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Entry version 161 (31 Jul 2019)
Sequence version 1 (01 Oct 2000)
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Protein

NADH-ubiquinone oxidoreductase chain 4L

Gene

mt-Nd4l

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductaseImported, TranslocaseUniRule annotation
Biological processElectron transport, Respiratory chainUniRule annotation, Transport
LigandNADUniRule annotation, UbiquinoneUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 4LUniRule annotation (EC:7.1.1.2UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mt-Nd4lImported
Synonyms:mt-Nd4Imported, ND4LImported, Nd4lImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates if the gene coding for the protein originates from the hydrogenosome, the mitochondrion, the nucleomorph, different plastids or a plasmid. The absence of this section means that the gene is located in one of the main chromosomal element(s).<p><a href='/help/encoded_on' target='_top'>More...</a></p>Encoded oniMitochondrionImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:102497 mt-Nd4l

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei29 – 47HelicalUniRule annotationAdd BLAST19
Transmembranei59 – 79HelicalUniRule annotationAdd BLAST21

Keywords - Cellular componenti

Membrane, MitochondrionUniRule annotationImported

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9MD77

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9MD77

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000065947 Expressed in 19 organ(s), highest expression level in adult mammalian kidney

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9MD77 baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9MD77

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the complex I subunit 4L family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4669 Eukaryota
COG0713 LUCA

KEGG Orthology (KO)

More...
KOi
K03882

Identification of Orthologs from Complete Genome Data

More...
OMAi
LCLEGMM

Database of Orthologous Groups

More...
OrthoDBi
1538435at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001133 NADH_UbQ_OxRdtase_chain4L/K
IPR039428 NUOK/Mnh_C1-like

The PANTHER Classification System

More...
PANTHERi
PTHR11434 PTHR11434, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00420 Oxidored_q2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9MD77-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSTFFNLTM AFSLSLLGTL MFRSHLMSTL LCLEGMVLSL FIMTSVTSLN
60 70 80 90
SNSMSSMPIP ITILVFAACE AAVGLALLVK VSNTYGTDYV QNLNLLQC
Length:98
Mass (Da):10,607
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i48CAF698FF5F4C29
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY466499 Genomic DNA Translation: AAR21203.1
AY533105 Genomic DNA Translation: AAS01434.1
AY533106 Genomic DNA Translation: AAS01447.1
AY533107 Genomic DNA Translation: AAS01460.1
AY533108 Genomic DNA Translation: AAS01473.1
AY999076 Genomic DNA Translation: AAX83020.1
DQ106412 Genomic DNA Translation: AAY96697.1
DQ106413 Genomic DNA Translation: AAY96710.1
EF108330 Genomic DNA Translation: ABK79101.1
EF108331 Genomic DNA Translation: ABK79114.1
EF108332 Genomic DNA Translation: ABK79127.1
EF108333 Genomic DNA Translation: ABK79140.1
EF108334 Genomic DNA Translation: ABK79153.1
EF108335 Genomic DNA Translation: ABK79166.1
EF108336 Genomic DNA Translation: ABK79179.1
EF108337 Genomic DNA Translation: ABK79192.1
EF108338 Genomic DNA Translation: ABK79205.1
EF108339 Genomic DNA Translation: ABK79218.1
EF108340 Genomic DNA Translation: ABK79231.1
EF108341 Genomic DNA Translation: ABK79244.1
EU312160 Genomic DNA Translation: ABX79710.1
EU312161 Genomic DNA Translation: ABX79723.1
EU315228 Genomic DNA Translation: ABX79736.1
EU315229 Genomic DNA Translation: ABX79749.1
EU450583 Genomic DNA Translation: ACA01531.1
FJ803909 Genomic DNA Translation: ACN91103.1
HQ586004 Genomic DNA Translation: ADR03164.1
HQ877407 Genomic DNA Translation: ADW83074.1
JF286601 Genomic DNA Translation: ADZ23172.1
HQ675026 Genomic DNA Translation: AEN03377.1
HQ675027 Genomic DNA Translation: AEN03390.1
HQ675028 Genomic DNA Translation: AEN03403.1
HQ675029 Genomic DNA Translation: AEN03416.1
HQ675030 Genomic DNA Translation: AEN03429.1
HQ675031 Genomic DNA Translation: AEN03442.1
JQ003190 Genomic DNA Translation: AEV56605.1
KP090294 Genomic DNA Translation: AJE26564.1
KP260514 Genomic DNA Translation: AJK91494.1
KP260515 Genomic DNA Translation: AJK91507.1
KP260516 Genomic DNA Translation: AJK91520.1
KP260517 Genomic DNA Translation: AJK91533.1
KR020497 Genomic DNA Translation: AKS10720.1
KY018919 Genomic DNA Translation: ART65701.1
AB042524 Genomic DNA Translation: BAA95648.1
AB042523 Genomic DNA Translation: BAA95661.1
AB042809 Genomic DNA Translation: BAA95803.1
AB049357 Genomic DNA Translation: BAB13809.1
AK140187 mRNA Translation: BAE24269.1
AK144853 mRNA Translation: BAE26101.1
AK153747 mRNA Translation: BAE32167.1
AK157367 mRNA Translation: BAE34067.1
AP013030 Genomic DNA Translation: BAM93591.1
AP013031 Genomic DNA Translation: BAM93604.1
AP013054 Genomic DNA Translation: BAN16600.1
AP014540 Genomic DNA Translation: BAO42858.1
AP014541 Genomic DNA Translation: BAO42871.1
AP014941 Genomic DNA Translation: BAS29540.1
AJ489607 Genomic DNA Translation: CAD33915.1
AJ512208 Genomic DNA Translation: CAD54440.1

