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Entry version 121 (11 Dec 2019)
Sequence version 4 (06 Feb 2013)
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Protein

Cell division cycle protein 73

Gene

cdc-73

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the PAF1 complex which is a multifunctional complex involved in transcription initiation via genetic interactions with TATA-binding proteins, elongation and transcription-coupled histone modification.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-112382 Formation of RNA Pol II elongation complex
R-CEL-201722 Formation of the beta-catenin:TCF transactivating complex
R-CEL-674695 RNA Polymerase II Pre-transcription Events
R-CEL-75955 RNA Polymerase II Transcription Elongation
R-CEL-8866654 E3 ubiquitin ligases ubiquitinate target proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cell division cycle protein 73By similarity
Alternative name(s):
RNA polymerase-associated protein CDC73By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cdc-73Imported
ORF Names:F35F11.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

More...
WormBasei
F35F11.1 ; CE48035 ; WBGene00018064 ; cdc-73

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi mediated knock-down is embryonic lethal. Embryogenesis proceeds more slowly, with embryos displaying defects in the positioning and shape of epidermal cells. 60% of embryos arrest at the bean stage of embryogenesis without any significant change in body shape. Nuclear localization of rtf-1 is unaffected.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004315111 – 517Cell division cycle protein 73Add BLAST517

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9N5U5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9N5U5

PeptideAtlas

More...
PeptideAtlasi
Q9N5U5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00018064 Expressed in 5 organ(s), highest expression level in material anatomical entity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the PAF1 complex which consists of at least cdc-73, ctr-9, leo-1, pafo-1 and rtfo-1.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-966 PAF1 complex

Database of interacting proteins

More...
DIPi
DIP-25821N

STRING: functional protein association networks

More...
STRINGi
6239.F35F11.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9N5U5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CDC73 family.Sequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3786 Eukaryota
COG5157 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000001114

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000022407

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9N5U5

KEGG Orthology (KO)

More...
KOi
K15175

Identification of Orthologs from Complete Genome Data

More...
OMAi
NVARWAV

Database of Orthologous Groups

More...
OrthoDBi
720340at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.11990, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007852 Cdc73/Parafibromin
IPR031336 CDC73_C
IPR038103 CDC73_C_sf
IPR032041 Cdc73_N

The PANTHER Classification System

More...
PANTHERi
PTHR12466 PTHR12466, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05179 CDC73_C, 1 hit
PF16050 CDC73_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9N5U5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPLEALQKH VQRPEEFPLR EVTVSGISYV AFGDYAYKKD TETSLQIYGK
60 70 80 90 100
SDEFYSLESL VVFLKYSHEN HGVYVKEAAA AGVRAVTRID RKNVTEYLQG
110 120 130 140 150
DRTDFPALMN QVNPLSLRQL LHSSEPEAKK PRLDGEAAGE PMDTSTSDEP
160 170 180 190 200
QESAVSAAKK EVEIRALNDN LTKDRIAEMR RKRQSHREKG IVTIDESLST
210 220 230 240 250
LTSASLPKTR IHKTRENVML GARDLSNVLD IITSAQRQWD LNEKKEKVAA
260 270 280 290 300
VHATNLSKDQ SGAAGGQQQR SGYSRYAQEA FAHEKTKEIQ TEGSFIGSNF
310 320 330 340 350
SSIKQGHHAV QKAPDAPPGR PPLAKPIQLL TSSTATSSGS SAAQNGSKRT
360 370 380 390 400
SRSPIIIVPS AMNTMINLYN VRDILQNFSY VPVDQRRKET NKKPVDLAIQ
410 420 430 440 450
RQKNGVTYNI RVIDNAEKLA NDDWDRVIAV FVMGVAWQFK GWKWNGNPTD
460 470 480 490 500
IFTHIPAFHF HVDQDKPVAQ VMQWNVHKIP VSATKRHMDK ARFSQVWETI
510
ENFVRKNKPH LTARLGL
Length:517
Mass (Da):58,093
Last modified:February 6, 2013 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6D8CEE84B50EC47C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FO081297 Genomic DNA Translation: CCD70582.2

NCBI Reference Sequences

More...
RefSeqi
NP_500465.4, NM_068064.6

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F35F11.1.1; F35F11.1.1; WBGene00018064

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
177160

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_F35F11.1

UCSC genome browser

More...
UCSCi
F35F11.1 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081297 Genomic DNA Translation: CCD70582.2
RefSeqiNP_500465.4, NM_068064.6

3D structure databases

SMRiQ9N5U5
ModBaseiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-966 PAF1 complex
DIPiDIP-25821N
STRINGi6239.F35F11.1

Proteomic databases

EPDiQ9N5U5
PaxDbiQ9N5U5
PeptideAtlasiQ9N5U5

Genome annotation databases

EnsemblMetazoaiF35F11.1.1; F35F11.1.1; WBGene00018064
GeneIDi177160
KEGGicel:CELE_F35F11.1
UCSCiF35F11.1 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
177160
WormBaseiF35F11.1 ; CE48035 ; WBGene00018064 ; cdc-73

Phylogenomic databases

eggNOGiKOG3786 Eukaryota
COG5157 LUCA
GeneTreeiENSGT00390000001114
HOGENOMiHOG000022407
InParanoidiQ9N5U5
KOiK15175
OMAiNVARWAV
OrthoDBi720340at2759

Enzyme and pathway databases

ReactomeiR-CEL-112382 Formation of RNA Pol II elongation complex
R-CEL-201722 Formation of the beta-catenin:TCF transactivating complex
R-CEL-674695 RNA Polymerase II Pre-transcription Events
R-CEL-75955 RNA Polymerase II Transcription Elongation
R-CEL-8866654 E3 ubiquitin ligases ubiquitinate target proteins

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9N5U5

Gene expression databases

BgeeiWBGene00018064 Expressed in 5 organ(s), highest expression level in material anatomical entity

Family and domain databases

Gene3Di3.40.50.11990, 1 hit
InterProiView protein in InterPro
IPR007852 Cdc73/Parafibromin
IPR031336 CDC73_C
IPR038103 CDC73_C_sf
IPR032041 Cdc73_N
PANTHERiPTHR12466 PTHR12466, 1 hit
PfamiView protein in Pfam
PF05179 CDC73_C, 1 hit
PF16050 CDC73_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCDC73_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9N5U5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 7, 2015
Last sequence update: February 6, 2013
Last modified: December 11, 2019
This is version 121 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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