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UniProtKB - Q9N5U5 (CDC73_CAEEL)
Protein
Cell division cycle protein 73
Gene
cdc-73
Organism
Caenorhabditis elegans
Status
Functioni
Component of the PAF1 complex which is a multifunctional complex involved in transcription initiation via genetic interactions with TATA-binding proteins, elongation and transcription-coupled histone modification.
By similarityGO - Molecular functioni
- RNA polymerase II complex binding Source: GO_Central
GO - Biological processi
- histone modification Source: InterPro
- positive regulation of transcription elongation from RNA polymerase II promoter Source: GO_Central
- recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex Source: GO_Central
- transcription elongation from RNA polymerase II promoter Source: InterPro
Keywordsi
Molecular function | Activator |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-CEL-112382, Formation of RNA Pol II elongation complex R-CEL-201722, Formation of the beta-catenin:TCF transactivating complex R-CEL-674695, RNA Polymerase II Pre-transcription Events R-CEL-75955, RNA Polymerase II Transcription Elongation |
Names & Taxonomyi
Protein namesi | Recommended name: Cell division cycle protein 73By similarityAlternative name(s): RNA polymerase-associated protein CDC73By similarity |
Gene namesi | Name:cdc-73Imported ORF Names:F35F11.1Imported |
Organismi | Caenorhabditis elegansImported |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | F35F11.1 ; CE48035 ; WBGene00018064 ; cdc-73 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Note: Nuclear localization depends on pafo-1, leo-1 and ctr-9.1 Publication
Nucleus
- Cdc73/Paf1 complex Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Disruption phenotypei
RNAi mediated knock-down is embryonic lethal. Embryogenesis proceeds more slowly, with embryos displaying defects in the positioning and shape of epidermal cells. 60% of embryos arrest at the bean stage of embryogenesis without any significant change in body shape. Nuclear localization of rtf-1 is unaffected.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000431511 | 1 – 517 | Cell division cycle protein 73Add BLAST | 517 |
Proteomic databases
EPDi | Q9N5U5 |
PaxDbi | Q9N5U5 |
PeptideAtlasi | Q9N5U5 |
PRIDEi | Q9N5U5 |
Expressioni
Gene expression databases
Bgeei | WBGene00018064, Expressed in material anatomical entity and 5 other tissues |
Interactioni
Subunit structurei
Component of the PAF1 complex which consists of at least cdc-73, ctr-9, leo-1, pafo-1 and rtfo-1.
By similarityGO - Molecular functioni
- RNA polymerase II complex binding Source: GO_Central
Protein-protein interaction databases
ComplexPortali | CPX-966, PAF1 complex |
DIPi | DIP-25821N |
STRINGi | 6239.F35F11.1 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 124 – 159 | DisorderedSequence analysisAdd BLAST | 36 | |
Regioni | 306 – 326 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 332 – 351 | DisorderedSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the CDC73 family.Sequence analysis
Phylogenomic databases
eggNOGi | KOG3786, Eukaryota |
GeneTreei | ENSGT00390000001114 |
HOGENOMi | CLU_025849_0_1_1 |
InParanoidi | Q9N5U5 |
OMAi | NVARWAV |
OrthoDBi | 720340at2759 |
PhylomeDBi | Q9N5U5 |
Family and domain databases
Gene3Di | 3.40.50.11990, 1 hit |