NCBI Reference Sequences

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RefSeqi
NP_904336.1, NC_005089.1
YP_220558.1, NC_006914.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
17720
3338903

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:17720

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY466499 Genomic DNA Translation: AAR21203.1
AY533105 Genomic DNA Translation: AAS01434.1
AY533106 Genomic DNA Translation: AAS01447.1
AY533107 Genomic DNA Translation: AAS01460.1
AY533108 Genomic DNA Translation: AAS01473.1
AY999076 Genomic DNA Translation: AAX83020.1
DQ106412 Genomic DNA Translation: AAY96697.1
DQ106413 Genomic DNA Translation: AAY96710.1
EF108330 Genomic DNA Translation: ABK79101.1
EF108331 Genomic DNA Translation: ABK79114.1
EF108332 Genomic DNA Translation: ABK79127.1
EF108333 Genomic DNA Translation: ABK79140.1
EF108334 Genomic DNA Translation: ABK79153.1
EF108335 Genomic DNA Translation: ABK79166.1
EF108336 Genomic DNA Translation: ABK79179.1
EF108337 Genomic DNA Translation: ABK79192.1
EF108338 Genomic DNA Translation: ABK79205.1
EF108339 Genomic DNA Translation: ABK79218.1
EF108340 Genomic DNA Translation: ABK79231.1
EF108341 Genomic DNA Translation: ABK79244.1
EU312160 Genomic DNA Translation: ABX79710.1
EU312161 Genomic DNA Translation: ABX79723.1
EU315228 Genomic DNA Translation: ABX79736.1
EU315229 Genomic DNA Translation: ABX79749.1
EU450583 Genomic DNA Translation: ACA01531.1
FJ803909 Genomic DNA Translation: ACN91103.1
HQ586004 Genomic DNA Translation: ADR03164.1
HQ877407 Genomic DNA Translation: ADW83074.1
JF286601 Genomic DNA Translation: ADZ23172.1
HQ675026 Genomic DNA Translation: AEN03377.1
HQ675027 Genomic DNA Translation: AEN03390.1
HQ675028 Genomic DNA Translation: AEN03403.1
HQ675029 Genomic DNA Translation: AEN03416.1
HQ675030 Genomic DNA Translation: AEN03429.1
HQ675031 Genomic DNA Translation: AEN03442.1
JQ003190 Genomic DNA Translation: AEV56605.1
KP090294 Genomic DNA Translation: AJE26564.1
KP260514 Genomic DNA Translation: AJK91494.1
KP260515 Genomic DNA Translation: AJK91507.1
KP260516 Genomic DNA Translation: AJK91520.1
KP260517 Genomic DNA Translation: AJK91533.1
KR020497 Genomic DNA Translation: AKS10720.1
KY018919 Genomic DNA Translation: ART65701.1
AB042524 Genomic DNA Translation: BAA95648.1
AB042523 Genomic DNA Translation: BAA95661.1
AB042809 Genomic DNA Translation: BAA95803.1
AB049357 Genomic DNA Translation: BAB13809.1
AK140187 mRNA Translation: BAE24269.1
AK144853 mRNA Translation: BAE26101.1
AK153747 mRNA Translation: BAE32167.1
AK157367 mRNA Translation: BAE34067.1
AP013030 Genomic DNA Translation: BAM93591.1
AP013031 Genomic DNA Translation: BAM93604.1
AP013054 Genomic DNA Translation: BAN16600.1
AP014540 Genomic DNA Translation: BAO42858.1
AP014541 Genomic DNA Translation: BAO42871.1
AP014941 Genomic DNA Translation: BAS29540.1
AJ489607 Genomic DNA Translation: CAD33915.1
AJ512208 Genomic DNA Translation: CAD54440.1
RefSeqiNP_904336.1, NC_005089.1
YP_220558.1, NC_006914.1

3D structure databases

SMRiQ9MD77
ModBaseiSearch...

PTM databases

SwissPalmiQ9MD77

Proteomic databases

MaxQBiQ9MD77

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi17720
3338903
KEGGimmu:17720

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4539
MGIiMGI:102497 mt-Nd4l

Phylogenomic databases

eggNOGiKOG4669 Eukaryota
COG0713 LUCA
KOiK03882
OMAiLCLEGMM
OrthoDBi1538435at2759

Miscellaneous databases

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000065947 Expressed in 19 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiQ9MD77 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR001133 NADH_UbQ_OxRdtase_chain4L/K
IPR039428 NUOK/Mnh_C1-like
PANTHERiPTHR11434 PTHR11434, 1 hit
PfamiView protein in Pfam
PF00420 Oxidored_q2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9MD77_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9MD77
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: July 31, 2019
This is version 161 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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