Zinc finger protein sens

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• bHLH transcription factor binding Source: FlyBase <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Senseless physically interacts with proneural proteins and functions as a transcriptional co-activator."
    Acar M., Jafar-Nejad H., Giagtzoglou N., Yallampalli S., David G., He Y., Delidakis C., Bellen H.J.
    Development 133:1979-1989(2006) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: FlyBaseInferred from direct assayⁱ
  • "Hox and senseless antagonism functions as a molecular switch to regulate EGF secretion in the Drosophila PNS."
    Li-Kroeger D., Witt L.M., Grimes H.L., Cook T.A., Gebelein B.
    Dev Cell 15:298-308(2008) [PubMed] [Europe PMC] [Abstract]
• metal ion binding Source: UniProtKB-KW
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: FlyBaseInferred from direct assayⁱ
  • "Hox and senseless antagonism functions as a molecular switch to regulate EGF secretion in the Drosophila PNS."
    Li-Kroeger D., Witt L.M., Grimes H.L., Cook T.A., Gebelein B.
    Dev Cell 15:298-308(2008) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• axon guidance Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Coordinate control of synaptic-layer specificity and rhodopsins in photoreceptor neurons."
    Morey M., Yee S.K., Herman T., Nern A., Blanco E., Zipursky S.L.
    Nature 456:795-799(2008) [PubMed] [Europe PMC] [Abstract]
• chaeta morphogenesis Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Evidence that nervy, the Drosophila homolog of ETO/MTG8, promotes mechanosensory organ development by enhancing Notch signaling."
    Wildonger J., Mann R.S.
    Dev Biol 286:507-520(2005) [PubMed] [Europe PMC] [Abstract]
• compound eye photoreceptor development Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Senseless represses nuclear transduction of Egfr pathway activation."
    Frankfort B.J., Mardon G.
    Development 131:563-570(2004) [PubMed] [Europe PMC] [Abstract]
• negative regulation of apoptotic process Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Switch of rhodopsin expression in terminally differentiated Drosophila sensory neurons."
    Sprecher S.G., Desplan C.
    Nature 454:533-537(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: FlyBaseInferred from direct assayⁱ
  • "Hox and senseless antagonism functions as a molecular switch to regulate EGF secretion in the Drosophila PNS."
    Li-Kroeger D., Witt L.M., Grimes H.L., Cook T.A., Gebelein B.
    Dev Cell 15:298-308(2008) [PubMed] [Europe PMC] [Abstract]
• Notch signaling pathway Source: UniProtKB-KW
• peripheral nervous system development Source: FlyBaseInferred from mutant phenotypeⁱ
  • Ref.1

    "Senseless, a Zn finger transcription factor, is necessary and sufficient for sensory organ development in Drosophila."
    Nolo R., Abbott L.A., Bellen H.J.
    Cell 102:349-362(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DNA-BINDING, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
• photoreceptor cell differentiation Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Binary cell fate decisions and fate transformation in the Drosophila larval eye."
    Mishra A.K., Tsachaki M., Rister J., Ng J., Celik A., Sprecher S.G.
    PLoS Genet 9:e1004027-e1004027(2013) [PubMed] [Europe PMC] [Abstract]
• photoreceptor cell morphogenesis Source: FlyBaseInferred from mutant phenotypeⁱ
  • Ref.5

    "senseless repression of rough is required for R8 photoreceptor differentiation in the developing Drosophila eye."
    Frankfort B.J., Nolo R., Zhang Z., Bellen H., Mardon G.
    Neuron 32:403-414(2001) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, TISSUE SPECIFICITY.
• positive regulation of transcription by RNA polymerase II Source: GOC
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• sensory organ development Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Senseless and Daughterless confer neuronal identity to epithelial cells in the Drosophila wing margin."
    Jafar-Nejad H., Tien A.C., Acar M., Bellen H.J.
    Development 133:1683-1692(2006) [PubMed] [Europe PMC] [Abstract]
  • "Senseless physically interacts with proneural proteins and functions as a transcriptional co-activator."
    Acar M., Jafar-Nejad H., Giagtzoglou N., Yallampalli S., David G., He Y., Delidakis C., Bellen H.J.
    Development 133:1979-1989(2006) [PubMed] [Europe PMC] [Abstract]
• sensory organ precursor cell fate determination Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Senseless and Daughterless confer neuronal identity to epithelial cells in the Drosophila wing margin."
    Jafar-Nejad H., Tien A.C., Acar M., Bellen H.J.
    Development 133:1683-1692(2006) [PubMed] [Europe PMC] [Abstract]
• visual perception Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• bHLH transcription factor binding Source: FlyBaseInferred from direct assayⁱ
  • "Senseless physically interacts with proneural proteins and functions as a transcriptional co-activator."
    Acar M., Jafar-Nejad H., Giagtzoglou N., Yallampalli S., David G., He Y., Delidakis C., Bellen H.J.
    Development 133:1979-1989(2006) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Compositional bias

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MNHLSPPPSP HSQQPSPAGL GCHGAALDKQ WMQRASAFNT VIASAAAQKL 
        60         70         80         90        100
NGRDLPFLYN PLLYSSALLW PQFLLSSATA LGTPLTPMTP KSPASVVLGQ 
       110        120        130        140        150
RDRDFALTPE KEHELQMNNN NENSKQDYQE QDEDMPLNLS TKERITSDDS 
       160        170        180        190        200
NRDQYHSSSN NSSRSSSSSE VEQLHPMTSL NVTPPPLSAV NLKSSSTPQQ 
       210        220        230        240        250
QRQRSQGNII WSPASMCERS ARREQYGLKM EEQGDEEEHQ VDPIVRKFKY 
       260        270        280        290        300
ERRTASISSL QSPISSLSAP ASNAVQDLEF EVAQQQLYAH RSAFMAGLTG 
       310        320        330        340        350
NNLELLTQHL KLKSEQPQQQ QQQHRIKDEQ QQDNRSAAAL MNLVAAAEFG 
       360        370        380        390        400
YMRNQHQQPQ QQQQQQLHHQ QQPQQHQHQQ QHPDSTATDV ARRSSSSSSY 
       410        420        430        440        450
QGENEEKRSG RNFQCKQCGK SFKRSSTLST HLLIHSDTRP YPCQYCGKRF 
       460        470        480        490        500
HQKSDMKKHT YIHTGEKPHK CTVCLKAFSQ SSNLITHMRK HTGYKPFGCH 
       510        520        530        540 
LCDQSFQRKV DLRRHRESRH EEAPPVEDLK PLKMEVSSSS C          

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Drosophila
   Drosophila: entries, gene names and cross-references to FlyBase