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Protein

Chloroquine resistance transporter

Gene

CRT

Organism
Plasmodium falciparum
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May regulate endogenous transporter.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.7.20.1 the drug/metabolite transporter (dmt) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chloroquine resistance transporter
Short name:
PfCRT
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CRT
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparum
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5833 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 58CytoplasmicSequence analysisAdd BLAST58
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei59 – 79HelicalSequence analysisAdd BLAST21
Topological domaini80 – 90LumenalSequence analysisAdd BLAST11
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Topological domaini112 – 127CytoplasmicSequence analysisAdd BLAST16
Transmembranei128 – 148HelicalSequence analysisAdd BLAST21
Topological domaini149 – 154LumenalSequence analysis6
Transmembranei155 – 175HelicalSequence analysisAdd BLAST21
Topological domaini176 – 178CytoplasmicSequence analysis3
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Topological domaini200 – 209LumenalSequence analysis10
Transmembranei210 – 230HelicalSequence analysisAdd BLAST21
Topological domaini231 – 248CytoplasmicSequence analysisAdd BLAST18
Transmembranei249 – 269HelicalSequence analysisAdd BLAST21
Topological domaini270 – 317LumenalSequence analysisAdd BLAST48
Transmembranei318 – 338HelicalSequence analysisAdd BLAST21
Topological domaini339 – 346CytoplasmicSequence analysis8
Transmembranei347 – 367HelicalSequence analysisAdd BLAST21
Topological domaini368 – 377LumenalSequence analysis10
Transmembranei378 – 398HelicalSequence analysisAdd BLAST21
Topological domaini399 – 424CytoplasmicSequence analysisAdd BLAST26

GO - Cellular componenti

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane, Vacuole

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1795182

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003853551 – 424Chloroquine resistance transporterAdd BLAST424

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi88N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9N623

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9N623

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CRT-like transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IYRE Eukaryota
ENOG4111P31 LUCA

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013936 CRT-like
IPR017258 Transprt_Chloroquine

