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Entry version 142 (23 Feb 2022)
Sequence version 1 (01 Oct 2000)
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Protein

ABC transporter G family member 40

Gene

ABCG40

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

High affinity abscisic acid (ABA) transporter that mediates the import of ABA, with a preference for (+)-ABA, through the plasma membrane, especially in guard cells, and is involved in the intercellular and intracellular ABA signaling pathways leading, for example, to stomatal closure, thus conferring drought tolerance (PubMed:20935463, PubMed:20133880, PubMed:26517905).

Together with ABCG30, import into the embryo the ABA delivered from the endosperm via ABCG25 and ABCG31-mediated export to suppress radicle extension and subsequent embryonic growth (PubMed:26334616).

May be a general defense protein (By similarity).

Functions as a pump to exclude Pb2+ ions and/or Pb2+-containing toxic compounds from the cytoplasm. Contributes to Pb2+ ions resistance. Confers some resistance to the terpene sclareol (PubMed:14526118, PubMed:15923333).

2 PublicationsBy similarity4 Publications

(Microbial infection) Involved in resistance response to the pathogenic oomycetes Phytophthora infestans and Phytophthora capsici.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by glibenclamide, verapamil and vanadate (ABC transporters inhibitors).1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1 µM for abscisic acid1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi187 – 194ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi870 – 877ATP 2PROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAbscisic acid signaling pathway, Plant defense, Stress response, Transport
LigandATP-binding, Nucleotide-binding

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.1.205.10, the atp-binding cassette (abc) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ABC transporter G family member 401 Publication
Short name:
ABC transporter ABCG.401 Publication
Short name:
AtABCG401 Publication
Alternative name(s):
Pleiotropic drug resistance protein 122 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ABCG401 Publication
Synonyms:PDR122 Publications, PDR91 Publication
Ordered Locus Names:At1g15520Imported
ORF Names:T16N11.3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G15520

The Arabidopsis Information Resource

More...
TAIRi
locus:2196593, AT1G15520

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei523 – 543HelicalSequence analysisAdd BLAST21
Transmembranei562 – 582HelicalSequence analysisAdd BLAST21
Transmembranei611 – 631HelicalSequence analysisAdd BLAST21
Transmembranei643 – 663HelicalSequence analysisAdd BLAST21
Transmembranei667 – 687HelicalSequence analysisAdd BLAST21
Transmembranei696 – 716HelicalSequence analysisAdd BLAST21
Transmembranei756 – 776HelicalSequence analysisAdd BLAST21
Transmembranei1174 – 1194HelicalSequence analysisAdd BLAST21
Transmembranei1207 – 1227HelicalSequence analysisAdd BLAST21
Transmembranei1257 – 1277HelicalSequence analysisAdd BLAST21
Transmembranei1284 – 1304HelicalSequence analysisAdd BLAST21
Transmembranei1314 – 1334HelicalSequence analysisAdd BLAST21
Transmembranei1341 – 1361HelicalSequence analysisAdd BLAST21
Transmembranei1395 – 1415HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Increased susceptibility to the oomycetes Phytophthora brassicae and Phytophthora capsici (PubMed:26011556). Decreased abscisic acid (ABA) uptake through the plasma membrane and strongly delayed up-regulation of ABA responsive genes (e.g. NCED3, ABR1 and RD29B), and associated with a slow stomatal closure in response to ABA and osmotic stress resulting in reduced drought tolerance (PubMed:20133880). Impairment in ABA regulation of seed germination and root development (PubMed:20133880). Early seeds germination on imbibition without stratification, and reduced abscisic acid (ABA)-mediated inhibition of seeds germination (PubMed:26334616).3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002346391 – 1423ABC transporter G family member 40Add BLAST1423

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi16N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi376N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi729N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi895N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei962PhosphothreonineCombined sources1
Glycosylationi1375N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9M9E1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
244393

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9M9E1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Mostly observed in inflorescence meristems relative to cauline leaves and developing siliques (PubMed:22525244). Ubiquitous with higher levels in leaves, stems and flowers (PubMed:12430018, PubMed:14526118, PubMed:15923333, PubMed:20133880). Also present in primary and lateral roots (PubMed:20133880). In seeds, mainly expressed in the embryo and, to a lesser extent, in the endosperm (PubMed:26334616).6 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In leaves, mostly observed in guard cells.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Circadian-regulation. Expression increase during the dark phase and decrease during the light phase. Induced by cycloheximide (CHX), sclareol, and heavy metals such as Pb2+ ions. ETR1-, EIN2-, JAR1-, NPR1- and EDS5-dependent induction by incompatible fungal pathogens (A.brassicicola), by compatible fungal pathogens (S.sclerotiorum and F.oxysporum), and by compatible bacterial pathogens (P.syringae pv tomato). Also induced by phytohormones such as salicylic acid (SA), methyl jasmonate (MeJA) and ethylene. Induced by abscisic acid (ABA) treatment and drought via a WRKY1-mediated regulation (PubMed:20133880, PubMed:26820136). In cauline leaves, activated by cold stress, but repressed by heat stress (PubMed:22525244). Within inflorescence meristems, down-regulated by both cold and heat stress treatments (PubMed:22525244). In developing siliques, activated by cold stress, but unaffected by heat stress (PubMed:22525244).6 Publications

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9M9E1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9M9E1, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with LECRK91 and LECRK92.

1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT1G15520.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9M9E1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini154 – 427ABC transporter 1PROSITE-ProRule annotationAdd BLAST274
Domaini505 – 718ABC transmembrane type-2 1Sequence analysisAdd BLAST214
Domaini825 – 1077ABC transporter 2PROSITE-ProRule annotationAdd BLAST253
Domaini1150 – 1364ABC transmembrane type-2 2Sequence analysisAdd BLAST215

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 36DisorderedSequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 18Polar residuesSequence analysisAdd BLAST18
Compositional biasi19 – 36Basic and acidic residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0065, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000604_35_6_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9M9E1

Identification of Orthologs from Complete Genome Data

More...
OMAi
SIFHWQD

Database of Orthologous Groups

More...
OrthoDBi
324553at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9M9E1

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03232, ABCG_PDR_domain2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.300, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR013525, ABC_2_trans
IPR029481, ABC_trans_N
IPR003439, ABC_transporter-like_ATP-bd
IPR043926, ABCG_dom
IPR034003, ABCG_PDR_2
IPR027417, P-loop_NTPase
IPR013581, PDR_assoc

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01061, ABC2_membrane, 2 hits
PF19055, ABC2_membrane_7, 1 hit
PF00005, ABC_tran, 2 hits
PF14510, ABC_trans_N, 1 hit
PF08370, PDR_assoc, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50893, ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9M9E1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGTSFHQAS NSMRRNSSVW KKDSGREIFS RSSREEDDEE ALRWAALEKL
60 70 80 90 100
PTFDRLRKGI LTASHAGGPI NEIDIQKLGF QDTKKLLERL IKVGDDEHEK
110 120 130 140 150
LLWKLKKRID RVGIDLPTIE VRFDHLKVEA EVHVGGRALP TFVNFISNFA
160 170 180 190 200
DKFLNTLHLV PNRKKKFTIL NDVSGIVKPG RMALLLGPPS SGKTTLLLAL
210 220 230 240 250
AGKLDQELKQ TGRVTYNGHG MNEFVPQRTA AYIGQNDVHI GEMTVRETFA
260 270 280 290 300
YAARFQGVGS RYDMLTELAR REKEANIKPD PDIDIFMKAM STAGEKTNVM
310 320 330 340 350
TDYILKILGL EVCADTMVGD DMLRGISGGQ KKRVTTGEML VGPSRALFMD
360 370 380 390 400
EISTGLDSST TYQIVNSLRN YVHIFNGTAL ISLLQPAPET FNLFDDIILI
410 420 430 440 450
AEGEIIYEGP RDHVVEFFET MGFKCPPRKG VADFLQEVTS KKDQMQYWAR
460 470 480 490 500
RDEPYRFIRV REFAEAFQSF HVGRRIGDEL ALPFDKTKSH PAALTTKKYG
510 520 530 540 550
VGIKELVKTS FSREYLLMKR NSFVYYFKFG QLLVMAFLTM TLFFRTEMQK
560 570 580 590 600
KTEVDGSLYT GALFFILMML MFNGMSELSM TIAKLPVFYK QRDLLFYPAW
610 620 630 640 650
VYSLPPWLLK IPISFMEAAL TTFITYYVIG FDPNVGRLFK QYILLVLMNQ
660 670 680 690 700
MASALFKMVA ALGRNMIVAN TFGAFAMLVF FALGGVVLSR DDIKKWWIWG
710 720 730 740 750
YWISPIMYGQ NAILANEFFG HSWSRAVENS SETLGVTFLK SRGFLPHAYW
760 770 780 790 800
YWIGTGALLG FVVLFNFGFT LALTFLNSLG KPQAVIAEEP ASDETELQSA
810 820 830 840 850
RSEGVVEAGA NKKRGMVLPF EPHSITFDNV VYSVDMPQEM IEQGTQEDRL
860 870 880 890 900
VLLKGVNGAF RPGVLTALMG VSGAGKTTLM DVLAGRKTGG YIDGNITISG
910 920 930 940 950
YPKNQQTFAR ISGYCEQTDI HSPHVTVYES LVYSAWLRLP KEVDKNKRKI
960 970 980 990 1000
FIEEVMELVE LTPLRQALVG LPGESGLSTE QRKRLTIAVE LVANPSIIFM
1010 1020 1030 1040 1050
DEPTSGLDAR AAAIVMRTVR NTVDTGRTVV CTIHQPSIDI FEAFDELFLL
1060 1070 1080 1090 1100
KRGGEEIYVG PLGHESTHLI NYFESIQGIN KITEGYNPAT WMLEVSTTSQ
1110 1120 1130 1140 1150
EAALGVDFAQ VYKNSELYKR NKELIKELSQ PAPGSKDLYF PTQYSQSFLT
1160 1170 1180 1190 1200
QCMASLWKQH WSYWRNPPYT AVRFLFTIGI ALMFGTMFWD LGGKTKTRQD
1210 1220 1230 1240 1250
LSNAMGSMYT AVLFLGLQNA ASVQPVVNVE RTVFYREQAA GMYSAMPYAF
1260 1270 1280 1290 1300
AQVFIEIPYV LVQAIVYGLI VYAMIGFEWT AVKFFWYLFF MYGSFLTFTF
1310 1320 1330 1340 1350
YGMMAVAMTP NHHIASVVSS AFYGIWNLFS GFLIPRPSMP VWWEWYYWLC
1360 1370 1380 1390 1400
PVAWTLYGLI ASQFGDITEP MADSNMSVKQ FIREFYGYRE GFLGVVAAMN
1410 1420
VIFPLLFAVI FAIGIKSFNF QKR
Length:1,423
Mass (Da):161,017
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB40CFF2797486D23
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1P8AW07A0A1P8AW07_ARATH
Pleiotropic drug resistance 12
ABCG40 ATABCG40, ATP-binding cassette G40, ATPDR12, PDR12, PLEIOTROPIC DRUG RESISTANCE 12
1,292Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC013453 Genomic DNA Translation: AAF71978.1
CP002684 Genomic DNA Translation: AEE29332.1
BK001011 Genomic DNA Translation: DAA00880.1

Protein sequence database of the Protein Information Resource

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PIRi
A86289

NCBI Reference Sequences

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RefSeqi
NP_173005.1, NM_101421.3

Genome annotation databases

Ensembl plant genome annotation project

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EnsemblPlantsi
AT1G15520.1; AT1G15520.1; AT1G15520

Database of genes from NCBI RefSeq genomes

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GeneIDi
838122

Gramene; a comparative resource for plants

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Gramenei
AT1G15520.1; AT1G15520.1; AT1G15520

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
ath:AT1G15520

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013453 Genomic DNA Translation: AAF71978.1
CP002684 Genomic DNA Translation: AEE29332.1
BK001011 Genomic DNA Translation: DAA00880.1
PIRiA86289
RefSeqiNP_173005.1, NM_101421.3

3D structure databases

SMRiQ9M9E1
ModBaseiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G15520.1

Protein family/group databases

TCDBi3.A.1.205.10, the atp-binding cassette (abc) superfamily

PTM databases

iPTMnetiQ9M9E1

Proteomic databases

PaxDbiQ9M9E1
ProteomicsDBi244393

Genome annotation databases

EnsemblPlantsiAT1G15520.1; AT1G15520.1; AT1G15520
GeneIDi838122
GrameneiAT1G15520.1; AT1G15520.1; AT1G15520
KEGGiath:AT1G15520

Organism-specific databases

AraportiAT1G15520
TAIRilocus:2196593, AT1G15520

Phylogenomic databases

eggNOGiKOG0065, Eukaryota
HOGENOMiCLU_000604_35_6_1
InParanoidiQ9M9E1
OMAiSIFHWQD
OrthoDBi324553at2759
PhylomeDBiQ9M9E1

Miscellaneous databases

Protein Ontology

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PROi
PR:Q9M9E1

Gene expression databases

ExpressionAtlasiQ9M9E1, baseline and differential
GenevisibleiQ9M9E1, AT

Family and domain databases

CDDicd03232, ABCG_PDR_domain2, 1 hit
Gene3Di3.40.50.300, 2 hits
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR013525, ABC_2_trans
IPR029481, ABC_trans_N
IPR003439, ABC_transporter-like_ATP-bd
IPR043926, ABCG_dom
IPR034003, ABCG_PDR_2
IPR027417, P-loop_NTPase
IPR013581, PDR_assoc
PfamiView protein in Pfam
PF01061, ABC2_membrane, 2 hits
PF19055, ABC2_membrane_7, 1 hit
PF00005, ABC_tran, 2 hits
PF14510, ABC_trans_N, 1 hit
PF08370, PDR_assoc, 1 hit
SMARTiView protein in SMART
SM00382, AAA, 2 hits
SUPFAMiSSF52540, SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS50893, ABC_TRANSPORTER_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAB40G_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9M9E1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 1, 2000
Last modified: February 23, 2022
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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