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Entry version 162 (13 Nov 2019)
Sequence version 3 (01 Mar 2004)
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Protein

Son of sevenless homolog

Gene

sos-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes the exchange of Ras-bound GDP by GTP (By similarity). May regulate signaling pathways downstream of receptor tyrosine kinase, egl-15 and let-23 (PubMed:10880441). Required for larval and male spicule development, fluid homeostasis, vulva induction, spermatogenesis, and oogenesis by promoting meiosis prophase exit during oocyte maturation (PubMed:10880441, PubMed:17339331). Required for the delamination of G1 cell by promoting the loss of cell junctions and detachment from the excretory system during larval development (PubMed:25371363). Plays a role in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine (PubMed:15990870). Regulates synaptic levels of nAchR subunit lev-1 in the nerve cord (PubMed:15990870).By similarity4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-1433557 Signaling by SCF-KIT
R-CEL-1433559 Regulation of KIT signaling
R-CEL-179812 GRB2 events in EGFR signaling
R-CEL-180336 SHC1 events in EGFR signaling
R-CEL-186763 Downstream signal transduction
R-CEL-193648 NRAGE signals death through JNK
R-CEL-194840 Rho GTPase cycle
R-CEL-1963640 GRB2 events in ERBB2 signaling
R-CEL-210993 Tie2 Signaling
R-CEL-2179392 EGFR Transactivation by Gastrin
R-CEL-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins
R-CEL-375165 NCAM signaling for neurite out-growth
R-CEL-416482 G alpha (12/13) signalling events
R-CEL-5654688 SHC-mediated cascade:FGFR1
R-CEL-5654693 FRS-mediated FGFR1 signaling
R-CEL-5654699 SHC-mediated cascade:FGFR2
R-CEL-5654700 FRS-mediated FGFR2 signaling
R-CEL-5654704 SHC-mediated cascade:FGFR3
R-CEL-5654706 FRS-mediated FGFR3 signaling
R-CEL-5654712 FRS-mediated FGFR4 signaling
R-CEL-5673001 RAF/MAP kinase cascade
R-CEL-74751 Insulin receptor signalling cascade
R-CEL-8851805 MET activates RAS signaling
R-CEL-9607240 FLT3 Signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9N5D3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Son of sevenless homolog1 Publication
Alternative name(s):
Guanine nucleotide exchange factor for RASCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sos-1Imported
Synonyms:let-341Imported
ORF Names:T28F12.3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

WormBase

More...
WormBasei
T28F12.3a ; CE36328 ; WBGene00004947 ; sos-1

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown results in 8% early larval lethality of the progeny. Surviving animals display slow growth, thin body morphology and both spermatogenesis and oogenesis are arrested at the pachytene stage of meiosis I. In addition, males have short and crumpled spicules. RNAi-mediated knockdown prevents multi-vulva induction in let60 n1046, let-23 sa62 or lin-15 n765 mutants and fluid accumulation in clr-1 e1745ts mutant.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi322G → R in sy262; restores normal vulva induction in let-23 sy-1 mutant. 1 Publication1
Mutagenesisi980E → K in cs41; temperature sensitive mutant in which G1 cell fails to delaminate during the excretory system development. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004359551 – 1493Son of sevenless homologCuratedAdd BLAST1493

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9N5D3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9N5D3

PeptideAtlas

More...
PeptideAtlasi
Q9N5D3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00004947 Expressed in 4 organ(s), highest expression level in pharyngeal muscle cell (C elegans)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with cmd-1 in the presence of Ca2+.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9N5D3, 2 interactors

Molecular INTeraction database

More...
MINTi
Q9N5D3

STRING: functional protein association networks

More...
STRINGi
6239.T28F12.3

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9N5D3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini244 – 448DHPROSITE-ProRule annotationAdd BLAST205
Domaini496 – 606PHPROSITE-ProRule annotationAdd BLAST111
Domaini656 – 824N-terminal Ras-GEFPROSITE-ProRule annotationAdd BLAST169
Domaini897 – 1164Ras-GEFPROSITE-ProRule annotationAdd BLAST268

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1264 – 1485Pro-richPROSITE-ProRule annotationAdd BLAST222

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The DH (DBL-homology) domain may inhibit the Ras-GEF domain, thereby preventing excessive let-60/Ras activation.1 Publication

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3417 Eukaryota
ENOG410XR96 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000169087

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000153279

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9N5D3

KEGG Orthology (KO)

More...
KOi
K03099

Identification of Orthologs from Complete Genome Data

More...
OMAi
KFLDECR

Database of Orthologous Groups

More...
OrthoDBi
576110at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9N5D3

