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Entry version 106 (29 Sep 2021)
Sequence version 1 (01 Oct 2000)
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Protein

U11/U12 small nuclear ribonucleoprotein 48 kDa protein

Gene

SNRNP48

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Likely involved in U12-type 5' splice site recognition.

By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi101ZincPROSITE-ProRule annotation1
Metal bindingi107ZincPROSITE-ProRule annotation1
Metal bindingi117ZincPROSITE-ProRule annotation1
Metal bindingi121ZincPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri98 – 125CHHC U11-48K-typePROSITE-ProRule annotationAdd BLAST28

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein
Biological processmRNA processing, mRNA splicing
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
U11/U12 small nuclear ribonucleoprotein 48 kDa protein
Short name:
U11/U12 snRNP 48 kDa protein
Short name:
U11/U12-48K
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SNRNP48
Ordered Locus Names:At3g04160
ORF Names:T6K12.22
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT3G04160

The Arabidopsis Information Resource

More...
TAIRi
locus:2103030, AT3G04160

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus, Spliceosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004298291 – 712U11/U12 small nuclear ribonucleoprotein 48 kDa proteinAdd BLAST712

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9M8X2

PRoteomics IDEntifications database

More...
PRIDEi
Q9M8X2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
242605 [Q9M8X2-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9M8X2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9M8X2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9M8X2, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Not found in the major spliceosome (By similarity).

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT3G04160.2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni562 – 712DisorderedSequence analysisAdd BLAST151

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi564 – 586Polar residuesSequence analysisAdd BLAST23
Compositional biasi587 – 665Basic and acidic residuesSequence analysisAdd BLAST79
Compositional biasi675 – 693Basic and acidic residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The CHHC region interacts with the 5' splice site of the U12-type intron.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri98 – 125CHHC U11-48K-typePROSITE-ProRule annotationAdd BLAST28

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QSM9, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_367008_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
LIPCPFN

Database of Orthologous Groups

More...
OrthoDBi
1626841at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9M8X2

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032845, Snrnp48
IPR022776, TRM13/UPF0224_CHHC_Znf_dom

The PANTHER Classification System

More...
PANTHERi
PTHR21402:SF10, PTHR21402:SF10, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05253, zf-U11-48K, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51800, ZF_CHHC_U11_48K, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9M8X2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDRPPSLPHY QNPNPNLFYH YPPPNSNPNF FFRPPPPPLQ NPNNYSIVPS
60 70 80 90 100
PPPIRELSGT LSSLKSLLSE CQRTLDSLSQ NLALDHSSLL QKDENGCFVR
110 120 130 140 150
CPFDSNHFMP PEALFLHSLR CPNTLDLIHL LESFSSYRNT LELPCELQLN
160 170 180 190 200
NGDGDLCISL DDLADFGSNF FYRDCPGAVK FSELDGKKRT LTLPHVLSVE
210 220 230 240 250
CSDFVGSDEK VKKIVLDKCL GVLPSDLCAM KNEIDQWRDF PSSYSSSVLS
260 270 280 290 300
SIVGSKVVEI SALRKWILVN STRYGVIIDT FMRDHIFLLF RLCLKSAVKE
310 320 330 340 350
ACGFRMESDA TDVGEQKIMS CKSSTFECPV FIQVLSWLAS QLAVLYGEGN
360 370 380 390 400
GKFFALDMFK QCIVESASQV MLFRLEGTRS KCSGVVEDLD DARLRNKDVI
410 420 430 440 450
MEKPFENSSG GECGKTLDSP QVISVSRVSA AVAALYERSL LEEKIRAVRY
460 470 480 490 500
AQPLTRYQRA AELGFMTAKA DEERNRRCSY RPIIDHDGRP RQRSLNQDMD
510 520 530 540 550
KMKTREELLA EERDYKRRRM SYRGKKVKRT PRQVLHDMIE EYTEEIKLAG
560 570 580 590 600
GIGCFEKGMP LQSRSPIGND QKESDFGYSI PSTDKQWKGE NRADIEYPID
610 620 630 640 650
NRQNSDKVKR HDEYDSGSSQ RQQSHRSYKH SDRRDDKLRD RRKDKHNDRR
660 670 680 690 700
DDEFTRTKRH SIEGESYQNY RSSREKSSSD YKTKRDDPYD RRSQQPRNQN
710
LFEDRYIPTE KE
Length:712
Mass (Da):81,967
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1C5488FB93C46E3B
GO
Isoform 2 (identifier: Q9M8X2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     460-472: AAELGFMTAKADE → IISCLHLSLIPHDVS

