UniProtKB - Q9MZL5 (CACB2_BOVIN)
Voltage-dependent L-type calcium channel subunit beta-2
CACNB2
Functioni
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 492 | Required for CaMK2D-bindingBy similarity | 1 |
GO - Molecular functioni
- high voltage-gated calcium channel activity Source: GO_Central
GO - Biological processi
- chemical synaptic transmission Source: GO_Central
- neuromuscular junction development Source: GO_Central
- regulation of voltage-gated calcium channel activity Source: GO_Central
Keywordsi
Molecular function | Calcium channel, Ion channel, Voltage-gated channel |
Biological process | Calcium transport, Ion transport, Transport |
Ligand | Calcium |
Names & Taxonomyi
Protein namesi | Recommended name: Voltage-dependent L-type calcium channel subunit beta-2Short name: CAB2 Alternative name(s): Calcium channel voltage-dependent subunit beta 2 |
Gene namesi | Name:CACNB2 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSBTAG00000022000 |
VGNCi | VGNC:26684, CACNB2 |
Subcellular locationi
Plasma membrane
- sarcolemma By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Plasma Membrane
- L-type voltage-gated calcium channel complex Source: UniProtKB
- voltage-gated calcium channel complex Source: GO_Central
Other locations
- synapse Source: GOC
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000144050 | 1 – 603 | Voltage-dependent L-type calcium channel subunit beta-2Add BLAST | 603 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 149 | PhosphoserineBy similarity | 1 | |
Modified residuei | 152 | PhosphoserineBy similarity | 1 | |
Modified residuei | 163 | PhosphoserineBy similarity | 1 | |
Modified residuei | 493 | PhosphoserineBy similarity | 1 | |
Modified residuei | 497 | Phosphothreonine; by CaMK2DBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q9MZL5 |
PRIDEi | Q9MZL5 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000022000, Expressed in heart and 96 other tissues |
ExpressionAtlasi | Q9MZL5, baseline and differential |
Interactioni
Subunit structurei
Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2.
Interacts with CACNA1C (By similarity).
Interacts with RRAD. Interaction with RRAD regulates the trafficking of CACNA1C to the cell membrane.
Interacts with TMIGD2 (By similarity).
Interacts with CAMK2D.
Interacts with CBARP (By similarity).
Interacts with CAMK2A (By similarity).
By similarityProtein-protein interaction databases
ComplexPortali | CPX-3193, Cardiac muscle VGCC complex |
IntActi | Q9MZL5, 2 interactors |
STRINGi | 9913.ENSBTAP00000029344 |
Chemistry databases
BindingDBi | Q9MZL5 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 59 – 128 | SH3PROSITE-ProRule annotationAdd BLAST | 70 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 135 – 206 | DisorderedSequence analysisAdd BLAST | 72 | |
Regioni | 432 – 603 | DisorderedSequence analysisAdd BLAST | 172 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 139 – 170 | Polar residuesSequence analysisAdd BLAST | 32 | |
Compositional biasi | 189 – 203 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 432 – 454 | Polar residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 457 – 475 | Basic and acidic residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 497 – 603 | Basic and acidic residuesSequence analysisAdd BLAST | 107 |
Sequence similaritiesi
Keywords - Domaini
SH3 domainPhylogenomic databases
eggNOGi | KOG3812, Eukaryota |
GeneTreei | ENSGT00950000182837 |
HOGENOMi | CLU_021995_3_0_1 |
InParanoidi | Q9MZL5 |
OrthoDBi | 926074at2759 |
TreeFami | TF316195 |
Family and domain databases
CDDi | cd12040, SH3_CACNB2, 1 hit |
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR035605, CACNB2_SH3 IPR008145, GK/Ca_channel_bsu IPR027417, P-loop_NTPase IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR005444, VDCC_L_b2su IPR000584, VDCC_L_bsu |