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00155 RasGEF, 1 hit
cd06224 REM, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.20.10, 1 hit
1.10.840.10, 2 hits
1.20.900.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR009072 Histone-fold
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR008937 Ras-like_GEF
IPR000651 Ras-like_Gua-exchang_fac_N
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR036964 RASGEF_cat_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR23113 PTHR23113, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00169 PH, 1 hit
PF00617 RasGEF, 1 hit
PF00618 RasGEF_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233 PH, 1 hit
SM00147 RasGEF, 1 hit
SM00229 RasGEFN, 1 hit
SM00325 RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47113 SSF47113, 1 hit
SSF48065 SSF48065, 1 hit
SSF48366 SSF48366, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50009 RASGEF_CAT, 1 hit
PS50212 RASGEF_NTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9N5D3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSIMSISLHS ASSDTVSLTS RRTISTSKHW AAIFDERIYQ ICNIVHPGLP
60 70 80 90 100
IDNAAVEHIR YFLQSIVFEL IEARATSVVE VDKTAKKLFA FGLQTVCKEA
110 120 130 140 150
WDNMHQQLQK HKYQKALKTV LESQHRLAAV IKETLGPREK EKKDREKKEI
160 170 180 190 200
ERIACYIYYA CESVTEDVLR LTGNYVKNIR NSEQKITMAN LDVAMNGDKA
210 220 230 240 250
LMELRTKLRN EEEAESPGGF GFLSEFEEFV AEETEEKTLS NSQTYESVAV
260 270 280 290 300
DFLRDERRFI RELNRINVFR RRIESVAATD VDKQIVCNLF GNLTEIHDLA
310 320 330 340 350
LKIERTLEDA IELSDTQCIG MGIWEHGEAY EFDTYTFYIR RDGGEMNETR
360 370 380 390 400
HATYVINDNI KALLESERFA SLFQSGEHYL GSSLDGQSFR LAVQYVLPQL
410 420 430 440 450
LHIPIFHIYQ YHEYITRLHQ LSSSEEDRRD LNDCRSAFER VVGCVSDMSP
460 470 480 490 500
ELKTKITQFL DQQAKSEKIY NVKRLNEIQS SIDGFTGSPI GKTCNELEKD
510 520 530 540 550
GDLGMIRPSL QFSSEITKNK KWKTERFVYI FDQMIVLCKR HRNTLKFKDR
560 570 580 590 600
LAVHSIDVFD IPDSEVTNCF KIESHDKSSL PKIYHFVCKN PEEKRQWMAV
610 620 630 640 650
LVKVTTKSVL DRILDNHEKE EAKRIPLVVP GPDQYRFSEP DTEDNISFED
660 670 680 690 700
YTSSSGIPVI KCGTVLKLIE RLTYHSYTDS KYILTFLISY RSFCTPNDLF
710 720 730 740 750
SLLLERFNIP TPKKLQQPKQ GGGPLAGRYD TVQSHGLSAI SSSSCINPLC
760 770 780 790 800
EQKFRKEFQQ PIQLRVLSVI NQWVKLHWYD FQCDPVLLDA LELFLNRCCD
810 820 830 840 850
PREGLSKQHK KFCKTILALI EKRVKNPPGI MQQPNENGDK GAADEGHVNS
860 870 880 890 900
AFVFGDDQQH PPQHQVYTNE SPKETNQVLW HTAQKGDVDH YDLLTLHPIE
910 920 930 940 950
IGRQLTLLHS DLYRAIQPIE LVEAAWTKAE KWRKSPQLLR LTDHSTLLTY
960 970 980 990 1000
WVSRSIVETE SLEERMAMFN RVLEVMSVFE ELHNFTGLVA FYSALNSSCI
1010 1020 1030 1040 1050
FRLKWCWDGL DNEKKKCFDR FNTLCERRWQ EMQKRLSSIN PPCIPFFGHY
1060 1070 1080 1090 1100
LSNIYFLEQG NSTFVNKSPP HGAAGAQKQQ KDDLKASDPE NSNKQFKQLV
1110 1120 1130 1140 1150
SFLKLRKISN VIREIQIFQD QRYSLTLEPT IRQFFESINP KNDFKSNEDL
1160 1170 1180 1190 1200
EEYLYNKSLE IQPKGLDTPT AELKPKHNAS TLRSPGVKPP KAAGNHYSAN
1210 1220 1230 1240 1250
HPIGLHLHSQ NSHSAPHAMS SQSSTVPNTP LSAHETKRSL SHNQDDAPLQ
1260 1270 1280 1290 1300
QFVDIRFERK GTHPKIPVLQ PPPLLPRSSR ANQSNSVSLP PTTQAPMPPA
1310 1320 1330 1340 1350
PKSSGMMSTA TSPTTLTTTT TPSSAGGPPP KLHPRRMTQQ PMSPLAKSPL
1360 1370 1380 1390 1400
TPSRDNSSPS AFQFPVVYEA STAPPLPPRP STSSDVSSSP STSGSTSSAT
1410 1420 1430 1440 1450
KENQEQLRVI FDREESHSPT VRLSVPLPPA LPPPRGSSVF RAPPPLPPKS
1460 1470 1480 1490
NRHNSNSPTL SSEQPFEDPM SPSIFVNTPP PPLPPKTYRS SNK
Length:1,493
Mass (Da):169,916
Last modified:March 1, 2004 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2E61A851ACA2ECF9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A486WXD9A0A486WXD9_CAEEL
Son of sevenless homolog
sos-1 CELE_T28F12.3, T28F12.3
1,493Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284605 Genomic DNA Translation: CCD72268.1
AF251308 mRNA Translation: AAF82360.1

