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Protein

Signal transducer and activator of transcription 1

Gene

sta-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Carries out a dual function: signal transduction and activation of transcription. Activated STAT proteins play a role in repression of dauer formation. Neuronal expression is held in check by negative signals through the TGF-beta pathway that target the daf-3 transcription factor.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DNA-binding transcription factor activity Source: InterPro
  • sequence-specific DNA binding Source: WormBase

GO - Biological processi

  • dauer larval development Source: WormBase
  • positive regulation of transcription by RNA polymerase II Source: WormBase
  • signal transduction Source: InterPro

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-1059683 Interleukin-6 signaling
R-CEL-1169408 ISG15 antiviral mechanism
R-CEL-1251985 Nuclear signaling by ERBB4
R-CEL-1266695 Interleukin-7 signaling
R-CEL-2586552 Signaling by Leptin
R-CEL-3249367 STAT6-mediated induction of chemokines
R-CEL-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-CEL-6783783 Interleukin-10 signaling
R-CEL-6785807 Interleukin-4 and Interleukin-13 signaling
R-CEL-877300 Interferon gamma signaling
R-CEL-877312 Regulation of IFNG signaling
R-CEL-8854691 Interleukin-20 family signaling
R-CEL-8875791 MET activates STAT3
R-CEL-8983432 Interleukin-15 signaling
R-CEL-8984722 Interleukin-35 Signalling
R-CEL-8985947 Interleukin-9 signaling
R-CEL-9008059 Interleukin-37 signaling
R-CEL-9020558 Interleukin-2 signaling
R-CEL-9020591 Interleukin-12 signaling
R-CEL-9020933 Interleukin-23 signaling
R-CEL-9020956 Interleukin-27 signaling
R-CEL-909733 Interferon alpha/beta signaling
R-CEL-982772 Growth hormone receptor signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9NAD6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Signal transducer and activator of transcription 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sta-11 Publication
ORF Names:Y51H4A.17
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

More...
WormBasei
Y51H4A.17a ; CE35668 ; WBGene00013111 ; sta-1
Y51H4A.17b ; CE41061 ; WBGene00013111 ; sta-1
Y51H4A.17c ; CE22342 ; WBGene00013111 ; sta-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002339061 – 706Signal transducer and activator of transcription 1Add BLAST706

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NAD6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NAD6

PeptideAtlas

More...
PeptideAtlasi
Q9NAD6

PRoteomics IDEntifications database

More...
PRIDEi
Q9NAD6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NAD6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in adult and larval pharynx, head ganglia, tail ganglia, ventral nerve cord and body muscles.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00013111 Expressed in 4 organ(s), highest expression level in pharyngeal muscle cell (C elegans)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a homodimer or a heterodimer with a related family member.By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
F37C4.5O444002EBI-312137,EBI-312011

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
43543, 16 interactors

Database of interacting proteins

More...
DIPi
DIP-24746N

Protein interaction database and analysis system

More...
IntActi
Q9NAD6, 8 interactors

STRING: functional protein association networks

More...
STRINGi
6239.Y51H4A.17a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9NAD6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NAD6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini477 – 574SH2Sequence analysisAdd BLAST98

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the transcription factor STAT family.Sequence analysis

Keywords - Domaini

SH2 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3667 Eukaryota
ENOG410XPN8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159048

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000276912

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9NAD6

KEGG Orthology (KO)

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KOi
K11224

Identification of Orthologs from Complete Genome Data

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OMAi
TMDERGH

Database of Orthologous Groups

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OrthoDBi
327469at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NAD6

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.630, 1 hit
3.30.505.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR001217 STAT
IPR013800 STAT_TF_alpha
IPR015988 STAT_TF_coiled-coil
IPR013801 STAT_TF_DNA-bd
IPR012345 STAT_TF_DNA-bd_N

