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Entry version 144 (07 Apr 2021)
Sequence version 2 (01 Oct 2001)
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Protein
Submitted name:

Importin N-terminal domain-containing protein

Gene

imb-3

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transportARBA annotation, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Importin N-terminal domain-containing proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:imb-3Imported
ORF Names:C53D5.6Imported, CELE_C53D5.6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
C53D5.6 ; CE26971 ; WBGene00002077 ; imb-3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

CytoplasmARBA annotation, NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9N5V3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9N5V3

PeptideAtlas

More...
PeptideAtlasi
Q9N5V3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00002077, Expressed in material anatomical entity and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

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DIPi
DIP-26917N

Protein interaction database and analysis system

More...
IntActi
Q9N5V3, 9 interactors

STRING: functional protein association networks

More...
STRINGi
6239.C53D5.6

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9N5V3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 94Importin N-terminalInterPro annotationAdd BLAST71

Keywords - Domaini

RepeatARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2171, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000169161

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003794_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9N5V3

Identification of Orthologs from Complete Genome Data

More...
OMAi
AQYLMHC

Database of Orthologous Groups

More...
OrthoDBi
90499at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9N5V3

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR000357, HEAT
IPR001494, Importin-beta_N
IPR040122, Importin_beta
IPR041653, Importin_rep_4
IPR041389, Importin_rep_6

The PANTHER Classification System

More...
PANTHERi
PTHR10527, PTHR10527, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02985, HEAT, 1 hit
PF18808, Importin_rep_4, 1 hit
PF18829, Importin_rep_6, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50166, IMPORTIN_B_NT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9N5V3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDVNQFTELI TKLQSADNDI RKQAEEVYEK IEGPTKVAAL FEAYTHHTNN
60 70 80 90 100
SDARSTVLVF LRRVLARDWD AIWETLNEEN KQRILAKVLE MIVHETELSI
110 120 130 140 150
KKKIADLISE IASNLIDDSG DMTWGGVLEL MDHCLKSEDL TGNYIALLIL
160 170 180 190 200
RGCPIIFGNR LAHFLPTLKV VLEKCMATPD LQIKATAVRA VIAFAVDNDE
210 220 230 240 250
EKDVVRLMTS LVPNVLQVCN ETSDEDDSDG PLGEFAELAS SLPKCLNTHM
260 270 280 290 300
SQVLQVTLAI AGNKEKNEMV RQNAIEVICS YMESAPKGLK KYAPGALGPI
310 320 330 340 350
LETLLSCMTE MDDDVLNEWL NEIEEEEDYE DIPIIAESAI DRVACCINGK
360 370 380 390 400
VMLPVFLPLV EKLLTSEDWK MKHAALRAFS AVGEGCQRSM EPHIEQIMAH
410 420 430 440 450
ITNYVNDAHP RVQYAACNAI GQMSSDFAPT LQKKCHAAVI PALLESLDRT
460 470 480 490 500
DVPRVCAHAA SALVNFAEEC PKSIIGQYLP FILQKLENVL SAVFNRLGDK
510 520 530 540 550
RYQVVVENIV TAIASVAEAA EELFKEHHAR LIPNLVHILQ NVGELKELRG
560 570 580 590 600
KTIECISLIG YAVGKEQFHA TAIEILNLLG DGMKDLAIDD PQYSYMISSW
610 620 630 640 650
TRFCSILGAD FAPFLPVVMD PVLRAARYRP DFNIFNNEDV HENEEGVEYH
660 670 680 690 700
GIGGEKTVGI RTSGLEEKAT ACDMLVAFAK EMKEAFMPYV VDVYELAIKN
710 720 730 740 750
LDFGLHDGVR TASAEIMPCL LTCVEKQGLA DKRRLWCEFL KALTTSMEEE
760 770 780 790 800
DDVEILASFM TTIGSCIEVM KTEGIAEEEV QLIISVLLKQ LENYGKRMSD
810 820 830 840 850
RPVEDEDDDD AEAKEELDYF MELEASCLGA ISDLTHSLMK EFKGTIFEGM
860 870 880 890 900
INVFNCAIQL IEGSKQYFER QWGMCLLDDA IEFGVGHMPT RFPKLIPIMY
910 920 930 940 950
KLLGDEYPEV RQAASYGFGV MAINYHQISD YRNEILSCLE PLAAMIQRED
960 970 980 990 1000
ARATEESTVA TENAISAFAK IIGNVPLPAE AYGKVVEMFL SWLPTYSDTE
1010 1020 1030 1040 1050
ESPYIYTCLA ELFDKQDAAL FGPENQNLPR IFLVCLLSIA NDAFNDDDSG
1060 1070 1080 1090
NQTKQRIVTI LKQIYASFPQ FAQQDGIDEH LTSVLQQTLN GQ
Length:1,092
Mass (Da):122,033
Last modified:October 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i81DC1EECC3EC6552
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CCD67936.1

NCBI Reference Sequences

More...
RefSeqi
NP_490715.1, NM_058314.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C53D5.6.1; C53D5.6.1; WBGene00002077

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3565440

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_C53D5.6

UCSC genome browser

More...
UCSCi
C53D5.6, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CCD67936.1
RefSeqiNP_490715.1, NM_058314.4

3D structure databases

SMRiQ9N5V3
ModBaseiSearch...

Protein-protein interaction databases

DIPiDIP-26917N
IntActiQ9N5V3, 9 interactors
STRINGi6239.C53D5.6

Proteomic databases

EPDiQ9N5V3
PaxDbiQ9N5V3
PeptideAtlasiQ9N5V3

Genome annotation databases

EnsemblMetazoaiC53D5.6.1; C53D5.6.1; WBGene00002077
GeneIDi3565440
KEGGicel:CELE_C53D5.6
UCSCiC53D5.6, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3565440
WormBaseiC53D5.6 ; CE26971 ; WBGene00002077 ; imb-3

Phylogenomic databases

eggNOGiKOG2171, Eukaryota
GeneTreeiENSGT00940000169161
HOGENOMiCLU_003794_0_0_1
InParanoidiQ9N5V3
OMAiAQYLMHC
OrthoDBi90499at2759
PhylomeDBiQ9N5V3

Gene expression databases

BgeeiWBGene00002077, Expressed in material anatomical entity and 5 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR000357, HEAT
IPR001494, Importin-beta_N
IPR040122, Importin_beta
IPR041653, Importin_rep_4
IPR041389, Importin_rep_6
PANTHERiPTHR10527, PTHR10527, 1 hit
PfamiView protein in Pfam
PF02985, HEAT, 1 hit
PF18808, Importin_rep_4, 1 hit
PF18829, Importin_rep_6, 1 hit
SUPFAMiSSF48371, SSF48371, 2 hits
PROSITEiView protein in PROSITE
PS50166, IMPORTIN_B_NT, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9N5V3_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9N5V3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2001
Last modified: April 7, 2021
This is version 144 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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