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Entry version 139 (07 Apr 2021)
Sequence version 1 (01 Oct 2000)
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Protein

ABC transporter G family member 40

Gene

ABCG40

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

High affinity abscisic acid (ABA) transporter that mediates the import of ABA, with a preference for (+)-ABA, through the plasma membrane, especially in guard cells, and is involved in the intercellular and intracellular ABA signaling pathways leading, for example, to stomatal closure, thus conferring drought tolerance (PubMed:20935463, PubMed:20133880, PubMed:26517905). Together with ABCG30, import into the embryo the ABA delivered from the endosperm via ABCG25 and ABCG31-mediated export to suppress radicle extension and subsequent embryonic growth (PubMed:26334616). May be a general defense protein (By similarity). Functions as a pump to exclude Pb2+ ions and/or Pb2+-containing toxic compounds from the cytoplasm. Contributes to Pb2+ ions resistance. Confers some resistance to the terpene sclareol (PubMed:14526118, PubMed:15923333).2 PublicationsBy similarity4 Publications
(Microbial infection) Involved in resistance response to the pathogenic oomycetes Phytophthora infestans and Phytophthora capsici.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by glibenclamide, verapamil and vanadate (ABC transporters inhibitors).1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1 µM for abscisic acid1 Publication

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi187 – 194ATP 1PROSITE-ProRule annotation8
    Nucleotide bindingi870 – 877ATP 2PROSITE-ProRule annotation8

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Biological processAbscisic acid signaling pathway, Plant defense, Stress response, Transport
    LigandATP-binding, Nucleotide-binding

    Protein family/group databases

    Transport Classification Database

    More...
    TCDBi
    3.A.1.205.10, the atp-binding cassette (abc) superfamily

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    ABC transporter G family member 401 Publication
    Short name:
    ABC transporter ABCG.401 Publication
    Short name:
    AtABCG401 Publication
    Alternative name(s):
    Pleiotropic drug resistance protein 122 Publications
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:ABCG401 Publication
    Synonyms:PDR122 Publications, PDR91 Publication
    Ordered Locus Names:At1g15520Imported
    ORF Names:T16N11.3Imported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

    Organism-specific databases

    Arabidopsis Information Portal

    More...
    Araporti
    AT1G15520

    The Arabidopsis Information Resource

    More...
    TAIRi
    locus:2196593, AT1G15520

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei523 – 543HelicalSequence analysisAdd BLAST21
    Transmembranei562 – 582HelicalSequence analysisAdd BLAST21
    Transmembranei611 – 631HelicalSequence analysisAdd BLAST21
    Transmembranei643 – 663HelicalSequence analysisAdd BLAST21
    Transmembranei667 – 687HelicalSequence analysisAdd BLAST21
    Transmembranei696 – 716HelicalSequence analysisAdd BLAST21
    Transmembranei756 – 776HelicalSequence analysisAdd BLAST21
    Transmembranei1174 – 1194HelicalSequence analysisAdd BLAST21
    Transmembranei1207 – 1227HelicalSequence analysisAdd BLAST21
    Transmembranei1257 – 1277HelicalSequence analysisAdd BLAST21
    Transmembranei1284 – 1304HelicalSequence analysisAdd BLAST21
    Transmembranei1314 – 1334HelicalSequence analysisAdd BLAST21
    Transmembranei1341 – 1361HelicalSequence analysisAdd BLAST21
    Transmembranei1395 – 1415HelicalSequence analysisAdd BLAST21

    Keywords - Cellular componenti

    Cell membrane, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

    Increased susceptibility to the oomycetes Phytophthora brassicae and Phytophthora capsici (PubMed:26011556). Decreased abscisic acid (ABA) uptake through the plasma membrane and strongly delayed up-regulation of ABA responsive genes (e.g. NCED3, ABR1 and RD29B), and associated with a slow stomatal closure in response to ABA and osmotic stress resulting in reduced drought tolerance (PubMed:20133880). Impairment in ABA regulation of seed germination and root development (PubMed:20133880). Early seeds germination on imbibition without stratification, and reduced abscisic acid (ABA)-mediated inhibition of seeds germination (PubMed:26334616).3 Publications

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002346391 – 1423ABC transporter G family member 40Add BLAST1423

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi16N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
    Glycosylationi376N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
    Glycosylationi729N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
    Glycosylationi895N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei962PhosphothreonineCombined sources1
    Glycosylationi1375N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9M9E1

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9M9E1

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    244393

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q9M9E1

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Mostly observed in inflorescence meristems relative to cauline leaves and developing siliques (PubMed:22525244). Ubiquitous with higher levels in leaves, stems and flowers (PubMed:12430018, PubMed:14526118, PubMed:15923333, PubMed:20133880). Also present in primary and lateral roots (PubMed:20133880). In seeds, mainly expressed in the embryo and, to a lesser extent, in the endosperm (PubMed:26334616).6 Publications

    <p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

    In leaves, mostly observed in guard cells.1 Publication

    <p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    Circadian-regulation. Expression increase during the dark phase and decrease during the light phase. Induced by cycloheximide (CHX), sclareol, and heavy metals such as Pb2+ ions. ETR1-, EIN2-, JAR1-, NPR1- and EDS5-dependent induction by incompatible fungal pathogens (A.brassicicola), by compatible fungal pathogens (S.sclerotiorum and F.oxysporum), and by compatible bacterial pathogens (P.syringae pv tomato). Also induced by phytohormones such as salicylic acid (SA), methyl jasmonate (MeJA) and ethylene. Induced by abscisic acid (ABA) treatment and drought via a WRKY1-mediated regulation (PubMed:20133880, PubMed:26820136). In cauline leaves, activated by cold stress, but repressed by heat stress (PubMed:22525244). Within inflorescence meristems, down-regulated by both cold and heat stress treatments (PubMed:22525244). In developing siliques, activated by cold stress, but unaffected by heat stress (PubMed:22525244).6 Publications

    Gene expression databases

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q9M9E1, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9M9E1, AT

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Interacts with LECRK91 and LECRK92.

    1 Publication

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    3702.AT1G15520.1

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q9M9E1

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini154 – 427ABC transporter 1PROSITE-ProRule annotationAdd BLAST274
    Domaini505 – 718ABC transmembrane type-2 1Sequence analysisAdd BLAST214
    Domaini825 – 1077ABC transporter 2PROSITE-ProRule annotationAdd BLAST253
    Domaini1150 – 1364ABC transmembrane type-2 2Sequence analysisAdd BLAST215

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG0065, Eukaryota

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_000604_35_6_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9M9E1

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    GWEDRIP

    Database of Orthologous Groups

    More...
    OrthoDBi
    324553at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9M9E1

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd03232, ABCG_PDR_domain2, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR003593, AAA+_ATPase
    IPR013525, ABC_2_trans
    IPR029481, ABC_trans_N
    IPR003439, ABC_transporter-like
    IPR043926, ABCG_dom
    IPR034003, ABCG_PDR_2
    IPR027417, P-loop_NTPase
    IPR013581, PDR_assoc

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01061, ABC2_membrane, 2 hits
    PF19055, ABC2_membrane_7, 1 hit
    PF00005, ABC_tran, 2 hits
    PF14510, ABC_trans_N, 1 hit
    PF08370, PDR_assoc, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00382, AAA, 2 hits

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF52540, SSF52540, 2 hits

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50893, ABC_TRANSPORTER_2, 2 hits

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

    Q9M9E1-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MEGTSFHQAS NSMRRNSSVW KKDSGREIFS RSSREEDDEE ALRWAALEKL
    60 70 80 90 100
    PTFDRLRKGI LTASHAGGPI NEIDIQKLGF QDTKKLLERL IKVGDDEHEK
    110 120 130 140 150
    LLWKLKKRID RVGIDLPTIE VRFDHLKVEA EVHVGGRALP TFVNFISNFA
    160 170 180 190 200
    DKFLNTLHLV PNRKKKFTIL NDVSGIVKPG RMALLLGPPS SGKTTLLLAL
    210 220 230 240 250
    AGKLDQELKQ TGRVTYNGHG MNEFVPQRTA AYIGQNDVHI GEMTVRETFA
    260 270 280 290 300
    YAARFQGVGS RYDMLTELAR REKEANIKPD PDIDIFMKAM STAGEKTNVM
    310 320 330 340 350
    TDYILKILGL EVCADTMVGD DMLRGISGGQ KKRVTTGEML VGPSRALFMD
    360 370 380 390 400
    EISTGLDSST TYQIVNSLRN YVHIFNGTAL ISLLQPAPET FNLFDDIILI
    410 420 430 440 450
    AEGEIIYEGP RDHVVEFFET MGFKCPPRKG VADFLQEVTS KKDQMQYWAR
    460 470 480 490 500
    RDEPYRFIRV REFAEAFQSF HVGRRIGDEL ALPFDKTKSH PAALTTKKYG
    510 520 530 540 550
    VGIKELVKTS FSREYLLMKR NSFVYYFKFG QLLVMAFLTM TLFFRTEMQK
    560 570 580 590 600
    KTEVDGSLYT GALFFILMML MFNGMSELSM TIAKLPVFYK QRDLLFYPAW
    610 620 630 640 650
    VYSLPPWLLK IPISFMEAAL TTFITYYVIG FDPNVGRLFK QYILLVLMNQ
    660 670 680 690 700
    MASALFKMVA ALGRNMIVAN TFGAFAMLVF FALGGVVLSR DDIKKWWIWG
    710 720 730 740 750
    YWISPIMYGQ NAILANEFFG HSWSRAVENS SETLGVTFLK SRGFLPHAYW
    760 770 780 790 800
    YWIGTGALLG FVVLFNFGFT LALTFLNSLG KPQAVIAEEP ASDETELQSA
    810 820 830 840 850
    RSEGVVEAGA NKKRGMVLPF EPHSITFDNV VYSVDMPQEM IEQGTQEDRL
    860 870 880 890 900
    VLLKGVNGAF RPGVLTALMG VSGAGKTTLM DVLAGRKTGG YIDGNITISG
    910 920 930 940 950
    YPKNQQTFAR ISGYCEQTDI HSPHVTVYES LVYSAWLRLP KEVDKNKRKI
    960 970 980 990 1000
    FIEEVMELVE LTPLRQALVG LPGESGLSTE QRKRLTIAVE LVANPSIIFM
    1010 1020 1030 1040 1050
    DEPTSGLDAR AAAIVMRTVR NTVDTGRTVV CTIHQPSIDI FEAFDELFLL
    1060 1070 1080 1090 1100
    KRGGEEIYVG PLGHESTHLI NYFESIQGIN KITEGYNPAT WMLEVSTTSQ
    1110 1120 1130 1140 1150
    EAALGVDFAQ VYKNSELYKR NKELIKELSQ PAPGSKDLYF PTQYSQSFLT
    1160 1170 1180 1190 1200
    QCMASLWKQH WSYWRNPPYT AVRFLFTIGI ALMFGTMFWD LGGKTKTRQD
    1210 1220 1230 1240 1250
    LSNAMGSMYT AVLFLGLQNA ASVQPVVNVE RTVFYREQAA GMYSAMPYAF
    1260 1270 1280 1290 1300
    AQVFIEIPYV LVQAIVYGLI VYAMIGFEWT AVKFFWYLFF MYGSFLTFTF
    1310 1320 1330 1340 1350
    YGMMAVAMTP NHHIASVVSS AFYGIWNLFS GFLIPRPSMP VWWEWYYWLC
    1360 1370 1380 1390 1400
    PVAWTLYGLI ASQFGDITEP MADSNMSVKQ FIREFYGYRE GFLGVVAAMN
    1410 1420
    VIFPLLFAVI FAIGIKSFNF QKR
    Length:1,423
    Mass (Da):161,017
    Last modified:October 1, 2000 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB40CFF2797486D23
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A1P8AW07A0A1P8AW07_ARATH
    Pleiotropic drug resistance 12
    ABCG40 ATABCG40, ATP-binding cassette G40, ATPDR12, PDR12, PLEIOTROPIC DRUG RESISTANCE 12
    1,292Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

