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Entry version 140 (16 Oct 2019)
Sequence version 1 (01 Oct 2000)
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Protein

Serine/threonine-protein kinase plk-2

Gene

plk-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine-protein kinase which plays a role, during oogenesis, in chromosome pairing and synapsis, by facilitating the recruitment and attachment of meiotic chromosomes to the nuclear envelope during prophase (PubMed:22018922, PubMed:22018921). Regulates the formation of sun-1 patches along the nuclear envelope (PubMed:22018922, PubMed:22018921). Promotes meiotic nuclei apoptosis in response to chromosomal asynapsis (PubMed:22018922). Plays a redundant role with plk-1 in the establishment of cell polarity downstream of mex-5 and mex-6 during the first embryonic cell divisions (PubMed:18199581). Plays a role in nicotinic acetylcholine receptor-mediated sensitivity to nicotine but not levamisole (PubMed:15990870). Regulates motility (PubMed:15990870).4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei65ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei159Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi42 – 50ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processMeiosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.11.21 1045

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-156711 Polo-like kinase mediated events
R-CEL-162658 Golgi Cisternae Pericentriolar Stack Reorganization
R-CEL-2299718 Condensation of Prophase Chromosomes
R-CEL-2500257 Resolution of Sister Chromatid Cohesion
R-CEL-2565942 Regulation of PLK1 Activity at G2/M Transition
R-CEL-68884 Mitotic Telophase/Cytokinesis
R-CEL-69273 Cyclin A/B1/B2 associated events during G2/M transition

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9N2L7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase plk-2 (EC:2.7.11.211 Publication)
Alternative name(s):
Polo-like kinase 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:plk-2
ORF Names:Y71F9B.7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
Y71F9B.7 ; CE22877 ; WBGene00004043 ; plk-2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mutants are viable and fertile but about 30-percent of the progeny die at the embryonic stage. Surviving adults are mostly male (PubMed:22018922). Impaired chromosome pairing and synapsis during meiotic prophase. Asymmetric disassembly of the synaptonemal complex fails at the diplotene stage. Partial mis-segregation of chromosomes. Increased germline apoptosis (PubMed:22018922). Simultaneous knockdown of plk-1 and plk-2 causes a loss in pie-1 polarization in the 1-cell embryo, an increased association with the oocyte pronuclei and a decrease in pie-1 degradation in embryonic somatic cells (PubMed:18199581).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi197P → L in vv44; Loss of proper chromosome pairing and early initiation of synapsis resulting in a loss of chiasma formation and chromosome segregation during oocyte meiosis I. Severe embryonic lethality and the few surviving adults are mostly male. Loss of sun-1 and zyg-12 patch formation along the nuclear envelope and of sun-1 phosphorylation at 'Thr-12' during early prophase. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000865701 – 632Serine/threonine-protein kinase plk-2Add BLAST632

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9N2L7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9N2L7

PeptideAtlas

More...
PeptideAtlasi
Q9N2L7

PRoteomics IDEntifications database

More...
PRIDEi
Q9N2L7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9N2L7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in oocytes.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in the early stages of embryogenesis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00004043 Expressed in 4 organ(s), highest expression level in material anatomical entity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via POLO box domain) with mex-5 and mex-6 (PubMed:18199581, PubMed:22018922).

Interacts (via POLO box domain) with him-8 (via N-terminus); the interaction mediates plk-2 recruitment to the pairing region of X chromosomes during meiosis (PubMed:22018922).

Interacts with sun-1 (PubMed:22018921). May interact with nicotinic acetylcholine receptor (PubMed:15990870).

4 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
37319, 6 interactors

Protein interaction database and analysis system

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IntActi
Q9N2L7, 2 interactors

Molecular INTeraction database

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MINTi
Q9N2L7

STRING: functional protein association networks

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STRINGi
6239.Y71F9B.7

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9N2L7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini36 – 287Protein kinasePROSITE-ProRule annotationAdd BLAST252
Domaini412 – 476POLO box 1PROSITE-ProRule annotationAdd BLAST65
Domaini511 – 580POLO box 2PROSITE-ProRule annotationAdd BLAST70

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0575 Eukaryota
ENOG410XQBP LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000166918

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000248546

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9N2L7

KEGG Orthology (KO)

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KOi
K06631

Identification of Orthologs from Complete Genome Data

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OMAi
HPPFESK

Database of Orthologous Groups

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OrthoDBi
507604at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9N2L7