Show »
Length:714
Mass (Da):82,261
Checksum:i5D4D80D45C84C194
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_055299460 – 472AAELG…AKADE → IISCLHLSLIPHDVS in isoform 2. CuratedAdd BLAST13

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC016829 Genomic DNA Translation: AAF26797.1
CP002686 Genomic DNA Translation: AEE74045.1
CP002686 Genomic DNA Translation: AEE74046.1
CP002686 Genomic DNA Translation: ANM64538.1

NCBI Reference Sequences

More...
RefSeqi
NP_001189804.1, NM_001202875.1 [Q9M8X2-2]
NP_001326557.1, NM_001337505.1 [Q9M8X2-1]
NP_187066.1, NM_111287.3 [Q9M8X2-1]

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT3G04160.1; AT3G04160.1; AT3G04160 [Q9M8X2-1]
AT3G04160.2; AT3G04160.2; AT3G04160 [Q9M8X2-2]
AT3G04160.3; AT3G04160.3; AT3G04160 [Q9M8X2-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
819571

Gramene; a comparative resource for plants

More...
Gramenei
AT3G04160.1; AT3G04160.1; AT3G04160 [Q9M8X2-1]
AT3G04160.2; AT3G04160.2; AT3G04160 [Q9M8X2-2]
AT3G04160.3; AT3G04160.3; AT3G04160 [Q9M8X2-1]

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT3G04160

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC016829 Genomic DNA Translation: AAF26797.1
CP002686 Genomic DNA Translation: AEE74045.1
CP002686 Genomic DNA Translation: AEE74046.1
CP002686 Genomic DNA Translation: ANM64538.1
RefSeqiNP_001189804.1, NM_001202875.1 [Q9M8X2-2]
NP_001326557.1, NM_001337505.1 [Q9M8X2-1]
NP_187066.1, NM_111287.3 [Q9M8X2-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi3702.AT3G04160.2

PTM databases

iPTMnetiQ9M8X2

Proteomic databases

PaxDbiQ9M8X2
PRIDEiQ9M8X2
ProteomicsDBi242605 [Q9M8X2-1]

Genome annotation databases

EnsemblPlantsiAT3G04160.1; AT3G04160.1; AT3G04160 [Q9M8X2-1]
AT3G04160.2; AT3G04160.2; AT3G04160 [Q9M8X2-2]
AT3G04160.3; AT3G04160.3; AT3G04160 [Q9M8X2-1]
GeneIDi819571
GrameneiAT3G04160.1; AT3G04160.1; AT3G04160 [Q9M8X2-1]
AT3G04160.2; AT3G04160.2; AT3G04160 [Q9M8X2-2]
AT3G04160.3; AT3G04160.3; AT3G04160 [Q9M8X2-1]
KEGGiath:AT3G04160

Organism-specific databases

AraportiAT3G04160
TAIRilocus:2103030, AT3G04160

Phylogenomic databases

eggNOGiENOG502QSM9, Eukaryota
HOGENOMiCLU_367008_0_0_1
OMAiLIPCPFN
OrthoDBi1626841at2759
PhylomeDBiQ9M8X2

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9M8X2

Gene expression databases

ExpressionAtlasiQ9M8X2, baseline and differential
GenevisibleiQ9M8X2, AT

Family and domain databases

InterProiView protein in InterPro
IPR032845, Snrnp48
IPR022776, TRM13/UPF0224_CHHC_Znf_dom
PANTHERiPTHR21402:SF10, PTHR21402:SF10, 1 hit
PfamiView protein in Pfam
PF05253, zf-U11-48K, 1 hit
PROSITEiView protein in PROSITE
PS51800, ZF_CHHC_U11_48K, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiU1148_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9M8X2
Secondary accession number(s): F4J3L0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 9, 2014
Last sequence update: October 1, 2000
Last modified: September 29, 2021
This is version 106 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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