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Entry version 126 (29 Sep 2021)
Sequence version 2 (01 Mar 2003)
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Protein
Submitted name:

XPC (Xeroderma Pigmentosum group C) DNA repair gene homolog

Gene

xpc-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA damage, DNA repairARBA annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-3108214, SUMOylation of DNA damage response and repair proteins
R-CEL-5696394, DNA Damage Recognition in GG-NER
R-CEL-5696395, Formation of Incision Complex in GG-NER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
XPC (Xeroderma Pigmentosum group C) DNA repair gene homologImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:xpc-1Imported
ORF Names:CELE_Y76B12C.2Imported, Y76B12C.2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

More...
WormBasei
Y76B12C.2 ; CE31668 ; WBGene00022296 ; xpc-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9N4C3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9N4C3

PeptideAtlas

More...
PeptideAtlasi
Q9N4C3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00022296, Expressed in material anatomical entity and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9N4C3, 1 interactor

STRING: functional protein association networks

More...
STRINGi
6239.Y76B12C.2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini827 – 881BHD_1InterPro annotationAdd BLAST55
Domaini883 – 938BHD_2InterPro annotationAdd BLAST56
Domaini945 – 1019BHD_3InterPro annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 76DisorderedSequence analysisAdd BLAST76
Regioni106 – 375DisorderedSequence analysisAdd BLAST270
Regioni439 – 470DisorderedSequence analysisAdd BLAST32
Regioni670 – 713DisorderedSequence analysisAdd BLAST44
Regioni1062 – 1098DisorderedSequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi8 – 22Polar residuesSequence analysisAdd BLAST15
Compositional biasi46 – 63Polar residuesSequence analysisAdd BLAST18
Compositional biasi120 – 134Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi151 – 168Polar residuesSequence analysisAdd BLAST18
Compositional biasi171 – 191Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi192 – 241Polar residuesSequence analysisAdd BLAST50
Compositional biasi248 – 276Basic and acidic residuesSequence analysisAdd BLAST29
Compositional biasi361 – 375Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi691 – 713Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi1062 – 1083Basic and acidic residuesSequence analysisAdd BLAST22

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the XPC family.ARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2179, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000005194

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_283172_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9N4C3

Identification of Orthologs from Complete Genome Data

More...
OMAi
VEERNYW

Database of Orthologous Groups

More...
OrthoDBi
562905at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9N4C3

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.2460, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018327, BHD_2
IPR004583, DNA_repair_Rad4
IPR038765, Papain-like_cys_pep_sf
IPR018325, Rad4/PNGase_transGLS-fold
IPR018326, Rad4_beta-hairpin_dom1
IPR018328, Rad4_beta-hairpin_dom3
IPR042488, Rad4_BHD3_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12135, PTHR12135, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10403, BHD_1, 1 hit
PF10405, BHD_3, 1 hit
PF03835, Rad4, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01030, BHD_1, 1 hit
SM01031, BHD_2, 1 hit
SM01032, BHD_3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001, SSF54001, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9N4C3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METRRRSSRL QQQTTSDLNA REEPQPSEPP VKRARGAKKN EAPSTAPMPP
60 70 80 90 100
KTTKKSTKPS RKQGSPIEAE LDEMGFELEN EEEAEIVVQK SKKNGRKLVK
110 120 130 140 150
IDENLRISAE NGSKSSNFLE ENRMEIDEKP GNLAKKSSKN GSRVVKSDEK
160 170 180 190 200
SENLVQSVPK STTNGSKVAI IEDDPEIRAE NGVKSSKSDE KPDFSAQNGS
210 220 230 240 250
KLAQNAPNRI SRPRRSVTTA KKVSYVPSDD QLELSSSSSE LESSSEDEDT
260 270 280 290 300
EIRPKTGSKI AKKREKSFKI SESESSSESP DDESEASEAS EDPSIPGPSE
310 320 330 340 350
PRKRRKIQRK STLSSGGATT KDLHWPKCSK ASIARKTGNP GSKNAAKKPA
360 370 380 390 400
KSSLRMAQKQ KPDQPWKKNL KDYETDRKLA KGERRMLEYR HVAHAYVARG
410 420 430 440 450
KIEEITYDEA YKLHEMMKKA YFAGRSLLDA AVLDPVEFEK SQKNVKKSEK
460 470 480 490 500
NDEKNTAGDS SSSEDEWEEM EHFQPPIIDD NIEVSIDHEG GGGDDGEEVV
510 520 530 540 550
KDWWAIYLRQ EINRKIREMW ENTHKVHLLC FMAHLKFVVK IALDESLVPS
560 570 580 590 600
LMMSQLPNGY LKFIGEPVVP IDIMKNLVKW FADAFRPLNG VVSVASIEQD
610 620 630 640 650
SLLEGHEARY PETRRLTALV DAKCFETDLD RATLLFCLLR GLELTTRLVV
660 670 680 690 700
NVRAIPRRWD KTQQKELQNE LSKFRELSRS RSTTPGEKSL EIQEKSGEKS
710 720 730 740 750
QKPAKKGQKS EKKAAKKVVV EERNYWVEYW QPREKRWICV DPLHKSVDEP
760 770 780 790 800
LSIHEHSASP ISYVFAIDNK QGICEVSQRY AMDCVKQDFR RRRTNPKWVA
810 820 830 840 850
WTLFLPPFAA NSERKKWEMM QMREDLVKRP LPTVMSEYKN HPLYALEKDL
860 870 880 890 900
LKFEAIYPPP ATQKPLGQIR GHNVYPRSTV FTLQGENNWL KLARSVKIGE
910 920 930 940 950
KPYKIVKARP DPRIPVEDRE DKFLDVYGYW QTEKYRRPPL KNGKIPHNEY
960 970 980 990 1000
GNVYMFNENM CPLDCTYLKL SGLVQISRKL GKQCIPAVVG WAFDGGFTHP
1010 1020 1030 1040 1050
VIDGAIVLEK DAIDFINAWE KLESGRAEKE EKQRVEKIHE NWKKLIKGML
1060 1070 1080 1090 1100
RLAYVRKQFG HPAAEKPTKR QKIGGKTEEI EENEGGAGPP SSVDHITDNT
1110
EQITPMHGFS LDDFINKKK
Length:1,119
Mass (Da):127,566
Last modified:March 1, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i46884873104074C9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CCD73179.1

