AACS

Functionⁱ

Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity).By similarity

Catalytic activityⁱ

ATP + acetoacetate + CoA = AMP + diphosphate + acetoacetyl-CoA.

GO - Molecular functionⁱ

acetoacetate-CoA ligase activity Source: UniProtKB-EC
ATP binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

fatty acid metabolic process Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ligase
Biological process	Fatty acid metabolism, Lipid metabolism
Ligand	ATP-binding, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Acetoacetyl-CoA synthetase (EC:6.2.1.16)
Gene namesⁱ	Name:AACS ORF Names:QccE-10783, QccE-14415, QflA-13650
Organismⁱ	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifierⁱ	9541 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Cercopithecoidea › Cercopithecidae › Cercopithecinae › Macaca

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000315785	1 – 672	Acetoacetyl-CoA synthetaseAdd BLAST		672

Proteomic databases

PRIDEⁱ	Q9N0E1

PRIDEⁱ

Q9N0E1

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9N0E1
SMRⁱ	Q9N0E1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the ATP-dependent AMP-binding enzyme family.Curated

Phylogenomic databases

HOVERGENⁱ	HBG059947
KEGG Orthology (KO) More...KOⁱ	K01907

Family and domain databases

InterProⁱ	View protein in InterPro IPR005914 Acac_CoA_synth IPR032387 ACAS_N IPR020845 AMP-binding_CS IPR000873 AMP-dep_Synth/Lig
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF16177 ACAS_N, 1 hit PF00501 AMP-binding, 1 hit
TIGRFAMsⁱ	TIGR01217 ac_ac_CoA_syn, 1 hit
PROSITEⁱ	View protein in PROSITE PS00455 AMP_BINDING, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9N0E1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSKEERPGRE EILECQVMWE PDSKKNTQMD RFRAAVGAAC GLALENYDDL 
        60         70         80         90        100
YRWSVESYSD FWAEFWKFSG IVFSRAYDEV VDTSKGIADV PEWFKGSRLN 
       110        120        130        140        150
YAENLLRHKE NDRVALYVAR EGKEEIVKVT FEELRQEVAL FAAAMRKMGV 
       160        170        180        190        200
KKGDRVVGYL PNSEHAVEAM LAAASIGAIW SSTSPDFGVN GVLDRFSQIQ 
       210        220        230        240        250
PKLIFSVEAV VYNGKEHSHM EKLQQVVKGL PDLKKVVVIP YVSSREKIDL 
       260        270        280        290        300
SKIPNSVFLD DFLATGTSEQ APQLEFEQLP FSHPLFIMFS SGTTGAPKCM 
       310        320        330        340        350
VHSAGGTLIQ HLKEHLLHGN MTSSDILLCY TTAGWMMWNW MVSILATGAA 
       360        370        380        390        400
MVLYDGSPLV PTPNVLWDLV DRIGITVLVT GAKWLSVLEE KAMKPVETHS 
       410        420        430        440        450
LQMLHTILST GSPLKAQSYE YVYRCIKSSI LLGSISGGTD IISCFMGHNF 
       460        470        480        490        500
SLPVYKGEIQ ARNLGMAVEA WNEEGKAVWG ESGELVCTKP IPCQPTHFWN 
       510        520        530        540        550
DENGSKYRKA YFSKFPGIWA HGDYCRINPK TGGIIMLGRS DGTLNPNGVR 
       560        570        580        590        600
FGSSEIYNIV ESFEEVEDSL CVPQYNKFRE ERVILFLKMA SGHAFQPDLV 
       610        620        630        640        650
KRIRDAIRVG LSARHVPSLI LETKGIPYTL NGKKVEVAVK QIIAGKAVEQ 
       660        670 
GGAFSNPETL DLYRDIPELQ GF

Length:672

Mass (Da):75,046

Last modified:October 1, 2000 - v1

Checksum:ⁱDF31672A8E204528

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	7	P → A in BAB41151 (Ref. 1) Curated	1
Sequence conflictⁱ	110	E → D in BAE01877 (Ref. 2) Curated	1
Sequence conflictⁱ	271	A → V in BAE01877 (Ref. 2) Curated	1
Sequence conflictⁱ	337	M → V in BAE01877 (Ref. 2) Curated	1
Sequence conflictⁱ	400	S → G in BAB41151 (Ref. 1) Curated	1
Sequence conflictⁱ	400	S → G in BAE01877 (Ref. 2) Curated	1
Sequence conflictⁱ	505	S → N in BAB41151 (Ref. 1) Curated	1
Sequence conflictⁱ	505	S → N in BAE01877 (Ref. 2) Curated	1
Sequence conflictⁱ	578	F → Y in BAE01877 (Ref. 2) Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB045989 mRNA Translation: BAB01571.1 AB060214 mRNA Translation: BAB41151.1 AB169796 mRNA Translation: BAE01877.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001270939.1, NM_001284010.1
UniGeneⁱ	Mfa.1592

Genome annotation databases

GeneIDⁱ	102145658
KEGGⁱ	mcf:102145658

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9N0E1	Acetoacetyl-CoA synthetase		HUMAN		672	UniRef90_Q86V21
Acetoacetyl-CoA synthetase		PIG		795
Acetoacetyl-CoA synthetase		AILME		674
Acetoacetyl-CoA synthetase		MACMU		672
Acetoacetyl-CoA synthetase		MACFA		672
+58

Protein	Similar proteins		Species	Score	Length	Source
Q9N0E1	Acetoacetyl-CoA synthetase		RAT		672	UniRef50_Q9JMI1
Acetoacetyl-CoA synthetase		CHICK		667
Acetoacetyl-CoA synthetase		HUMAN		672
Acetoacetyl-CoA synthetase		XENTR		672
Acetoacetyl-CoA synthetase		MOUSE		672
+392

Entry informationⁱ

Entry nameⁱ	AACS_MACFA
Accessionⁱ	Q9N0E1Primary (citable) accession number: Q9N0E1 Secondary accession number(s): Q4R4U8, Q9BE28
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
	Last sequence update:	October 1, 2000
	Last modified:	March 15, 2017
	This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB - Q9N0E1 (AACS_MACFA)

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Acetoacetyl-CoA synthetase

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Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Cytosol

Cytosol

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Molecule processing

Proteomic databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Experimental Info

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Entry informationⁱ

UniProt is an ELIXIR core data resource

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9N0E1 (AACS_MACFA)

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Acetoacetyl-CoA synthetase

AACS

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Cytosol

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Entry informationⁱ