTHR11801 PTHR11801, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF01017 STAT_alpha, 1 hit
PF02864 STAT_bind, 1 hit
SUPFAMiSSF47655 SSF47655, 1 hit
SSF49417 SSF49417, 1 hit
SSF55550 SSF55550, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTAT1_CAEEL
AccessioniPrimary (citable) accession number: Q9NAD6
Secondary accession number(s): A5HWB4, Q29TW4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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