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Protein

Interleukin-23 subunit alpha

Gene

IL23A

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processAntiviral defense, Immunity, Inflammatory response, Innate immunity, Tissue remodeling

Enzyme and pathway databases

ReactomeiR-SSC-9020933 Interleukin-23 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-23 subunit alpha
Short name:
IL-23 subunit alpha
Short name:
IL-23-A
Alternative name(s):
Interleukin-23 subunit p19
Short name:
IL-23p19
Gene namesi
Name:IL23A
Synonyms:SGRF
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000025949023 – 193Interleukin-23 subunit alphaAdd BLAST171

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-23 (By similarity).By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ9N2H9
SMRiQ9N2H9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-6 superfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00390000006482
HOGENOMiHOG000048728
HOVERGENiHBG081786
InParanoidiQ9N2H9
KOiK05426

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR010831 IL-23_alpha
PANTHERiPTHR15947 PTHR15947, 1 hit
PfamiView protein in Pfam
PF16649 IL23, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9N2H9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGSRAVMLM LLLLLLPWTS QGRAVPEGSS PAWAQGQQLS QQLCTLAWTA
60 70 80 90 100
HLPMGHVDLP REEGDDETTS EVPHIQCGDG CDPQGLRDNS QSCLQRIHQG
110 120 130 140 150
LVFYEKLLGS DIFTGEPSLH PDGSVGQLHA SLLGLRQLLQ PEGHHWETEQ
160 170 180 190
TPSPSPSQPW QRLLLRLKIL RSLQAFVAVA ARVFAHGAAT LSQ
Length:193
Mass (Da):21,132
Last modified:October 1, 2000 - v1
Checksum:i05F28DE94810B9E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030002 Genomic DNA Translation: BAA93688.1
RefSeqiNP_001123708.1, NM_001130236.1
UniGeneiSsc.56047

Genome annotation databases

EnsembliENSSSCT00000047550; ENSSSCP00000039363; ENSSSCG00000033520
GeneIDi100155546
KEGGissc:100155546

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030002 Genomic DNA Translation: BAA93688.1
RefSeqiNP_001123708.1, NM_001130236.1
UniGeneiSsc.56047

3D structure databases

ProteinModelPortaliQ9N2H9
SMRiQ9N2H9
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000047550; ENSSSCP00000039363; ENSSSCG00000033520
GeneIDi100155546
KEGGissc:100155546

Organism-specific databases

CTDi51561

Phylogenomic databases

GeneTreeiENSGT00390000006482
HOGENOMiHOG000048728
HOVERGENiHBG081786
InParanoidiQ9N2H9
KOiK05426

Enzyme and pathway databases

ReactomeiR-SSC-9020933 Interleukin-23 signaling

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR010831 IL-23_alpha
PANTHERiPTHR15947 PTHR15947, 1 hit
PfamiView protein in Pfam
PF16649 IL23, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIL23A_PIG
AccessioniPrimary (citable) accession number: Q9N2H9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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