InterProi | View protein in InterPro IPR007852, Cdc73/Parafibromin IPR031336, CDC73_C IPR038103, CDC73_C_sf IPR032041, Cdc73_N |
PANTHERi | PTHR12466, PTHR12466, 1 hit |
Pfami | View protein in Pfam PF05179, CDC73_C, 1 hit PF16050, CDC73_N, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9N5U5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDPLEALQKH VQRPEEFPLR EVTVSGISYV AFGDYAYKKD TETSLQIYGK
60 70 80 90 100
SDEFYSLESL VVFLKYSHEN HGVYVKEAAA AGVRAVTRID RKNVTEYLQG
110 120 130 140 150
DRTDFPALMN QVNPLSLRQL LHSSEPEAKK PRLDGEAAGE PMDTSTSDEP
160 170 180 190 200
QESAVSAAKK EVEIRALNDN LTKDRIAEMR RKRQSHREKG IVTIDESLST
210 220 230 240 250
LTSASLPKTR IHKTRENVML GARDLSNVLD IITSAQRQWD LNEKKEKVAA
260 270 280 290 300
VHATNLSKDQ SGAAGGQQQR SGYSRYAQEA FAHEKTKEIQ TEGSFIGSNF
310 320 330 340 350
SSIKQGHHAV QKAPDAPPGR PPLAKPIQLL TSSTATSSGS SAAQNGSKRT
360 370 380 390 400
SRSPIIIVPS AMNTMINLYN VRDILQNFSY VPVDQRRKET NKKPVDLAIQ
410 420 430 440 450
RQKNGVTYNI RVIDNAEKLA NDDWDRVIAV FVMGVAWQFK GWKWNGNPTD
460 470 480 490 500
IFTHIPAFHF HVDQDKPVAQ VMQWNVHKIP VSATKRHMDK ARFSQVWETI
510
ENFVRKNKPH LTARLGL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FO081297 Genomic DNA Translation: CCD70582.2 |
RefSeqi | NP_500465.4, NM_068064.6 |
Genome annotation databases
EnsemblMetazoai | F35F11.1.1; F35F11.1.1; WBGene00018064 |
GeneIDi | 177160 |
KEGGi | cel:CELE_F35F11.1 |
UCSCi | F35F11.1, c. elegans |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FO081297 Genomic DNA Translation: CCD70582.2 |
RefSeqi | NP_500465.4, NM_068064.6 |
3D structure databases
SMRi | Q9N5U5 |
ModBasei | Search... |
Protein-protein interaction databases
ComplexPortali | CPX-966, PAF1 complex |
DIPi | DIP-25821N |
STRINGi | 6239.F35F11.1 |
Proteomic databases
EPDi | Q9N5U5 |
PaxDbi | Q9N5U5 |
PeptideAtlasi | Q9N5U5 |
PRIDEi | Q9N5U5 |
Genome annotation databases
EnsemblMetazoai | F35F11.1.1; F35F11.1.1; WBGene00018064 |
GeneIDi | 177160 |
KEGGi | cel:CELE_F35F11.1 |
UCSCi | F35F11.1, c. elegans |
Organism-specific databases
CTDi | 177160 |
WormBasei | F35F11.1 ; CE48035 ; WBGene00018064 ; cdc-73 |
Phylogenomic databases
eggNOGi | KOG3786, Eukaryota |
GeneTreei | ENSGT00390000001114 |
HOGENOMi | CLU_025849_0_1_1 |
InParanoidi | Q9N5U5 |
OMAi | NVARWAV |
OrthoDBi | 720340at2759 |
PhylomeDBi | Q9N5U5 |
Enzyme and pathway databases
Reactomei | R-CEL-112382, Formation of RNA Pol II elongation complex R-CEL-201722, Formation of the beta-catenin:TCF transactivating complex R-CEL-674695, RNA Polymerase II Pre-transcription Events R-CEL-75955, RNA Polymerase II Transcription Elongation |
Miscellaneous databases
PROi | PR:Q9N5U5 |
Gene expression databases
Bgeei | WBGene00018064, Expressed in material anatomical entity and 5 other tissues |
Family and domain databases
Gene3Di | 3.40.50.11990, 1 hit |
InterProi | View protein in InterPro IPR007852, Cdc73/Parafibromin IPR031336, CDC73_C IPR038103, CDC73_C_sf IPR032041, Cdc73_N |
PANTHERi | PTHR12466, PTHR12466, 1 hit |
Pfami | View protein in Pfam PF05179, CDC73_C, 1 hit PF16050, CDC73_N, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CDC73_CAEEL | |
Accessioni | Q9N5U5Primary (citable) accession number: Q9N5U5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 7, 2015 |
Last sequence update: | February 6, 2013 | |
Last modified: | September 29, 2021 | |
This is version 127 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase - SIMILARITY comments
Index of protein domains and families