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UniProtKB - Q9MAX3 (SUT12_ARATH)
Protein
Sulfate transporter 1.2
Gene
SULTR1;2
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
High-affinity H+/sulfate cotransporter that mediates the uptake of the environmental sulfate by plant roots. Plays a central role in the regulation of sulfate assimilation. Unable to transport molybdate.
3 PublicationsMiscellaneous
Sel1 mutations in the gene lead to the resistance of the plant to selenate, a toxic analog of sulfate.
Activity regulationi
Interaction with OASA1 negatively impacts the transporter activity.1 Publication
GO - Molecular functioni
- anion:anion antiporter activity Source: GO_Central
- secondary active sulfate transmembrane transporter activity Source: InterPro
- symporter activity Source: UniProtKB-KW
GO - Biological processi
- cellular response to sulfate starvation Source: TAIR
Keywordsi
Biological process | Sulfate transport, Symport, Transport |
Protein family/group databases
TCDBi | 2.A.53.1.6, the sulfate permease (sulp) family |
Names & Taxonomyi
Protein namesi | Recommended name: Sulfate transporter 1.2 |
Gene namesi | Name:SULTR1;2 Ordered Locus Names:At1g78000 ORF Names:F28K19.22 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT1G78000 |
TAIRi | locus:2029396, AT1G78000 |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: TAIR
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 91 | CytoplasmicSequence analysisAdd BLAST | 91 | |
Transmembranei | 92 – 112 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 113 – 116 | ExtracellularSequence analysis | 4 | |
Transmembranei | 117 – 137 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 138 – 141 | CytoplasmicSequence analysis | 4 | |
Transmembranei | 142 – 162 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 163 – 173 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 174 – 194 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 195 – 215 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 216 – 253 | ExtracellularSequence analysisAdd BLAST | 38 | |
Transmembranei | 254 – 274 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 275 – 280 | CytoplasmicSequence analysis | 6 | |
Transmembranei | 281 – 301 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 302 – 339 | ExtracellularSequence analysisAdd BLAST | 38 | |
Transmembranei | 340 – 360 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 361 – 372 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 373 – 393 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 394 – 409 | ExtracellularSequence analysisAdd BLAST | 16 | |
Transmembranei | 410 – 430 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 431 – 438 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 439 – 459 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 460 – 466 | ExtracellularSequence analysis | 7 | |
Transmembranei | 467 – 487 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 488 – 653 | CytoplasmicSequence analysisAdd BLAST | 166 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 511 | I → T in sel1-8; reduces drastically sulfate transport activity. | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080173 | 1 – 653 | Sulfate transporter 1.2Add BLAST | 653 |
Proteomic databases
PaxDbi | Q9MAX3 |
ProteomicsDBi | 226753 |
PTM databases
iPTMneti | Q9MAX3 |
Expressioni
Tissue specificityi
Expressed in lateral root cap, root hairs, epidermal and cortical cells of roots.1 Publication
Inductioni
In roots by sulfate starvation.1 Publication
Gene expression databases
ExpressionAtlasi | Q9MAX3, baseline and differential |
Genevisiblei | Q9MAX3, AT |
Interactioni
Subunit structurei
Homodimer.
Interacts with OASA1 through its STAS domain.
