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Protein

Endolysin

Gene

HK022_71

Organism
Escherichia phage HK022 (Bacteriophage HK022)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Endolysin with transglycosylase activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.UniRule annotation

Catalytic activityi

Endolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei19UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntimicrobial, Bacteriolytic enzymeUniRule annotation, LyaseUniRule annotation
Biological processCytolysis, Host cell lysis by virusUniRule annotation, Viral release from host cell

Protein family/group databases

CAZyiGH104 Glycoside Hydrolase Family 104

Names & Taxonomyi

Protein namesi
Recommended name:
EndolysinUniRule annotation (EC:4.2.2.n2UniRule annotation)
Alternative name(s):
Lysis proteinUniRule annotation
LysozymeUniRule annotation
TransglycosylaseUniRule annotation
Gene namesi
ORF Names:HK022_71Imported
OrganismiEscherichia phage HK022 (Bacteriophage HK022)Imported
Taxonomic identifieri10742 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesSiphoviridaeHk97virus
Virus hostiEscherichia coli [TaxID: 562]
Proteomesi
  • UP000009088 Componenti: Genome

Subcellular locationi

  • Host cytoplasm UniRule annotation
  • Note: The endolysin is cytoplasmic, but can reach the periplasmic space with the help of the holins which disrupt the host cell membrane.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasmUniRule annotation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ9MCT2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 24 family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG090000W9

Family and domain databases

CDDicd00736 bacteriophage_lambda_lysozyme, 1 hit
HAMAPiMF_04109 ENDOLYSIN_LAMBDA, 1 hit
InterProiView protein in InterPro
IPR034691 Endolysin_lambda_type
IPR002196 Glyco_hydro_24
IPR023346 Lysozyme-like_dom_sf
PfamiView protein in Pfam
PF00959 Phage_lysozyme, 1 hit
SUPFAMiSSF53955 SSF53955, 1 hit

Sequencei

Sequence statusi: Complete.

Q9MCT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEINNQRKA FLDMLAWSEG TDNGRQKTRN HGYDVIVGGE LFTDYSDHPR
60 70 80 90 100
KLVTLNPKLK STAAGRYQLL SRWWDAYRKQ LGLKDFSPKS QDAVALQQIK
110 120 130 140 150
ERGALPMIDR GDIRQAIDRC SNIWASLPGA GYGQFEHKAD KLIAKFKEAG

GTVREIEV
Length:158
Mass (Da):17,894
Last modified:October 1, 2000 - v1
Checksum:iCB4FCF7AB7150038
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069308 Genomic DNA Translation: AAF30387.1
RefSeqiNP_037696.1, NC_002166.1

Genome annotation databases

GeneIDi1262473
KEGGivg:1262473

Similar proteinsi

Entry informationi

Entry nameiQ9MCT2_BPHK0
AccessioniPrimary (citable) accession number: Q9MCT2
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: June 20, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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