Pfami | View protein in Pfam PF00625, Guanylate_kin, 1 hit PF12052, VGCC_beta4Aa_N, 1 hit |
PRINTSi | PR01626, LCACHANNELB PR01628, LCACHANNELB2 |
SMARTi | View protein in SMART SM00072, GuKc, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50002, SH3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MQCCGLVHRR RARVSYGSAD SYTSRPSDSD VSLEEDREAV RREAERQAQA
60 70 80 90 100
QLEKAKTKPV AFAVRTNVSY SAAHEDDVPV PGMAISFEAK DFLHVKEKFN
110 120 130 140 150
NDWWIGRLVK EGCEIGFIPS PVKLENMRLQ HEQRAKQGKF YSSKSGGNSS
160 170 180 190 200
SSLGDIVPSS RKSTPPSSAI DIDATGLDAE DNDIPANHRS PKPSANSVTS
210 220 230 240 250
PHSKEKRMPF FKKTEHTPPY DVVPSMRPVV LVGPSLKGYE VTDMMQKALF
260 270 280 290 300
DFLKHRFEGR ISITRVTADI SLAKRSVLNN PSKHAIIERS NTRSSLAEVQ
310 320 330 340 350
SEIERIFELA RTLQLVVLDA DTINHPAQLS KTSLAPIIVY VKISSPKVLQ
360 370 380 390 400
RLIKSRGKSQ AKHLNVQMVA ADKLAQCPPE LFDVILDENQ LEDACEHLAD
410 420 430 440 450
YLEAYWKATH PPSSSLPNPL LSRTLATSTL PVSPTLASNS QGSQGDQRTD
460 470 480 490 500
RGAPGRSASQ AEEEHCPEPV KKAQHRSSTQ HHNHRSGTSR GLSRQETLDS
510 520 530 540 550
ETQESRDSAY AEPKEEYSHE HADHYAPHRD HNHREEPHGG GEHRHREPRH
560 570 580 590 600
RSRDPDREQD HNESNKQRSR HKSKDRYCDK DGEGLSRRRN EAADWNRDVY
IRQ
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q1MK14 | A0A3Q1MK14_BOVIN | Voltage-dependent L-type calcium ch... | CACNB2 | 614 | Annotation score: | ||
A0A3Q1LVX8 | A0A3Q1LVX8_BOVIN | Voltage-dependent L-type calcium ch... | CACNB2 | 610 | Annotation score: | ||
A0A3Q1MBH6 | A0A3Q1MBH6_BOVIN | Voltage-dependent L-type calcium ch... | CACNB2 | 604 | Annotation score: | ||
A0A3Q1MA95 | A0A3Q1MA95_BOVIN | Voltage-dependent L-type calcium ch... | CACNB2 | 589 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF174417 mRNA Translation: AAF26681.1 |
RefSeqi | NP_786983.1, NM_175789.2 |
Genome annotation databases
Ensembli | ENSBTAT00000029344; ENSBTAP00000029344; ENSBTAG00000022000 |
GeneIDi | 327667 |
KEGGi | bta:327667 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF174417 mRNA Translation: AAF26681.1 |
RefSeqi | NP_786983.1, NM_175789.2 |
3D structure databases
AlphaFoldDBi | Q9MZL5 |
SMRi | Q9MZL5 |
ModBasei | Search... |
Protein-protein interaction databases
ComplexPortali | CPX-3193, Cardiac muscle VGCC complex |
IntActi | Q9MZL5, 2 interactors |
STRINGi | 9913.ENSBTAP00000029344 |
Chemistry databases
BindingDBi | Q9MZL5 |
Proteomic databases
PaxDbi | Q9MZL5 |
PRIDEi | Q9MZL5 |
Genome annotation databases
Ensembli | ENSBTAT00000029344; ENSBTAP00000029344; ENSBTAG00000022000 |
GeneIDi | 327667 |
KEGGi | bta:327667 |
Organism-specific databases
CTDi | 783 |
VEuPathDBi | HostDB:ENSBTAG00000022000 |
VGNCi | VGNC:26684, CACNB2 |
Phylogenomic databases
eggNOGi | KOG3812, Eukaryota |
GeneTreei | ENSGT00950000182837 |
HOGENOMi | CLU_021995_3_0_1 |
InParanoidi | Q9MZL5 |
OrthoDBi | 926074at2759 |
TreeFami | TF316195 |
Gene expression databases
Bgeei | ENSBTAG00000022000, Expressed in heart and 96 other tissues |
ExpressionAtlasi | Q9MZL5, baseline and differential |
Family and domain databases
CDDi | cd12040, SH3_CACNB2, 1 hit |
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR035605, CACNB2_SH3 IPR008145, GK/Ca_channel_bsu IPR027417, P-loop_NTPase IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR005444, VDCC_L_b2su IPR000584, VDCC_L_bsu |
Pfami | View protein in Pfam PF00625, Guanylate_kin, 1 hit PF12052, VGCC_beta4Aa_N, 1 hit |
PRINTSi | PR01626, LCACHANNELB PR01628, LCACHANNELB2 |
SMARTi | View protein in SMART SM00072, GuKc, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50002, SH3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CACB2_BOVIN | |
Accessioni | Q9MZL5Primary (citable) accession number: Q9MZL5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 2, 2002 |
Last sequence update: | October 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 138 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families