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Entry version 155 (16 Oct 2019)
Sequence version 2 (01 Oct 2001)
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Protein
Submitted name:

TIR domain-containing protein

Gene

tol-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-193634 Axonal growth inhibition (RHOA activation)
R-CEL-977606 Regulation of Complement cascade

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
TIR domain-containing proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tol-1Imported
ORF Names:C07F11.1Imported, CELE_C07F11.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
C07F11.1 ; CE28818 ; WBGene00006593 ; tol-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei997 – 1021HelicalSequence analysisAdd BLAST25

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500433081424 – 1221Sequence analysisAdd BLAST1198

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9N5Z3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9N5Z3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00006593 Expressed in 5 organ(s), highest expression level in multi-cellular organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-24325N

Protein interaction database and analysis system

More...
IntActi
Q9N5Z3, 1 interactor

STRING: functional protein association networks

More...
STRINGi
6239.C07F11.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1054 – 1194TIRInterPro annotationAdd BLAST141

Keywords - Domaini

Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4641 Eukaryota
COG4886 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000175807

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9N5Z3

Identification of Orthologs from Complete Genome Data

More...
OMAi
QINDELC

Database of Orthologous Groups

More...
OrthoDBi
282372at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9N5Z3

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.10140, 1 hit
3.80.10.10, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000157 TIR_dom
IPR035897 Toll_tir_struct_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13855 LRR_8, 4 hits
PF13676 TIR_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369 LRR_TYP, 13 hits
SM00255 TIR, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52200 SSF52200, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450 LRR, 22 hits
PS50104 TIR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9N5Z3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRRKMKLFLF LLLVINICRS AAANGDECPK FCKCAPDPVQ PTSKLLLCDY
60 70 80 90 100
SSKNTTITPI ASSNYDQVAN IRSLFISCDN NNFQFPDAYF KSLTALHHLR
110 120 130 140 150
IVGCETTHFS VKLFEDLAAL RRLELDQIST ASTSFEMTED VLMPLARLEK
160 170 180 190 200
FSLTRSRNIE LPQRLLCSLP HLQVLNISSN ELPSLRREES CVAQQLLIVD
210 220 230 240 250
LSRNRLTNIE QFLRGIPAIR QISVAYNSIA ELDLSLATPF LQQLDAEANR
260 270 280 290 300
IVDLTSLPGT VVHVNLAGNA LKRVPDAVAE LASLVALNVS RNEIEAGNSS
310 320 330 340 350
VFSSPELEML DASYNKLDSL PVEWLQKCEK RIAHLHLEHN SIEQLTGGVL
360 370 380 390 400
ANATNLQTLD LSSNQLRVFR DEVLPENSKI GNLRLSNNSL ELLEPSSLSG
410 420 430 440 450
LKLESLDLSH NKLTEVPAAI GKVEQLKKVD LSHNRIAKVY QYVLNKIKQL
460 470 480 490 500
HTVDLSNNQL QSIGPYIFSD SSELHSLDVS NNEISLLFKD AFARCPKLRK
510 520 530 540 550
ISMKMNKIKS LDEGLTEASG LRRLDVSHNE ILVLKWSALP ENLEILNADN
560 570 580 590 600
NDINLLTAAS MSPSTANLKS VSLSNNGITI MNADQIPNSL ESLDVSNNRL
610 620 630 640 650
AKLGKTALAA KSQLRRLNLK GNLLTVVATE SMKVVEAVHP LKVEISENPL
660 670 680 690 700
ICDCQMGWMI GGAKPKVLIQ DSETASCSHA VDGHQIQIQS LSKKDLLCPY
710 720 730 740 750
KSVCEPECIC CQYGNCDCKS VCPANCRCFR DDQFNINIVR CHGNSSMVPK
760 770 780 790 800
REFVVSELPV SATEIILSGV TLPQLRTHSF IGRLRLQRLH INGTGLRSIQ
810 820 830 840 850
PKAFHTLPAL KTLDLSDNSL ISLSGEEFLK CGEVSQLFLN GNRFSTLSRG
860 870 880 890 900
IFEKLPNLKY LTLHNNSLED IPQVLHSTAL SKISLSSNPL RCDCSGGSQQ
910 920 930 940 950
HLHHRRDPKA HPFWEHNAAE WFSLHRHLVV DFPKVECWEN VTKAFLTNDT
960 970 980 990 1000
TVLSAYPPNM GNDVFVMPIE EFLRDYNSTI CVPFSSGFFG QDPQNSILFV
1010 1020 1030 1040 1050
IITISIAVLL CVLVILAISF IRKSHDAINQ RRYKASSLNC STSAGSSPLP
1060 1070 1080 1090 1100
VPLLSYHAFV SYSKKDEKMV IDQLCRPLED EDYQLCLLHR DGPTYCSNLH
1110 1120 1130 1140 1150
AISDELIAQM DSSQCLILVL TKHFLENEWK TLQIKTSHQL FAKNRAKRVI
1160 1170 1180 1190 1200
AVLGDGVDAN LLDDELGQIL RKHTRIEMRS HLFWTLLHSS LPSRLPLPSN
1210 1220
SGDDSSQLYS DIYGIVPSDV V
Length:1,221
Mass (Da):136,093
Last modified:October 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB1FAE447CD04B10F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CCD63554.1

NCBI Reference Sequences

More...
RefSeqi
NP_001020983.1, NM_001025812.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C07F11.1.1; C07F11.1.1; WBGene00006593

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
171635

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_C07F11.1

UCSC genome browser

More...
UCSCi
C07F11.1 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CCD63554.1
RefSeqiNP_001020983.1, NM_001025812.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

DIPiDIP-24325N
IntActiQ9N5Z3, 1 interactor
STRINGi6239.C07F11.1

Proteomic databases

EPDiQ9N5Z3
PaxDbiQ9N5Z3

Genome annotation databases

EnsemblMetazoaiC07F11.1.1; C07F11.1.1; WBGene00006593
GeneIDi171635
KEGGicel:CELE_C07F11.1
UCSCiC07F11.1 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
171635
WormBaseiC07F11.1 ; CE28818 ; WBGene00006593 ; tol-1

Phylogenomic databases

eggNOGiKOG4641 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00940000175807
InParanoidiQ9N5Z3
OMAiQINDELC
OrthoDBi282372at2759
PhylomeDBiQ9N5Z3

Enzyme and pathway databases

ReactomeiR-CEL-193634 Axonal growth inhibition (RHOA activation)
R-CEL-977606 Regulation of Complement cascade

Gene expression databases

BgeeiWBGene00006593 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Family and domain databases

Gene3Di3.40.50.10140, 1 hit
3.80.10.10, 5 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000157 TIR_dom
IPR035897 Toll_tir_struct_dom_sf
PfamiView protein in Pfam
PF13855 LRR_8, 4 hits
PF13676 TIR_2, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 13 hits
SM00255 TIR, 1 hit
SUPFAMiSSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 22 hits
PS50104 TIR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9N5Z3_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9N5Z3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2001
Last modified: October 16, 2019
This is version 155 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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