UniProtKB - Q9N0E1 (AACS_MACFA)
Protein
Acetoacetyl-CoA synthetase
Gene
AACS
Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Functioni
Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity).By similarity
Catalytic activityi
- EC:6.2.1.16
GO - Molecular functioni
- acetoacetate-CoA ligase activity Source: UniProtKB-EC
- ATP binding Source: UniProtKB-KW
GO - Biological processi
- fatty acid metabolic process Source: UniProtKB-KW
Keywordsi
Molecular function | Ligase |
Biological process | Fatty acid metabolism, Lipid metabolism |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:AACS ORF Names:QccE-10783, QccE-14415, QflA-13650 |
Organismi | Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) |
Taxonomic identifieri | 9541 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca |
Proteomesi |
|
Subcellular locationi
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000315785 | 1 – 672 | Acetoacetyl-CoA synthetaseAdd BLAST | 672 |
Family & Domainsi
Sequence similaritiesi
Belongs to the ATP-dependent AMP-binding enzyme family.Curated
Phylogenomic databases
eggNOGi | KOG1175, Eukaryota |
OrthoDBi | 899666at2759 |
Family and domain databases
Gene3Di | 3.40.50.12780, 1 hit |
InterProi | View protein in InterPro IPR005914, Acac_CoA_synth IPR032387, ACAS_N IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, AMP-dep_Synthh-like_sf |
Pfami | View protein in Pfam PF16177, ACAS_N, 1 hit PF00501, AMP-binding, 1 hit |
TIGRFAMsi | TIGR01217, ac_ac_CoA_syn, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9N0E1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKEERPGRE EILECQVMWE PDSKKNTQMD RFRAAVGAAC GLALENYDDL
60 70 80 90 100
YRWSVESYSD FWAEFWKFSG IVFSRAYDEV VDTSKGIADV PEWFKGSRLN
110 120 130 140 150
YAENLLRHKE NDRVALYVAR EGKEEIVKVT FEELRQEVAL FAAAMRKMGV
160 170 180 190 200
KKGDRVVGYL PNSEHAVEAM LAAASIGAIW SSTSPDFGVN GVLDRFSQIQ
210 220 230 240 250
PKLIFSVEAV VYNGKEHSHM EKLQQVVKGL PDLKKVVVIP YVSSREKIDL
260 270 280 290 300
SKIPNSVFLD DFLATGTSEQ APQLEFEQLP FSHPLFIMFS SGTTGAPKCM
310 320 330 340 350
VHSAGGTLIQ HLKEHLLHGN MTSSDILLCY TTAGWMMWNW MVSILATGAA
360 370 380 390 400
MVLYDGSPLV PTPNVLWDLV DRIGITVLVT GAKWLSVLEE KAMKPVETHS
410 420 430 440 450
LQMLHTILST GSPLKAQSYE YVYRCIKSSI LLGSISGGTD IISCFMGHNF
460 470 480 490 500
SLPVYKGEIQ ARNLGMAVEA WNEEGKAVWG ESGELVCTKP IPCQPTHFWN
510 520 530 540 550
DENGSKYRKA YFSKFPGIWA HGDYCRINPK TGGIIMLGRS DGTLNPNGVR
560 570 580 590 600
FGSSEIYNIV ESFEEVEDSL CVPQYNKFRE ERVILFLKMA SGHAFQPDLV
610 620 630 640 650
KRIRDAIRVG LSARHVPSLI LETKGIPYTL NGKKVEVAVK QIIAGKAVEQ
660 670
GGAFSNPETL DLYRDIPELQ GF
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 7 | P → A in BAB41151 (Ref. 1) Curated | 1 | |
Sequence conflicti | 110 | E → D in BAE01877 (Ref. 2) Curated | 1 | |
Sequence conflicti | 271 | A → V in BAE01877 (Ref. 2) Curated | 1 | |
Sequence conflicti | 337 | M → V in BAE01877 (Ref. 2) Curated | 1 | |
Sequence conflicti | 400 | S → G in BAB41151 (Ref. 1) Curated | 1 | |
Sequence conflicti | 400 | S → G in BAE01877 (Ref. 2) Curated | 1 | |
Sequence conflicti | 505 | S → N in BAB41151 (Ref. 1) Curated | 1 | |
Sequence conflicti | 505 | S → N in BAE01877 (Ref. 2) Curated | 1 | |
Sequence conflicti | 578 | F → Y in BAE01877 (Ref. 2) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB045989 mRNA Translation: BAB01571.1 AB060214 mRNA Translation: BAB41151.1 AB169796 mRNA Translation: BAE01877.1 |
RefSeqi | NP_001270939.1, NM_001284010.1 |
Genome annotation databases
GeneIDi | 102145658 |
KEGGi | mcf:102145658 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB045989 mRNA Translation: BAB01571.1 AB060214 mRNA Translation: BAB41151.1 AB169796 mRNA Translation: BAE01877.1 |
RefSeqi | NP_001270939.1, NM_001284010.1 |
3D structure databases
SMRi | Q9N0E1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9541.XP_005572665.1 |
Genome annotation databases
GeneIDi | 102145658 |
KEGGi | mcf:102145658 |
Organism-specific databases
CTDi | 65985 |
Phylogenomic databases
eggNOGi | KOG1175, Eukaryota |
OrthoDBi | 899666at2759 |
Family and domain databases
Gene3Di | 3.40.50.12780, 1 hit |
InterProi | View protein in InterPro IPR005914, Acac_CoA_synth IPR032387, ACAS_N IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, AMP-dep_Synthh-like_sf |
Pfami | View protein in Pfam PF16177, ACAS_N, 1 hit PF00501, AMP-binding, 1 hit |
TIGRFAMsi | TIGR01217, ac_ac_CoA_syn, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AACS_MACFA | |
Accessioni | Q9N0E1Primary (citable) accession number: Q9N0E1 Secondary accession number(s): Q4R4U8, Q9BE28 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | October 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 66 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families