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UniProtKB - Q9N1E2 (G6PI_RABIT)

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Protein

Glucose-6-phosphate isomerase

Gene

GPI

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons (By similarity).By similarity

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI)
  3. ATP-dependent 6-phosphofructokinase, platelet type (PFKP), ATP-dependent 6-phosphofructokinase (PFKP), ATP-dependent 6-phosphofructokinase, muscle type (PFKM), ATP-dependent 6-phosphofructokinase (PFKP), ATP-dependent 6-phosphofructokinase (PFKM)
  4. Fructose-bisphosphate aldolase B (ALDOB), Fructose-bisphosphate aldolase (ALDOC), Fructose-bisphosphate aldolase A (ALDOA)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei358Proton donor1
Active sitei3891
Active sitei5191

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionCytokine, Isomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

BRENDAi5.3.1.9 1749
SABIO-RKiQ9N1E2
UniPathwayiUPA00109; UER00181

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Autocrine motility factor
Short name:
AMF
Neuroleukin
Short name:
NLK
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:GPI
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Secreted

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1770045

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001805412 – 558Glucose-6-phosphate isomeraseAdd BLAST557

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei12N6-acetyllysineBy similarity1
Modified residuei107PhosphoserineBy similarity1
Modified residuei109PhosphothreonineBy similarity1
Modified residuei142N6-acetyllysineBy similarity1
Modified residuei185Phosphoserine; by CK2By similarity1
Modified residuei250PhosphothreonineBy similarity1
Modified residuei454N6-acetyllysine; alternateBy similarity1
Modified residuei454N6-malonyllysine; alternateBy similarity1
Modified residuei454N6-succinyllysine; alternateBy similarity1
Modified residuei455PhosphoserineBy similarity1

Post-translational modificationi

ISGylated.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PRIDEiQ9N1E2

Interactioni

Subunit structurei

Homodimer in the catalytically active form, monomer in the secreted form.5 Publications

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000001250

Chemistry databases

BindingDBiQ9N1E2

Structurei

Secondary structure

1558
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 6Combined sources4
Helixi8 – 20Combined sources13
Helixi21 – 23Combined sources3
Helixi26 – 31Combined sources6
Helixi36 – 39Combined sources4
Beta strandi41 – 45Combined sources5
Beta strandi50 – 54Combined sources5
Beta strandi57 – 59Combined sources3
Helixi62 – 74Combined sources13
Helixi77 – 85Combined sources9
Turni92 – 95Combined sources4
Helixi100 – 103Combined sources4
Beta strandi112 – 118Combined sources7
Helixi119 – 138Combined sources20
Beta strandi151 – 155Combined sources5
Helixi158 – 160Combined sources3
Helixi162 – 170Combined sources9
Helixi172 – 174Combined sources3
Beta strandi180 – 184Combined sources5
Helixi189 – 196Combined sources8
Helixi201 – 203Combined sources3
Beta strandi204 – 209Combined sources6
Beta strandi211 – 213Combined sources3
Helixi216 – 233Combined sources18
Helixi236 – 238Combined sources3
Helixi239 – 242Combined sources4
Beta strandi243 – 248Combined sources6
Helixi250 – 256Combined sources7
Helixi260 – 262Combined sources3
Beta strandi263 – 265Combined sources3
Helixi272 – 274Combined sources3
Turni276 – 278Combined sources3
Helixi279 – 281Combined sources3
Helixi282 – 288Combined sources7
Helixi290 – 309Combined sources20
Helixi312 – 314Combined sources3
Helixi316 – 329Combined sources14
Beta strandi335 – 341Combined sources7
Helixi343 – 345Combined sources3
Helixi348 – 360Combined sources13
Beta strandi378 – 380Combined sources3
Turni384 – 386Combined sources3
Helixi387 – 389Combined sources3
Helixi392 – 397Combined sources6
Beta strandi398 – 400Combined sources3
Beta strandi404 – 411Combined sources8
Helixi417 – 419Combined sources3
Helixi420 – 438Combined sources19
Helixi442 – 451Combined sources10
Helixi456 – 462Combined sources7
Helixi463 – 466Combined sources4
Beta strandi474 – 481Combined sources8
Helixi484 – 504Combined sources21
Helixi513 – 515Combined sources3
Helixi516 – 529Combined sources14
Beta strandi530 – 533Combined sources4
Helixi540 – 552Combined sources13