The PANTHER Classification System

More...
PANTHERi
PTHR11801 PTHR11801, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00017 SH2, 1 hit
PF01017 STAT_alpha, 1 hit
PF02864 STAT_bind, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47655 SSF47655, 1 hit
SSF49417 SSF49417, 1 hit
SSF55550 SSF55550, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform a (identifier: Q9NAD6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMGSSSQELQ TALTDVSKTC HHLWEENKDL QGRFVNELGE LQRLQMVIAQ
60 70 80 90 100
LEQQQRLENV FTVKQQMTEL QKRAATLYEH LTQKRNDIVI KLNDGTNFAT
110 120 130 140 150
MLQTQLIGEK LFSWKNAQKL AQIGMPFDNR EQLLDEIQIE FEFLADQNWQ
160 170 180 190 200
LNMFSCWMLD LLRRAPQLND GLAQATIGKL TAITEQLNKL LFMLVSQSFI
210 220 230 240 250
VSVQPEPVLK TQHKFVTEVR LLIGDKLGIR QHLVNTNVSV KIIAEDEAKQ
260 270 280 290 300
LSVDYDAHKE IRNNKTVGTI SNDFEKLTMN ERGHLAAKFN NSKLTRIAHR
310 320 330 340 350
KPPPKGASDL KCAASMQAAT DQKYALLFFI TPFQMGNLSK EEQFDVWTLS
360 370 380 390 400
LPIMVTVHGS QDCDAQVAIL WHRAFASISR NPNTTDVTAV TWDNLAIMLR
410 420 430 440 450
NKFSLFTGAR RPLSDSDLAY LSEKMLMPNV ADQKPITFHR FAKQAMRDDL
460 470 480 490 500
PFSFWEWFFS IMQLIKQKLL KFWDEGWCIG FISKNDASQS MMMCQHSSFL
510 520 530 540 550
LRFSDSQTGA VSIGFVCEEA DGQKIPFHLA PFTIKDLDQL SLASRIASCP
560 570 580 590 600
QLKDIRYMYP AIDKEEMLRF FESEERHRVG GGDSPTGYIQ SEIVMVAKTN
610 620 630 640 650
GNFRRMSNAP SMFGADSPSP LSVQSKLDWS PGEVHQNHMM EMSDELGQIL
660 670 680 690 700
TVSDMSGDVE TLLGPAFKNN ITNYNPHDGN HQHNLHFVDM SQQGMMQQHH

NQFYPS
Note: No experimental confirmation available.
Length:706
Mass (Da):80,581
Last modified:July 5, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i39F3755A1573A03C
GO
Isoform b (identifier: Q9NAD6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     557-567: YMYPAIDKEEM → LVLDAKSLPCC
     568-706: Missing.

Note: No experimental confirmation available.
Show »
Length:567
Mass (Da):64,737
Checksum:i236E842DAB74F7D2
GO
Isoform c (identifier: Q9NAD6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     602-604: Missing.

Note: No experimental confirmation available.
Show »
Length:703
Mass (Da):80,164
Checksum:i18BD9D0862D91C35
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_038159557 – 567YMYPAIDKEEM → LVLDAKSLPCC in isoform b. CuratedAdd BLAST11
Alternative sequenceiVSP_038160568 – 706Missing in isoform b. CuratedAdd BLAST139
Alternative sequenceiVSP_038161602 – 604Missing in isoform c. 1 Publication3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY943817 mRNA Translation: AAY18583.1
AL132952 Genomic DNA Translation: CAB61149.2
AL132952 Genomic DNA Translation: CAN86928.1
AL132952 Genomic DNA Translation: CAN99759.1

NCBI Reference Sequences

More...
RefSeqi
NP_001122814.1, NM_001129342.2 [Q9NAD6-2]
NP_001122815.1, NM_001129343.2 [Q9NAD6-3]
NP_502974.2, NM_070573.4 [Q9NAD6-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Cel.21727

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
Y51H4A.17a; Y51H4A.17a; WBGene00013111 [Q9NAD6-1]
Y51H4A.17b; Y51H4A.17b; WBGene00013111 [Q9NAD6-2]
Y51H4A.17c; Y51H4A.17c; WBGene00013111 [Q9NAD6-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
178465

