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Protein

Acetoacetyl-CoA synthetase

Gene

AACS

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity).By similarity

Catalytic activityi

ATP + acetoacetate + CoA = AMP + diphosphate + acetoacetyl-CoA.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processFatty acid metabolism, Lipid metabolism
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Acetoacetyl-CoA synthetase (EC:6.2.1.16)
Gene namesi
Name:AACS
ORF Names:QccE-10783, QccE-14415, QflA-13650
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003157851 – 672Acetoacetyl-CoA synthetaseAdd BLAST672

Proteomic databases

PRIDEiQ9N0E1

Structurei

3D structure databases

ProteinModelPortaliQ9N0E1
SMRiQ9N0E1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG059947
KOiK01907

Family and domain databases

InterProiView protein in InterPro
IPR005914 Acac_CoA_synth
IPR032387 ACAS_N
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
PfamiView protein in Pfam
PF16177 ACAS_N, 1 hit
PF00501 AMP-binding, 1 hit
TIGRFAMsiTIGR01217 ac_ac_CoA_syn, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

Q9N0E1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKEERPGRE EILECQVMWE PDSKKNTQMD RFRAAVGAAC GLALENYDDL
60 70 80 90 100
YRWSVESYSD FWAEFWKFSG IVFSRAYDEV VDTSKGIADV PEWFKGSRLN
110 120 130 140 150
YAENLLRHKE NDRVALYVAR EGKEEIVKVT FEELRQEVAL FAAAMRKMGV
160 170 180 190 200
KKGDRVVGYL PNSEHAVEAM LAAASIGAIW SSTSPDFGVN GVLDRFSQIQ
210 220 230 240 250
PKLIFSVEAV VYNGKEHSHM EKLQQVVKGL PDLKKVVVIP YVSSREKIDL
260 270 280 290 300
SKIPNSVFLD DFLATGTSEQ APQLEFEQLP FSHPLFIMFS SGTTGAPKCM
310 320 330 340 350
VHSAGGTLIQ HLKEHLLHGN MTSSDILLCY TTAGWMMWNW MVSILATGAA
360 370 380 390 400
MVLYDGSPLV PTPNVLWDLV DRIGITVLVT GAKWLSVLEE KAMKPVETHS
410 420 430 440 450
LQMLHTILST GSPLKAQSYE YVYRCIKSSI LLGSISGGTD IISCFMGHNF
460 470 480 490 500
SLPVYKGEIQ ARNLGMAVEA WNEEGKAVWG ESGELVCTKP IPCQPTHFWN
510 520 530 540 550
DENGSKYRKA YFSKFPGIWA HGDYCRINPK TGGIIMLGRS DGTLNPNGVR
560 570 580 590 600
FGSSEIYNIV ESFEEVEDSL CVPQYNKFRE ERVILFLKMA SGHAFQPDLV
610 620 630 640 650
KRIRDAIRVG LSARHVPSLI LETKGIPYTL NGKKVEVAVK QIIAGKAVEQ
660 670
GGAFSNPETL DLYRDIPELQ GF
Length:672
Mass (Da):75,046
Last modified:October 1, 2000 - v1
Checksum:iDF31672A8E204528
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7P → A in BAB41151 (Ref. 1) Curated1
Sequence conflicti110E → D in BAE01877 (Ref. 2) Curated1
Sequence conflicti271A → V in BAE01877 (Ref. 2) Curated1
Sequence conflicti337M → V in BAE01877 (Ref. 2) Curated1
Sequence conflicti400S → G in BAB41151 (Ref. 1) Curated1
Sequence conflicti400S → G in BAE01877 (Ref. 2) Curated1
Sequence conflicti505S → N in BAB41151 (Ref. 1) Curated1
Sequence conflicti505S → N in BAE01877 (Ref. 2) Curated1
Sequence conflicti578F → Y in BAE01877 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB045989 mRNA Translation: BAB01571.1
AB060214 mRNA Translation: BAB41151.1
AB169796 mRNA Translation: BAE01877.1
RefSeqiNP_001270939.1, NM_001284010.1
UniGeneiMfa.1592

Genome annotation databases

GeneIDi102145658
KEGGimcf:102145658

Similar proteinsi

Entry informationi

Entry nameiAACS_MACFA
AccessioniPrimary (citable) accession number: Q9N0E1
Secondary accession number(s): Q4R4U8, Q9BE28
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2000
Last modified: March 15, 2017
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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