3D structure databases

ProteinModelPortaliQ9N1E2
SMRiQ9N1E2
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9N1E2

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Phylogenomic databases

eggNOGiKOG2446 Eukaryota
COG0166 LUCA
HOGENOMiHOG000261370
HOVERGENiHBG002877
InParanoidiQ9N1E2
KOiK01810

Family and domain databases

CDDicd05015 SIS_PGI_1, 1 hit
cd05016 SIS_PGI_2, 1 hit
Gene3Di1.10.1390.10, 1 hit
HAMAPiMF_00473 G6P_isomerase, 1 hit
InterProiView protein in InterPro
IPR001672 G6P_Isomerase
IPR023096 G6P_Isomerase_C
IPR018189 Phosphoglucose_isomerase_CS
IPR035476 SIS_PGI_1
IPR035482 SIS_PGI_2
PANTHERiPTHR11469 PTHR11469, 1 hit
PfamiView protein in Pfam
PF00342 PGI, 1 hit
PRINTSiPR00662 G6PISOMERASE
PROSITEiView protein in PROSITE
PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit
PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit
PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9N1E2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALTRNPQF QKLQQWHREH GSELNLRHLF DTDKERFNHF SLTLNTNHGH 
        60         70         80         90        100
ILLDYSKNLV TEEVMHMLLD LAKSRGVEAA RESMFNGEKI NSTEDRAVLH 
       110        120        130        140        150
VALRNRSNTP IVVDGKDVMP EVNKVLDKMK AFCQRVRSGD WKGYTGKTIT 
       160        170        180        190        200
DVINIGIGGS DLGPLMVTEA LKPYSSGGPR VWFVSNIDGT HIAKTLACLN 
       210        220        230        240        250
PESSLFIIAS KTFTTQETIT NAETAKDWFL LSAKDPSTVA KHFVALSTNT 
       260        270        280        290        300
AKVKEFGIDP QNMFEFWDWV GGRYSLWSAI GLSIALHVGF DNFEQLLSGA 
       310        320        330        340        350
HWMDQHFRTT PLEKNAPVLL AMLGIWYINC FGCETQAVLP YDQYLHRFAA 
       360        370        380        390        400
YFQQGDMESN GKYITKSGAR VDHQTGPIVW GEPGTNGQHA FYQLIHQGTK 
       410        420        430        440        450
MIPCDFLIPV QTQHPIRKGL HHKILLANFL AQTEALMKGK STEEARKELQ 
       460        470        480        490        500
AAGKSPEDLM KLLPHKVFEG NRPTNSIVFT KLTPFILGAL IAMYEHKIFV 
       510        520        530        540        550
QGVVWDINSF DQWGVELGKQ LAKKIEPELD GSSPVTSHDS STNGLINFIK 

QQREAKIQ
Length:558
Mass (Da):62,747
Last modified:January 23, 2007 - v3
Checksum:iBB4E3AB31BBD55E4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti223E → K in AAF35988 (PubMed:10653639).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF199601 mRNA Translation: AAF13713.2
AF222069 mRNA Translation: AAF35988.1
RefSeqiNP_001075538.1, NM_001082069.2
UniGeneiOcu.278

Genome annotation databases

GeneIDi100008744
KEGGiocu:100008744

Similar proteinsi

Entry informationi

Entry nameiG6PI_RABIT
AccessioniPrimary (citable) accession number: Q9N1E2
Secondary accession number(s): Q9N184
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 113 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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