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Entry version 127 (29 Sep 2021)
Sequence version 1 (01 Oct 2000)
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Protein

NAD(P)H oxidase (H(2)O(2)-forming)

Gene

THOX2

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.

ARBA annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: thyroid hormone biosynthesis

This protein is involved in the pathway thyroid hormone biosynthesis, which is part of Hormone biosynthesis.ARBA annotation
View all proteins of this organism that are known to be involved in the pathway thyroid hormone biosynthesis and in Hormone biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi598 – 609PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi634 – 645PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase, PeroxidaseARBA annotation
Biological processThyroid hormones biosynthesisARBA annotation
LigandCalciumPROSITE-ProRule annotationARBA annotation, FADARBA annotation, Flavoprotein, NADPARBA annotation

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00194

Protein family/group databases

PeroxiBase, a peroxidase database

More...
PeroxiBasei
3337, CfaDuOx02

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NAD(P)H oxidase (H(2)O(2)-forming)ARBA annotation (EC:1.6.3.1ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:THOX2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9615 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei364 – 388HelicalSequence analysisAdd BLAST25
Transmembranei797 – 815HelicalSequence analysisAdd BLAST19
Transmembranei848 – 865HelicalSequence analysisAdd BLAST18
Transmembranei909 – 927HelicalSequence analysisAdd BLAST19
Transmembranei939 – 965HelicalSequence analysisAdd BLAST27
Transmembranei977 – 999HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini585 – 620EF-handInterPro annotationAdd BLAST36
Domaini621 – 656EF-handInterPro annotationAdd BLAST36
Domaini1026 – 1132FAD-binding FR-typeInterPro annotationAdd BLAST107

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni396 – 416DisorderedSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the peroxidase family.ARBA annotation

Keywords - Domaini

RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00051, EFh, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.640.10, 1 hit
3.40.50.80, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR034818, DUOX2
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR013112, FAD-bd_8
IPR017927, FAD-bd_FR_type
IPR013130, Fe3_Rdtase_TM_dom
IPR013121, Fe_red_NAD-bd_6
IPR039261, FNR_nucleotide-bd
IPR019791, Haem_peroxidase_animal
IPR010255, Haem_peroxidase_sf
IPR037120, Haem_peroxidase_sf_animal
IPR017938, Riboflavin_synthase-like_b-brl

