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Entry version 177 (02 Jun 2021)
Sequence version 1 (01 Oct 2000)
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Protein

NADH-ubiquinone oxidoreductase chain 5

Gene

mt-Nd5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductaseImported
Biological processElectron transport, Respiratory chainARBA annotation, Transport
LigandNADUniRule annotation, UbiquinoneUniRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 5UniRule annotation (EC:7.1.1.2UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mt-Nd5Imported
Synonyms:mt-ND5Imported, mt-Nd6Imported, ND5Imported, Nd5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates if the gene coding for the protein originates from the hydrogenosome, the mitochondrion, the nucleomorph, different plastids or a plasmid. The absence of this section means that the gene is located in one of the main chromosomal element(s).<p><a href='/help/encoded_on' target='_top'>More...</a></p>Encoded oniMitochondrionImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:102496, mt-Nd5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei6 – 27HelicalUniRule annotationAdd BLAST22
Transmembranei39 – 56HelicalUniRule annotationAdd BLAST18
Transmembranei84 – 105HelicalUniRule annotationAdd BLAST22
Transmembranei117 – 134HelicalUniRule annotationAdd BLAST18
Transmembranei140 – 160HelicalUniRule annotationAdd BLAST21
Transmembranei172 – 191HelicalUniRule annotationAdd BLAST20
Transmembranei211 – 233HelicalUniRule annotationAdd BLAST23
Transmembranei245 – 266HelicalUniRule annotationAdd BLAST22
Transmembranei272 – 294HelicalUniRule annotationAdd BLAST23
Transmembranei301 – 319HelicalUniRule annotationAdd BLAST19
Transmembranei325 – 347HelicalUniRule annotationAdd BLAST23
Transmembranei368 – 386HelicalUniRule annotationAdd BLAST19
Transmembranei406 – 432HelicalUniRule annotationAdd BLAST27
Transmembranei453 – 472HelicalUniRule annotationAdd BLAST20
Transmembranei484 – 504HelicalUniRule annotationAdd BLAST21
Transmembranei586 – 604HelicalUniRule annotationAdd BLAST19

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000064367, Expressed in Ammon's horn and 82 other tissues

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini66 – 121Proton_antipo_NInterPro annotationAdd BLAST56
Domaini134 – 418Proton_antipo_MInterPro annotationAdd BLAST285
Domaini422 – 601NADH5_CInterPro annotationAdd BLAST180

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the complex I subunit 5 family.UniRule annotationARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationARBA annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007100_6_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
GVGIMSF

Database of Orthologous Groups

More...
OrthoDBi
526738at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010934, NADH_DH_su5_C
IPR003945, NADHpl_OxRdtase_5
IPR001750, ND/Mrp_mem
IPR001516, Proton_antipo_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06455, NADH5_C, 1 hit
PF00361, Proton_antipo_M, 1 hit
PF00662, Proton_antipo_N, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01974, NDH_I_L, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9MD82-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNIFTTSILL IFILLLSPIL ISMSNLIKHI NFPLYTTTSI KFSFIISLLP
60 70 80 90 100
LLMFFHNNME YMITTWHWVT MNSMELKMSF KTDFFSILFT SVALFVTWSI
110 120 130 140 150
MQFSSWYMHS DPNINRFIKY LTLFLITMLI LTSANNMFQL FIGWEGVGIM
160 170 180 190 200
SFLLIGWWYG RTDANTAALQ AILYNRIGDI GFILAMVWFS LNMNSWELQQ
210 220 230 240 250
IMFSNNNDNL IPLMGLLIAA TGKSAQFGLH PWLPSAMEGP TPVSALLHSS
260 270 280 290 300
TMVVAGIFLL VRFHPLTTNN NFILTTMLCL GALTTLFTAI CALTQNDIKK
310 320 330 340 350
IIAFSTSSQL GLMMVTLGMN QPHLAFLHIC THAFFKAMLF MCSGSIIHSL
360 370 380 390 400
ADEQDIRKMG NITKIMPFTS SCLVIGSLAL TGMPFLTGFY SKDLIIEAIN
410 420 430 440 450
TCNTNAWALL ITLIATSMTA MYSMRIIYFV TMTKPRFPPL ISINENDPDL
460 470 480 490 500
MNPIKRLAFG SIFAGFVISY NIPPTSIPVL TMPWFLKTTA LIISVLGFLI
510 520 530 540 550
ALELNNLTMK LSMNKANPYS SFSTLLGFFP SIIHRITPMK SLNLSLKTSL
560 570 580 590 600
TLLDLIWLEK TIPKSTSTLH TNMTTLTTNQ KGLIKLYFMS FLINIILIII