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13118 POLO_box_1, 1 hit
cd13117 POLO_box_2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.1120.30, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR033701 POLO_box_1
IPR033695 POLO_box_2
IPR000959 POLO_box_dom
IPR036947 POLO_box_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069 Pkinase, 1 hit
PF00659 POLO_box, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50078 POLO_BOX, 2 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9N2L7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQRVQPSAAR VKSQKKEKAP PDVPDVILDG ERKTRYEKGK FLGKGGFAHC
60 70 80 90 100
YELRNKSTGE LFAGKVVPKA LLIKQYQRDK MAQEVQIHRN LQHRNVVKLY
110 120 130 140 150
HFFEDKSNVY ITLELCPRRS LMELHKRRKA VTEPEARYFT YQIVEGVLYL
160 170 180 190 200
HNLKIVHRDL KLGNLFLNDE LQVKIGDFGL ATTCDNDERK KTLCGTPNYI
210 220 230 240 250
APEVLNKIGH SFEVDLWAIG CILYILLFGH PPFESKSLEE TYSRIKNNNY
260 270 280 290 300
VIPTSASAAA SQLIRVLLDP VPSRRPNARA VCRDHFFKSG FMPARLPVSC
310 320 330 340 350
LTMVPHLNDD EYAEENVSPS GTIDQRGPHQ AGRSGLSAIP AHLVSRNSER
360 370 380 390 400
QQTHRMEAYR QPTDCYLSNL LAQVNDLLAT PTADIDDAEA ALDSYQSPEA
410 420 430 440 450
LPVFWISKWV DYSDKYGIGY QLCDNSVGVL FNDNSRIMLD TAGTQLTYIE
460 470 480 490 500
KTEKEHYFDM ESAIPSGLQK KMTLLKYFRS YMNDHLLQAG QQVTRKVGDD
510 520 530 540 550
LARLPTLRVW FRTKSAIVLH LSNGTVQINF FNDHIKMVLC PLMQAVTFID
560 570 580 590 600
ENKRMFTYKF SHLAENGCPE KFLHRIQYAK CMIQRLVEEH TKEETKHNAP
610 620 630
AANAVRLPST SSNVRLESAA DIQPAYPSSS RR
Length:632
Mass (Da):72,071
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1B2EBB58C15ABBD9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF194964 mRNA Translation: AAF28314.1
FO081276 Genomic DNA Translation: CCD70415.1

NCBI Reference Sequences

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RefSeqi
NP_491036.1, NM_058635.6

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
Y71F9B.7.1; Y71F9B.7.1; WBGene00004043

Database of genes from NCBI RefSeq genomes

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GeneIDi
171838

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
cel:CELE_Y71F9B.7

UCSC genome browser

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UCSCi
Y71F9B.7.1 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF194964 mRNA Translation: AAF28314.1
FO081276 Genomic DNA Translation: CCD70415.1
RefSeqiNP_491036.1, NM_058635.6

3D structure databases

SMRiQ9N2L7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi37319, 6 interactors
IntActiQ9N2L7, 2 interactors
MINTiQ9N2L7
STRINGi6239.Y71F9B.7

PTM databases

iPTMnetiQ9N2L7

Proteomic databases

EPDiQ9N2L7
PaxDbiQ9N2L7
PeptideAtlasiQ9N2L7
PRIDEiQ9N2L7

Genome annotation databases

EnsemblMetazoaiY71F9B.7.1; Y71F9B.7.1; WBGene00004043
GeneIDi171838
KEGGicel:CELE_Y71F9B.7
UCSCiY71F9B.7.1 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
171838
WormBaseiY71F9B.7 ; CE22877 ; WBGene00004043 ; plk-2

Phylogenomic databases

eggNOGiKOG0575 Eukaryota
ENOG410XQBP LUCA
GeneTreeiENSGT00940000166918
HOGENOMiHOG000248546
InParanoidiQ9N2L7
KOiK06631
OMAiHPPFESK
OrthoDBi507604at2759
PhylomeDBiQ9N2L7

Enzyme and pathway databases

BRENDAi2.7.11.21 1045
ReactomeiR-CEL-156711 Polo-like kinase mediated events
R-CEL-162658 Golgi Cisternae Pericentriolar Stack Reorganization
R-CEL-2299718 Condensation of Prophase Chromosomes
R-CEL-2500257 Resolution of Sister Chromatid Cohesion
R-CEL-2565942 Regulation of PLK1 Activity at G2/M Transition
R-CEL-68884 Mitotic Telophase/Cytokinesis
R-CEL-69273 Cyclin A/B1/B2 associated events during G2/M transition
SignaLinkiQ9N2L7

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9N2L7

Gene expression databases

BgeeiWBGene00004043 Expressed in 4 organ(s), highest expression level in material anatomical entity

Family and domain databases

CDDicd13118 POLO_box_1, 1 hit
cd13117 POLO_box_2, 1 hit
Gene3Di3.30.1120.30, 2 hits
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR033701 POLO_box_1
IPR033695 POLO_box_2
IPR000959 POLO_box_dom
IPR036947 POLO_box_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PF00659 POLO_box, 2 hits
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50078 POLO_BOX, 2 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLK2_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9N2L7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: October 1, 2000
Last modified: October 16, 2019
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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