1 PublicationBinary interactionsi
Q9MAX3
With | #Exp. | IntAct |
---|---|---|
OASA1 [P47998] | 5 | EBI-8772960,EBI-1633418 |
Protein-protein interaction databases
BioGRIDi | 29354, 7 interactors |
IntActi | Q9MAX3, 4 interactors |
STRINGi | 3702.AT1G78000.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 522 – 645 | STASPROSITE-ProRule annotationAdd BLAST | 124 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 30 | DisorderedSequence analysisAdd BLAST | 30 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0236, Eukaryota |
HOGENOMi | CLU_003182_13_2_1 |
InParanoidi | Q9MAX3 |
OMAi | KKRDRHH |
OrthoDBi | 690428at2759 |
PhylomeDBi | Q9MAX3 |
Family and domain databases
Gene3Di | 3.30.750.24, 1 hit |
InterProi | View protein in InterPro IPR030314, High_sul_transp IPR018045, S04_transporter_CS IPR011547, SLC26A/SulP_dom IPR001902, SLC26A/SulP_fam IPR002645, STAS_dom IPR036513, STAS_dom_sf |
PANTHERi | PTHR11814, PTHR11814, 1 hit PTHR11814:SF207, PTHR11814:SF207, 1 hit |
Pfami | View protein in Pfam PF01740, STAS, 1 hit PF00916, Sulfate_transp, 1 hit |
SUPFAMi | SSF52091, SSF52091, 1 hit |
TIGRFAMsi | TIGR00815, sulP, 1 hit |
PROSITEi | View protein in PROSITE PS01130, SLC26A, 1 hit PS50801, STAS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
Q9MAX3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSRAHPVDG SPATDGGHVP MKPSPTRHKV GIPPKQNMFK DFMYTFKETF
60 70 80 90 100
FHDDPLRDFK DQPKSKQFML GLQSVFPVFD WGRNYTFKKF RGDLISGLTI
110 120 130 140 150
ASLCIPQDIG YAKLANLDPK YGLYSSFVPP LVYACMGSSR DIAIGPVAVV
160 170 180 190 200
SLLLGTLLRA EIDPNTSPDE YLRLAFTATF FAGITEAALG FFRLGFLIDF
210 220 230 240 250
LSHAAVVGFM GGAAITIALQ QLKGFLGIKK FTKKTDIISV LESVFKAAHH
260 270 280 290 300
GWNWQTILIG ASFLTFLLTS KIIGKKSKKL FWVPAIAPLI SVIVSTFFVY
310 320 330 340 350
ITRADKQGVQ IVKHLDQGIN PSSFHLIYFT GDNLAKGIRI GVVAGMVALT
360 370 380 390 400
EAVAIGRTFA AMKDYQIDGN KEMVALGMMN VVGSMSSCYV ATGSFSRSAV
410 420 430 440 450
NFMAGCQTAV SNIIMSIVVL LTLLFLTPLF KYTPNAILAA IIINAVIPLI
460 470 480 490 500
DIQAAILIFK VDKLDFIACI GAFFGVIFVS VEIGLLIAVS ISFAKILLQV
510 520 530 540 550
TRPRTAVLGN IPRTSVYRNI QQYPEATMVP GVLTIRVDSA IYFSNSNYVR
560 570 580 590 600
ERIQRWLHEE EEKVKAASLP RIQFLIIEMS PVTDIDTSGI HALEDLYKSL
610 620 630 640 650
QKRDIQLILA NPGPLVIGKL HLSHFADMLG QDNIYLTVAD AVEACCPKLS
NEV
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1P8AQP6 | A0A1P8AQP6_ARATH | Sulfate transporter 12 | SULTR1;2 SEL1, SELENATE RESISTANT 1, SULFATE TRANSPORTER, sulfate transporter 1;2, At1g78000 | 614 | Annotation score: | ||
A0A1P8AQM4 | A0A1P8AQM4_ARATH | Sulfate transporter 12 | SULTR1;2 SEL1, SELENATE RESISTANT 1, SULFATE TRANSPORTER, sulfate transporter 1;2, At1g78000 | 595 | Annotation score: | ||
A0A1P8AQN0 | A0A1P8AQN0_ARATH | Sulfate transporter 12 | SULTR1;2 SEL1, SELENATE RESISTANT 1, SULFATE TRANSPORTER, sulfate transporter 1;2, At1g78000 | 460 | Annotation score: | ||
A0A1P8AQR2 | A0A1P8AQR2_ARATH | Sulfate transporter 12 | SULTR1;2 SEL1, SELENATE RESISTANT 1, SULFATE TRANSPORTER, sulfate transporter 1;2, At1g78000 | 514 | Annotation score: |
Sequence cautioni