LYSINLE
Length:607
Mass (Da):68,475
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i31C10862CDC78B10
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY466499 Genomic DNA Translation: AAR21205.1
AY533105 Genomic DNA Translation: AAS01436.1
AY533106 Genomic DNA Translation: AAS01449.1
AY533107 Genomic DNA Translation: AAS01462.1
AY533108 Genomic DNA Translation: AAS01475.1
AY999076 Genomic DNA Translation: AAX83022.1
EF108330 Genomic DNA Translation: ABK79103.1
EF108331 Genomic DNA Translation: ABK79116.1
EF108332 Genomic DNA Translation: ABK79129.1
EF108333 Genomic DNA Translation: ABK79142.1
EF108334 Genomic DNA Translation: ABK79155.1
EF108335 Genomic DNA Translation: ABK79168.1
EF108336 Genomic DNA Translation: ABK79181.1
EF108337 Genomic DNA Translation: ABK79194.1
EF108338 Genomic DNA Translation: ABK79207.1
EF108339 Genomic DNA Translation: ABK79220.1
EF108340 Genomic DNA Translation: ABK79233.1
EF108341 Genomic DNA Translation: ABK79246.1
EU312160 Genomic DNA Translation: ABX79712.1
EU312161 Genomic DNA Translation: ABX79725.1
EU315228 Genomic DNA Translation: ABX79738.1
EU315229 Genomic DNA Translation: ABX79751.1
EU450583 Genomic DNA Translation: ACA01533.1
FJ803909 Genomic DNA Translation: ACN91105.1
HQ586004 Genomic DNA Translation: ADR03166.1
HQ877407 Genomic DNA Translation: ADW83076.1
JF286601 Genomic DNA Translation: ADZ23173.1
HQ675026 Genomic DNA Translation: AEN03379.1
HQ675027 Genomic DNA Translation: AEN03392.1
HQ675028 Genomic DNA Translation: AEN03405.1
HQ675029 Genomic DNA Translation: AEN03418.1
HQ675030 Genomic DNA Translation: AEN03431.1
HQ675031 Genomic DNA Translation: AEN03444.1
JQ003190 Genomic DNA Translation: AEV56607.1
KP090294 Genomic DNA Translation: AJE26566.1
KP260514 Genomic DNA Translation: AJK91496.1
KP260515 Genomic DNA Translation: AJK91509.1
KP260516 Genomic DNA Translation: AJK91522.1
KP260517 Genomic DNA Translation: AJK91535.1
KR020497 Genomic DNA Translation: AKS10722.1
KY018919 Genomic DNA Translation: ART65703.1
AB042524 Genomic DNA Translation: BAA95650.1
AB042523 Genomic DNA Translation: BAA95663.1
AB042809 Genomic DNA Translation: BAA95805.1
AB049357 Genomic DNA Translation: BAB13811.1
AK140457 mRNA Translation: BAE24397.1
AP013030 Genomic DNA Translation: BAM93593.1
AP014540 Genomic DNA Translation: BAO42860.1
AP014541 Genomic DNA Translation: BAO42873.1
AJ489607 Genomic DNA Translation: CAD33917.1
AJ512208 Genomic DNA Translation: CAD54442.1
MT937073 Genomic DNA Translation: QPG85865.1

NCBI Reference Sequences

More...
RefSeqi
NP_904338.1, NC_005089.1
YP_220560.1, NC_006914.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
17721
3338890