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
cel:CELE_Y51H4A.17

UCSC genome browser

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UCSCi
Y51H4A.17a c. elegans

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY943817 mRNA Translation: AAY18583.1
AL132952 Genomic DNA Translation: CAB61149.2
AL132952 Genomic DNA Translation: CAN86928.1
AL132952 Genomic DNA Translation: CAN99759.1
RefSeqiNP_001122814.1, NM_001129342.2 [Q9NAD6-2]
NP_001122815.1, NM_001129343.2 [Q9NAD6-3]
NP_502974.2, NM_070573.4 [Q9NAD6-1]
UniGeneiCel.21727

3D structure databases

ProteinModelPortaliQ9NAD6
SMRiQ9NAD6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi43543, 16 interactors
DIPiDIP-24746N
IntActiQ9NAD6, 8 interactors
STRINGi6239.Y51H4A.17a

PTM databases

iPTMnetiQ9NAD6

Proteomic databases

EPDiQ9NAD6
PaxDbiQ9NAD6
PeptideAtlasiQ9NAD6
PRIDEiQ9NAD6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY51H4A.17a; Y51H4A.17a; WBGene00013111 [Q9NAD6-1]
Y51H4A.17b; Y51H4A.17b; WBGene00013111 [Q9NAD6-2]
Y51H4A.17c; Y51H4A.17c; WBGene00013111 [Q9NAD6-3]
GeneIDi178465
KEGGicel:CELE_Y51H4A.17
UCSCiY51H4A.17a c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
178465
WormBaseiY51H4A.17a ; CE35668 ; WBGene00013111 ; sta-1
Y51H4A.17b ; CE41061 ; WBGene00013111 ; sta-1
Y51H4A.17c ; CE22342 ; WBGene00013111 ; sta-1

Phylogenomic databases

eggNOGiKOG3667 Eukaryota
ENOG410XPN8 LUCA
GeneTreeiENSGT00940000159048
HOGENOMiHOG000276912
InParanoidiQ9NAD6
KOiK11224
OMAiTMDERGH
OrthoDBi327469at2759
PhylomeDBiQ9NAD6

Enzyme and pathway databases

ReactomeiR-CEL-1059683 Interleukin-6 signaling
R-CEL-1169408 ISG15 antiviral mechanism
R-CEL-1251985 Nuclear signaling by ERBB4
R-CEL-1266695 Interleukin-7 signaling
R-CEL-2586552 Signaling by Leptin
R-CEL-3249367 STAT6-mediated induction of chemokines
R-CEL-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-CEL-6783783 Interleukin-10 signaling
R-CEL-6785807 Interleukin-4 and Interleukin-13 signaling
R-CEL-877300 Interferon gamma signaling
R-CEL-877312 Regulation of IFNG signaling
R-CEL-8854691 Interleukin-20 family signaling
R-CEL-8875791 MET activates STAT3
R-CEL-8983432 Interleukin-15 signaling
R-CEL-8984722 Interleukin-35 Signalling
R-CEL-8985947 Interleukin-9 signaling
R-CEL-9008059 Interleukin-37 signaling
R-CEL-9020558 Interleukin-2 signaling
R-CEL-9020591 Interleukin-12 signaling
R-CEL-9020933 Interleukin-23 signaling
R-CEL-9020956 Interleukin-27 signaling
R-CEL-909733 Interferon alpha/beta signaling
R-CEL-982772 Growth hormone receptor signaling
SignaLinkiQ9NAD6

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9NAD6

Gene expression databases

BgeeiWBGene00013111 Expressed in 4 organ(s), highest expression level in pharyngeal muscle cell (C elegans)

Family and domain databases

Gene3Di2.60.40.630, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR001217 STAT
IPR013800 STAT_TF_alpha
IPR015988 STAT_TF_coiled-coil
IPR013801 STAT_TF_DNA-bd
IPR012345 STAT_TF_DNA-bd_N
PANTHERiPTHR11801 PTHR11801, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF01017 STAT_alpha, 1 hit
PF02864 STAT_bind, 1 hit
SUPFAMiSSF47655 SSF47655, 1 hit
SSF49417 SSF49417, 1 hit
SSF55550 SSF55550, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTAT1_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NAD6
Secondary accession number(s): A5HWB4, Q29TW4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: July 5, 2004
Last modified: January 16, 2019
This is version 151 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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