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Protein

Ragulator complex protein LAMTOR2 homolog

Gene

lmtr-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. May activate the TOR signaling cascade in response to amino acids.By similarity

GO - Molecular functioni

  • guanyl-nucleotide exchange factor activity Source: GO_Central
  • protein-containing complex scaffold activity Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-CEL-5674135 MAP2K and MAPK activation
R-CEL-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Ragulator complex protein LAMTOR2 homologBy similarity
Alternative name(s):
Late endosomal/lysosomal adapter and MAPK and MTOR activator 1Imported
Gene namesi
Name:lmtr-2Imported
ORF Names:Y97E10AR.7Imported
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiY97E10AR.7 ; CE25642 ; WBGene00022402 ; lmtr-2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002209621 – 124Ragulator complex protein LAMTOR2 homologCuratedAdd BLAST124

Proteomic databases

EPDiQ9N2U6
PaxDbiQ9N2U6
PeptideAtlasiQ9N2U6
PRIDEiQ9N2U6

Expressioni

Gene expression databases

BgeeiWBGene00022402 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Interactioni

Subunit structurei

Part of the Ragulator complex.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi44219, 2 interactors
IntActiQ9N2U6, 2 interactors
STRINGi6239.Y97E10AR.7.3

Structurei

3D structure databases

ProteinModelPortaliQ9N2U6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GAMAD family.Curated

Phylogenomic databases

eggNOGiKOG4107 Eukaryota
ENOG4111GWH LUCA
GeneTreeiENSGT00390000006100
InParanoidiQ9N2U6
KOiK20398
OMAiCECGHVA
OrthoDBiEOG091G0W0V
PhylomeDBiQ9N2U6

Family and domain databases

InterProiView protein in InterPro
IPR037587 LAMTOR2-like
IPR004942 Roadblock/LAMTOR2_dom
PANTHERiPTHR13323 PTHR13323, 1 hit
PfamiView protein in Pfam
PF03259 Robl_LC7, 1 hit
SMARTiView protein in SMART
SM00960 Robl_LC7, 1 hit

Sequencei

Sequence statusi: Complete.

Q9N2U6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLKQKALVDV LGQVNTSGVD GSWLFNKEGL LLAYVGSEQK AVASNVSSAL
60 70 80 90 100
IASVWAALER RANDLKETIL VLENGVIGCT LVARTMLLAV KADKSADLGM
110 120
VRAKLHTLAA YLEQPILSIS HDLG
Length:124
Mass (Da):13,188
Last modified:October 1, 2000 - v1
Checksum:iAA4585E1C15C4532
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081378 Genomic DNA Translation: CCD71184.1
RefSeqiNP_505061.1, NM_072660.5
UniGeneiCel.17957

Genome annotation databases

EnsemblMetazoaiY97E10AR.7.1; Y97E10AR.7.1; WBGene00022402
Y97E10AR.7.2; Y97E10AR.7.2; WBGene00022402
GeneIDi179177
KEGGicel:CELE_Y97E10AR.7
UCSCiY97E10AR.7.2 c. elegans

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081378 Genomic DNA Translation: CCD71184.1
RefSeqiNP_505061.1, NM_072660.5
UniGeneiCel.17957

3D structure databases

ProteinModelPortaliQ9N2U6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi44219, 2 interactors
IntActiQ9N2U6, 2 interactors
STRINGi6239.Y97E10AR.7.3

Proteomic databases

EPDiQ9N2U6
PaxDbiQ9N2U6
PeptideAtlasiQ9N2U6
PRIDEiQ9N2U6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY97E10AR.7.1; Y97E10AR.7.1; WBGene00022402
Y97E10AR.7.2; Y97E10AR.7.2; WBGene00022402
GeneIDi179177
KEGGicel:CELE_Y97E10AR.7
UCSCiY97E10AR.7.2 c. elegans

Organism-specific databases

CTDi179177
WormBaseiY97E10AR.7 ; CE25642 ; WBGene00022402 ; lmtr-2

Phylogenomic databases

eggNOGiKOG4107 Eukaryota
ENOG4111GWH LUCA
GeneTreeiENSGT00390000006100
InParanoidiQ9N2U6
KOiK20398
OMAiCECGHVA
OrthoDBiEOG091G0W0V
PhylomeDBiQ9N2U6

Enzyme and pathway databases

ReactomeiR-CEL-5674135 MAP2K and MAPK activation
R-CEL-6798695 Neutrophil degranulation

Miscellaneous databases

PROiPR:Q9N2U6

Gene expression databases

BgeeiWBGene00022402 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Family and domain databases

InterProiView protein in InterPro
IPR037587 LAMTOR2-like
IPR004942 Roadblock/LAMTOR2_dom
PANTHERiPTHR13323 PTHR13323, 1 hit
PfamiView protein in Pfam
PF03259 Robl_LC7, 1 hit
SMARTiView protein in SMART
SM00960 Robl_LC7, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLTOR2_CAEEL
AccessioniPrimary (citable) accession number: Q9N2U6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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