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Protein

Probable 3',5'-cyclic phosphodiesterase pde-6

Gene

pde-6

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.By similarity

Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei502Proton donorBy similarity1
Metal bindingi506Divalent metal cation 1By similarity1
Metal bindingi542Divalent metal cation 1By similarity1
Metal bindingi543Divalent metal cation 1By similarity1
Metal bindingi543Divalent metal cation 2By similarity1
Metal bindingi656Divalent metal cation 1By similarity1

GO - Molecular functioni

  • 3',5'-cyclic-AMP phosphodiesterase activity Source: WormBase
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • negative regulation of oocyte maturation Source: WormBase
  • signal transduction Source: InterPro

Keywordsi

Molecular functionHydrolase
LigandcGMP, Metal-binding

Enzyme and pathway databases

ReactomeiR-CEL-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 3',5'-cyclic phosphodiesterase pde-6 (EC:3.1.4.17)
Gene namesi
Name:pde-6
ORF Names:Y95B8A.10
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiY95B8A.10a ; CE23151 ; WBGene00022389 ; pde-6

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001988491 – 760Probable 3',5'-cyclic phosphodiesterase pde-6Add BLAST760

Proteomic databases

EPDiQ9N2V9
PaxDbiQ9N2V9
PeptideAtlasiQ9N2V9
PRIDEiQ9N2V9

PTM databases

iPTMnetiQ9N2V9

Expressioni

Gene expression databases

BgeeiWBGene00022389 Expressed in 4 organ(s), highest expression level in multi-cellular organism

Interactioni

Protein-protein interaction databases

STRINGi6239.Y95B8A.10a

Structurei

3D structure databases

ProteinModelPortaliQ9N2V9
SMRiQ9N2V9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini426 – 750PDEasePROSITE-ProRule annotationAdd BLAST325

Sequence similaritiesi

Belongs to the cyclic nucleotide phosphodiesterase family.By similarity

Phylogenomic databases

eggNOGiKOG1229 Eukaryota
ENOG410XP9B LUCA
GeneTreeiENSGT00760000118889
HOGENOMiHOG000272633
InParanoidiQ9N2V9
KOiK18437
OMAiHYVSISR
OrthoDBiEOG091G0337
PhylomeDBiQ9N2V9

Family and domain databases

CDDicd00077 HDc, 1 hit
Gene3Di1.10.1300.10, 1 hit
InterProiView protein in InterPro
IPR003607 HD/PDEase_dom
IPR035965 PAS-like_dom_sf
IPR023088 PDEase
IPR002073 PDEase_catalytic_dom
IPR036971 PDEase_catalytic_dom_sf
IPR023174 PDEase_CS
PfamiView protein in Pfam
PF00233 PDEase_I, 1 hit
PRINTSiPR00387 PDIESTERASE1
SMARTiView protein in SMART
SM00471 HDc, 1 hit
SUPFAMiSSF55785 SSF55785, 1 hit
PROSITEiView protein in PROSITE
PS00126 PDEASE_I_1, 1 hit
PS51845 PDEASE_I_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9N2V9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDRSGVGGE EGEKSVLGAS AHSQAGRRQQ HTPAARRGAQ RAPAATAAAA
60 70 80 90 100
SRPVFAMRWC CGGSYSENGG GGGGSRGAPP TPLLTVAATS SSTAHDTFGP
110 120 130 140 150
MQVKMLKTAV IVTEGTGESV LLDSLRASGW ICTVSFPTQA TSDVESICPL
160 170 180 190 200
AVFIDLRVPH PSQIAKDVSS VSTEEVLIVS IAEKHISEKR RRALAQSNII
210 220 230 240 250
HHVTWNTRDV VLFDYVGRLA NRIRALPALF AVLDETDQAV EICDEQRVVQ
260 270 280 290 300
YVNRAYENVT GCIRSEVIGQ PESEMRRKSL PRARGEEERR RSCDWKFIRV
310 320 330 340 350
PFANNSQFVY MKRSNTTGDT AAIFRDVSLK SLKSQTGGIE APISEVLTML
360 370 380 390 400
RDVSARVDGE PAQTIKDAMK VLSSHELYAP SINRFRDADR IATQYYDGLI
410 420 430 440 450
RLHHPARQRK RSVVDAHREK RGSHGERRRV SADVKNALEN DNCWKFDILH
460 470 480 490 500
LEKVSDHHAL SQVGMKVFER WKVCDVLGCS DDLLHRWILS IEAHYHAGNT
510 520 530 540 550
YHNATHAADV LQATSFFLDS PSVAVHVNES HAVAALLAAA VHDLDHPGRG
560 570 580 590 600
NAYLINTRQS LAILYNDNSI LENHHIALAF QLTLQHNANV NIFSSLSREE
610 620 630 640 650
FIQMRHAMVE MVLATDISRH FEYLAKFNKM HVTDVPEEQR DTNSLTICDM
660 670 680 690 700
LVKCADISNP AREWGLCQRW AHRIVEEYFE QTREEKEKGL PVTMEVFDRN
710 720 730 740 750
TCNVPITQCG FIDMFAREAF ATFTEFAKLG ELSDQLESNY EKWKVMTSQW
760
TPTHNTNLVL
Length:760
Mass (Da):84,881
Last modified:October 1, 2000 - v1
Checksum:i2BDD7274D30B34B5
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G8JYF6G8JYF6_CAEEL
Phosphodiesterase
pde-6 CELE_Y95B8A.10, Y95B8A.10
697Annotation score:
V6CIW4V6CIW4_CAEEL
Phosphodiesterase
pde-6 CELE_Y95B8A.10, Y95B8A.10
486Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081787 Genomic DNA Translation: CCD73546.1
RefSeqiNP_490787.1, NM_058386.1
UniGeneiCel.16242