The sequence AAF17685 differs from that shown. Reason: Erroneous gene model prediction.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB042322 mRNA Translation: BAA95484.1 AC009243 Genomic DNA Translation: AAF17685.1 Sequence problems. CP002684 Genomic DNA Translation: AEE36055.1 CP002684 Genomic DNA Translation: AEE36056.1 CP002684 Genomic DNA Translation: ANM58967.1 AK227518 mRNA Translation: BAE99518.1 |
PIRi | D96809 |
RefSeqi | NP_001321366.1, NM_001334809.1 NP_565166.1, NM_106449.3 NP_849899.1, NM_179568.2 |
Genome annotation databases
EnsemblPlantsi | AT1G78000.1; AT1G78000.1; AT1G78000 AT1G78000.2; AT1G78000.2; AT1G78000 AT1G78000.3; AT1G78000.3; AT1G78000 |
GeneIDi | 844135 |
Gramenei | AT1G78000.1; AT1G78000.1; AT1G78000 AT1G78000.2; AT1G78000.2; AT1G78000 AT1G78000.3; AT1G78000.3; AT1G78000 |
KEGGi | ath:AT1G78000 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB042322 mRNA Translation: BAA95484.1 AC009243 Genomic DNA Translation: AAF17685.1 Sequence problems. CP002684 Genomic DNA Translation: AEE36055.1 CP002684 Genomic DNA Translation: AEE36056.1 CP002684 Genomic DNA Translation: ANM58967.1 AK227518 mRNA Translation: BAE99518.1 |
PIRi | D96809 |
RefSeqi | NP_001321366.1, NM_001334809.1 NP_565166.1, NM_106449.3 NP_849899.1, NM_179568.2 |
3D structure databases
SMRi | Q9MAX3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 29354, 7 interactors |
IntActi | Q9MAX3, 4 interactors |
STRINGi | 3702.AT1G78000.1 |
Protein family/group databases
TCDBi | 2.A.53.1.6, the sulfate permease (sulp) family |
PTM databases
iPTMneti | Q9MAX3 |
Proteomic databases
PaxDbi | Q9MAX3 |
ProteomicsDBi | 226753 |
Genome annotation databases
EnsemblPlantsi | AT1G78000.1; AT1G78000.1; AT1G78000 AT1G78000.2; AT1G78000.2; AT1G78000 AT1G78000.3; AT1G78000.3; AT1G78000 |
GeneIDi | 844135 |
Gramenei | AT1G78000.1; AT1G78000.1; AT1G78000 AT1G78000.2; AT1G78000.2; AT1G78000 AT1G78000.3; AT1G78000.3; AT1G78000 |
KEGGi | ath:AT1G78000 |
Organism-specific databases
Araporti | AT1G78000 |
TAIRi | locus:2029396, AT1G78000 |
Phylogenomic databases
eggNOGi | KOG0236, Eukaryota |
HOGENOMi | CLU_003182_13_2_1 |
InParanoidi | Q9MAX3 |
OMAi | KKRDRHH |
OrthoDBi | 690428at2759 |
PhylomeDBi | Q9MAX3 |
Miscellaneous databases
PROi | PR:Q9MAX3 |
Gene expression databases
ExpressionAtlasi | Q9MAX3, baseline and differential |
Genevisiblei | Q9MAX3, AT |
Family and domain databases
Gene3Di | 3.30.750.24, 1 hit |
InterProi | View protein in InterPro IPR030314, High_sul_transp IPR018045, S04_transporter_CS IPR011547, SLC26A/SulP_dom IPR001902, SLC26A/SulP_fam IPR002645, STAS_dom IPR036513, STAS_dom_sf |
PANTHERi | PTHR11814, PTHR11814, 1 hit PTHR11814:SF207, PTHR11814:SF207, 1 hit |
Pfami | View protein in Pfam PF01740, STAS, 1 hit PF00916, Sulfate_transp, 1 hit |
SUPFAMi | SSF52091, SSF52091, 1 hit |
TIGRFAMsi | TIGR00815, sulP, 1 hit |
PROSITEi | View protein in PROSITE PS01130, SLC26A, 1 hit PS50801, STAS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SUT12_ARATH | |
Accessioni | Q9MAX3Primary (citable) accession number: Q9MAX3 Secondary accession number(s): Q0WTN0, Q9SH00 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 26, 2003 |
Last sequence update: | October 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 138 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families