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:17721

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY466499 Genomic DNA Translation: AAR21205.1
AY533105 Genomic DNA Translation: AAS01436.1
AY533106 Genomic DNA Translation: AAS01449.1
AY533107 Genomic DNA Translation: AAS01462.1
AY533108 Genomic DNA Translation: AAS01475.1
AY999076 Genomic DNA Translation: AAX83022.1
EF108330 Genomic DNA Translation: ABK79103.1
EF108331 Genomic DNA Translation: ABK79116.1
EF108332 Genomic DNA Translation: ABK79129.1
EF108333 Genomic DNA Translation: ABK79142.1
EF108334 Genomic DNA Translation: ABK79155.1
EF108335 Genomic DNA Translation: ABK79168.1
EF108336 Genomic DNA Translation: ABK79181.1
EF108337 Genomic DNA Translation: ABK79194.1
EF108338 Genomic DNA Translation: ABK79207.1
EF108339 Genomic DNA Translation: ABK79220.1
EF108340 Genomic DNA Translation: ABK79233.1
EF108341 Genomic DNA Translation: ABK79246.1
EU312160 Genomic DNA Translation: ABX79712.1
EU312161 Genomic DNA Translation: ABX79725.1
EU315228 Genomic DNA Translation: ABX79738.1
EU315229 Genomic DNA Translation: ABX79751.1
EU450583 Genomic DNA Translation: ACA01533.1
FJ803909 Genomic DNA Translation: ACN91105.1
HQ586004 Genomic DNA Translation: ADR03166.1
HQ877407 Genomic DNA Translation: ADW83076.1
JF286601 Genomic DNA Translation: ADZ23173.1
HQ675026 Genomic DNA Translation: AEN03379.1
HQ675027 Genomic DNA Translation: AEN03392.1
HQ675028 Genomic DNA Translation: AEN03405.1
HQ675029 Genomic DNA Translation: AEN03418.1
HQ675030 Genomic DNA Translation: AEN03431.1
HQ675031 Genomic DNA Translation: AEN03444.1
JQ003190 Genomic DNA Translation: AEV56607.1
KP090294 Genomic DNA Translation: AJE26566.1
KP260514 Genomic DNA Translation: AJK91496.1
KP260515 Genomic DNA Translation: AJK91509.1
KP260516 Genomic DNA Translation: AJK91522.1
KP260517 Genomic DNA Translation: AJK91535.1
KR020497 Genomic DNA Translation: AKS10722.1
KY018919 Genomic DNA Translation: ART65703.1
AB042524 Genomic DNA Translation: BAA95650.1
AB042523 Genomic DNA Translation: BAA95663.1
AB042809 Genomic DNA Translation: BAA95805.1
AB049357 Genomic DNA Translation: BAB13811.1
AK140457 mRNA Translation: BAE24397.1
AP013030 Genomic DNA Translation: BAM93593.1
AP014540 Genomic DNA Translation: BAO42860.1
AP014541 Genomic DNA Translation: BAO42873.1
AJ489607 Genomic DNA Translation: CAD33917.1
AJ512208 Genomic DNA Translation: CAD54442.1
MT937073 Genomic DNA Translation: QPG85865.1
RefSeqiNP_904338.1, NC_005089.1
YP_220560.1, NC_006914.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
35363, 247 antibodies

Genome annotation databases

GeneIDi17721
3338890
KEGGimmu:17721

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4540
MGIiMGI:102496, mt-Nd5

Phylogenomic databases

HOGENOMiCLU_007100_6_0_1
OMAiGVGIMSF
OrthoDBi526738at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
mt-Nd5, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000064367, Expressed in Ammon's horn and 82 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR010934, NADH_DH_su5_C
IPR003945, NADHpl_OxRdtase_5
IPR001750, ND/Mrp_mem
IPR001516, Proton_antipo_N
PfamiView protein in Pfam
PF06455, NADH5_C, 1 hit
PF00361, Proton_antipo_M, 1 hit
PF00662, Proton_antipo_N, 1 hit
TIGRFAMsiTIGR01974, NDH_I_L, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9MD82_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9MD82
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: June 2, 2021
This is version 177 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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