NCBI Reference Sequences

More...
RefSeqi
NP_500156.2, NM_067755.5

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
Y76B12C.2.1; Y76B12C.2.1; WBGene00022296

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
177002

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_Y76B12C.2

UCSC genome browser

More...
UCSCi
Y76B12C.2, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CCD73179.1
RefSeqiNP_500156.2, NM_067755.5

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ9N4C3, 1 interactor
STRINGi6239.Y76B12C.2

Proteomic databases

EPDiQ9N4C3
PaxDbiQ9N4C3
PeptideAtlasiQ9N4C3

Genome annotation databases

EnsemblMetazoaiY76B12C.2.1; Y76B12C.2.1; WBGene00022296
GeneIDi177002
KEGGicel:CELE_Y76B12C.2
UCSCiY76B12C.2, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
177002
WormBaseiY76B12C.2 ; CE31668 ; WBGene00022296 ; xpc-1

Phylogenomic databases

eggNOGiKOG2179, Eukaryota
GeneTreeiENSGT00390000005194
HOGENOMiCLU_283172_0_0_1
InParanoidiQ9N4C3
OMAiVEERNYW
OrthoDBi562905at2759
PhylomeDBiQ9N4C3

Enzyme and pathway databases

ReactomeiR-CEL-3108214, SUMOylation of DNA damage response and repair proteins
R-CEL-5696394, DNA Damage Recognition in GG-NER
R-CEL-5696395, Formation of Incision Complex in GG-NER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9N4C3

Gene expression databases

BgeeiWBGene00022296, Expressed in material anatomical entity and 5 other tissues

Family and domain databases

Gene3Di3.30.70.2460, 1 hit
InterProiView protein in InterPro
IPR018327, BHD_2
IPR004583, DNA_repair_Rad4
IPR038765, Papain-like_cys_pep_sf
IPR018325, Rad4/PNGase_transGLS-fold
IPR018326, Rad4_beta-hairpin_dom1
IPR018328, Rad4_beta-hairpin_dom3
IPR042488, Rad4_BHD3_sf
PANTHERiPTHR12135, PTHR12135, 1 hit
PfamiView protein in Pfam
PF10403, BHD_1, 1 hit
PF10405, BHD_3, 1 hit
PF03835, Rad4, 1 hit
SMARTiView protein in SMART
SM01030, BHD_1, 1 hit
SM01031, BHD_2, 1 hit
SM01032, BHD_3, 1 hit
SUPFAMiSSF54001, SSF54001, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9N4C3_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9N4C3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: March 1, 2003
Last modified: September 29, 2021
This is version 126 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
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