The PANTHER Classification System

More...
PANTHERi
PTHR11972:SF67, PTHR11972:SF67, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03098, An_peroxidase, 1 hit
PF00036, EF-hand_1, 1 hit
PF08022, FAD_binding_8, 1 hit
PF01794, Ferric_reduct, 1 hit
PF08030, NAD_binding_6, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00457, ANPEROXIDASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00054, EFh, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473, SSF47473, 1 hit
SSF48113, SSF48113, 1 hit
SSF52343, SSF52343, 1 hit
SSF63380, SSF63380, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS51384, FAD_FR, 1 hit
PS50292, PEROXIDASE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q9MZF3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
GGLYAFGAER GNRDPFLQAL GLLWFRYHNL CAQRLARQHP HWGDEELFQH
60 70 80 90 100
ARKRVIATYQ NIALYEWLPS FLQKTLPKYT GYHPFLDPSI SPEFLVASEQ
110 120 130 140 150
FFSTMVPPGV YMRNASCHFQ MVLTKDLGSS PALRVCNSYW LRENANLNSA
160 170 180 190 200
QAVDQLLLGM ASQISELEDR IVVEDLRDYW PGSGKFSRTD YVASSIQRGR
210 220 230 240 250
DMGLPSYTQA LMALGLEIPR NWSHINPNVD AQVLEATAAL YNQDLTRLEL
260 270 280 290 300
LPGGLLESHG DPGSLFSAII LDQFVRLRDG DRYWFENTRN GLFSKEEIAE
310 320 330 340 350
IKNTTFWDVL VAVTNVNHSA LQPNVFIWHD GAPCPQPRQL TTQGLPQCVP
360 370 380 390 400
LTVFDYFEGS GPGFGITIVA LCCLPLVSLL ISGVVAHFRG RERKRLQKKG
410 420 430 440 450
KESVKKEAAK DGVPAMEWPG PREKSYPITI QLLPDRRLQV LDRKLSVLRT
460 470 480 490 500
VQLQPPQQVN LILSSNRGCH TLLLKIPKEY DLVLLFNSEE ERGTFVQHLQ
510 520 530 540 550
DFCVQWSLGL DVAEMRENEL FRRAVTKQQR GRILEIFFRY LFAQVLDIDQ
560 570 580 590 600
ADAGTLPLNS SQKVREALTC ELSRAEFAES LGLKPQDMFV ESMFSLADKD
610 620 630 640 650
GNGYLSFREF LDILVVFMKG SPEDKSRLMF TMYDLDANGF LSKDEFFTMM
660 670 680 690 700
RSFIEISNNC LSKAQLTEVV ESMFRESGFQ DKEELTWEDF HFMLRDHDSE
710 720 730 740 750
LRRTQLCVRG VGDIFKPNIS CRVSFITRTP GKRSCSQDLE FSASEAPELG
760 770 780 790 800
GPGLKKRFGK KVVGPTPRLY TEALKEKMQR GLLAQKLRQY KRFVENYRRH
810 820 830 840 850
IVCVVVFSAI CAGLFAERAY YYAFASPPSG IAETTFVGII LSRGTAASIS
860 870 880 890 900
FMFSYILLTM CRNLITFLRE TFLNRYVPFD AAVDFHRWIA MAAVVLAILH
910 920 930 940 950
SAGHAVNVFI FSVSPLSLLA CIFPNIFMND GSQLPQKFYW WFFQTVPGMT
960 970 980 990 1000
GVLLLLVLAI MYVFASHHFR RRSFRGFWLT HHLYIVLYVL LIIHGSFGLI
1010 1020 1030 1040 1050
QLPRFYIYFL VPALIYVGDK LVSLSRKKVE ISVVKAELLP SGVTHLQFQR
1060 1070 1080 1090 1100
PQGFEYKSGQ WVRIACLALG TNEYHPFTLT SAPHEDTLSL HIRAVGPWTT
1110 1120 1130 1140 1150
RLRETYSLPK GDGCARYPKL YLDGPFGEGH QEWHKFEVSV LVGGGIGVTP
1160 1170 1180 1190 1200
FASILKDLVF KSSLGSQMLC KKIYFIWVTR TQRQFEWLAD IIREVEENDH
1210 1220 1230 1240 1250
QDLVSVHIYI TQLAEKFDLR TTMLYICERH FQKVLNRSLF TGLRSITHFG
1260 1270 1280 1290 1300
RPPFEPFFKS LQEVHPQVPK IGVFSCGPSR NDQECREGLS AHQQAGPGPL

RCTTYENF
Length:1,308
Mass (Da):149,256
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i511AD3F3D5684BEA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF230498 mRNA Translation: AAF73924.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF230498 mRNA Translation: AAF73924.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

PeroxiBasei3337, CfaDuOx02

Enzyme and pathway databases

UniPathwayiUPA00194

Family and domain databases

CDDicd00051, EFh, 2 hits
Gene3Di1.10.640.10, 1 hit
3.40.50.80, 1 hit
InterProiView protein in InterPro
IPR034818, DUOX2
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR013112, FAD-bd_8
IPR017927, FAD-bd_FR_type
IPR013130, Fe3_Rdtase_TM_dom
IPR013121, Fe_red_NAD-bd_6
IPR039261, FNR_nucleotide-bd
IPR019791, Haem_peroxidase_animal
IPR010255, Haem_peroxidase_sf
IPR037120, Haem_peroxidase_sf_animal
IPR017938, Riboflavin_synthase-like_b-brl
PANTHERiPTHR11972:SF67, PTHR11972:SF67, 1 hit
PfamiView protein in Pfam
PF03098, An_peroxidase, 1 hit
PF00036, EF-hand_1, 1 hit
PF08022, FAD_binding_8, 1 hit
PF01794, Ferric_reduct, 1 hit
PF08030, NAD_binding_6, 1 hit
PRINTSiPR00457, ANPEROXIDASE
SMARTiView protein in SMART
SM00054, EFh, 2 hits
SUPFAMiSSF47473, SSF47473, 1 hit
SSF48113, SSF48113, 1 hit
SSF52343, SSF52343, 1 hit
SSF63380, SSF63380, 1 hit
PROSITEiView protein in PROSITE
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS51384, FAD_FR, 1 hit
PS50292, PEROXIDASE_3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9MZF3_CANLF
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9MZF3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: September 29, 2021
This is version 127 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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