UniProtKB - Q9NA26 (VPS28_CAEEL)
Protein
Vacuolar protein sorting-associated protein 28 homolog
Gene
vps-28
Organism
Caenorhabditis elegans
Status
Functioni
Component of the ESCRT-I complex, a regulator of vesicular trafficking process.2 Publications
GO - Molecular functioni
- protein-containing complex binding Source: GO_Central
GO - Biological processi
- protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: GO_Central
- receptor catabolic process Source: WormBase
Keywordsi
Biological process | Protein transport, Transport |
Enzyme and pathway databases
Reactomei | R-CEL-917729, Endosomal Sorting Complex Required For Transport (ESCRT) |
Names & Taxonomyi
Protein namesi | Recommended name: Vacuolar protein sorting-associated protein 28 homologAlternative name(s): ESCRT-I complex subunit VPS28 |
Gene namesi | Name:vps-28 ORF Names:Y87G2A.10 |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | Y87G2A.10a ; CE23139 ; WBGene00013598 ; vps-28 |
Subcellular locationi
Endosome
- Endosome By similarity
Endosome
- ESCRT I complex Source: WormBase
Keywords - Cellular componenti
EndosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000120953 | 1 – 210 | Vacuolar protein sorting-associated protein 28 homologAdd BLAST | 210 |
Proteomic databases
EPDi | Q9NA26 |
PaxDbi | Q9NA26 |
PeptideAtlasi | Q9NA26 |
Expressioni
Tissue specificityi
Expressed in embryos.1 Publication
Gene expression databases
Bgeei | WBGene00013598, Expressed in multi-cellular organism and 5 other tissues |
Interactioni
Subunit structurei
Component of the ESCRT-I complex (endosomal sorting complex required for transport I).
1 PublicationProtein-protein interaction databases
BioGRIDi | 38623, 15 interactors |
IntActi | Q9NA26, 1 interactor |
STRINGi | 6239.Y87G2A.10a |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 106 | VPS28 N-terminalPROSITE-ProRule annotationAdd BLAST | 106 | |
Domaini | 110 – 206 | VPS28 C-terminalPROSITE-ProRule annotationAdd BLAST | 97 |
Sequence similaritiesi
Belongs to the VPS28 family.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG3284, Eukaryota |
GeneTreei | ENSGT00390000007486 |
HOGENOMi | CLU_076417_2_0_1 |
InParanoidi | Q9NA26 |
OMAi | GPETGKW |
OrthoDBi | 1281819at2759 |
PhylomeDBi | Q9NA26 |
Family and domain databases
Gene3Di | 1.20.120.1130, 1 hit 1.20.1440.200, 1 hit |
InterProi | View protein in InterPro IPR037202, ESCRT_assembly_dom IPR007143, Vps28 IPR017899, VPS28_C IPR037206, VPS28_C_sf IPR017898, VPS28_N IPR038358, VPS28_N_sf |
PANTHERi | PTHR12937, PTHR12937, 1 hit |
Pfami | View protein in Pfam PF03997, VPS28, 1 hit |
PIRSFi | PIRSF017535, VPS28, 1 hit |
SUPFAMi | SSF140111, SSF140111, 1 hit SSF140427, SSF140427, 1 hit |
PROSITEi | View protein in PROSITE PS51310, VPS28_C, 1 hit PS51313, VPS28_N, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9NA26-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSQNANLMR EVRLFENHSE REQMENLSEL FAVLNALEHL EKMFSRDHVS
60 70 80 90 100
ADEYKSECFK LIDQYKVTMR LVHGATSIED FAKKYRLHCP AAIERIREGR
110 120 130 140 150
PITVKDDQGN VLKHIASIVE QFITFLDALR LNTRAVDDLY PGLDDLYNAI
160 170 180 190 200
NTTSRVPIDA IVTTKVKKWH DRLSSMAASD EISDEDARQM IFDVESAYQA
210
FNKALNELKH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL110500 Genomic DNA Translation: CAB54493.1 |
PIRi | T27471 |
RefSeqi | NP_493382.1, NM_060981.5 |
Genome annotation databases
EnsemblMetazoai | Y87G2A.10a.1; Y87G2A.10a.1; WBGene00013598 |
GeneIDi | 173229 |
KEGGi | cel:CELE_Y87G2A.10 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL110500 Genomic DNA Translation: CAB54493.1 |
PIRi | T27471 |
RefSeqi | NP_493382.1, NM_060981.5 |
3D structure databases
SMRi | Q9NA26 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 38623, 15 interactors |
IntActi | Q9NA26, 1 interactor |
STRINGi | 6239.Y87G2A.10a |
Proteomic databases
EPDi | Q9NA26 |
PaxDbi | Q9NA26 |
PeptideAtlasi | Q9NA26 |
Genome annotation databases
EnsemblMetazoai | Y87G2A.10a.1; Y87G2A.10a.1; WBGene00013598 |
GeneIDi | 173229 |
KEGGi | cel:CELE_Y87G2A.10 |
Organism-specific databases
CTDi | 173229 |
WormBasei | Y87G2A.10a ; CE23139 ; WBGene00013598 ; vps-28 |
Phylogenomic databases
eggNOGi | KOG3284, Eukaryota |
GeneTreei | ENSGT00390000007486 |
HOGENOMi | CLU_076417_2_0_1 |
InParanoidi | Q9NA26 |
OMAi | GPETGKW |
OrthoDBi | 1281819at2759 |
PhylomeDBi | Q9NA26 |
Enzyme and pathway databases
Reactomei | R-CEL-917729, Endosomal Sorting Complex Required For Transport (ESCRT) |
Miscellaneous databases
PROi | PR:Q9NA26 |
Gene expression databases
Bgeei | WBGene00013598, Expressed in multi-cellular organism and 5 other tissues |
Family and domain databases
Gene3Di | 1.20.120.1130, 1 hit 1.20.1440.200, 1 hit |
InterProi | View protein in InterPro IPR037202, ESCRT_assembly_dom IPR007143, Vps28 IPR017899, VPS28_C IPR037206, VPS28_C_sf IPR017898, VPS28_N IPR038358, VPS28_N_sf |
PANTHERi | PTHR12937, PTHR12937, 1 hit |
Pfami | View protein in Pfam PF03997, VPS28, 1 hit |
PIRSFi | PIRSF017535, VPS28, 1 hit |
SUPFAMi | SSF140111, SSF140111, 1 hit SSF140427, SSF140427, 1 hit |
PROSITEi | View protein in PROSITE PS51310, VPS28_C, 1 hit PS51313, VPS28_N, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VPS28_CAEEL | |
Accessioni | Q9NA26Primary (citable) accession number: Q9NA26 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2001 |
Last sequence update: | October 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 115 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase - SIMILARITY comments
Index of protein domains and families