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UniProtKB - Q9N658 (GFI1_DROME)
Protein
Zinc finger protein sens
Gene
sens
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Transcription factor both necessary and sufficient for proper development of most cell types of the embryonic and adult peripheral nervous system (PNS). Essential component of the proneural Notch signaling pathway required for proper sensory organ precursor (SOP) differentiation. Correct expression requires expression of scalloped (sd). Repression of rough (ro) in R8 photoreceptor is an essential mechanism of R8 cell fate determination.
3 PublicationsRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 413 – 435 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 441 – 463 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 469 – 491 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 497 – 520 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- bHLH transcription factor binding Source: FlyBase
- DNA-binding transcription factor activity Source: GO_Central
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: FlyBase
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: FlyBase
GO - Biological processi
- axon guidance Source: FlyBase
- chaeta morphogenesis Source: FlyBase
- compound eye photoreceptor development Source: FlyBase
- negative regulation of apoptotic process Source: FlyBase
- negative regulation of transcription by RNA polymerase II Source: FlyBase
- Notch signaling pathway Source: UniProtKB-KW
- peripheral nervous system development Source: FlyBase
- photoreceptor cell differentiation Source: FlyBase
- photoreceptor cell morphogenesis Source: FlyBase
- positive regulation of transcription by RNA polymerase II Source: GOC
- regulation of transcription by RNA polymerase II Source: GO_Central
- sensory organ development Source: FlyBase
- sensory organ precursor cell fate determination Source: FlyBase
- visual perception Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Notch signaling pathway, Sensory transduction, Transcription, Transcription regulation, Vision |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
SignaLinki | Q9N658 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein sensAlternative name(s): Protein senseless |
Gene namesi | Name:sens Synonyms:Lyra ORF Names:CG32120 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0002573, sens |
VEuPathDBi | VectorBase:FBgn0002573 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nucleus Source: FlyBase
Other locations
- polytene chromosome Source: FlyBase
Keywords - Cellular componenti
NucleusPathology & Biotechi
Disruption phenotypei
Mutants abolish the further up-regulation and maintenance of proneural gene expression in the SOPs.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000046922 | 1 – 541 | Zinc finger protein sensAdd BLAST | 541 |
Proteomic databases
PaxDbi | Q9N658 |
Expressioni
Tissue specificityi
Almost exclusively restricted to precursors and early differentiating cells of the embryonic PNS. Expressed in the R8 photoreceptor during third instar eye development beginning within the morphogenetic furrow of the eye imaginal disk.2 Publications
Gene expression databases
Bgeei | FBgn0002573, Expressed in saliva-secreting gland and 47 other tissues |
ExpressionAtlasi | Q9N658, baseline and differential |
Genevisiblei | Q9N658, DM |
Interactioni
GO - Molecular functioni
- bHLH transcription factor binding Source: FlyBase
Protein-protein interaction databases
BioGRIDi | 69594, 31 interactors |
STRINGi | 7227.FBpp0075596 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 21 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 110 – 216 | DisorderedSequence analysisAdd BLAST | 107 | |
Regioni | 313 – 334 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 354 – 412 | DisorderedSequence analysisAdd BLAST | 59 | |
Regioni | 514 – 541 | DisorderedSequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 126 – 151 | Basic and acidic residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 152 – 213 | Polar residuesSequence analysisAdd BLAST | 62 | |
Compositional biasi | 354 – 403 | Polar residuesSequence analysisAdd BLAST | 50 | |
Compositional biasi | 514 – 529 | Basic and acidic residuesSequence analysisAdd BLAST | 16 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 413 – 435 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 441 – 463 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 469 – 491 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 497 – 520 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000156166 |
HOGENOMi | CLU_030838_0_0_1 |
InParanoidi | Q9N658 |
OMAi | KFKYERR |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9N658 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
i Sequence
Sequence statusi: Complete.