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08627 CRT-like, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037671 Transprt_Chloroquine_res, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9N623-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKFASKKNNQ KNSSKNDERY RELDNLVQEG NGSRLGGGSC LGKCAHVFKL
60 70 80 90 100
IFKEIKDNIF IYILSIIYLS VCVMNKIFAK RTLNKIGNYS FVTSETHNFI
110 120 130 140 150
CMIMFFIVYS LFGNKKGNSK ERHRSFNLQF FAISMLDACS VILAFIGLTR
160 170 180 190 200
TTGNIQSFVL QLSIPINMFF CFLILRYRYH LYNYLGAVII VVTIALVEMK
210 220 230 240 250
LSFETQEENS IIFNLVLISA LIPVCFSNMT REIVFKKYKI DILRLNAMVS
260 270 280 290 300
FFQLFTSCLI LPVYTLPFLK QLHLPYNEIW TNIKNGFACL FLGRNTVVEN
310 320 330 340 350
CGLGMAKLCD DCDGAWKTFA LFSFFNICDN LITSYIIDKF STMTYTIVSC
360 370 380 390 400
IQGPAIAIAY YFKFLAGDVV REPRLLDFVT LFGYLFGSII YRVGNIILER
410 420
KKMRNEENED SEGELTNVDS IITQ
Length:424
Mass (Da):48,675
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEC642763C5C73732
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti72C → R Reduced sensitivity to quinine. 1 Publication1
Natural varianti72C → S1 Publication1
Natural varianti74M → I4 Publications1
Natural varianti75N → E5 Publications1
Natural varianti75N → K1 Publication1
Natural varianti76K → I Reduced sensitivity to quinine. 3 Publications1
Natural varianti76K → N Reduced sensitivity to quinine. 2 Publications1
Natural varianti76K → T in chloroquine resistance type 1; associated with S-220 and in chloroquine resistance type 2; associated with T-144, Y-160 and D-326; reduced sensitivity to drugs. 7 Publications1
Natural varianti97H → Q1 Publication1
Natural varianti123H → R1 Publication1
Natural varianti144A → T in chloroquine resistance type 2; associated with T-76, Y-160 and D-326. 1 Publication1
Natural varianti152T → A1 Publication1
Natural varianti160L → Y in chloroquine resistance type 2; associated with T-76, T-144 and D-326. 1 Publication1
Natural varianti163S → R May repel chloroquine from moving through the channel, leading to higher chloroquine accumulation at its site of action. 1 Publication1
Natural varianti205T → A1 Publication1
Natural varianti220A → S in chloroquine resistance type 1; associated with T-76. 5 Publications1
Natural varianti271Q → E4 Publications1
Natural varianti275P → L1 Publication1
Natural varianti326N → D in chloroquine resistance type 2; associated with T-76, T-144 and Y-160. 3 Publications1
Natural varianti326N → S4 Publications1
Natural varianti333T → S1 Publication1
Natural varianti334S → N1 Publication1
Natural varianti352Q → K Reduced sensitivity to quinine. 1 Publication1
Natural varianti352Q → R Reduced sensitivity to quinine. 1 Publication1
Natural varianti356I → L2 Publications1
Natural varianti356I → T1 Publication1
Natural varianti356I → V1 Publication1
Natural varianti371R → I5 Publications1
Natural varianti371R → T1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF030694 Genomic DNA Translation: AAF26926.1
AF233064 mRNA Translation: AAF60271.1
AF233065 mRNA Translation: AAF60272.1
AF233066 mRNA Translation: AAF60273.1
AF233067 mRNA Translation: AAF60274.1
AF233068 mRNA Translation: AAF60275.1
AF495376 Genomic DNA Translation: AAO85506.1
AF495377 Genomic DNA Translation: AAO85507.1
AF495378 Genomic DNA Translation: AAO85508.1
AY651315 mRNA Translation: AAU00067.1
AF468006 mRNA Translation: AAL75580.1
DQ156107 mRNA Translation: AAZ81606.1
DQ156108 mRNA Translation: AAZ81607.1
DQ156109 mRNA Translation: AAZ81608.1
DQ533840 mRNA Translation: ABF82363.1
AY254700 mRNA Translation: AAP79044.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030694 Genomic DNA Translation: AAF26926.1
AF233064 mRNA Translation: AAF60271.1
AF233065 mRNA Translation: AAF60272.1
AF233066 mRNA Translation: AAF60273.1
AF233067 mRNA Translation: AAF60274.1
AF233068 mRNA Translation: AAF60275.1
AF495376 Genomic DNA Translation: AAO85506.1
AF495377 Genomic DNA Translation: AAO85507.1
AF495378 Genomic DNA Translation: AAO85508.1
AY651315 mRNA Translation: AAU00067.1
AF468006 mRNA Translation: AAL75580.1
DQ156107 mRNA Translation: AAZ81606.1
DQ156108 mRNA Translation: AAZ81607.1
DQ156109 mRNA Translation: AAZ81608.1
DQ533840 mRNA Translation: ABF82363.1
AY254700 mRNA Translation: AAP79044.1

3D structure databases

ProteinModelPortaliQ9N623
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

BindingDBiQ9N623
ChEMBLiCHEMBL1795182

Protein family/group databases

TCDBi2.A.7.20.1 the drug/metabolite transporter (dmt) superfamily

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IYRE Eukaryota
ENOG4111P31 LUCA

Family and domain databases

InterProiView protein in InterPro
IPR013936 CRT-like
IPR017258 Transprt_Chloroquine
PfamiView protein in Pfam
PF08627 CRT-like, 1 hit
PIRSFiPIRSF037671 Transprt_Chloroquine_res, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCRT_PLAFA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9N623
Secondary accession number(s): Q19AE2
, Q3Y5Z4, Q3Y5Z5, Q3Y5Z6, Q68PG1, Q6X529, Q7KQ06, Q86M68, Q86M69, Q86M70, Q8T9R7, Q9N653, Q9NH61
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: October 1, 2000
Last modified: January 31, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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