NCBI Reference Sequences

More...
RefSeqi
NP_504235.2, NM_071834.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
T28F12.3.1; T28F12.3.1; WBGene00004947

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
178846

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_T28F12.3

UCSC genome browser

More...
UCSCi
T28F12.3 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA Translation: CCD72268.1
AF251308 mRNA Translation: AAF82360.1
RefSeqiNP_504235.2, NM_071834.4

3D structure databases

SMRiQ9N5D3
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9N5D3, 2 interactors
MINTiQ9N5D3
STRINGi6239.T28F12.3

Proteomic databases

EPDiQ9N5D3
PaxDbiQ9N5D3
PeptideAtlasiQ9N5D3

Genome annotation databases

EnsemblMetazoaiT28F12.3.1; T28F12.3.1; WBGene00004947
GeneIDi178846
KEGGicel:CELE_T28F12.3
UCSCiT28F12.3 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
178846
WormBaseiT28F12.3a ; CE36328 ; WBGene00004947 ; sos-1

Phylogenomic databases

eggNOGiKOG3417 Eukaryota
ENOG410XR96 LUCA
GeneTreeiENSGT00940000169087
HOGENOMiHOG000153279
InParanoidiQ9N5D3
KOiK03099
OMAiKFLDECR
OrthoDBi576110at2759
PhylomeDBiQ9N5D3

Enzyme and pathway databases

ReactomeiR-CEL-1433557 Signaling by SCF-KIT
R-CEL-1433559 Regulation of KIT signaling
R-CEL-179812 GRB2 events in EGFR signaling
R-CEL-180336 SHC1 events in EGFR signaling
R-CEL-186763 Downstream signal transduction
R-CEL-193648 NRAGE signals death through JNK
R-CEL-194840 Rho GTPase cycle
R-CEL-1963640 GRB2 events in ERBB2 signaling
R-CEL-210993 Tie2 Signaling
R-CEL-2179392 EGFR Transactivation by Gastrin
R-CEL-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins
R-CEL-375165 NCAM signaling for neurite out-growth
R-CEL-416482 G alpha (12/13) signalling events
R-CEL-5654688 SHC-mediated cascade:FGFR1
R-CEL-5654693 FRS-mediated FGFR1 signaling
R-CEL-5654699 SHC-mediated cascade:FGFR2
R-CEL-5654700 FRS-mediated FGFR2 signaling
R-CEL-5654704 SHC-mediated cascade:FGFR3
R-CEL-5654706 FRS-mediated FGFR3 signaling
R-CEL-5654712 FRS-mediated FGFR4 signaling
R-CEL-5673001 RAF/MAP kinase cascade
R-CEL-74751 Insulin receptor signalling cascade
R-CEL-8851805 MET activates RAS signaling
R-CEL-9607240 FLT3 Signaling
SignaLinkiQ9N5D3

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9N5D3

Gene expression databases

BgeeiWBGene00004947 Expressed in 4 organ(s), highest expression level in pharyngeal muscle cell (C elegans)

Family and domain databases

CDDicd00155 RasGEF, 1 hit
cd06224 REM, 1 hit
Gene3Di1.10.20.10, 1 hit
1.10.840.10, 2 hits
1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR009072 Histone-fold
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR008937 Ras-like_GEF
IPR000651 Ras-like_Gua-exchang_fac_N
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR036964 RASGEF_cat_dom_sf
PANTHERiPTHR23113 PTHR23113, 3 hits
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF00617 RasGEF, 1 hit
PF00618 RasGEF_N, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00147 RasGEF, 1 hit
SM00229 RasGEFN, 1 hit
SM00325 RhoGEF, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
SSF48065 SSF48065, 1 hit
SSF48366 SSF48366, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50009 RASGEF_CAT, 1 hit
PS50212 RASGEF_NTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSOS_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9N5D3
Secondary accession number(s): Q9NBD3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2016
Last sequence update: March 1, 2004
Last modified: November 13, 2019
This is version 162 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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