Q9N658-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNHLSPPPSP HSQQPSPAGL GCHGAALDKQ WMQRASAFNT VIASAAAQKL
60 70 80 90 100
NGRDLPFLYN PLLYSSALLW PQFLLSSATA LGTPLTPMTP KSPASVVLGQ
110 120 130 140 150
RDRDFALTPE KEHELQMNNN NENSKQDYQE QDEDMPLNLS TKERITSDDS
160 170 180 190 200
NRDQYHSSSN NSSRSSSSSE VEQLHPMTSL NVTPPPLSAV NLKSSSTPQQ
210 220 230 240 250
QRQRSQGNII WSPASMCERS ARREQYGLKM EEQGDEEEHQ VDPIVRKFKY
260 270 280 290 300
ERRTASISSL QSPISSLSAP ASNAVQDLEF EVAQQQLYAH RSAFMAGLTG
310 320 330 340 350
NNLELLTQHL KLKSEQPQQQ QQQHRIKDEQ QQDNRSAAAL MNLVAAAEFG
360 370 380 390 400
YMRNQHQQPQ QQQQQQLHHQ QQPQQHQHQQ QHPDSTATDV ARRSSSSSSY
410 420 430 440 450
QGENEEKRSG RNFQCKQCGK SFKRSSTLST HLLIHSDTRP YPCQYCGKRF
460 470 480 490 500
HQKSDMKKHT YIHTGEKPHK CTVCLKAFSQ SSNLITHMRK HTGYKPFGCH
510 520 530 540
LCDQSFQRKV DLRRHRESRH EEAPPVEDLK PLKMEVSSSS C
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF212312 mRNA Translation: AAF32280.1 AF212313 Genomic DNA Translation: AAF32281.1 AE014296 Genomic DNA Translation: AAN11834.1 BT022164 mRNA Translation: AAY51558.1 |
RefSeqi | NP_524818.1, NM_080079.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0075862; FBpp0075596; FBgn0002573 |
GeneIDi | 45328 |
KEGGi | dme:Dmel_CG32120 |
UCSCi | CG32120-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF212312 mRNA Translation: AAF32280.1 AF212313 Genomic DNA Translation: AAF32281.1 AE014296 Genomic DNA Translation: AAN11834.1 BT022164 mRNA Translation: AAY51558.1 |
RefSeqi | NP_524818.1, NM_080079.3 |
3D structure databases
AlphaFoldDBi | Q9N658 |
SMRi | Q9N658 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 69594, 31 interactors |
STRINGi | 7227.FBpp0075596 |
Proteomic databases
PaxDbi | Q9N658 |
Protocols and materials databases
DNASUi | 45328 |
Genome annotation databases
EnsemblMetazoai | FBtr0075862; FBpp0075596; FBgn0002573 |
GeneIDi | 45328 |
KEGGi | dme:Dmel_CG32120 |
UCSCi | CG32120-RA, d. melanogaster |
Organism-specific databases
CTDi | 45328 |
FlyBasei | FBgn0002573, sens |
VEuPathDBi | VectorBase:FBgn0002573 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000156166 |
HOGENOMi | CLU_030838_0_0_1 |
InParanoidi | Q9N658 |
OMAi | KFKYERR |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9N658 |
Enzyme and pathway databases
SignaLinki | Q9N658 |
Miscellaneous databases
BioGRID-ORCSi | 45328, 0 hits in 3 CRISPR screens |
ChiTaRSi | sens, fly |
GenomeRNAii | 45328 |
PROi | PR:Q9N658 |
Gene expression databases
Bgeei | FBgn0002573, Expressed in saliva-secreting gland and 47 other tissues |
ExpressionAtlasi | Q9N658, baseline and differential |
Genevisiblei | Q9N658, DM |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | GFI1_DROME | |
Accessioni | Q9N658Primary (citable) accession number: Q9N658 Secondary accession number(s): Q4V6Z2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 5, 2004 |
Last sequence update: | October 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 154 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase