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Protein

Gap junction delta-4 protein

Gene

GJD4

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction delta-4 protein
Alternative name(s):
Connexin-40.1
Short name:
Cx40.1
Gene namesi
Name:GJD4
ORF Names:QccE-15512
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19CytoplasmicSequence analysisAdd BLAST19
Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Topological domaini41 – 76ExtracellularSequence analysisAdd BLAST36
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Topological domaini98 – 146CytoplasmicSequence analysisAdd BLAST49
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Topological domaini168 – 196ExtracellularSequence analysisAdd BLAST29
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Topological domaini218 – 370CytoplasmicSequence analysisAdd BLAST153

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003130101 – 370Gap junction delta-4 proteinAdd BLAST370

Proteomic databases

PRIDEiQ9N0B3

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.By similarity

Family & Domainsi

Sequence similaritiesi

Belongs to the connexin family. Delta-type subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG062544
KOiK07630

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PRINTSiPR00206 CONNEXIN
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9N0B3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGVDLLGFL IITLNCNVTM XGKLWFVLTM LLRMLVIVLA GRPVYQDEQE
60 70 80 90 100
RFVCNTLQPG CANVCYDVFS PVSHLRFWLI QGVCVLLPSA VFSVYVLHRG
110 120 130 140 150
ATLAALGPRR CPEPRDTASG QRRCPGSCRE RGGLEVPDFS AGYIIHLLLR
160 170 180 190 200
TLLEAAFGAL NYLLFGFLAP NKFPCTRPPC TGVVDCYVSR PTEKSLLMLF
210 220 230 240 250
LWAVSALSFL LGLADLVCSL RRLMRRRPGP PTSPSIRKQS GAPGHPEGRP
260 270 280 290 300
TDKEGGREQE GAPAPPVARA GGEGAGSPRV TSRVSGHTKI PDEDASEVTS
310 320 330 340 350
SASEKLGRQP RGRPYREAAQ DPRGSGSEEQ PSAAPSHLAA HPSCSRLQPP
360 370
DPPASSVGAP HLRARKSEWV
Length:370
Mass (Da):40,019
Last modified:January 15, 2008 - v2
Checksum:iEDDA3D75424E4C16
GO

Sequence cautioni

The sequence BAB01599 differs from that shown. Reason: Frameshift at position 21.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046017 mRNA Translation: BAB01599.1 Frameshift.
RefSeqiNP_001306359.1, NM_001319430.1
UniGeneiMfa.6432

Genome annotation databases

GeneIDi102131448
KEGGimcf:102131448

Similar proteinsi

Entry informationi

Entry nameiCXD4_MACFA
AccessioniPrimary (citable) accession number: Q9N0B3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: May 23, 2018
This is version 58 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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