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    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AC013453 Genomic DNA Translation: AAF71978.1
    CP002684 Genomic DNA Translation: AEE29332.1
    BK001011 Genomic DNA Translation: DAA00880.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    A86289

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_173005.1, NM_101421.3

    Genome annotation databases

    Ensembl plant genome annotation project

    More...
    EnsemblPlantsi
    AT1G15520.1; AT1G15520.1; AT1G15520

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    838122

    Gramene; a comparative resource for plants

    More...
    Gramenei
    AT1G15520.1; AT1G15520.1; AT1G15520

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    ath:AT1G15520

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AC013453 Genomic DNA Translation: AAF71978.1
    CP002684 Genomic DNA Translation: AEE29332.1
    BK001011 Genomic DNA Translation: DAA00880.1
    PIRiA86289
    RefSeqiNP_173005.1, NM_101421.3

    3D structure databases

    SMRiQ9M9E1
    ModBaseiSearch...

    Protein-protein interaction databases

    STRINGi3702.AT1G15520.1

    Protein family/group databases

    TCDBi3.A.1.205.10, the atp-binding cassette (abc) superfamily

    PTM databases

    iPTMnetiQ9M9E1

    Proteomic databases

    PaxDbiQ9M9E1
    PRIDEiQ9M9E1
    ProteomicsDBi244393

    Genome annotation databases

    EnsemblPlantsiAT1G15520.1; AT1G15520.1; AT1G15520
    GeneIDi838122
    GrameneiAT1G15520.1; AT1G15520.1; AT1G15520
    KEGGiath:AT1G15520

    Organism-specific databases

    AraportiAT1G15520
    TAIRilocus:2196593, AT1G15520

    Phylogenomic databases

    eggNOGiKOG0065, Eukaryota
    HOGENOMiCLU_000604_35_6_1
    InParanoidiQ9M9E1
    OMAiGWEDRIP
    OrthoDBi324553at2759
    PhylomeDBiQ9M9E1

    Miscellaneous databases

    Protein Ontology

    More...
    PROi
    PR:Q9M9E1

    Gene expression databases

    ExpressionAtlasiQ9M9E1, baseline and differential
    GenevisibleiQ9M9E1, AT

    Family and domain databases

    CDDicd03232, ABCG_PDR_domain2, 1 hit
    InterProiView protein in InterPro
    IPR003593, AAA+_ATPase
    IPR013525, ABC_2_trans
    IPR029481, ABC_trans_N
    IPR003439, ABC_transporter-like
    IPR043926, ABCG_dom
    IPR034003, ABCG_PDR_2
    IPR027417, P-loop_NTPase
    IPR013581, PDR_assoc
    PfamiView protein in Pfam
    PF01061, ABC2_membrane, 2 hits
    PF19055, ABC2_membrane_7, 1 hit
    PF00005, ABC_tran, 2 hits
    PF14510, ABC_trans_N, 1 hit
    PF08370, PDR_assoc, 1 hit
    SMARTiView protein in SMART
    SM00382, AAA, 2 hits
    SUPFAMiSSF52540, SSF52540, 2 hits
    PROSITEiView protein in PROSITE
    PS50893, ABC_TRANSPORTER_2, 2 hits

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAB40G_ARATH
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9M9E1
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
    Last sequence update: October 1, 2000
    Last modified: April 7, 2021
    This is version 139 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families
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