Genome annotation databases

EnsemblMetazoaiY95B8A.10a; Y95B8A.10a; WBGene00022389
GeneIDi190808
KEGGicel:CELE_Y95B8A.10
UCSCiY95B8A.10a c. elegans

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081787 Genomic DNA Translation: CCD73546.1
RefSeqiNP_490787.1, NM_058386.1
UniGeneiCel.16242

3D structure databases

ProteinModelPortaliQ9N2V9
SMRiQ9N2V9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.Y95B8A.10a

PTM databases

iPTMnetiQ9N2V9

Proteomic databases

EPDiQ9N2V9
PaxDbiQ9N2V9
PeptideAtlasiQ9N2V9
PRIDEiQ9N2V9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY95B8A.10a; Y95B8A.10a; WBGene00022389
GeneIDi190808
KEGGicel:CELE_Y95B8A.10
UCSCiY95B8A.10a c. elegans

Organism-specific databases

CTDi190808
WormBaseiY95B8A.10a ; CE23151 ; WBGene00022389 ; pde-6

Phylogenomic databases

eggNOGiKOG1229 Eukaryota
ENOG410XP9B LUCA
GeneTreeiENSGT00760000118889
HOGENOMiHOG000272633
InParanoidiQ9N2V9
KOiK18437
OMAiHYVSISR
OrthoDBiEOG091G0337
PhylomeDBiQ9N2V9

Enzyme and pathway databases

ReactomeiR-CEL-418555 G alpha (s) signalling events

Miscellaneous databases

PROiPR:Q9N2V9

Gene expression databases

BgeeiWBGene00022389 Expressed in 4 organ(s), highest expression level in multi-cellular organism

Family and domain databases

CDDicd00077 HDc, 1 hit
Gene3Di1.10.1300.10, 1 hit
InterProiView protein in InterPro
IPR003607 HD/PDEase_dom
IPR035965 PAS-like_dom_sf
IPR023088 PDEase
IPR002073 PDEase_catalytic_dom
IPR036971 PDEase_catalytic_dom_sf
IPR023174 PDEase_CS
PfamiView protein in Pfam
PF00233 PDEase_I, 1 hit
PRINTSiPR00387 PDIESTERASE1
SMARTiView protein in SMART
SM00471 HDc, 1 hit
SUPFAMiSSF55785 SSF55785, 1 hit
PROSITEiView protein in PROSITE
PS00126 PDEASE_I_1, 1 hit
PS51845 PDEASE_I_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPDE6_CAEEL
AccessioniPrimary (citable) accession number: Q9N2V9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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Main funding by: National Institutes of Health

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