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Protein

Interleukin-13

Gene

IL13

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-13
Short name:
IL-13
Gene namesi
Name:IL13
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000024732819 – 131Interleukin-13Add BLAST113

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi47 ↔ 75By similarity
Glycosylationi48N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi56N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi63 ↔ 89By similarity
Glycosylationi71N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9N0W9
PRIDEiQ9N0W9

Interactioni

Subunit structurei

Interacts with IL13RA2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000001250

Structurei

3D structure databases

ProteinModelPortaliQ9N0W9
SMRiQ9N0W9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-4/IL-13 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JCI3 Eukaryota
ENOG4111BX2 LUCA
HOGENOMiHOG000113028
HOVERGENiHBG006140
InParanoidiQ9N0W9
KOiK05435

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR020470 IL-13
IPR001325 IL-4/IL-13
IPR018096 IL-4/IL-13_CS
PANTHERiPTHR45413 PTHR45413, 1 hit
PfamiView protein in Pfam
PF03487 IL13, 1 hit
PRINTSiPR01929 INTRLEUKIN13
SMARTiView protein in SMART
SM00190 IL4_13, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00838 INTERLEUKIN_4_13, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q9N0W9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALWLTVVIA LTCLGGLASP SPVTPSPTLK ELIEELVNIT QNQASLCNGS
60 70 80 90 100
MVWSVNLTAG MYCAALESLI NVSDCSAIQR TQRMLKALCS QKPAAGQISS
110 120 130
ERSRDTKIEV IQLVKNLLTY VRGVYRHGNF R
Length:131
Mass (Da):14,268
Last modified:October 1, 2000 - v1
Checksum:i9A142B4D0F80370F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G1K273G1K273_CANLF
Interleukin-13
IL13
141Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF244915 mRNA Translation: AAF63204.1
RefSeqiNP_001003384.1, NM_001003384.1
UniGeneiCfa.3566

Genome annotation databases

GeneIDi442990
KEGGicfa:442990

Similar proteinsi

Entry informationi

Entry nameiIL13_CANLF
AccessioniPrimary (citable) accession number: Q9N0W9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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